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Aliases for FAM122B Gene

Aliases for FAM122B Gene

  • Family With Sequence Similarity 122B 2 3 5
  • Synoviocyte Proliferation Associated In Collagen-Induced Arthritis 2 3
  • Protein FAM122B 3
  • SPACIA2 3

External Ids for FAM122B Gene

Previous GeneCards Identifiers for FAM122B Gene

  • GC0XM133731
  • GC0XM133903
  • GC0XM123302

Summaries for FAM122B Gene

GeneCards Summary for FAM122B Gene

FAM122B (Family With Sequence Similarity 122B) is a Protein Coding gene. An important paralog of this gene is FAM122A.

Gene Wiki entry for FAM122B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM122B Gene

Genomics for FAM122B Gene

Regulatory Elements for FAM122B Gene

Enhancers for FAM122B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG134795 1 ENCODE 0.7 +0.4 435 2.2 ATF1 CREB3L1 ARID4B SIN3A DMAP1 GLI4 GLIS2 KDM4B ZNF263 SP3 RPL36AP54 FAM122C FAM122B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FAM122B on UCSC Golden Path with GeneCards custom track

Promoters for FAM122B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248975 232 1601 CREB3L1 ARID4B SIN3A DMAP1 GLI4 GLIS2 KDM4B ZNF263 SP3 NFYC

Genomic Location for FAM122B Gene

134,769,566 bp from pter
134,797,232 bp from pter
27,667 bases
Minus strand

Genomic View for FAM122B Gene

Genes around FAM122B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM122B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM122B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM122B Gene

Proteins for FAM122B Gene

  • Protein details for FAM122B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM122B
    Protein Accession:
    Secondary Accessions:
    • A8K902
    • Q6PIM2
    • Q6ZU47
    • Q6ZV64
    • Q6ZVE4
    • Q8TB75

    Protein attributes for FAM122B Gene

    247 amino acids
    Molecular mass:
    26928 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32419.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM122B Gene


neXtProt entry for FAM122B Gene

Post-translational modifications for FAM122B Gene

  • Isoform 3 and isoform 4 are phosphorylated on Ser-62 and Ser-64.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM122B Gene

Domains & Families for FAM122B Gene

Protein Domains for FAM122B Gene


Suggested Antigen Peptide Sequences for FAM122B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM122 family.
  • Belongs to the FAM122 family.
genes like me logo Genes that share domains with FAM122B: view

No data available for Gene Families for FAM122B Gene

Function for FAM122B Gene

genes like me logo Genes that share phenotypes with FAM122B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM122B Gene

Localization for FAM122B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM122B gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM122B Gene

Pathways & Interactions for FAM122B Gene

SuperPathways for FAM122B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM122B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM122B Gene

Drugs & Compounds for FAM122B Gene

No Compound Related Data Available

Transcripts for FAM122B Gene

Unigene Clusters for FAM122B Gene

Family with sequence similarity 122B:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM122B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP7: - - - - -
SP8: - -
SP9: - -

Relevant External Links for FAM122B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM122B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM122B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM122B Gene

This gene is overexpressed in Fetal testis (35.1), Testis (20.4), and Fetal ovary (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM122B Gene

Protein tissue co-expression partners for FAM122B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM122B Gene:


SOURCE GeneReport for Unigene cluster for FAM122B Gene:


Evidence on tissue expression from TISSUES for FAM122B Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with FAM122B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM122B Gene

Orthologs for FAM122B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM122B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM122B 35
  • 98 (a)
(Canis familiaris)
Mammalia FAM122B 34 35
  • 91.35 (n)
(Mus musculus)
Mammalia Fam122b 34 16 35
  • 87.31 (n)
(Rattus norvegicus)
Mammalia Fam122b 34
  • 87.31 (n)
(Ornithorhynchus anatinus)
Mammalia FAM122B 35
  • 83 (a)
(Monodelphis domestica)
Mammalia FAM122B 35
  • 77 (a)
(Bos Taurus)
Mammalia FAM122B 35
  • 76 (a)
(Gallus gallus)
Aves FAM122B 34 35
  • 78.2 (n)
(Anolis carolinensis)
Reptilia FAM122B 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC550042 34
  • 67.8 (n)
(Danio rerio)
Actinopterygii fam122b 35
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4497 35
  • 13 (a)
Species where no ortholog for FAM122B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM122B Gene

Gene Tree for FAM122B (if available)
Gene Tree for FAM122B (if available)

Paralogs for FAM122B Gene

Paralogs for FAM122B Gene

(4) SIMAP similar genes for FAM122B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM122B: view

Variants for FAM122B Gene

Sequence variations from dbSNP and Humsavar for FAM122B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000413629 -- 134,791,526(+) TGAGT(A/C)TGGAG intron-variant
rs1000636478 -- 134,774,386(+) CTCTT(C/T)GCTAC intron-variant
rs1000841775 -- 134,795,986(+) AAGTC(A/G)CCACC intron-variant, upstream-variant-2KB
rs1000928044 -- 134,796,848(+) GCACC(C/G)AGGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001022098 -- 134,794,195(+) CGCCC(C/T)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM122B Gene

Variant ID Type Subtype PubMed ID
dgv1323e201 CNV deletion 23290073
dgv1324e201 CNV deletion 23290073
esv2740487 CNV deletion 23290073
esv2740488 CNV deletion 23290073
esv2740489 CNV deletion 23290073

Variation tolerance for FAM122B Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM122B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM122B Gene

Disorders for FAM122B Gene

Relevant External Links for FAM122B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FAM122B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM122B Gene

Publications for FAM122B Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for FAM122B Gene

Sources for FAM122B Gene

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