Aliases for FAM122B Gene
Aliases for FAM122B Gene
External Ids for FAM122B Gene
- HGNC: 30490
- Entrez Gene: 159090
- Ensembl: ENSG00000156504
- UniProtKB: Q7Z309
Previous GeneCards Identifiers for FAM122B Gene
- GC0XM133731
- GC0XM133903
- GC0XM123302
Summaries for FAM122B Gene
GeneCards Summary for FAM122B Gene
FAM122B (Family With Sequence Similarity 122B) is a Protein Coding gene. An important paralog of this gene is FAM122C.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM122B Gene
Genomics for FAM122B Gene
Regulatory Elements for FAM122B Gene
Enhancers for FAM122B Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around FAM122B on UCSC Golden Path with GeneCards custom track
Promoters for FAM122B Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around FAM122B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FAM122B Gene
- Chromosome:
- X
- Start:
- 134,769,566 bp from pter
- End:
- 134,797,232 bp from pter
- Size:
- 27,667 bases
- Orientation:
- Minus strand
Genomic View for FAM122B Gene
Genes around FAM122B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq26.3 by Ensembl
- Xq26.3 by Entrez Gene
- Xq26.3 by HGNC
FAM122B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM122B Gene
Proteins for FAM122B Gene
-
Protein details for FAM122B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z309-F122B_HUMAN
- Recommended name:
- Protein FAM122B
- Protein Accession:
- Q7Z309
- A8K902
- Q6PIM2
- Q6ZU47
- Q6ZV64
- Q6ZVE4
- Q8TB75
Protein attributes for FAM122B Gene
- Size:
- 247 amino acids
- Molecular mass:
- 26928 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH32419.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FAM122B Gene
Post-translational modifications for FAM122B Gene
- Isoform 3 and isoform 4 are phosphorylated on Ser-62 and Ser-64.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FAM122B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FAM122B
- Novus Biologicals Antibodies for FAM122B
- Invitrogen Antibodies for FAM122B
- GeneTex FAM122B antibody for FAM122B
-
Santa Cruz Biotechnology (SCBT) Antibodies for FAM122B
Protein Products
-
OriGene Purified Proteins for FAM122B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM122B
- Origene Custom Protein Services for FAM122B
- Search GeneTex for Proteins for FAM122B
Assay Products
No data available for DME Specific Peptides for FAM122B Gene
Domains & Families for FAM122B Gene
Suggested Antigen Peptide Sequences for FAM122B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7Z309- Family:
-
- Belongs to the FAM122 family.
No data available for Gene Families for FAM122B Gene
Function for FAM122B Gene
Phenotypes for FAM122B Gene
- MGI mutant phenotypes for FAM122B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FAM122B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for FAM122B
CRISPR Products
-
OriGene CRISPR knockouts for FAM122B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM122B
- GenScript: Design CRISPR guide RNA sequences for FAM122B
miRNA for FAM122B Gene
- miRTarBase miRNAs that target FAM122B
-
- hsa-mir-425-5p (MIRT016650)
- hsa-mir-124-3p (MIRT022784)
- hsa-mir-103a-3p (MIRT027061)
- hsa-mir-16-5p (MIRT031788)
- hsa-mir-877-3p (MIRT036810)
- hsa-mir-877-5p (MIRT037269)
- hsa-mir-3148 (MIRT502491)
- hsa-mir-3610 (MIRT502492)
- hsa-mir-144-3p (MIRT502493)
- hsa-mir-548e-5p (MIRT502494)
- hsa-mir-6838-5p (MIRT502495)
- hsa-mir-15a-5p (MIRT502496)
- hsa-mir-497-5p (MIRT502497)
- hsa-mir-424-5p (MIRT502498)
- hsa-mir-195-5p (MIRT502499)
- hsa-mir-15b-5p (MIRT502500)
- hsa-mir-891a-3p (MIRT558003)
- hsa-mir-3688-5p (MIRT558004)
- hsa-mir-299-3p (MIRT558005)
- hsa-mir-4491 (MIRT558006)
- hsa-mir-4657 (MIRT558007)
miRNA Products
- Search ViGene Biosciences for FAM122B
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FAM122B
- Browse OriGene Inhibitory RNA Products For FAM122B
Clone Products
- OriGene clones in human for FAM122B
- OriGene ORF clones in human,mouse,rat for FAM122B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM122B Gene
Localization for FAM122B Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM122B Gene
Pathways & Interactions for FAM122B Gene
More details on SuperPathways for FAM122B
No Data Available
Interacting Proteins for FAM122B Gene
No data available for Pathways by source and SIGNOR curated interactions for FAM122B Gene
Transcripts for FAM122B Gene
mRNA/cDNA for FAM122B Gene
- (21) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (150) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FAM122B Gene
- Family with sequence similarity 122B:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for FAM122B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM122B
- GenScript: Design CRISPR guide RNA sequences for FAM122B
miRNA Products
- Search ViGene Biosciences for FAM122B
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FAM122B
- Browse OriGene Inhibitory RNA Products For FAM122B
Clone Products
- OriGene clones in human for FAM122B
- OriGene ORF clones in human,mouse,rat for FAM122B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Expression for FAM122B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Fetal testis (35.1), Testis (20.4), and Fetal ovary (13.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM122B Gene
SOURCE GeneReport for Unigene cluster for FAM122B Gene Hs.404706
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for FAM122B
-
OriGene qPCR primer pairs and template standards for FAM122B
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FAM122B Gene
Orthologs for FAM122B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | FAM122B 35 |
|
||
| FAM122B 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Fam122b 35 |
|
||
| Fam122b 16 |
|
||||
| Fam122b 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Fam122b 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM122B 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FAM122B 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM122B 36 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | FAM122B 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM122B 35 |
|
||
| FAM122B 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | FAM122B 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC550042 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fam122b 36 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG4497 36 |
|
OneToMany |
- Species with no ortholog for FAM122B:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FAM122B Gene
(4) SIMAP similar genes for FAM122B Gene using alignment to 1 proteins:
Variants for FAM122B Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs747759268 | -- | 134,792,037(+) | TCATT(C/T)GTAAA | intron-variant | |
| rs747800984 | -- | 134,786,344(+) | AACTC(-/T)TATCT | intron-variant | |
| rs747852154 | -- | 134,788,199(+) | CACGT(-/TA)TATAT | intron-variant | |
| rs747978922 | -- | 134,794,116(+) | TGGTC(-/G)GGGGG | intron-variant | |
| rs748004636 | -- | 134,778,915(+) | TCACG(A/C)CATTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740487 | CNV | Deletion | 23290073 |
| esv2740488 | CNV | Deletion | 23290073 |
| esv2740489 | CNV | Deletion | 23290073 |
| dgv1381e201 | CNV | Deletion | 23290073 |
| dgv1382e201 | CNV | Deletion | 23290073 |
Residual Variation Intolerance Score:
66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.57;
12.29% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FAM122B Gene
Disorders for FAM122B Gene
Relevant External Links for FAM122B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FAM122B
No disorders were found for FAM122B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM122B Gene
Publications for FAM122B Gene
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 67
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
Products for FAM122B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Custom Antibody ServicesOriGene Antibodies for FAM122B
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- Custom Assay Services
- OriGene Purified Proteins for FAM122B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM122B
- Origene Custom Protein Services for FAM122B
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for FAM122B
- Browse OriGene Inhibitory RNA Products For FAM122B
- OriGene qPCR primer pairs for FAM122B
- OriGene qPCR primer pairs and template standards for FAM122B
- OriGene CRISPR knockouts for FAM122B
- OriGene clones in human for FAM122B
- OriGene ORF clones in human,mouse,rat for FAM122B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for FAM122B
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- GenScript Custom overexpressing Cell Line Services for FAM122B
- GenScript: Design CRISPR guide RNA sequences for FAM122B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FAM122B
- Novus Biologicals Antibodies for FAM122B
- Novus Biologicals proteins and lysates for FAM122B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Search ViGene Biosciences for FAM122B
- Search ViGene Biosciences for FAM122B
- Santa Cruz Biotechnology (SCBT) Antibodies for FAM122B
- Search Santa Cruz Biotechnology (SCBT) for FAM122B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FAM122B
Sources for FAM122B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon