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Aliases for CYP8B1 Gene

Aliases for CYP8B1 Gene

  • Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 2 3
  • CYP12 3 4 6
  • Cytochrome P450, Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase), Polypeptide 1 2 3
  • 7-Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase 3 4
  • Sterol 12-Alpha-Hydroxylase 3 4
  • Cytochrome P450 8B1 3 4
  • CYPVIIIB1 3 4
  • 7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase 3
  • 7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase 3
  • EC 1.14.13.95 4
  • CP8B 3

External Ids for CYP8B1 Gene

Summaries for CYP8B1 Gene

Entrez Gene Summary for CYP8B1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP8B1 Gene

CYP8B1 (Cytochrome P450, Family 8, Subfamily B, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP7B1.

UniProtKB/Swiss-Prot for CYP8B1 Gene

  • Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids

Gene Wiki entry for CYP8B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP8B1 Gene

Genomics for CYP8B1 Gene

Genomic Location for CYP8B1 Gene

Start:
42,856,005 bp from pter
End:
42,876,165 bp from pter
Size:
20,161 bases
Orientation:
Minus strand

Genomic View for CYP8B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP8B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP8B1 Gene

Regulatory Elements for CYP8B1 Gene

Proteins for CYP8B1 Gene

  • Protein details for CYP8B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNU6-CP8B1_HUMAN
    Recommended name:
    7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
    Protein Accession:
    Q9UNU6
    Secondary Accessions:
    • B2RCY3
    • O75958
    • Q6NWT2
    • Q6NWT3

    Protein attributes for CYP8B1 Gene

    Size:
    501 amino acids
    Molecular mass:
    58068 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP8B1 Gene

Proteomics data for CYP8B1 Gene at MOPED

Post-translational modifications for CYP8B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP8B1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP8B1 Gene

Domains for CYP8B1 Gene

Gene Families for CYP8B1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP8B1 Gene

Suggested Antigen Peptide Sequences for CYP8B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNU6

UniProtKB/Swiss-Prot:

CP8B1_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • Q9UNU6
genes like me logo Genes that share domains with CYP8B1: view

Function for CYP8B1 Gene

Molecular function for CYP8B1 Gene

GENATLAS Biochemistry: cytochrome P450 subfamily VIIIB polypeptide 1,hepatic microsomal enzyme,involved in bile synthesis,controlling the ratio of cholic acid over chenodeoxycholic cholic acid in bile
UniProtKB/Swiss-Prot CatalyticActivity: 7-alpha-hydroxycholest-4-en-3-one + NADPH + O(2) = 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function: Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids

Enzyme Numbers (IUBMB) for CYP8B1 Gene

Gene Ontology (GO) - Molecular Function for CYP8B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding IEA --
GO:0008397 sterol 12-alpha-hydroxylase activity IBA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0019825 oxygen binding TAS 10051404
genes like me logo Genes that share ontologies with CYP8B1: view
genes like me logo Genes that share phenotypes with CYP8B1: view

Animal Models for CYP8B1 Gene

MGI Knock Outs for CYP8B1:

miRNA for CYP8B1 Gene

miRTarBase miRNAs that target CYP8B1

No data available for Transcription Factor Targeting and HOMER Transcription for CYP8B1 Gene

Localization for CYP8B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP8B1 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP8B1 Gene COMPARTMENTS Subcellular localization image for CYP8B1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
nucleus 2
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP8B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP8B1: view

Pathways for CYP8B1 Gene

genes like me logo Genes that share pathways with CYP8B1: view

Interacting Proteins for CYP8B1 Gene

Gene Ontology (GO) - Biological Process for CYP8B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IBA --
GO:0006699 bile acid biosynthetic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008206 bile acid metabolic process TAS --
GO:0016125 sterol metabolic process TAS --
genes like me logo Genes that share ontologies with CYP8B1: view

Compounds for CYP8B1 Gene

(3) HMDB Compounds for CYP8B1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6

(4) Novoseek inferred chemical compound relationships for CYP8B1 Gene

Compound -log(P) Hits PubMed IDs
cholic acid 88.2 7
chenodeoxycholic acid 87.2 2
sterol 78.3 11
cholesterol 52 6
genes like me logo Genes that share compounds with CYP8B1: view

Transcripts for CYP8B1 Gene

mRNA/cDNA for CYP8B1 Gene

Unigene Clusters for CYP8B1 Gene

Cytochrome P450, family 8, subfamily B, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP8B1 Gene

No ASD Table

Relevant External Links for CYP8B1 Gene

GeneLoc Exon Structure for
CYP8B1
ECgene alternative splicing isoforms for
CYP8B1

Expression for CYP8B1 Gene

mRNA expression in normal human tissues for CYP8B1 Gene

mRNA differential expression in normal tissues according to GTEx for CYP8B1 Gene

This gene is overexpressed in Liver (50.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP8B1 Gene

SOURCE GeneReport for Unigene cluster for CYP8B1 Gene Hs.447793

mRNA Expression by UniProt/SwissProt for CYP8B1 Gene

Q9UNU6-CP8B1_HUMAN
Tissue specificity: Liver
genes like me logo Genes that share expressions with CYP8B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CYP8B1 Gene

Orthologs for CYP8B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP8B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP8B1 36
  • 99 (a)
OneToOne
LOC736962 35
  • 99.53 (n)
  • 98.8 (a)
cow
(Bos Taurus)
Mammalia CYP8B1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP8B1 36
  • 81 (a)
OneToOne
LOC485619 35
  • 83.57 (n)
  • 80.84 (a)
mouse
(Mus musculus)
Mammalia Cyp8b1 35
  • 79 (n)
  • 75 (a)
Cyp8b1 16
Cyp8b1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cyp8b1 35
  • 79.56 (n)
  • 74.55 (a)
chicken
(Gallus gallus)
Aves CYP8B1 35
  • 59.39 (n)
  • 54.55 (a)
lizard
(Anolis carolinensis)
Reptilia CYP8B1 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64456 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488168 35
  • 59.57 (n)
  • 56.02 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1855 35
zebrafish
(Danio rerio)
Actinopterygii cyp8b1 35
  • 58.74 (n)
  • 52.87 (a)
cyp8b1 36
  • 50 (a)
OneToMany
cyp8b2 36
  • 49 (a)
OneToMany
cyp8b3 36
  • 50 (a)
OneToMany
wufk74d09 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
CSA.4049 36
  • 33 (a)
ManyToMany
Species with no ortholog for CYP8B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP8B1 Gene

ENSEMBL:
Gene Tree for CYP8B1 (if available)
TreeFam:
Gene Tree for CYP8B1 (if available)

Paralogs for CYP8B1 Gene

Paralogs for CYP8B1 Gene

Selected SIMAP similar genes for CYP8B1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CYP8B1: view

Variants for CYP8B1 Gene

Sequence variations from dbSNP and Humsavar for CYP8B1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs734969 -- 42,876,414(+) GCTGT(C/T)GTGAG upstream-variant-2KB
rs735320 -- 42,874,386(-) GACCC(A/G)CAGCG synonymous-codon, reference
rs741817 -- 42,875,019(-) CAGGG(G/T)GTACC reference, synonymous-codon
rs760193 -- 42,876,805(-) CCCAA(A/G)ATGGA upstream-variant-2KB
rs760194 -- 42,876,746(-) GCATC(A/G)ATGCC upstream-variant-2KB

Relevant External Links for CYP8B1 Gene

HapMap Linkage Disequilibrium report
CYP8B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYP8B1 Gene

Disorders for CYP8B1 Gene

Relevant External Links for CYP8B1

Genetic Association Database (GAD)
CYP8B1
Human Genome Epidemiology (HuGE) Navigator
CYP8B1
genes like me logo Genes that share disorders with CYP8B1: view

No data available for UniProtKB/Swiss-Prot for CYP8B1 Gene

Publications for CYP8B1 Gene

  1. Structure and chromosomal assignment of the sterol 12alpha- hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P- 450 gene devoid of introns. (PMID: 10051404) Gaafvels M. … Eggertsen G. (Genomics 1999) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression. (PMID: 11535594) Zhang M. … Chiang J.Y. (J. Biol. Chem. 2001) 3 23
  4. Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes. (PMID: 16937432) Ellis E.C. (World J. Gastroenterol. 2006) 3 23
  5. Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones. (PMID: 17585019) Li Y. … Shay N.F. (J. Nutr. 2007) 3 23

Products for CYP8B1 Gene

Sources for CYP8B1 Gene

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