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Aliases for CYP4B1 Gene

Aliases for CYP4B1 Gene

  • Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily IVB, Polypeptide 1 2 3
  • Cytochrome P450-HP 3 4
  • EC 1.14.14.1 4 63
  • CYPIVB1 3 4
  • Microsomal Monooxygenase 3
  • Cytochrome P450 4B1 3
  • P-450HP 3

External Ids for CYP4B1 Gene

Previous GeneCards Identifiers for CYP4B1 Gene

  • GC01P046958
  • GC01P046221
  • GC01P046651
  • GC01P046634
  • GC01P046976
  • GC01P047037
  • GC01P047264
  • GC01P045380
  • GC01P047227

Summaries for CYP4B1 Gene

Entrez Gene Summary for CYP4B1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP4B1 Gene

CYP4B1 (Cytochrome P450, Family 4, Subfamily B, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP4F12.

UniProtKB/Swiss-Prot for CYP4B1 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP4B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP4B1 Gene

Genomics for CYP4B1 Gene

Regulatory Elements for CYP4B1 Gene

Genomic Location for CYP4B1 Gene

Start:
46,757,838 bp from pter
End:
46,819,413 bp from pter
Size:
61,576 bases
Orientation:
Plus strand

Genomic View for CYP4B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP4B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP4B1 Gene

Proteins for CYP4B1 Gene

  • Protein details for CYP4B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13584-CP4B1_HUMAN
    Recommended name:
    Cytochrome P450 4B1
    Protein Accession:
    P13584
    Secondary Accessions:
    • Q1HBI2
    • Q8TD85
    • Q8WWF2
    • Q8WWU9
    • Q8WWV0

    Protein attributes for CYP4B1 Gene

    Size:
    511 amino acids
    Molecular mass:
    58991 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP4B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP4B1 Gene

Proteomics data for CYP4B1 Gene at MOPED

Selected DME Specific Peptides for CYP4B1 Gene

Post-translational modifications for CYP4B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for CYP4B1 Gene

Gene Families for CYP4B1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP4B1 Gene

Suggested Antigen Peptide Sequences for CYP4B1 Gene

Graphical View of Domain Structure for InterPro Entry

P13584

UniProtKB/Swiss-Prot:

CP4B1_HUMAN :
  • P13584
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP4B1: view

Function for CYP4B1 Gene

Molecular function for CYP4B1 Gene

GENATLAS Biochemistry: cytochrome P450,subfamily IVB1,expressed in lung
UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
UniProtKB/Swiss-Prot Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens

Enzyme Numbers (IUBMB) for CYP4B1 Gene

Gene Ontology (GO) - Molecular Function for CYP4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding IEA --
GO:0008144 drug binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0018585 fluorene oxygenase activity IEA --
genes like me logo Genes that share ontologies with CYP4B1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP4B1 Gene

Localization for CYP4B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP4B1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP4B1 Gene COMPARTMENTS Subcellular localization image for CYP4B1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 2
peroxisome 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with CYP4B1: view

Pathways for CYP4B1 Gene

genes like me logo Genes that share pathways with CYP4B1: view

Gene Ontology (GO) - Biological Process for CYP4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006725 cellular aromatic compound metabolic process --
GO:0006805 xenobiotic metabolic process TAS --
GO:0018879 biphenyl metabolic process IEA --
GO:0018917 fluorene metabolic process IEA --
GO:0042738 exogenous drug catabolic process IEA --
genes like me logo Genes that share ontologies with CYP4B1: view

Compounds for CYP4B1 Gene

(49) HMDB Compounds for CYP4B1 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(3) Drugbank Compounds for CYP4B1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Midazolam
  • Dea No. 2884
59467-70-8 enzyme substrate
Phenobarbital
  • Fenobarbital
50-06-6 enzyme inducer
Thiamine
  • Thiadoxine
59-43-8 enzyme inducer

(5) Novoseek inferred chemical compound relationships for CYP4B1 Gene

Compound -log(P) Hits PubMed IDs
4-ipomeanol 91.7 5
2-aminofluorene 84.7 5
3-methylindole 76.9 1
2-aminoanthracene 73 3
lauric acid 63.6 2

(2) PharmGKB related drug/compound annotations for CYP4B1 Gene

Drug/compound Annotation
docetaxel CA
thalidomide CA
genes like me logo Genes that share compounds with CYP4B1: view

Transcripts for CYP4B1 Gene

Unigene Clusters for CYP4B1 Gene

Cytochrome P450, family 4, subfamily B, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP4B1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for CYP4B1 Gene

GeneLoc Exon Structure for
CYP4B1
ECgene alternative splicing isoforms for
CYP4B1

Expression for CYP4B1 Gene

mRNA expression in normal human tissues for CYP4B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP4B1 Gene

This gene is overexpressed in Nerve - Tibial (6.8), Lung (5.2), Bladder (4.8), Adipose - Visceral (Omentum) (4.3), and Adipose - Subcutaneous (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP4B1 Gene

SOURCE GeneReport for Unigene cluster for CYP4B1 Gene Hs.436317

mRNA Expression by UniProt/SwissProt for CYP4B1 Gene

P13584-CP4B1_HUMAN
Tissue specificity: Detected in the liver and lung (at protein level).
genes like me logo Genes that share expressions with CYP4B1: view

Orthologs for CYP4B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP4B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP4B1 36
  • 98 (a)
OneToOne
LOC456557 35
  • 99.4 (n)
  • 98.71 (a)
cow
(Bos Taurus)
Mammalia CYP4B1 35
  • 84.67 (n)
  • 82.78 (a)
CYP4B1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP4B1 35
  • 87.28 (n)
  • 86.89 (a)
CYP4B1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp4b1 35
  • 86.14 (n)
  • 85.74 (a)
Cyp4b1 16
Cyp4b1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP4B1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYP4B1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp4b1 35
  • 86.48 (n)
  • 86.55 (a)
chicken
(Gallus gallus)
Aves LOC771974 35
  • 65.17 (n)
  • 59.71 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487918 35
  • 60.61 (n)
  • 57.14 (a)
zebrafish
(Danio rerio)
Actinopterygii cyp4t8 35
  • 57.89 (n)
  • 51.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp4ae1 37
  • 34 (a)
Cyp4d2 37
  • 37 (a)
Cyp4e3 37
  • 28 (a)
Cyp4d8 37
  • 35 (a)
Cyp4s3 37
  • 34 (a)
Cyp4p1 37
  • 30 (a)
Cyp313a1 37
  • 26 (a)
Cyp4aa1 37
  • 27 (a)
Cyp4d1 37
  • 33 (a)
Cyp313b1 37
  • 24 (a)
Cyp4d20 37
  • 32 (a)
Cyp4c3 37
  • 33 (a)
Cyp4e1 37
  • 29 (a)
Cyp311a1 37
  • 30 (a)
Cyp4g1 37
  • 29 (a)
Cyp4p2 37
  • 30 (a)
Cyp4ac1 37
  • 30 (a)
Cyp4ad1 37
  • 27 (a)
Cyp4d14 37
  • 35 (a)
Cyp4g15 37
  • 35 (a)
Cyp312a1 37
  • 28 (a)
Cyp4p3 37
  • 29 (a)
Cyp4e2 37
  • 30 (a)
Cyp4ac2 37
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea F01D5.9 37
  • 36 (a)
Y80D3A.5 37
  • 32 (a)
F28G4.1 37
  • 32 (a)
C26F1.2 37
  • 29 (a)
Y17G9B.3 37
  • 32 (a)
Y5H2B.5 37
  • 32 (a)
B0331.1 37
  • 31 (a)
Y38C9B.1 37
  • 34 (a)
Species with no ortholog for CYP4B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP4B1 Gene

ENSEMBL:
Gene Tree for CYP4B1 (if available)
TreeFam:
Gene Tree for CYP4B1 (if available)

Paralogs for CYP4B1 Gene

genes like me logo Genes that share paralogs with CYP4B1: view

Variants for CYP4B1 Gene

Sequence variations from dbSNP and Humsavar for CYP4B1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs590582 -- 46,800,957(-) TAATG(C/G)GGCTA intron-variant
rs632133 -- 46,798,823(-) AACAG(G/T)CAATG upstream-variant-2KB
rs632233 -- 46,798,533(-) GGCTC(A/G)CAATG upstream-variant-2KB
rs632645 -- 46,798,461(-) CCAGG(C/T)CAGAA upstream-variant-2KB
rs634431 -- 46,798,019(-) AACAG(C/T)GGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYP4B1 Gene

Variant ID Type Subtype PubMed ID
nsv870792 CNV Gain 21882294
nsv870538 CNV Gain 21882294

Relevant External Links for CYP4B1 Gene

HapMap Linkage Disequilibrium report
CYP4B1
Human Gene Mutation Database (HGMD)
CYP4B1
Locus Specific Mutation Databases (LSDB)
CYP4B1
The Human Cytochrome P450 Allele Nomenclature Database
CYP4B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP4B1 Gene

Disorders for CYP4B1 Gene

(6) Novoseek inferred disease relationships for CYP4B1 Gene

Disease -log(P) Hits PubMed IDs
bladder tumors 36.6 2
bladder cancer 31.4 6
glioma 13 1
cancer lung 0 1
tumors 0 5

Relevant External Links for CYP4B1

Genetic Association Database (GAD)
CYP4B1
Human Genome Epidemiology (HuGE) Navigator
CYP4B1
genes like me logo Genes that share disorders with CYP4B1: view

No data available for UniProtKB/Swiss-Prot for CYP4B1 Gene

Publications for CYP4B1 Gene

  1. Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. (PMID: 12142726) Lo-Guidice J.-M. … Broly F. (Pharmacogenetics 2002) 3 4 23 48
  2. Human CYP4B1 gene in the japanese population analyzed by denaturing HPLC. (PMID: 15499177) Hiratsuka M. … Mizugaki M. (Drug Metab. Pharmacokinet. 2004) 3 48
  3. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 48
  4. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A. … Campo E. (Cancer Res. 2008) 3 48
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 48

Products for CYP4B1 Gene

Sources for CYP4B1 Gene

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