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Aliases for CYP3A4 Gene

Aliases for CYP3A4 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 4 2 3 5
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4 2 3
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 2 3
  • Taurochenodeoxycholate 6-Alpha-Hydroxylase 3 4
  • 1,8-Cineole 2-Exo-Monooxygenase 3 4
  • Cholesterol 25-Hydroxylase 3 4
  • Albendazole Monooxygenase 3 4
  • Albendazole Sulfoxidase 3 4
  • Quinine 3-Monooxygenase 3 4
  • Cytochrome P450 NF-25 3 4
  • Cytochrome P450-PCN1 3 4
  • Cytochrome P450 3A3 3 4
  • Cytochrome P450 HLp 3 4
  • Nifedipine Oxidase 3 4
  • EC 1.14.14.1 4 63
  • CYPIIIA3 3 4
  • CYPIIIA4 3 4
  • CYP3A3 3 4
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3 3
  • Glucocorticoid-Inducible P450 3
  • P450-III, Steroid Inducible 3
  • EC 1.14.13.157 4
  • EC 1.14.13.32 4
  • EC 1.14.13.67 4
  • EC 1.14.13.97 4
  • EC 1.14.13.- 4
  • P450PCN1 3
  • P450C3 3
  • CYP3A 3
  • NF-25 3
  • CP33 3
  • CP34 3
  • HLP 3

External Ids for CYP3A4 Gene

Previous HGNC Symbols for CYP3A4 Gene

  • CYP3A3

Previous GeneCards Identifiers for CYP3A4 Gene

  • GC07M097889
  • GC07M098952
  • GC07M098967
  • GC07M098968
  • GC07M098892
  • GC07M098999
  • GC07M099192
  • GC07M099355
  • GC07M093991

Summaries for CYP3A4 Gene

Entrez Gene Summary for CYP3A4 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]

GeneCards Summary for CYP3A4 Gene

CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4) is a Protein Coding gene. Diseases associated with CYP3A4 include cyp3a4-related altered drug metabolism and exfoliative dermatitis. Among its related pathways are Bile secretion and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP3A4 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).

Tocris Summary for CYP3A4 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

Gene Wiki entry for CYP3A4 Gene

PharmGKB "VIP" Summary for CYP3A4 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for CYP3A4 Gene

Genomics for CYP3A4 Gene

Regulatory Elements for CYP3A4 Gene

Enhancers for CYP3A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP3A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP3A4 Gene

Chromosome:
7
Start:
99,756,960 bp from pter
End:
99,784,265 bp from pter
Size:
27,306 bases
Orientation:
Minus strand

Genomic View for CYP3A4 Gene

Genes around CYP3A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A4 Gene

Proteins for CYP3A4 Gene

  • Protein details for CYP3A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08684-CP3A4_HUMAN
    Recommended name:
    Cytochrome P450 3A4
    Protein Accession:
    P08684
    Secondary Accessions:
    • P05184
    • Q16757
    • Q9UK50

    Protein attributes for CYP3A4 Gene

    Size:
    503 amino acids
    Molecular mass:
    57343 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).

    Three dimensional structures from OCA and Proteopedia for CYP3A4 Gene

neXtProt entry for CYP3A4 Gene

Proteomics data for CYP3A4 Gene at MOPED

Post-translational modifications for CYP3A4 Gene

  • Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CYP3A4 (CYP3A4)

Domains & Families for CYP3A4 Gene

Gene Families for CYP3A4 Gene

Graphical View of Domain Structure for InterPro Entry

P08684

UniProtKB/Swiss-Prot:

CP3A4_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A4: view

Function for CYP3A4 Gene

Molecular function for CYP3A4 Gene

GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 4 (niphedipine oxidase);highly expressed in the liver,see CYP3A@,with a significant association of the wild type enzyme with epipodophyllotoxin-induced leukemogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
1,8-cineole + NADPH + O(2) = 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).
UniProtKB/Swiss-Prot Induction:
By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene Ontology (GO) - Molecular Function for CYP3A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS --
GO:0005496 steroid binding IDA 15256616
GO:0019825 oxygen binding TAS --
GO:0030343 vitamin D3 25-hydroxylase activity IDA 15546903
GO:0034875 caffeine oxidase activity IDA 18619574
genes like me logo Genes that share ontologies with CYP3A4: view
genes like me logo Genes that share phenotypes with CYP3A4: view

Animal Model Products

CRISPR Products

miRNA for CYP3A4 Gene

miRTarBase miRNAs that target CYP3A4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP3A4 Gene

Localization for CYP3A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A4 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP3A4 Gene COMPARTMENTS Subcellular localization image for CYP3A4 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytoskeleton 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CYP3A4 Gene

Pathways & Interactions for CYP3A4 Gene

SuperPathways for CYP3A4 Gene

Superpath Contained pathways
1 Metabolism of xenobiotics by cytochrome P450
2 Paroxetine Pathway, Pharmacokinetics
3 Gefitinib Pathway, Pharmacokinetics
4 Statin Pathway - Generalized, Pharmacokinetics
5 Phenytoin Pathway, Pharmacokinetics
genes like me logo Genes that share pathways with CYP3A4: view

Gene Ontology (GO) - Biological Process for CYP3A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008209 androgen metabolic process TAS 19651758
GO:0016098 monoterpenoid metabolic process IDA 16401082
GO:0036378 calcitriol biosynthetic process from calciol IDA 15546903
GO:0042359 vitamin D metabolic process IC 15546903
genes like me logo Genes that share ontologies with CYP3A4: view

No data available for SIGNOR curated interactions for CYP3A4 Gene

Drugs & Compounds for CYP3A4 Gene

(763) Drugs for CYP3A4 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omeprazole Approved, Investigational Pharma Activator, Enzyme, substrate, inhibitor, inducer H+,K+-ATPase inhibitor 327
Carbamazepine Approved, Investigational Pharma Enzyme, substrate, inducer 128
Clarithromycin Approved Pharma Target, Enzyme, substrate, inhibitor, inducer 252
Docetaxel Approved May 1996, Investigational Pharma Enzyme, substrate, inhibitor Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Fluvoxamine Approved, Investigational Pharma Enzyme, inhibitor 46

(119) Additional Compounds for CYP3A4 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Hydroxyquinine
  • 3-Hydroxyquinidine
  • 6'-Methoxycinchonan-3,9-diol
53467-23-5
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Paraxanthine
  • 1,7-Dimethyl-Xanthine
  • 1,7-Dimethylxanthine
611-59-6
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0

(5) Tocris Compounds for CYP3A4 Gene

Compound Action Cas Number
Ketoconazole Cytochrome P450c17 inhibitor 65277-42-1
Liarozole dihydrochloride Blocks retinoic acid metabolism
Omeprazole H+,K+-ATPase inhibitor 73590-58-6
TMS Cytochrome P450 1B1 inhibitor 24144-92-1
YM 511 Potent aromatase (CYP19) inhibitor 148869-05-0

(5) ApexBio Compounds for CYP3A4 Gene

Compound Action Cas Number
8-Methoxypsoralen CYP inhibitor 298-81-7
Alizarin Biological stain 72-48-0
Clarithromycin 81103-11-9
Cobicistat (GS-9350) Selective CYP3A inhibitor 1004316-88-4
PF-4981517 CYP3A4 inhibitor,potent and selective 1390637-82-7
genes like me logo Genes that share compounds with CYP3A4: view

Transcripts for CYP3A4 Gene

Unigene Clusters for CYP3A4 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A4 Gene

No ASD Table

Relevant External Links for CYP3A4 Gene

GeneLoc Exon Structure for
CYP3A4
ECgene alternative splicing isoforms for
CYP3A4

Expression for CYP3A4 Gene

mRNA expression in normal human tissues for CYP3A4 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A4 Gene

This gene is overexpressed in Liver (x43.8) and Small Intestine - Terminal Ileum (x6.9).

Protein differential expression in normal tissues from HIPED for CYP3A4 Gene

This gene is overexpressed in Gallbladder (35.3), Liver (24.7), and Fetal Liver (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP3A4 Gene



SOURCE GeneReport for Unigene cluster for CYP3A4 Gene Hs.728751

mRNA Expression by UniProt/SwissProt for CYP3A4 Gene

P08684-CP3A4_HUMAN
Tissue specificity: Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
genes like me logo Genes that share expression patterns with CYP3A4: view

Protein tissue co-expression partners for CYP3A4 Gene

Primer Products

In Situ Assay Products

Orthologs for CYP3A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP3A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP3A5 35
  • 82.64 (n)
  • 77.14 (a)
-- 36
  • 77 (a)
ManyToMany
CYP3A5 36
  • 71 (a)
ManyToMany
CYP3A5 36
  • 77 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CYP3A4 35
  • 84.56 (n)
  • 80.52 (a)
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
CYP3A12 36
  • 81 (a)
ManyToMany
CYP3A26 36
  • 78 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CYP3A4 35
  • 99.4 (n)
  • 98.41 (a)
CYP3A4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp3a2 35
  • 77.2 (n)
  • 71.77 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp3a11 36
  • 73 (a)
ManyToMany
Cyp3a13 36
  • 75 (a)
ManyToMany
Cyp3a16 36
  • 70 (a)
ManyToMany
Cyp3a25 36
  • 71 (a)
ManyToMany
Cyp3a41a 36
  • 71 (a)
ManyToMany
Cyp3a41b 36
  • 71 (a)
ManyToMany
Cyp3a44 36
  • 69 (a)
ManyToMany
Cyp3a57 36
  • 68 (a)
ManyToMany
Cyp3a59 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP3A4 35
  • 63.04 (n)
  • 61.09 (a)
CYP3A37 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487054 35
  • 60.78 (n)
  • 55.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68821 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6641 35
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 36
  • 54 (a)
ManyToMany
cyp3c1 36
  • 48 (a)
ManyToMany
cyp3c1l2 36
  • 51 (a)
ManyToMany
cyp3c4 36
  • 48 (a)
ManyToMany
si:dkey-21n8.3 36
  • 49 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp28a5 37
  • 24 (a)
Cyp28c1 37
  • 25 (a)
Cyp28d1 37
  • 27 (a)
Cyp28d2 37
  • 30 (a)
Cyp309a1 37
  • 24 (a)
Cyp309a2 37
  • 25 (a)
Cyp313a1 37
  • 27 (a)
Cyp313a2 37
  • 25 (a)
Cyp317a1 37
  • 24 (a)
Cyp6a13 37
  • 32 (a)
Cyp6a14 37
  • 33 (a)
Cyp6a17 37
  • 34 (a)
Cyp6a18 37
  • 31 (a)
Cyp6a19 37
  • 31 (a)
Cyp6a2 37
  • 32 (a)
Cyp6a20 37
  • 31 (a)
Cyp6a21 37
  • 30 (a)
Cyp6a22 37
  • 32 (a)
Cyp6a23 37
  • 35 (a)
Cyp6a8 37
  • 30 (a)
Cyp6a9 37
  • 31 (a)
Cyp6d2 37
  • 29 (a)
Cyp6d4 37
  • 33 (a)
Cyp6d5 37
  • 31 (a)
Cyp6g1 37
  • 33 (a)
Cyp6g2 37
  • 30 (a)
Cyp6t1 37
  • 26 (a)
Cyp6t3 37
  • 27 (a)
Cyp6u1 37
  • 26 (a)
Cyp6v1 37
  • 32 (a)
Cyp6w1 37
  • 30 (a)
Cyp9b1 37
  • 27 (a)
Cyp9b2 37
  • 32 (a)
Cyp9c1 37
  • 31 (a)
Cyp9f2 37
  • 33 (a)
Cyp9h1 37
  • 30 (a)
Cyp9f2 35
  • 47.35 (n)
  • 35.84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012293 35
  • 48.95 (n)
  • 41.35 (a)
worm
(Caenorhabditis elegans)
Secernentea C36A4.1 37
  • 31 (a)
C36A4.2 37
  • 30 (a)
C36A4.6 37
  • 28 (a)
F14F7.2 37
  • 31 (a)
F14F7.3 37
  • 32 (a)
F42A6.4 37
  • 28 (a)
K06G5.2 37
  • 25 (a)
T10B9.1 37
  • 30 (a)
T10B9.2 37
  • 30 (a)
T10B9.3 37
  • 29 (a)
T10B9.5 37
  • 30 (a)
T10B9.7 37
  • 30 (a)
T10B9.8 37
  • 29 (a)
ZK1320.4 37
  • 26 (a)
cyp-25A1 35
  • 46.71 (n)
  • 32.68 (a)
Species with no ortholog for CYP3A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A4 Gene

ENSEMBL:
Gene Tree for CYP3A4 (if available)
TreeFam:
Gene Tree for CYP3A4 (if available)

Paralogs for CYP3A4 Gene

Pseudogenes.org Pseudogenes for CYP3A4 Gene

genes like me logo Genes that share paralogs with CYP3A4: view

Variants for CYP3A4 Gene

Sequence variations from dbSNP and Humsavar for CYP3A4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs55785340 - 99,768,360(+) TATTG(A/G)GAGAA reference, missense
rs4986910 - 99,760,901(-) TGGCA(C/T)GAGGT reference, missense
rs12721634 - 99,784,038(-) TCTCC(C/T)GGCTG reference, missense
rs56324128 - 99,778,079(+) AAAAG(C/T)CCTGG reference, missense
rs55951658 - 99,770,202(+) AGAGA(A/C/T)GGCAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP3A4 Gene

Variant ID Type Subtype PubMed ID
nsv888771 CNV Loss 21882294
nsv482109 CNV Gain 20164927

Variation tolerance for CYP3A4 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP3A4 Gene

HapMap Linkage Disequilibrium report
CYP3A4
Human Gene Mutation Database (HGMD)
CYP3A4
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A4 Gene

Disorders for CYP3A4 Gene

MalaCards: The human disease database

(43) MalaCards diseases for CYP3A4 Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP3A4

Genetic Association Database (GAD)
CYP3A4
Human Genome Epidemiology (HuGE) Navigator
CYP3A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A4
genes like me logo Genes that share disorders with CYP3A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP3A4 Gene

Publications for CYP3A4 Gene

  1. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression. (PMID: 18332045) Cooper B.W. … Wallace A.D. (Toxicol. Sci. 2008) 3 23 25 26
  2. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. (PMID: 11714865) Dai D. … Goldstein J.A. (J. Pharmacol. Exp. Ther. 2001) 3 4 48 67
  3. A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. (PMID: 20147896) Dumond J.B. … Kashuba A.D. (Clin. Pharmacol. Ther. 2010) 3 25 26
  4. Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer. (PMID: 19011599) Lu H. … Waxman D.J. (Cancer Gene Ther. 2009) 23 25 26
  5. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. (PMID: 17998298) Svecova L. … Pavek P. (Drug Metab. Dispos. 2008) 23 25 26

Products for CYP3A4 Gene

Sources for CYP3A4 Gene

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