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Aliases for CYP3A Gene

Aliases for CYP3A Gene

  • Cytochrome P450, Family 3, Subfamily A 2 3
  • Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase) 2 3
  • CYP3A43 6
  • CYP3 3

External Ids for CYP3A Gene

Previous Symbols for CYP3A Gene

  • CYP3

Summaries for CYP3A Gene

Entrez Gene Summary for CYP3A Gene

  • The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes. These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes, CYP3A43, CYP3A4, CYP3A7 and CYP3A5. The region also contains two pseudogenes, CYP3A5P1 and CYP3A5P2, as well as several extra exons which may or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP3A Gene

CYP3A (Cytochrome P450, Family 3, Subfamily A) is a Genetic Locus gene. Among its related pathways are Metabolism and Chemical carcinogenesis.

Gene Wiki entry for CYP3A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A Gene

Genomics for CYP3A Gene

Genomic Location for CYP3A Gene

Orientation:
Unknown strand

Genomic View for CYP3A Gene

Cytogenetic band:

No data available for RefSeq DNA sequence and Regulatory Elements for CYP3A Gene

Proteins for CYP3A Gene

Post-translational modifications for CYP3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for CYP3A Gene

Domains for CYP3A Gene

Gene Families for CYP3A Gene

HGNC:
  • CYP :Cytochrome P450s
genes like me logo Genes that share domains with CYP3A: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for CYP3A Gene

Function for CYP3A Gene

Molecular function for CYP3A Gene

GENATLAS Biochemistry: cytochrome P450,family III (niphedipine oxidase),5 genes

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP3A Gene

Localization for CYP3A Gene

No data available for Gene Ontology (GO) - Cellular Components for CYP3A Gene

Pathways for CYP3A Gene

genes like me logo Genes that share pathways with CYP3A: view

Pathways by source for CYP3A Gene

Interacting Proteins for CYP3A Gene

Gene Ontology (GO) - Biological Process for CYP3A Gene

None

Compounds for CYP3A Gene

(8) Novoseek inferred chemical compound relationships for CYP3A Gene

Compound -log(P) Hits PubMed IDs
pregnenolone 16alpha-carbonitrile 78.1 2
6beta-hydroxycortisol 74.4 3
ketoconazole 49.1 1
rifampicin 46 3
dexamethasone 42 1

(13) PharmGKB related drug/compound annotations for CYP3A Gene

genes like me logo Genes that share compounds with CYP3A: view

Transcripts for CYP3A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A Gene

No ASD Table

Relevant External Links for CYP3A Gene

ECgene alternative splicing isoforms for
CYP3A

No data available for mRNA/cDNA for CYP3A Gene

Expression for CYP3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with CYP3A: view

Orthologs for CYP3A Gene

No data available for Orthologs and Evolution for CYP3A Gene

Paralogs for CYP3A Gene

No data available for Paralogs for CYP3A Gene

Variants for CYP3A Gene

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for CYP3A Gene

Disorders for CYP3A Gene

(1) Novoseek inferred disease relationships for CYP3A Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for CYP3A

Genetic Association Database (GAD)
CYP3A
Human Genome Epidemiology (HuGE) Navigator
CYP3A
genes like me logo Genes that share disorders with CYP3A: view

No data available for UniProtKB/Swiss-Prot for CYP3A Gene

Publications for CYP3A Gene

  1. Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans. (PMID: 12231541) Reid J.M. … Ames M.M. (Clin. Cancer Res. 2002) 3 23
  2. Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy. (PMID: 12237780) MartA-nez C. … AgA_ndez J.A. (Br. J. Cancer 2002) 3 23
  3. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. (PMID: 14977871) Sunman J.A. … Kashuba A.D. (Drug Metab. Dispos. 2004) 3 23
  4. Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PMID: 11266076) Gellner K. … Wojnowski L. (Pharmacogenetics 2001) 3 23
  5. Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4- cineole, a monoterpene cyclic ether, by rat and human liver microsomes. (PMID: 11695850) Miyazawa M. … Shimada T. (Xenobiotica 2001) 3 23

Products for CYP3A Gene

Sources for CYP3A Gene

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