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Aliases for CYP2J2 Gene

Aliases for CYP2J2 Gene

  • Cytochrome P450, Family 2, Subfamily J, Polypeptide 2 2 3
  • Cytochrome P450, Subfamily IIJ (Arachidonic Acid Epoxygenase) Polypeptide 2 2 3
  • Arachidonic Acid Epoxygenase 3 4
  • EC 1.14.14.1 4 63
  • CYPIIJ2 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Cytochrome P450 2J2 3
  • CPJ2 3

External Ids for CYP2J2 Gene

Previous GeneCards Identifiers for CYP2J2 Gene

  • GC01M060284
  • GC01M059282
  • GC01M059716
  • GC01M059728
  • GC01M060071
  • GC01M058469

Summaries for CYP2J2 Gene

Entrez Gene Summary for CYP2J2 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2J2 Gene

CYP2J2 (Cytochrome P450, Family 2, Subfamily J, Polypeptide 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2J2 Gene

  • This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools

Gene Wiki entry for CYP2J2 Gene

PharmGKB "VIP" Summary for CYP2J2 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2J2 Gene

Genomics for CYP2J2 Gene

Regulatory Elements for CYP2J2 Gene

Genomic Location for CYP2J2 Gene

Start:
59,893,308 bp from pter
End:
59,926,790 bp from pter
Size:
33,483 bases
Orientation:
Minus strand

Genomic View for CYP2J2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2J2 Gene

Proteins for CYP2J2 Gene

  • Protein details for CYP2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51589-CP2J2_HUMAN
    Recommended name:
    Cytochrome P450 2J2
    Protein Accession:
    P51589
    Secondary Accessions:
    • B2RD33
    • Q8TF13

    Protein attributes for CYP2J2 Gene

    Size:
    502 amino acids
    Molecular mass:
    57611 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2J2 Gene

Proteomics data for CYP2J2 Gene at MOPED

Selected DME Specific Peptides for CYP2J2 Gene

Post-translational modifications for CYP2J2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2J2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for CYP2J2 Gene

Gene Families for CYP2J2 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Suggested Antigen Peptide Sequences for CYP2J2 Gene

Graphical View of Domain Structure for InterPro Entry

P51589

UniProtKB/Swiss-Prot:

CP2J2_HUMAN :
  • P51589
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2J2: view

Function for CYP2J2 Gene

Molecular function for CYP2J2 Gene

GENATLAS Biochemistry:
cytochrome p450,subfamily 2J catalyzing the NADPH-dependent oxidation of arachidonic acid to form eicosanoids,highly expressed in heart,airway,pancreatic islet cells,intestinal vascular endothelium,involved in the bioactivation of fatty acids
UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function:
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools

Enzyme Numbers (IUBMB) for CYP2J2 Gene

Gene Ontology (GO) - Molecular Function for CYP2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IDA 11901223
GO:0008395 steroid hydroxylase activity IBA --
GO:0008404 arachidonic acid 14,15-epoxygenase activity IDA 11901223
GO:0008405 arachidonic acid 11,12-epoxygenase activity IDA 11901223
genes like me logo Genes that share ontologies with CYP2J2: view

Animal Model Products

CRISPR Products

miRNA for CYP2J2 Gene

miRTarBase miRNAs that target CYP2J2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2J2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP2J2 Gene

Localization for CYP2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2J2 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2J2 Gene COMPARTMENTS Subcellular localization image for CYP2J2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IBA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with CYP2J2: view

Pathways for CYP2J2 Gene

genes like me logo Genes that share pathways with CYP2J2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism in human,mouse,rat

Interacting Proteins for CYP2J2 Gene

Gene Ontology (GO) - Biological Process for CYP2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006690 icosanoid metabolic process TAS 8631948
GO:0006805 xenobiotic metabolic process TAS 11901223
GO:0008016 regulation of heart contraction TAS 8631948
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019373 epoxygenase P450 pathway TAS --
genes like me logo Genes that share ontologies with CYP2J2: view

Compounds for CYP2J2 Gene

(49) HMDB Compounds for CYP2J2 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(7) Drugbank Compounds for CYP2J2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Apixaban
503612-47-3 enzyme substrate
Astemizole
68844-77-9 enzyme substrate
Cholecalciferol
  • (+)-vitamin D3
67-97-0 enzyme substrate
Levomilnacipran
96847-55-1 enzyme substrate
Masoprocol
  • Dihydronorguaiaretic acid
500-38-9 enzyme inhibitor

(7) Novoseek inferred chemical compound relationships for CYP2J2 Gene

Compound -log(P) Hits PubMed IDs
ebastine 86.7 7
arachidonic acid 79.3 35
astemizole 67.9 6
terfenadine 63.8 2
20-hydroxyeicosatetraenoic acid 60 1
genes like me logo Genes that share compounds with CYP2J2: view

Transcripts for CYP2J2 Gene

Unigene Clusters for CYP2J2 Gene

Cytochrome P450, family 2, subfamily J, polypeptide 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2J2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2J2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - - - - - -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for CYP2J2 Gene

GeneLoc Exon Structure for
CYP2J2
ECgene alternative splicing isoforms for
CYP2J2

Expression for CYP2J2 Gene

mRNA expression in normal human tissues for CYP2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2J2 Gene

This gene is overexpressed in Heart - Left Ventricle (8.3), Heart - Atrial Appendage (6.9), and Liver (6.2).

Protein differential expression in normal tissues for CYP2J2 Gene

This gene is overexpressed in Fetal Liver (18.7), Liver (13.6), Gallbladder (9.3), Fetal heart (7.2), and Heart (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP2J2 Gene

SOURCE GeneReport for Unigene cluster for CYP2J2 Gene Hs.152096

mRNA Expression by UniProt/SwissProt for CYP2J2 Gene

P51589-CP2J2_HUMAN
Tissue specificity: Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney
genes like me logo Genes that share expressions with CYP2J2: view

Expression partners for CYP2J2 Gene

In Situ Assay Products

Orthologs for CYP2J2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2J2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC530929 35
  • 82.41 (n)
  • 80.41 (a)
-- 36
  • 78 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYP2J2 35
  • 84.36 (n)
  • 79.44 (a)
CYP2J2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp2j6 35
  • 78.4 (n)
  • 76.6 (a)
Cyp2j6 16
Cyp2j11 36
  • 68 (a)
OneToMany
Cyp2j12 36
  • 71 (a)
OneToMany
Cyp2j13 36
  • 72 (a)
OneToMany
Cyp2j5 36
  • 70 (a)
OneToMany
Cyp2j6 36
  • 76 (a)
OneToMany
Cyp2j7-ps 36
  • 70 (a)
OneToMany
Cyp2j8 36
  • 70 (a)
OneToMany
Cyp2j9 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC456896 35
  • 99.4 (n)
  • 98.8 (a)
CYP2J2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp2j4 35
  • 79.93 (n)
  • 76.2 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CYP2J2 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC424729 35
  • 61.08 (n)
  • 55.97 (a)
-- 36
  • 58 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CYP2J2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496620 35
  • 52.06 (n)
  • 48.01 (a)
zebrafish
(Danio rerio)
Actinopterygii cyp2p10 35
  • 55.62 (n)
  • 52.26 (a)
Dr.25426 35
cyp2ad2 36
  • 48 (a)
OneToMany
cyp2ad3 36
  • 47 (a)
OneToMany
cyp2ad6 36
  • 46 (a)
OneToMany
cyp2ae1 36
  • 46 (a)
OneToMany
cyp2j20 36
  • 50 (a)
OneToMany
cyp2n13 36
  • 48 (a)
OneToMany
cyp2p10 36
  • 51 (a)
OneToMany
cyp2p6 36
  • 46 (a)
OneToMany
cyp2p7 36
  • 50 (a)
OneToMany
cyp2p8 36
  • 51 (a)
OneToMany
cyp2p9 36
  • 50 (a)
OneToMany
cyp2v1 36
  • 48 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1599 35
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 33 (a)
Cyp303a1 37
  • 29 (a)
Cyp304a1 37
  • 28 (a)
Cyp305a1 37
  • 32 (a)
Cyp307a1 37
  • 27 (a)
Cyp305a1 35
  • 45.06 (n)
  • 34.75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012937 35
  • 47.69 (n)
  • 39.5 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.10 37
  • 29 (a)
B0213.11 37
  • 34 (a)
B0213.12 37
  • 32 (a)
B0213.14 37
  • 30 (a)
B0213.15 37
  • 32 (a)
B0304.3 37
  • 35 (a)
C12D5.7 37
  • 32 (a)
C34B7.3 37
  • 31 (a)
C41G6.1 37
  • 33 (a)
C45H4.17 37
  • 32 (a)
C45H4.2 37
  • 32 (a)
C49C8.4 37
  • 33 (a)
C50H11.15 37
  • 32 (a)
F14H3.10 37
  • 29 (a)
F41B5.2 37
  • 33 (a)
F41B5.3 37
  • 32 (a)
F41B5.4 37
  • 33 (a)
F41B5.7 37
  • 33 (a)
F42A9.5 37
  • 32 (a)
F44C8.1 37
  • 32 (a)
K05D4.4 37
  • 33 (a)
K07C6.2 37
  • 30 (a)
K07C6.3 37
  • 31 (a)
K09A11.2 37
  • 33 (a)
K09A11.4 37
  • 34 (a)
R08F11.3 37
  • 36 (a)
T09H2.1 37
  • 31 (a)
Y49C4A.9 37
  • 33 (a)
Y5H2B.6 37
  • 31 (a)
cyp-14A3 35
  • 46.7 (n)
  • 37.42 (a)
Species with no ortholog for CYP2J2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP2J2 Gene

ENSEMBL:
Gene Tree for CYP2J2 (if available)
TreeFam:
Gene Tree for CYP2J2 (if available)

Paralogs for CYP2J2 Gene

genes like me logo Genes that share paralogs with CYP2J2: view

Variants for CYP2J2 Gene

Sequence variations from dbSNP and Humsavar for CYP2J2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs890293 -- 59,926,822(-) GGAGC(G/T)AGGCG upstream-variant-2KB
rs1013280 -- 59,912,379(-) CATTC(C/T)CATAT intron-variant
rs1056595 -- 59,915,978(-) AACCG(C/G)CCCGT reference, synonymous-codon, nc-transcript-variant
rs1056596 -- 59,904,929(+) CCCCC(A/T)GAACG missense, reference, intron-variant
rs1056598 -- 59,893,620(-) GAAAG(C/T)AAGAA utr-variant-3-prime, nc-transcript-variant

Relevant External Links for CYP2J2 Gene

HapMap Linkage Disequilibrium report
CYP2J2
Human Gene Mutation Database (HGMD)
CYP2J2
Locus Specific Mutation Databases (LSDB)
CYP2J2
The Human Cytochrome P450 Allele Nomenclature Database
CYP2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYP2J2 Gene

Disorders for CYP2J2 Gene

(1) University of Copenhagen DISEASES for CYP2J2 Gene

(6) Novoseek inferred disease relationships for CYP2J2 Gene

Disease -log(P) Hits PubMed IDs
cardiovascular diseases 21.9 1
coronary artery disease 11.2 2
carcinoma 4.01 6
atherosclerosis 0 2
tumors 0 6

Relevant External Links for CYP2J2

Genetic Association Database (GAD)
CYP2J2
Human Genome Epidemiology (HuGE) Navigator
CYP2J2
genes like me logo Genes that share disorders with CYP2J2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for CYP2J2 Gene

Publications for CYP2J2 Gene

  1. Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. (PMID: 8631948) Wu S. … Zeldin D.C. (J. Biol. Chem. 1996) 3 4 23
  2. Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4. (PMID: 9570962) Ma J. … Zeldin D.C. (Genomics 1998) 2 3 23
  3. Cloning of CYP2J2 gene and identification of functional polymorphisms. (PMID: 11901223) King L.M. … Zeldin D.C. (Mol. Pharmacol. 2002) 3 4 23
  4. Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. (PMID: 12386130) Matsumoto S. … Yamazoe Y. (Drug Metab. Dispos. 2002) 3 4 23
  5. Cytochrome P450 2J2 polymorphism in healthy Caucasians and those with diabetes mellitus. (PMID: 14575523) Pucci L. … Longo V. (Am J Pharmacogenomics 2003) 3 23 48

Products for CYP2J2 Gene

Sources for CYP2J2 Gene

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