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Aliases for CYP2J2 Gene

Aliases for CYP2J2 Gene

  • Cytochrome P450 Family 2 Subfamily J Member 2 2 3 5
  • Cytochrome P450, Subfamily IIJ (Arachidonic Acid Epoxygenase) Polypeptide 2 2 3
  • Cytochrome P450, Family 2, Subfamily J, Polypeptide 2 2 3
  • Arachidonic Acid Epoxygenase 3 4
  • EC 1.14.14.1 4 63
  • CYPIIJ2 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • CPJ2 3

External Ids for CYP2J2 Gene

Previous GeneCards Identifiers for CYP2J2 Gene

  • GC01M060284
  • GC01M059282
  • GC01M059716
  • GC01M059728
  • GC01M060071
  • GC01M058469

Summaries for CYP2J2 Gene

Entrez Gene Summary for CYP2J2 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP2J2 Gene

CYP2J2 (Cytochrome P450 Family 2 Subfamily J Member 2) is a Protein Coding gene. Diseases associated with CYP2J2 include Clopidogrel Resistance. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and Linoleic acid metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2J2 Gene

  • This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Gene Wiki entry for CYP2J2 Gene

PharmGKB "VIP" Summary for CYP2J2 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2J2 Gene

Genomics for CYP2J2 Gene

Regulatory Elements for CYP2J2 Gene

Enhancers for CYP2J2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP2J2 on UCSC Golden Path with GeneCards custom track

Promoters for CYP2J2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYP2J2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP2J2 Gene

Chromosome:
1
Start:
59,893,308 bp from pter
End:
59,926,790 bp from pter
Size:
33,483 bases
Orientation:
Minus strand

Genomic View for CYP2J2 Gene

Genes around CYP2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2J2 Gene

Proteins for CYP2J2 Gene

  • Protein details for CYP2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51589-CP2J2_HUMAN
    Recommended name:
    Cytochrome P450 2J2
    Protein Accession:
    P51589
    Secondary Accessions:
    • B2RD33
    • Q8TF13

    Protein attributes for CYP2J2 Gene

    Size:
    502 amino acids
    Molecular mass:
    57611 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2J2 Gene

Proteomics data for CYP2J2 Gene at MOPED

Selected DME Specific Peptides for CYP2J2 Gene

Post-translational modifications for CYP2J2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2J2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP2J2 Gene

Gene Families for CYP2J2 Gene

Suggested Antigen Peptide Sequences for CYP2J2 Gene

Graphical View of Domain Structure for InterPro Entry

P51589

UniProtKB/Swiss-Prot:

CP2J2_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2J2: view

Function for CYP2J2 Gene

Molecular function for CYP2J2 Gene

GENATLAS Biochemistry:
cytochrome p450,subfamily 2J catalyzing the NADPH-dependent oxidation of arachidonic acid to form eicosanoids,highly expressed in heart,airway,pancreatic islet cells,intestinal vascular endothelium,involved in the bioactivation of fatty acids
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Enzyme Numbers (IUBMB) for CYP2J2 Gene

Gene Ontology (GO) - Molecular Function for CYP2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008392 arachidonic acid epoxygenase activity IDA,TAS --
GO:0008395 steroid hydroxylase activity IBA --
GO:0008404 arachidonic acid 14,15-epoxygenase activity IDA 11901223
GO:0070330 aromatase activity IEA --
genes like me logo Genes that share ontologies with CYP2J2: view
genes like me logo Genes that share phenotypes with CYP2J2: view

Animal Model Products

CRISPR Products

miRNA for CYP2J2 Gene

miRTarBase miRNAs that target CYP2J2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2J2 Gene

Localization for CYP2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2J2 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2J2 Gene COMPARTMENTS Subcellular localization image for CYP2J2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
cytosol 2
golgi apparatus 2
mitochondrion 2
plasma membrane 2
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CYP2J2 Gene

Pathways & Interactions for CYP2J2 Gene

genes like me logo Genes that share pathways with CYP2J2: view

Interacting Proteins for CYP2J2 Gene

Gene Ontology (GO) - Biological Process for CYP2J2 Gene

None

No data available for SIGNOR curated interactions for CYP2J2 Gene

Drugs & Compounds for CYP2J2 Gene

(26) Drugs for CYP2J2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Astemizole Approved, Withdrawn Pharma Pore Blocker, Enzyme, substrate 0
Masoprocol Approved Pharma Enzyme, inhibitor 9
Cholecalciferol Approved Nutra Enzyme, substrate Fat-soluble secosteroids 810,804
Apixaban Approved Pharma Enzyme, substrate Factor Xa inhibitor 121
Levomilnacipran Approved Pharma Enzyme, substrate 0

(27) Additional Compounds for CYP2J2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP2J2: view

Transcripts for CYP2J2 Gene

Unigene Clusters for CYP2J2 Gene

Cytochrome P450, family 2, subfamily J, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2J2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - - - - - -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for CYP2J2 Gene

GeneLoc Exon Structure for
CYP2J2
ECgene alternative splicing isoforms for
CYP2J2

Expression for CYP2J2 Gene

mRNA expression in normal human tissues for CYP2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2J2 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.3), Heart - Atrial Appendage (x6.9), and Liver (x6.2).

Protein differential expression in normal tissues from HIPED for CYP2J2 Gene

This gene is overexpressed in Fetal Liver (18.7), Liver (13.6), Gallbladder (9.3), Fetal heart (7.2), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2J2 Gene



SOURCE GeneReport for Unigene cluster for CYP2J2 Gene Hs.152096

mRNA Expression by UniProt/SwissProt for CYP2J2 Gene

P51589-CP2J2_HUMAN
Tissue specificity: Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.
genes like me logo Genes that share expression patterns with CYP2J2: view

Protein tissue co-expression partners for CYP2J2 Gene

Primer Products

Orthologs for CYP2J2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2J2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC530929 35
  • 82.41 (n)
  • 80.41 (a)
-- 36
  • 78 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYP2J2 35
  • 84.36 (n)
  • 79.44 (a)
CYP2J2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp2j6 35
  • 78.4 (n)
  • 76.6 (a)
Cyp2j6 16
Cyp2j11 36
  • 68 (a)
OneToMany
Cyp2j12 36
  • 71 (a)
OneToMany
Cyp2j13 36
  • 72 (a)
OneToMany
Cyp2j5 36
  • 70 (a)
OneToMany
Cyp2j6 36
  • 76 (a)
OneToMany
Cyp2j7-ps 36
  • 70 (a)
OneToMany
Cyp2j8 36
  • 70 (a)
OneToMany
Cyp2j9 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC456896 35
  • 99.4 (n)
  • 98.8 (a)
CYP2J2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp2j4 35
  • 79.93 (n)
  • 76.2 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CYP2J2 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC424729 35
  • 61.08 (n)
  • 55.97 (a)
-- 36
  • 58 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CYP2J2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496620 35
  • 52.06 (n)
  • 48.01 (a)
zebrafish
(Danio rerio)
Actinopterygii cyp2p10 35
  • 55.62 (n)
  • 52.26 (a)
Dr.25426 35
cyp2ad2 36
  • 48 (a)
OneToMany
cyp2ad3 36
  • 47 (a)
OneToMany
cyp2ad6 36
  • 46 (a)
OneToMany
cyp2ae1 36
  • 46 (a)
OneToMany
cyp2j20 36
  • 50 (a)
OneToMany
cyp2n13 36
  • 48 (a)
OneToMany
cyp2p10 36
  • 51 (a)
OneToMany
cyp2p6 36
  • 46 (a)
OneToMany
cyp2p7 36
  • 50 (a)
OneToMany
cyp2p8 36
  • 51 (a)
OneToMany
cyp2p9 36
  • 50 (a)
OneToMany
cyp2v1 36
  • 48 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1599 35
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 33 (a)
Cyp303a1 37
  • 29 (a)
Cyp304a1 37
  • 28 (a)
Cyp305a1 37
  • 32 (a)
Cyp307a1 37
  • 27 (a)
Cyp305a1 35
  • 45.06 (n)
  • 34.75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012937 35
  • 47.69 (n)
  • 39.5 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.10 37
  • 29 (a)
B0213.11 37
  • 34 (a)
B0213.12 37
  • 32 (a)
B0213.14 37
  • 30 (a)
B0213.15 37
  • 32 (a)
B0304.3 37
  • 35 (a)
C12D5.7 37
  • 32 (a)
C34B7.3 37
  • 31 (a)
C41G6.1 37
  • 33 (a)
C45H4.17 37
  • 32 (a)
C45H4.2 37
  • 32 (a)
C49C8.4 37
  • 33 (a)
C50H11.15 37
  • 32 (a)
F14H3.10 37
  • 29 (a)
F41B5.2 37
  • 33 (a)
F41B5.3 37
  • 32 (a)
F41B5.4 37
  • 33 (a)
F41B5.7 37
  • 33 (a)
F42A9.5 37
  • 32 (a)
F44C8.1 37
  • 32 (a)
K05D4.4 37
  • 33 (a)
K07C6.2 37
  • 30 (a)
K07C6.3 37
  • 31 (a)
K09A11.2 37
  • 33 (a)
K09A11.4 37
  • 34 (a)
R08F11.3 37
  • 36 (a)
T09H2.1 37
  • 31 (a)
Y49C4A.9 37
  • 33 (a)
Y5H2B.6 37
  • 31 (a)
cyp-14A3 35
  • 46.7 (n)
  • 37.42 (a)
Species with no ortholog for CYP2J2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP2J2 Gene

ENSEMBL:
Gene Tree for CYP2J2 (if available)
TreeFam:
Gene Tree for CYP2J2 (if available)

Paralogs for CYP2J2 Gene

genes like me logo Genes that share paralogs with CYP2J2: view

Variants for CYP2J2 Gene

Sequence variations from dbSNP and Humsavar for CYP2J2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_014317 -
VAR_014318 -
rs66515830 - 59,911,717(-) TATCA(A/T)TTGCT nc-transcript-variant, reference, missense
rs56053398 - 59,905,038(+) TCTGT(C/G/T)AATCT intron-variant, nc-transcript-variant, reference, missense
VAR_014321 -

Variation tolerance for CYP2J2 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2J2 Gene

Human Gene Mutation Database (HGMD)
CYP2J2
The Human Cytochrome P450 Allele Nomenclature Database
CYP2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYP2J2 Gene

Disorders for CYP2J2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CYP2J2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP2J2

Genetic Association Database (GAD)
CYP2J2
Human Genome Epidemiology (HuGE) Navigator
CYP2J2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2J2
genes like me logo Genes that share disorders with CYP2J2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2J2 Gene

Publications for CYP2J2 Gene

  1. Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. (PMID: 15861034) Lee S.S. … Shin J.G. (Pharmacogenet. Genomics 2005) 3 23 48 67
  2. Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. (PMID: 16842832) Aiba I. … Ohyama Y. (Steroids 2006) 23 25 26
  3. Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4. (PMID: 9570962) Ma J. … Zeldin D.C. (Genomics 1998) 2 3 23
  4. Cytochromes P450 are essential players in the vitamin D signaling system. (PMID: 20619365) Schuster I. (Biochim. Biophys. Acta 2011) 25 26
  5. The common functional polymorphism -50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes. (PMID: 19851119) Fava C. … Melander O. (J. Hypertens. 2010) 3 23

Products for CYP2J2 Gene

Sources for CYP2J2 Gene

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