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Aliases for ADRBK2 Gene

Aliases for ADRBK2 Gene

  • Adrenergic, Beta, Receptor Kinase 2 2 3 5
  • G-Protein-Coupled Receptor Kinase 3 3 4
  • EC 2.7.11.15 4 63
  • Beta-ARK-2 3 4
  • BARK2 3 4
  • GRK3 3 4
  • EC 2.7.11 63

External Ids for ADRBK2 Gene

Previous GeneCards Identifiers for ADRBK2 Gene

  • GC22P022657
  • GC22P024169
  • GC22P024285
  • GC22P025960
  • GC22P008764

Summaries for ADRBK2 Gene

Entrez Gene Summary for ADRBK2 Gene

  • The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRBK2 Gene

ADRBK2 (Adrenergic, Beta, Receptor Kinase 2) is a Protein Coding gene. Diseases associated with ADRBK2 include whim syndrome and cocaine abuse. Among its related pathways are Signaling by GPCR and Corticotropin-releasing hormone. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is GRK7.

UniProtKB/Swiss-Prot for ADRBK2 Gene

  • Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Gene Wiki entry for ADRBK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRBK2 Gene

Genomics for ADRBK2 Gene

Regulatory Elements for ADRBK2 Gene

Genomic Location for ADRBK2 Gene

Chromosome:
22
Start:
25,517,856 bp from pter
End:
25,729,294 bp from pter
Size:
211,439 bases
Orientation:
Plus strand

Genomic View for ADRBK2 Gene

Genes around ADRBK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRBK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRBK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRBK2 Gene

Proteins for ADRBK2 Gene

  • Protein details for ADRBK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35626-ARBK2_HUMAN
    Recommended name:
    Beta-adrenergic receptor kinase 2
    Protein Accession:
    P35626
    Secondary Accessions:
    • Q9UGW9

    Protein attributes for ADRBK2 Gene

    Size:
    688 amino acids
    Molecular mass:
    79710 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADRBK2 Gene

Proteomics data for ADRBK2 Gene at MOPED

Post-translational modifications for ADRBK2 Gene

Other Protein References for ADRBK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADRBK2 (GRK3)
  • Cloud-Clone Corp. Antibodies for ADRBK2

Domains & Families for ADRBK2 Gene

Suggested Antigen Peptide Sequences for ADRBK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35626

UniProtKB/Swiss-Prot:

ARBK2_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
  • Contains 1 RGS domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
genes like me logo Genes that share domains with ADRBK2: view

Function for ADRBK2 Gene

Molecular function for ADRBK2 Gene

GENATLAS Biochemistry:
beta-adrenergic receptor kinase 2
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.
UniProtKB/Swiss-Prot Function:
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Enzyme Numbers (IUBMB) for ADRBK2 Gene

Gene Ontology (GO) - Molecular Function for ADRBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047696 beta-adrenergic receptor kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with ADRBK2: view
genes like me logo Genes that share phenotypes with ADRBK2: view

Animal Models for ADRBK2 Gene

MGI Knock Outs for ADRBK2:

Animal Model Products

CRISPR Products

miRNA for ADRBK2 Gene

miRTarBase miRNAs that target ADRBK2

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRBK2 Gene

Localization for ADRBK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRBK2 Gene COMPARTMENTS Subcellular localization image for ADRBK2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ADRBK2 Gene

Pathways & Interactions for ADRBK2 Gene

genes like me logo Genes that share pathways with ADRBK2: view

Gene Ontology (GO) - Biological Process for ADRBK2 Gene

None

No data available for SIGNOR curated interactions for ADRBK2 Gene

Drugs & Compounds for ADRBK2 Gene

(11) Drugs for ADRBK2 Gene - From: HMDB, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
Zinc Approved Pharma 1477

(5) Additional Compounds for ADRBK2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ADRBK2: view

Transcripts for ADRBK2 Gene

Unigene Clusters for ADRBK2 Gene

Adrenergic, beta, receptor kinase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRBK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2:
SP3: -
SP4:

ExUns: 22 ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ADRBK2 Gene

GeneLoc Exon Structure for
ADRBK2
ECgene alternative splicing isoforms for
ADRBK2

Expression for ADRBK2 Gene

mRNA expression in normal human tissues for ADRBK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADRBK2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.6), Lymph node (11.2), Frontal cortex (9.8), Spleen (9.2), and Testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADRBK2 Gene



SOURCE GeneReport for Unigene cluster for ADRBK2 Gene Hs.657494

genes like me logo Genes that share expression patterns with ADRBK2: view

Protein tissue co-expression partners for ADRBK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADRBK2 Gene

Orthologs for ADRBK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRBK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRBK2 36
  • 100 (a)
OneToOne
ADRBK2 35
  • 99.27 (n)
  • 99.13 (a)
cow
(Bos Taurus)
Mammalia ADRBK2 35
  • 89.44 (n)
  • 95.49 (a)
ADRBK2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRBK2 36
  • 96 (a)
OneToOne
ADRBK2 35
  • 89.99 (n)
  • 95.98 (a)
mouse
(Mus musculus)
Mammalia Adrbk2 16
Adrbk2 36
  • 91 (a)
OneToOne
Adrbk2 35
  • 83.14 (n)
  • 91.42 (a)
oppossum
(Monodelphis domestica)
Mammalia ADRBK2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Adrbk2 35
  • 83.77 (n)
  • 91.13 (a)
chicken
(Gallus gallus)
Aves ADRBK2 35
  • 82.74 (n)
  • 93.39 (a)
ADRBK2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 83 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adrbk2 35
  • 82.7 (n)
  • 92.73 (a)
zebrafish
(Danio rerio)
Actinopterygii adrbk2 36
  • 91 (a)
OneToMany
adrbk2 35
  • 76.26 (n)
  • 90.55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012026 35
  • 63.41 (n)
  • 70.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gprk1 35
  • 63.19 (n)
  • 68.38 (a)
Gprk1 37
  • 66 (a)
Gprk1 36
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grk-2 35
  • 63.67 (n)
  • 68.04 (a)
grk-2 36
  • 65 (a)
OneToMany
W02B3.2 37
  • 69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3907 35
Species with no ortholog for ADRBK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRBK2 Gene

ENSEMBL:
Gene Tree for ADRBK2 (if available)
TreeFam:
Gene Tree for ADRBK2 (if available)

Paralogs for ADRBK2 Gene

Paralogs for ADRBK2 Gene

(11) SIMAP similar genes for ADRBK2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ADRBK2 Gene

genes like me logo Genes that share paralogs with ADRBK2: view

Variants for ADRBK2 Gene

Sequence variations from dbSNP and Humsavar for ADRBK2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2272859 - 25,703,574(+) TCACC(A/G)TGGTA nc-transcript-variant, reference, missense
rs55700971 - 25,604,413(+) GAGAG(A/C)AATGA intron-variant, nc-transcript-variant, reference, missense
rs55740593 - 25,604,442(+) TTTCA(A/G)TCAGA intron-variant, nc-transcript-variant, reference, missense
VAR_040382 A lung bronchoalveolar carcinoma sample
rs79101 -- 25,524,099(+) ACAGA(C/T)CATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRBK2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv1392e1 CNV Complex 17122850
dgv1393e1 CNV Complex 17122850
dgv175e55 CNV Gain 17911159
dgv778e201 CNV Deletion 23290073
dgv577n27 CNV Gain 19166990
nsv517205 CNV Gain+Loss 19592680
nsv471189 CNV Gain 18288195
esv2751952 CNV Gain 17911159
dgv828e199 CNV Deletion 23128226
nsv436347 CNV Deletion 17901297
esv2724087 CNV Deletion 23290073
nsv469691 CNV Complex 16826518
nsv471598 CNV Gain+Loss 15918152
nsv914952 CNV Gain 21882294
nsv9892 CNV Gain 18304495
esv26366 CNV Gain 19812545
nsv9893 CNV Gain 18304495
esv2724088 CNV Deletion 23290073

Variation tolerance for ADRBK2 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRBK2 Gene

HapMap Linkage Disequilibrium report
ADRBK2
Human Gene Mutation Database (HGMD)
ADRBK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRBK2 Gene

Disorders for ADRBK2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADRBK2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
whim syndrome
  • warts, hypogammaglobulinemia, infections, and myelokathexis
cocaine abuse
  • cocaine-related disorders
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADRBK2

Genetic Association Database (GAD)
ADRBK2
Human Genome Epidemiology (HuGE) Navigator
ADRBK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRBK2
genes like me logo Genes that share disorders with ADRBK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRBK2 Gene

Publications for ADRBK2 Gene

  1. Association analysis of GRK3 gene promoter variants in cocaine abuse. (PMID: 17621168) Guindalini C. … Breen G. (Psychiatr. Genet. 2007) 3 23 48 67
  2. Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PMID: 7695743) Calabrese G. … De Blasi A. (Genomics 1994) 2 3 23
  3. beta-Adrenoceptor and GRK3 expression in human lymphocytes is related to blood pressure and urinary albumin excretion. (PMID: 20216086) Oliver E. … D'Ocon P. (J. Hypertens. 2010) 3 23
  4. Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients. (PMID: 19766236) McCarthy M.J. … Turner E.E. (J Psychiatr Res 2010) 3 23
  5. Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling. (PMID: 18274673) Balabanian K. … Bachelerie F. (J. Clin. Invest. 2008) 3 23

Products for ADRBK2 Gene

Sources for ADRBK2 Gene

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