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Aliases for CYP2C18 Gene

Aliases for CYP2C18 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 18 2 3 5
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 18 2 3
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 18 2 3
  • EC 1.14.14.1 4 63
  • CYPIIC18 3 4
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 17 3
  • (S)-Mephenytoin Hydroxylase Associated Cytochrome P450 3
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Unspecific Monooxygenase 3
  • Cytochrome P450-6B/29C 3
  • Cytochrome P450-6b/29c 4
  • P450-6B/29C 3
  • P450IIC17 3
  • CYP2C17 3
  • CYP2C 3
  • CPCI 3

External Ids for CYP2C18 Gene

Previous HGNC Symbols for CYP2C18 Gene

  • CYP2C17

Previous GeneCards Identifiers for CYP2C18 Gene

  • GC10P095336
  • GC10M095677
  • GC10P096576
  • GC10P096107
  • GC10P096433
  • GC10P090071

Summaries for CYP2C18 Gene

Entrez Gene Summary for CYP2C18 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C18 Gene

CYP2C18 (Cytochrome P450 Family 2 Subfamily C Member 18) is a Protein Coding gene. Diseases associated with CYP2C18 include paralytic ileus and mediastinitis. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2C18 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP2C18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C18 Gene

Genomics for CYP2C18 Gene

Regulatory Elements for CYP2C18 Gene

Enhancers for CYP2C18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP2C18 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP2C18 Gene

Chromosome:
10
Start:
94,683,494 bp from pter
End:
94,736,190 bp from pter
Size:
52,697 bases
Orientation:
Plus strand

Genomic View for CYP2C18 Gene

Genes around CYP2C18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C18 Gene

Proteins for CYP2C18 Gene

  • Protein details for CYP2C18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33260-CP2CI_HUMAN
    Recommended name:
    Cytochrome P450 2C18
    Protein Accession:
    P33260
    Secondary Accessions:
    • B2R8K2
    • Q16703
    • Q16751
    • Q4VAT5
    • Q6GRG1

    Protein attributes for CYP2C18 Gene

    Size:
    490 amino acids
    Molecular mass:
    55711 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C18 Gene

    Alternative splice isoforms for CYP2C18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C18 Gene

Proteomics data for CYP2C18 Gene at MOPED

Post-translational modifications for CYP2C18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CYP2C18 Gene

Gene Families for CYP2C18 Gene

Protein Domains for CYP2C18 Gene

Suggested Antigen Peptide Sequences for CYP2C18 Gene

Graphical View of Domain Structure for InterPro Entry

P33260

UniProtKB/Swiss-Prot:

CP2CI_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C18: view

Function for CYP2C18 Gene

Molecular function for CYP2C18 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 18
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP2C18 Gene

Gene Ontology (GO) - Molecular Function for CYP2C18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS 8110777
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0019825 oxygen binding TAS --
genes like me logo Genes that share ontologies with CYP2C18: view

Phenotypes for CYP2C18 Gene

genes like me logo Genes that share phenotypes with CYP2C18: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP2C18 Gene

Localization for CYP2C18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C18 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2C18 Gene COMPARTMENTS Subcellular localization image for CYP2C18 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CYP2C18 Gene

Pathways & Interactions for CYP2C18 Gene

genes like me logo Genes that share pathways with CYP2C18: view

Interacting Proteins for CYP2C18 Gene

Gene Ontology (GO) - Biological Process for CYP2C18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
genes like me logo Genes that share ontologies with CYP2C18: view

No data available for SIGNOR curated interactions for CYP2C18 Gene

Drugs & Compounds for CYP2C18 Gene

(47) Drugs for CYP2C18 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tolbutamide Approved Pharma Inhibitor, Enzyme, substrate CAMP inhibitor 22
Clobazam Approved, Illicit Pharma Enzyme, substrate 19
Clotiazepam Approved, Illicit Pharma Enzyme, substrate 0
Desipramine Approved Pharma Enzyme, substrate 39
Lidocaine Approved Pharma Antagonist, Pore Blocker, Enzyme, substrate Anasthetic and class Ib antiarrhythmic agent 1138

(37) Additional Compounds for CYP2C18 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP2C18: view

Transcripts for CYP2C18 Gene

mRNA/cDNA for CYP2C18 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2C18 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C18 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2:
SP3: -
SP4: - -

Relevant External Links for CYP2C18 Gene

GeneLoc Exon Structure for
CYP2C18
ECgene alternative splicing isoforms for
CYP2C18

Expression for CYP2C18 Gene

mRNA expression in normal human tissues for CYP2C18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C18 Gene

This gene is overexpressed in Liver (x26.5), Esophagus - Mucosa (x8.2), and Small Intestine - Terminal Ileum (x4.9).

Protein differential expression in normal tissues from HIPED for CYP2C18 Gene

This gene is overexpressed in Stomach (55.8) and Liver (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2C18 Gene



SOURCE GeneReport for Unigene cluster for CYP2C18 Gene Hs.511872

genes like me logo Genes that share expression patterns with CYP2C18: view

Protein tissue co-expression partners for CYP2C18 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CYP2C18 Gene

Orthologs for CYP2C18 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP2C18 35
  • 86.27 (n)
  • 80.04 (a)
CYP2C18 36
  • 80 (a)
ManyToMany
CYP2C87 36
  • 78 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2c24 35
  • 83.3 (n)
  • 78.53 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 54 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp2c55 36
  • 76 (a)
OneToOne
Cyp2c55 16
Cyp2c55 35
  • 82 (n)
  • 76.28 (a)
chicken
(Gallus gallus)
Aves CYP2C45 35
  • 63.48 (n)
  • 58.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68450 35
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 32 (a)
Cyp303a1 37
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003067 35
  • 43.38 (n)
  • 31.07 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.10 37
  • 33 (a)
B0213.11 37
  • 38 (a)
B0213.14 37
  • 32 (a)
B0213.15 37
  • 32 (a)
B0213.16 37
  • 30 (a)
B0304.3 37
  • 31 (a)
C03G6.15 37
  • 28 (a)
C12D5.7 37
  • 33 (a)
C25E10.2 37
  • 29 (a)
C34B7.3 37
  • 31 (a)
C41G6.1 37
  • 32 (a)
C45H4.17 37
  • 30 (a)
C45H4.2 37
  • 31 (a)
C49C8.4 37
  • 32 (a)
C49G7.8 37
  • 27 (a)
C50H11.15 37
  • 32 (a)
F14H3.10 37
  • 29 (a)
F41B5.2 37
  • 32 (a)
F41B5.3 37
  • 33 (a)
F41B5.4 37
  • 33 (a)
F41B5.7 37
  • 32 (a)
F42A9.5 37
  • 33 (a)
F44C8.1 37
  • 33 (a)
K05D4.4 37
  • 30 (a)
K07C6.2 37
  • 29 (a)
K07C6.3 37
  • 29 (a)
K07C6.5 37
  • 29 (a)
K09A11.2 37
  • 34 (a)
K09A11.3 37
  • 32 (a)
K09A11.4 37
  • 33 (a)
K09D9.2 37
  • 28 (a)
R08F11.3 37
  • 31 (a)
T09H2.1 37
  • 31 (a)
T10H4.11 37
  • 31 (a)
Y49C4A.9 37
  • 31 (a)
Y5H2B.6 37
  • 29 (a)
Species with no ortholog for CYP2C18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2C18 Gene

ENSEMBL:
Gene Tree for CYP2C18 (if available)
TreeFam:
Gene Tree for CYP2C18 (if available)

Paralogs for CYP2C18 Gene

Pseudogenes.org Pseudogenes for CYP2C18 Gene

genes like me logo Genes that share paralogs with CYP2C18: view

Variants for CYP2C18 Gene

Sequence variations from dbSNP and Humsavar for CYP2C18 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_001254 -
rs1575933 -- 94,685,733(+) ctcta(C/T)gcttt intron-variant
rs1575934 -- 94,685,852(+) ttttg(A/G)ttaat intron-variant
rs1810769 -- 94,683,051(+) aaggg(C/T)tggag upstream-variant-2KB
rs1926706 -- 94,688,372(+) GGTAC(A/G)TGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2C18 Gene

Variant ID Type Subtype PubMed ID
esv2672446 CNV Deletion 23128226
nsv522538 CNV Loss 19592680
nsv7496 CNV Insertion 18451855
esv2739707 CNV Deletion 23290073
esv2657299 CNV Deletion 23128226
nsv895901 CNV Loss 21882294

Variation tolerance for CYP2C18 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.81; 86.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2C18 Gene

HapMap Linkage Disequilibrium report
CYP2C18
Human Gene Mutation Database (HGMD)
CYP2C18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C18 Gene

Disorders for CYP2C18 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CYP2C18 Gene - From: DISEASES

Disorder Aliases PubMed IDs
paralytic ileus
  • paralysis of intestine or colon
mediastinitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP2C18

Genetic Association Database (GAD)
CYP2C18
Human Genome Epidemiology (HuGE) Navigator
CYP2C18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2C18
genes like me logo Genes that share disorders with CYP2C18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C18 Gene

Publications for CYP2C18 Gene

  1. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. (PMID: 2009263) Romkes M. … Goldstein J.A. (Biochemistry 1991) 2 3 4 67
  2. Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. (PMID: 1896026) Furuya H. … Gonzalez F.J. (Mol. Pharmacol. 1991) 2 3 23
  3. SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. (PMID: 19934256) Preissner S. … Preissner R. (Nucleic Acids Res. 2010) 25 26
  4. A genome-wide association study of acenocoumarol maintenance dosage. (PMID: 19578179) Teichert M. … Stricker B.H. (Hum. Mol. Genet. 2009) 3 23
  5. Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone. (PMID: 19339376) LAPfgren S. … Ingelman-Sundberg M. (Drug Metab. Dispos. 2009) 23 25

Products for CYP2C18 Gene

Sources for CYP2C18 Gene

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