Aliases for GRK2 Gene
External Ids for GRK2 Gene
Previous HGNC Symbols for GRK2 Gene
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRK2 Gene
GRK2 (G Protein-Coupled Receptor Kinase 2) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. An important paralog of this gene is GRK3.
UniProtKB/Swiss-Prot for GRK2 Gene
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.