Aliases for GRK2 Gene
External Ids for GRK2 Gene
Previous HGNC Symbols for GRK2 Gene
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRK2 Gene
GRK2 (G Protein-Coupled Receptor Kinase 2) is a Protein Coding gene. Diseases associated with GRK2 include Heart Disease and Myocardial Infarction. Among its related pathways are Hedgehog Pathway and DAG and IP3 signaling. An important paralog of this gene is GRK3.
UniProtKB/Swiss-Prot for GRK2 Gene
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.