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Aliases for CYP2C9 Gene

Aliases for CYP2C9 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 9 2 3 5
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 2 3
  • Cholesterol 25-Hydroxylase 3 4
  • Cytochrome P450 PB-1 3 4
  • Cytochrome P-450MP 3 4
  • CYP2C10 3 4
  • CYPIIC9 3 4
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9 2
  • Cytochrome P-450 S-Mephenytoin 4-Hydroxylase 3
  • Flavoprotein-Linked Monooxygenase 3
  • (R)-Limonene 6-Monooxygenase 4
  • (S)-Limonene 6-Monooxygenase 4
  • (S)-Limonene 7-Monooxygenase 4
  • S-Mephenytoin 4-Hydroxylase 4
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 MP-4 4
  • Cytochrome P450 MP-8 4
  • EC 1.14.13.80 4
  • EC 1.14.13.48 4
  • EC 1.14.13.49 4
  • EC 1.14.99.38 4
  • EC 1.14.14.1 63
  • EC 1.14.13.- 4
  • P450IIC9 3
  • CYP2C 3
  • CPC9 3

External Ids for CYP2C9 Gene

Previous HGNC Symbols for CYP2C9 Gene

  • CYP2C10

Previous GeneCards Identifiers for CYP2C9 Gene

  • GC10P095591
  • GC10P095932
  • GC10P096829
  • GC10P096363
  • GC10P096688
  • GC10P090325

Summaries for CYP2C9 Gene

Entrez Gene Summary for CYP2C9 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C9 Gene

CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) is a Protein Coding gene. Diseases associated with CYP2C9 include coumarin resistance and cyp2c9-related altered drug metabolism. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2C9 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).

Gene Wiki entry for CYP2C9 Gene

PharmGKB "VIP" Summary for CYP2C9 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C9 Gene

Genomics for CYP2C9 Gene

Regulatory Elements for CYP2C9 Gene

Genomic Location for CYP2C9 Gene

Chromosome:
10
Start:
94,938,658 bp from pter
End:
94,989,391 bp from pter
Size:
50,734 bases
Orientation:
Plus strand

Genomic View for CYP2C9 Gene

Genes around CYP2C9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C9 Gene

Proteins for CYP2C9 Gene

  • Protein details for CYP2C9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11712-CP2C9_HUMAN
    Recommended name:
    Cytochrome P450 2C9
    Protein Accession:
    P11712
    Secondary Accessions:
    • P11713
    • Q16756
    • Q16872
    • Q5VX92
    • Q6IRV8
    • Q8WW80

    Protein attributes for CYP2C9 Gene

    Size:
    490 amino acids
    Molecular mass:
    55628 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C9 Gene

    Alternative splice isoforms for CYP2C9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C9 Gene

Proteomics data for CYP2C9 Gene at MOPED

Post-translational modifications for CYP2C9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CYP2C9 Gene

Gene Families for CYP2C9 Gene

Protein Domains for CYP2C9 Gene

Graphical View of Domain Structure for InterPro Entry

P11712

UniProtKB/Swiss-Prot:

CP2C9_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C9: view

Function for CYP2C9 Gene

Molecular function for CYP2C9 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 9
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.25 mM for S-mephenytoin {ECO:0000269 PubMed:3079764}; KM=46.24 uM for tolbutamide {ECO:0000269 PubMed:25994031}; KM=4.73 uM for diclofenac {ECO:0000269 PubMed:25994031}; KM=1.58 uM for losartan {ECO:0000269 PubMed:25994031}; Vmax=9.22 pmol/min/pmol enzyme with tolbutamide as substrate {ECO:0000269 PubMed:25994031}; Vmax=17.16 pmol/min/pmol enzyme with diclofenac as substrate {ECO:0000269 PubMed:25994031}; Vmax=210.30 pmol/min/pmol enzyme with losartan as substrate {ECO:0000269 PubMed:25994031};
UniProtKB/Swiss-Prot CatalyticActivity:
(+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Cholesterol + AH(2) + O(2) = 25-hydroxycholesterol + A + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).
UniProtKB/Swiss-Prot Induction:
By rifampicin.

Enzyme Numbers (IUBMB) for CYP2C9 Gene

Gene Ontology (GO) - Molecular Function for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0018675 (S)-limonene 6-monooxygenase activity IEA --
GO:0034875 caffeine oxidase activity IDA 18619574
genes like me logo Genes that share ontologies with CYP2C9: view
genes like me logo Genes that share phenotypes with CYP2C9: view

Human Phenotype Ontology for CYP2C9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP2C9 Gene

Localization for CYP2C9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C9 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2C9 Gene COMPARTMENTS Subcellular localization image for CYP2C9 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CYP2C9 Gene

Pathways & Interactions for CYP2C9 Gene

genes like me logo Genes that share pathways with CYP2C9: view

Gene Ontology (GO) - Biological Process for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0016098 monoterpenoid metabolic process IDA 16401082
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019373 epoxygenase P450 pathway TAS --
GO:0019627 urea metabolic process IDA 19029318
genes like me logo Genes that share ontologies with CYP2C9: view

No data available for SIGNOR curated interactions for CYP2C9 Gene

Drugs & Compounds for CYP2C9 Gene

(439) Drugs for CYP2C9 Gene - From: DrugBank, Novoseek, HMDB, ClinicalTrials, PharmGKB, FDA Approved Drugs, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor, Enzyme, substrate Selective cyclooxygenase-2 (COX-2) inhibitor 419
Flurbiprofen Approved, Investigational Pharma Channel blocker, Enzyme, substrate 40
Fluvoxamine Approved, Investigational Pharma Enzyme, inhibitor 46
Tolbutamide Approved Pharma Inhibitor, Enzyme, substrate, inhibitor CAMP inhibitor 21
Voriconazole Approved, Investigational Pharma Enzyme, substrate, inhibitor CYP51 inhibitor 124

(113) Additional Compounds for CYP2C9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Paraxanthine
  • 1,7-Dimethyl-Xanthine
  • 1,7-Dimethylxanthine
611-59-6
(-)-trans-Carveol
  • Carveol
1197-07-5
(+)-Limonene
  • (+)-(4R)-Limonene
  • (+)-(R)-Limonene
5989-27-5
genes like me logo Genes that share compounds with CYP2C9: view

Drug Products

Transcripts for CYP2C9 Gene

mRNA/cDNA for CYP2C9 Gene

Unigene Clusters for CYP2C9 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CYP2C9 Gene

GeneLoc Exon Structure for
CYP2C9
ECgene alternative splicing isoforms for
CYP2C9

Expression for CYP2C9 Gene

mRNA expression in normal human tissues for CYP2C9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C9 Gene

This gene is overexpressed in Liver (x49.5).

Protein differential expression in normal tissues from HIPED for CYP2C9 Gene

This gene is overexpressed in Gallbladder (43.7) and Liver (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2C9 Gene



SOURCE GeneReport for Unigene cluster for CYP2C9 Gene Hs.282624

genes like me logo Genes that share expression patterns with CYP2C9: view

Protein tissue co-expression partners for CYP2C9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CYP2C9 Gene

Orthologs for CYP2C9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100616515 35
  • 99.46 (n)
  • 99.39 (a)
CYP2C9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC505468 35
  • 83.79 (n)
  • 78.77 (a)
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
CYP2C18 36
  • 78 (a)
ManyToMany
CYP2C87 36
  • 78 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp2c66 16
Cyp2c29 36
  • 76 (a)
ManyToMany
Cyp2c37 36
  • 73 (a)
ManyToMany
Cyp2c38 36
  • 72 (a)
ManyToMany
Cyp2c39 36
  • 73 (a)
ManyToMany
Cyp2c40 36
  • 63 (a)
ManyToMany
Cyp2c50 36
  • 73 (a)
ManyToMany
Cyp2c54 36
  • 71 (a)
ManyToMany
Cyp2c65 36
  • 76 (a)
ManyToMany
Cyp2c66 36
  • 76 (a)
ManyToMany
Cyp2c67 36
  • 67 (a)
ManyToMany
Cyp2c68 36
  • 66 (a)
ManyToMany
Cyp2c69 36
  • 67 (a)
ManyToMany
Cyp2c66 35
  • 80.54 (n)
  • 76.01 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2c11 35
  • 80.75 (n)
  • 76.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 32 (a)
Cyp303a1 37
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.10 37
  • 32 (a)
B0213.12 37
  • 33 (a)
B0213.14 37
  • 33 (a)
B0213.15 37
  • 30 (a)
B0213.16 37
  • 29 (a)
B0304.3 37
  • 31 (a)
C03G6.15 37
  • 29 (a)
C12D5.7 37
  • 33 (a)
C25E10.2 37
  • 28 (a)
C34B7.3 37
  • 31 (a)
C41G6.1 37
  • 31 (a)
C45H4.17 37
  • 31 (a)
C45H4.2 37
  • 31 (a)
C49C8.4 37
  • 32 (a)
C49G7.8 37
  • 29 (a)
F14H3.10 37
  • 30 (a)
F41B5.2 37
  • 31 (a)
F41B5.3 37
  • 33 (a)
F41B5.4 37
  • 31 (a)
F41B5.7 37
  • 32 (a)
F42A9.5 37
  • 34 (a)
F44C8.1 37
  • 32 (a)
K07C6.2 37
  • 29 (a)
K07C6.3 37
  • 29 (a)
K07C6.5 37
  • 29 (a)
K09A11.3 37
  • 32 (a)
K09D9.2 37
  • 30 (a)
R08F11.3 37
  • 29 (a)
T09H2.1 37
  • 31 (a)
T10H4.10 37
  • 31 (a)
T10H4.11 37
  • 32 (a)
Y49C4A.9 37
  • 32 (a)
Y5H2B.6 37
  • 28 (a)
Species with no ortholog for CYP2C9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2C9 Gene

ENSEMBL:
Gene Tree for CYP2C9 (if available)
TreeFam:
Gene Tree for CYP2C9 (if available)

Paralogs for CYP2C9 Gene

Pseudogenes.org Pseudogenes for CYP2C9 Gene

genes like me logo Genes that share paralogs with CYP2C9: view

Variants for CYP2C9 Gene

Sequence variations from dbSNP and Humsavar for CYP2C9 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1799853 - 94,942,290(+) AGGAC(C/T)GTGTT reference, missense
rs1057909 - 94,981,294(+) GAGAT(A/G)CMTTG reference, missense
rs1057910 - 94,981,296(+) GATAC(A/C)TTGAC reference, missense
VAR_008346 -
rs56165452 - 94,981,297(+) ATACA(A/C/T)TGACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP2C9 Gene

Variant ID Type Subtype PubMed ID
esv2739707 CNV Deletion 23290073
esv2674280 CNV Deletion 23128226
esv2741937 CNV Deletion 23290073
nsv7497 CNV Insertion 18451855

Variation tolerance for CYP2C9 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2C9 Gene

HapMap Linkage Disequilibrium report
CYP2C9
Human Gene Mutation Database (HGMD)
CYP2C9
The Human Cytochrome P450 Allele Nomenclature Database
CYP2C9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C9 Gene

Disorders for CYP2C9 Gene

MalaCards: The human disease database

(25) MalaCards diseases for CYP2C9 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
coumarin resistance
  • warfarin sensitivity
cyp2c9-related altered drug metabolism
  • warfarin sensitivity
inherited blood coagulation disease
  • blood coagulation disorders, inherited
oral antidiabetic drugs toxicity or dose selection
esophageal candidiasis
  • candida esophagitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP2C9

Genetic Association Database (GAD)
CYP2C9
Human Genome Epidemiology (HuGE) Navigator
CYP2C9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2C9
genes like me logo Genes that share disorders with CYP2C9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C9 Gene

Publications for CYP2C9 Gene

  1. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. (PMID: 19202563) Sahi J. … LeCluyse E.L. (J. Biochem. Mol. Toxicol. 2009) 3 23 25 26
  2. Pharmacogenetics of oral anticoagulants: a basis for dose individualization. (PMID: 18698879) Stehle S. … Fuhr U. (Clin Pharmacokinet 2008) 3 23 25 26
  3. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. (PMID: 15606435) Zhang Y. … Zhou H. (Br J Clin Pharmacol 2005) 3 23 25 26
  4. Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. (PMID: 15790782) Bodin L. … Loriot M.A. (Blood 2005) 3 23 25 26
  5. Association between CYP2C9 genetic variants and anticoagulation- related outcomes during warfarin therapy. (PMID: 11926893) Higashi M.K. … Rettie A.E. (JAMA 2002) 3 4 48 67

Products for CYP2C9 Gene

Sources for CYP2C9 Gene

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