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Aliases for CYP2C8 Gene

Aliases for CYP2C8 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 8 2 3 5
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 8 2 3
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 2 3
  • S-Mephenytoin 4-Hydroxylase 3 4
  • Cytochrome P450 Form 1 3 4
  • Cytochrome P450 MP-12 3 4
  • Cytochrome P450 MP-20 3 4
  • Cytochrome P450 IIC2 3 4
  • EC 1.14.14.1 4 63
  • CYPIIC8 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • P450 Form 1 3
  • MP-12/MP-20 3
  • CPC8 3

External Ids for CYP2C8 Gene

Previous GeneCards Identifiers for CYP2C8 Gene

  • GC10M095689
  • GC10M096030
  • GC10M096927
  • GC10M096461
  • GC10M096786
  • GC10M090423

Summaries for CYP2C8 Gene

Entrez Gene Summary for CYP2C8 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CYP2C8 Gene

CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8) is a Protein Coding gene. Diseases associated with CYP2C8 include cyp2c8-related altered drug metabolism and osteonecrosis of the jaw. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2C8 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).

Gene Wiki entry for CYP2C8 Gene

PharmGKB "VIP" Summary for CYP2C8 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C8 Gene

Genomics for CYP2C8 Gene

Regulatory Elements for CYP2C8 Gene

Genomic Location for CYP2C8 Gene

Chromosome:
10
Start:
95,036,772 bp from pter
End:
95,069,498 bp from pter
Size:
32,727 bases
Orientation:
Minus strand

Genomic View for CYP2C8 Gene

Genes around CYP2C8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C8 Gene

Proteins for CYP2C8 Gene

  • Protein details for CYP2C8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10632-CP2C8_HUMAN
    Recommended name:
    Cytochrome P450 2C8
    Protein Accession:
    P10632
    Secondary Accessions:
    • A8K9N8
    • B0AZN2
    • B7Z1F6
    • Q5VX93
    • Q8WWB1
    • Q9UCZ9

    Protein attributes for CYP2C8 Gene

    Size:
    490 amino acids
    Molecular mass:
    55825 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C8 Gene

    Alternative splice isoforms for CYP2C8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C8 Gene

Proteomics data for CYP2C8 Gene at MOPED

Post-translational modifications for CYP2C8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for CYP2C8 Gene

Gene Families for CYP2C8 Gene

Protein Domains for CYP2C8 Gene

Suggested Antigen Peptide Sequences for CYP2C8 Gene

Graphical View of Domain Structure for InterPro Entry

P10632

UniProtKB/Swiss-Prot:

CP2C8_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C8: view

Function for CYP2C8 Gene

Molecular function for CYP2C8 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 8
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.18 uM for paclitaxel {ECO:0000269 PubMed:26427316}; KM=1.35 uM for amodiaquine {ECO:0000269 PubMed:26427316}; Vmax=2.18 pmol/min/pmol enzyme with paclitaxel as substrate {ECO:0000269 PubMed:26427316}; Vmax=11.30 pmol/min/pmol enzyme with amodiaquine as substrate {ECO:0000269 PubMed:26427316};
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
UniProtKB/Swiss-Prot Induction:
By phenobarbital.

Enzyme Numbers (IUBMB) for CYP2C8 Gene

Gene Ontology (GO) - Molecular Function for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0034875 caffeine oxidase activity IDA 18619574
genes like me logo Genes that share ontologies with CYP2C8: view

Phenotypes for CYP2C8 Gene

genes like me logo Genes that share phenotypes with CYP2C8: view

Animal Model Products

CRISPR Products

miRNA for CYP2C8 Gene

miRTarBase miRNAs that target CYP2C8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2C8 Gene

Localization for CYP2C8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C8 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2C8 Gene COMPARTMENTS Subcellular localization image for CYP2C8 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CYP2C8 Gene

Pathways & Interactions for CYP2C8 Gene

genes like me logo Genes that share pathways with CYP2C8: view

Interacting Proteins for CYP2C8 Gene

Gene Ontology (GO) - Biological Process for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IDA 19651758
GO:0006805 xenobiotic metabolic process TAS --
GO:0019373 epoxygenase P450 pathway TAS --
GO:0097267 omega-hydroxylase P450 pathway TAS --
genes like me logo Genes that share ontologies with CYP2C8: view

No data available for SIGNOR curated interactions for CYP2C8 Gene

Drugs & Compounds for CYP2C8 Gene

(244) Drugs for CYP2C8 Gene - From: DrugBank, HMDB, Novoseek, PharmGKB, FDA Approved Drugs, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved Pharma Enzyme, substrate Tubulin and Bcl2 inhibitor, Taxanes 2621
Rosiglitazone Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate, inhibitor Potent PPARγ agonist 220
Amodiaquine Approved Pharma Enzyme, substrate 93
Repaglinide Approved, Investigational Pharma Enzyme, substrate Kir6 (KATP) channel blocker 50
Lapatinib Approved March 2007, Investigational Pharma Enzyme, substrate EGFR/HER2 inhibitor,potent,selective and reversible, HER2 and EGFR kinase inhibitor, HER2 Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 294

(53) Additional Compounds for CYP2C8 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
genes like me logo Genes that share compounds with CYP2C8: view

Transcripts for CYP2C8 Gene

Unigene Clusters for CYP2C8 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - -
SP10:

Relevant External Links for CYP2C8 Gene

GeneLoc Exon Structure for
CYP2C8
ECgene alternative splicing isoforms for
CYP2C8

Expression for CYP2C8 Gene

mRNA expression in normal human tissues for CYP2C8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C8 Gene

This gene is overexpressed in Liver (x49.4).

Protein differential expression in normal tissues from HIPED for CYP2C8 Gene

This gene is overexpressed in Gallbladder (48.7) and Liver (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2C8 Gene



SOURCE GeneReport for Unigene cluster for CYP2C8 Gene Hs.709188

genes like me logo Genes that share expression patterns with CYP2C8: view

Protein tissue co-expression partners for CYP2C8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CYP2C8 Gene

Orthologs for CYP2C8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C8 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cyp2c39 35
  • 77.44 (n)
  • 71.98 (a)
Cyp2c39 16
Cyp2c29 36
  • 71 (a)
ManyToMany
Cyp2c37 36
  • 68 (a)
ManyToMany
Cyp2c38 36
  • 72 (a)
ManyToMany
Cyp2c39 36
  • 72 (a)
ManyToMany
Cyp2c40 36
  • 62 (a)
ManyToMany
Cyp2c50 36
  • 69 (a)
ManyToMany
Cyp2c54 36
  • 68 (a)
ManyToMany
Cyp2c65 36
  • 73 (a)
ManyToMany
Cyp2c66 36
  • 72 (a)
ManyToMany
Cyp2c67 36
  • 65 (a)
ManyToMany
Cyp2c68 36
  • 66 (a)
ManyToMany
Cyp2c69 36
  • 66 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CYP2C8 35
  • 98.91 (n)
  • 97.96 (a)
CYP2C8 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp2c7 35
  • 76.62 (n)
  • 68.71 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
CYP2C18 36
  • 77 (a)
ManyToMany
CYP2C87 36
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CYP2C21 36
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15643 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 33 (a)
Cyp303a1 37
  • 27 (a)
Cyp304a1 37
  • 27 (a)
Cyp307a1 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.10 37
  • 32 (a)
B0213.11 37
  • 39 (a)
B0213.16 37
  • 31 (a)
B0304.3 37
  • 30 (a)
C03G6.15 37
  • 30 (a)
C12D5.7 37
  • 33 (a)
C25E10.2 37
  • 28 (a)
C34B7.3 37
  • 31 (a)
C41G6.1 37
  • 31 (a)
C45H4.17 37
  • 32 (a)
C45H4.2 37
  • 32 (a)
C49C8.4 37
  • 33 (a)
C49G7.8 37
  • 30 (a)
C50H11.15 37
  • 33 (a)
F14H3.10 37
  • 30 (a)
F41B5.2 37
  • 31 (a)
F41B5.3 37
  • 32 (a)
F41B5.4 37
  • 33 (a)
F41B5.7 37
  • 31 (a)
F44C8.1 37
  • 33 (a)
K05D4.4 37
  • 31 (a)
K07C6.2 37
  • 30 (a)
K07C6.3 37
  • 30 (a)
K07C6.5 37
  • 30 (a)
K09A11.2 37
  • 33 (a)
K09A11.3 37
  • 32 (a)
K09A11.4 37
  • 33 (a)
K09D9.2 37
  • 30 (a)
R08F11.3 37
  • 31 (a)
T09H2.1 37
  • 30 (a)
T10H4.10 37
  • 29 (a)
T10H4.11 37
  • 31 (a)
Y49C4A.9 37
  • 32 (a)
Y5H2B.6 37
  • 29 (a)
Species with no ortholog for CYP2C8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP2C8 Gene

ENSEMBL:
Gene Tree for CYP2C8 (if available)
TreeFam:
Gene Tree for CYP2C8 (if available)

Paralogs for CYP2C8 Gene

Pseudogenes.org Pseudogenes for CYP2C8 Gene

genes like me logo Genes that share paralogs with CYP2C8: view

Variants for CYP2C8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C8 Gene

P10632-CP2C8_HUMAN
Several alleles are found in the human population, contributing to interindividual variations in the therapeutic efficacy and toxicity of a myriad of drugs such as paclitaxel or amodiaquine. The allele shown here is CYP2C8*1 (PubMed:26427316). CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIM:601129].

Sequence variations from dbSNP and Humsavar for CYP2C8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_001250 -
VAR_001251 -
VAR_001252 -
VAR_001253 -
rs1058930 - 95,058,362(+) TTTAT(A/C/G)GATTG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP2C8 Gene

Variant ID Type Subtype PubMed ID
nsv467436 CNV Loss 19166990

Variation tolerance for CYP2C8 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2C8 Gene

HapMap Linkage Disequilibrium report
CYP2C8
Human Gene Mutation Database (HGMD)
CYP2C8
The Human Cytochrome P450 Allele Nomenclature Database
CYP2C8

Disorders for CYP2C8 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CYP2C8 Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cyp2c8-related altered drug metabolism
  • rhabdomyolysis, cerivastatin-induced
osteonecrosis of the jaw
cauda equina syndrome
  • polyradiculopathy
male genital disorders
  • genital diseases, male
osteonecrosis
  • avascular necrosis of bone
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP2C8

Genetic Association Database (GAD)
CYP2C8
Human Genome Epidemiology (HuGE) Navigator
CYP2C8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2C8
genes like me logo Genes that share disorders with CYP2C8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C8 Gene

Publications for CYP2C8 Gene

  1. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis- retinoic acid. (PMID: 18413310) Schoch G.A. … Johnson E.F. (J. Biol. Chem. 2008) 3 23 25 26
  2. Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. (PMID: 11668219) Dai D. … Goldstein J.A. (Pharmacogenetics 2001) 3 4 48 67
  3. Examination of 209 drugs for inhibition of cytochrome P450 2C8. (PMID: 15601807) Walsky R.L. … Obach R.S. (J Clin Pharmacol 2005) 23 25 26
  4. Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8. (PMID: 15998357) Tornio A. … Backman J.T. (Basic Clin. Pharmacol. Toxicol. 2005) 23 25 26
  5. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. (PMID: 14676196) Schoch G.A. … Johnson E.F. (J. Biol. Chem. 2004) 3 23 25

Products for CYP2C8 Gene

Sources for CYP2C8 Gene

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