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Aliases for CYP2C8 Gene

Aliases for CYP2C8 Gene

  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 2 3
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 8 2 3
  • S-Mephenytoin 4-Hydroxylase 3 4
  • Cytochrome P450 Form 1 3 4
  • Cytochrome P450 MP-12 3 4
  • Cytochrome P450 MP-20 3 4
  • Cytochrome P450 IIC2 3 4
  • EC 1.14.14.1 4 63
  • CYPIIC8 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 2C8 3
  • P450 Form 1 3
  • MP-12/MP-20 3
  • CPC8 3

External Ids for CYP2C8 Gene

Previous GeneCards Identifiers for CYP2C8 Gene

  • GC10M095689
  • GC10M096030
  • GC10M096927
  • GC10M096461
  • GC10M096786
  • GC10M090423

Summaries for CYP2C8 Gene

Entrez Gene Summary for CYP2C8 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CYP2C8 Gene

CYP2C8 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 8) is a Protein Coding gene. Diseases associated with CYP2C8 include osteonecrosis of the jaw and osteonecrosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2C8 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).

Gene Wiki entry for CYP2C8 Gene

PharmGKB "VIP" Summary for CYP2C8 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C8 Gene

Genomics for CYP2C8 Gene

Regulatory Elements for CYP2C8 Gene

Genomic Location for CYP2C8 Gene

Start:
95,036,772 bp from pter
End:
95,069,497 bp from pter
Size:
32,726 bases
Orientation:
Minus strand

Genomic View for CYP2C8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2C8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C8 Gene

Proteins for CYP2C8 Gene

  • Protein details for CYP2C8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10632-CP2C8_HUMAN
    Recommended name:
    Cytochrome P450 2C8
    Protein Accession:
    P10632
    Secondary Accessions:
    • A8K9N8
    • B0AZN2
    • B7Z1F6
    • Q5VX93
    • Q8WWB1
    • Q9UCZ9

    Protein attributes for CYP2C8 Gene

    Size:
    490 amino acids
    Molecular mass:
    55825 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C8 Gene

    Alternative splice isoforms for CYP2C8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C8 Gene

Proteomics data for CYP2C8 Gene at MOPED

Post-translational modifications for CYP2C8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C8 Gene

Domains for CYP2C8 Gene

Gene Families for CYP2C8 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP2C8 Gene

Suggested Antigen Peptide Sequences for CYP2C8 Gene

Graphical View of Domain Structure for InterPro Entry

P10632

UniProtKB/Swiss-Prot:

CP2C8_HUMAN :
  • P10632
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C8: view

Function for CYP2C8 Gene

Molecular function for CYP2C8 Gene

GENATLAS Biochemistry: cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 8
UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
UniProtKB/Swiss-Prot Induction: By phenobarbital

Enzyme Numbers (IUBMB) for CYP2C8 Gene

Gene Ontology (GO) - Molecular Function for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 19651758
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
genes like me logo Genes that share ontologies with CYP2C8: view

Animal Model Products

CRISPR Products

miRNA for CYP2C8 Gene

miRTarBase miRNAs that target CYP2C8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2C8

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP2C8 Gene

Localization for CYP2C8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C8 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2C8 Gene COMPARTMENTS Subcellular localization image for CYP2C8 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
nucleus 2
cytosol 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with CYP2C8: view

Pathways for CYP2C8 Gene

genes like me logo Genes that share pathways with CYP2C8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cancer Drug Resistance in human,mouse,rat
    • Drug Metabolism in human,mouse,rat
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat

Interacting Proteins for CYP2C8 Gene

Gene Ontology (GO) - Biological Process for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IDA 19651758
GO:0006805 xenobiotic metabolic process TAS --
GO:0017144 drug metabolic process IDA 19651758
GO:0019369 arachidonic acid metabolic process TAS --
GO:0019373 epoxygenase P450 pathway TAS --
genes like me logo Genes that share ontologies with CYP2C8: view

Compounds for CYP2C8 Gene

(53) HMDB Compounds for CYP2C8 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(178) Drugbank Compounds for CYP2C8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
target
Abiraterone
154229-19-3 enzyme inhibitor
Acetaminophen
  • Acetaminofen
103-90-2 enzyme substrate
Acetylsalicylic acid
  • 2-Acetoxybenzenecarboxylic acid
50-78-2 enzyme substrate
Almotriptan
181183-52-8 enzyme substrate

(45) Novoseek inferred chemical compound relationships for CYP2C8 Gene

Compound -log(P) Hits PubMed IDs
androstane 82.4 3
sulfaphenazole 80.5 1
cerivastatin 74.6 9
paclitaxel 73.7 44
amodiaquine 72.2 4
genes like me logo Genes that share compounds with CYP2C8: view

Transcripts for CYP2C8 Gene

Unigene Clusters for CYP2C8 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2C8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - -
SP10:

Relevant External Links for CYP2C8 Gene

GeneLoc Exon Structure for
CYP2C8
ECgene alternative splicing isoforms for
CYP2C8

Expression for CYP2C8 Gene

mRNA expression in normal human tissues for CYP2C8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C8 Gene

This gene is overexpressed in Liver (49.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP2C8 Gene

SOURCE GeneReport for Unigene cluster for CYP2C8 Gene Hs.709188

genes like me logo Genes that share expressions with CYP2C8: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CYP2C8 Gene

Orthologs for CYP2C8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP2C8 35
  • 98.91 (n)
  • 97.96 (a)
CYP2C8 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
CYP2C18 36
  • 77 (a)
ManyToMany
CYP2C87 36
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CYP2C21 36
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cyp2c29 16
Cyp2c29 36
  • 71 (a)
ManyToMany
Cyp2c37 36
  • 68 (a)
ManyToMany
Cyp2c38 36
  • 72 (a)
ManyToMany
Cyp2c39 35
  • 77.44 (n)
  • 71.98 (a)
Cyp2c39 36
  • 72 (a)
ManyToMany
Cyp2c40 36
  • 62 (a)
ManyToMany
Cyp2c50 36
  • 69 (a)
ManyToMany
Cyp2c54 36
  • 68 (a)
ManyToMany
Cyp2c65 36
  • 73 (a)
ManyToMany
Cyp2c66 36
  • 72 (a)
ManyToMany
Cyp2c67 36
  • 65 (a)
ManyToMany
Cyp2c68 36
  • 66 (a)
ManyToMany
Cyp2c69 36
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2c7 35
  • 76.62 (n)
  • 68.71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15643 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
fruit fly
(Drosophila melanogaster)
Insecta Cyp304a1 37
  • 27 (a)
Cyp307a1 37
  • 27 (a)
Cyp18a1 37
  • 33 (a)
Cyp303a1 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea F14H3.10 37
  • 30 (a)
C41G6.1 37
  • 31 (a)
F41B5.2 37
  • 31 (a)
T10H4.11 37
  • 31 (a)
Y5H2B.6 37
  • 29 (a)
C45H4.2 37
  • 32 (a)
Y49C4A.9 37
  • 32 (a)
B0213.16 37
  • 31 (a)
F41B5.7 37
  • 31 (a)
K09A11.3 37
  • 32 (a)
C49C8.4 37
  • 33 (a)
C34B7.3 37
  • 31 (a)
B0213.10 37
  • 32 (a)
C50H11.15 37
  • 33 (a)
K09A11.4 37
  • 33 (a)
C25E10.2 37
  • 28 (a)
F41B5.3 37
  • 32 (a)
K07C6.2 37
  • 30 (a)
K09D9.2 37
  • 30 (a)
C12D5.7 37
  • 33 (a)
K07C6.5 37
  • 30 (a)
F44C8.1 37
  • 33 (a)
K05D4.4 37
  • 31 (a)
C49G7.8 37
  • 30 (a)
B0304.3 37
  • 30 (a)
C03G6.15 37
  • 30 (a)
F41B5.4 37
  • 33 (a)
K09A11.2 37
  • 33 (a)
R08F11.3 37
  • 31 (a)
B0213.11 37
  • 39 (a)
T09H2.1 37
  • 30 (a)
C45H4.17 37
  • 32 (a)
K07C6.3 37
  • 30 (a)
T10H4.10 37
  • 29 (a)
Species with no ortholog for CYP2C8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP2C8 Gene

ENSEMBL:
Gene Tree for CYP2C8 (if available)
TreeFam:
Gene Tree for CYP2C8 (if available)

Paralogs for CYP2C8 Gene

Pseudogenes.org Pseudogenes for CYP2C8 Gene

genes like me logo Genes that share paralogs with CYP2C8: view

Variants for CYP2C8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C8 Gene

P10632-CP2C8_HUMAN
CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIM:601129]

Sequence variations from dbSNP and Humsavar for CYP2C8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs947172 -- 95,048,884(-) ttttt(A/G)taggt intron-variant
rs947173 -- 95,048,734(-) ATCCC(A/G)CAGCT intron-variant
rs1058930 - 95,058,362(+) TTTAT(C/G)GATTG reference, missense
rs1058932 -- 95,037,104(-) GCTGC(C/T)GATCT utr-variant-3-prime
rs1113129 -- 95,051,288(+) cacaa(C/G)ctatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2C8 Gene

Variant ID Type Subtype PubMed ID
nsv467436 CNV Loss 19166990

Relevant External Links for CYP2C8 Gene

HapMap Linkage Disequilibrium report
CYP2C8
Human Gene Mutation Database (HGMD)
CYP2C8
Locus Specific Mutation Databases (LSDB)
CYP2C8
The Human Cytochrome P450 Allele Nomenclature Database
CYP2C8

Disorders for CYP2C8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CYP2C8 Gene including...

Search for CYP2C8 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CYP2C8 Gene

(2) Novoseek inferred disease relationships for CYP2C8 Gene

Disease -log(P) Hits PubMed IDs
tumors 0.922 2
cancer 0 1

Relevant External Links for CYP2C8

Genetic Association Database (GAD)
CYP2C8
Human Genome Epidemiology (HuGE) Navigator
CYP2C8
genes like me logo Genes that share disorders with CYP2C8: view

No data available for UniProtKB/Swiss-Prot for CYP2C8 Gene

Publications for CYP2C8 Gene

  1. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. (PMID: 14676196) Schoch G.A. … Johnson E.F. (J. Biol. Chem. 2004) 3 4 23 25
  2. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis- retinoic acid. (PMID: 18413310) Schoch G.A. … Johnson E.F. (J. Biol. Chem. 2008) 3 4 23 25
  3. Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide. (PMID: 14534525) Niemi M. … Neuvonen P.J. (Clin. Pharmacol. Ther. 2003) 3 23 48
  4. Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction. (PMID: 14646690) Yasar U. … Rane A. (Pharmacogenetics 2003) 3 23 48
  5. Development and evaluation of a rapid and reliable method for cytochrome P450 2C8 genotyping. (PMID: 15074466) Weise A. … PfA1tzner A. (Clin. Lab. 2004) 3 23 48

Products for CYP2C8 Gene

Sources for CYP2C8 Gene

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