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Aliases for CYP2C19 Gene

Aliases for CYP2C19 Gene

  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 2 3
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19 2 3
  • (R)-Limonene 6-Monooxygenase 3 4
  • (S)-Limonene 6-Monooxygenase 3 4
  • (S)-Limonene 7-Monooxygenase 3 4
  • Mephenytoin 4-Hydroxylase 3 4
  • Cytochrome P450-254C 3 4
  • Cytochrome P450-11A 3 4
  • CYPIIC17 3 4
  • CYPIIC19 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • S-Mephenytoin 4-Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P-450 II C 3
  • Cytochrome P450 2C19 3
  • EC 4
  • EC 4
  • EC 4
  • EC 63
  • EC 1.14.13.- 4
  • P450IIC19 3
  • P450C2C 3
  • CYP2C, 6
  • CYP2C 3
  • CPCJ 3

External Ids for CYP2C19 Gene

Previous HGNC Symbols for CYP2C19 Gene

  • CYP2C

Previous GeneCards Identifiers for CYP2C19 Gene

  • GC10P095415
  • GC10P095677
  • GC10P096574
  • GC10P096188
  • GC10P096189
  • GC10P096512
  • GC10P090150
  • GC10P096447

Summaries for CYP2C19 Gene

Entrez Gene Summary for CYP2C19 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C19 Gene

CYP2C19 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 19) is a Protein Coding gene. Diseases associated with CYP2C19 include mephenytoin poor metabolizer and voriconazole toxicity. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C9.

UniProtKB/Swiss-Prot for CYP2C19 Gene

  • Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine

Tocris Summary for CYP2C19 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They are found at high levels in the liver, where they have an important role in metabolism of drugs and endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis, cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP2C19 Gene

PharmGKB "VIP" Summary for CYP2C19 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for CYP2C19 Gene

Genomics for CYP2C19 Gene

Regulatory Elements for CYP2C19 Gene

Genomic Location for CYP2C19 Gene

94,762,624 bp from pter
94,853,260 bp from pter
90,637 bases
Plus strand

Genomic View for CYP2C19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2C19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C19 Gene

Proteins for CYP2C19 Gene

  • Protein details for CYP2C19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 2C19
    Protein Accession:
    Secondary Accessions:
    • P33259
    • Q8WZB1
    • Q8WZB2
    • Q9UCD4

    Protein attributes for CYP2C19 Gene

    490 amino acids
    Molecular mass:
    55931 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C19 Gene

neXtProt entry for CYP2C19 Gene

Proteomics data for CYP2C19 Gene at MOPED

Post-translational modifications for CYP2C19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C19 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CYP2C19 Gene

Gene Families for CYP2C19 Gene

  • CYP :Cytochrome P450s

Protein Domains for CYP2C19 Gene

Suggested Antigen Peptide Sequences for CYP2C19 Gene

Graphical View of Domain Structure for InterPro Entry



  • P33261
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C19: view

Function for CYP2C19 Gene

Molecular function for CYP2C19 Gene

GENATLAS Biochemistry: cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 19,with poor metabolizing phenotype mutant associated with CYP2C19,not predisposing to systemic lupus erythematosus
UniProtKB/Swiss-Prot CatalyticActivity: (+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity: (-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity: (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine
UniProtKB/Swiss-Prot Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens

Enzyme Numbers (IUBMB) for CYP2C19 Gene

Gene Ontology (GO) - Molecular Function for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 19651758
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IMP 18356043
GO:0016491 oxidoreductase activity IDA 16401082
genes like me logo Genes that share ontologies with CYP2C19: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP2C19 Gene

Localization for CYP2C19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C19 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CYP2C19 Gene COMPARTMENTS Subcellular localization image for CYP2C19 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle TAS 3442670
genes like me logo Genes that share ontologies with CYP2C19: view

Pathways for CYP2C19 Gene

genes like me logo Genes that share pathways with CYP2C19: view

Gene Ontology (GO) - Biological Process for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0016098 monoterpenoid metabolic process IDA 16401082
GO:0017144 drug metabolic process IDA 19219744
GO:0019369 arachidonic acid metabolic process TAS --
genes like me logo Genes that share ontologies with CYP2C19: view

Compounds for CYP2C19 Gene

(5) Tocris Compounds for CYP2C19 Gene

Compound Action Cas Number
Exemestane Steroidal aromatase (CYP19) inhibitor [107868-30-4]
Ketoconazole Cytochrome P450c17 inhibitor [65277-42-1]
Letrozole Potent, reversible non-steroidal aromatase inhibitor [112809-51-5]
Methoxyresorufin Fluorometric CYP450 substrate [5725-89-3]
Pentoxyresorufin Fluorometric cytochrome P450 substrate [87687-03-4]

(59) HMDB Compounds for CYP2C19 Gene

Compound Synonyms Cas Number PubMed IDs
  • Carveol
  • (+)-(4R)-Limonene
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available

(213) Drugbank Compounds for CYP2C19 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Acenocoumarin
152-72-7 enzyme substrate
Acetylsalicylic acid
  • 2-Acetoxybenzenecarboxylic acid
50-78-2 enzyme inducer
37115-32-5 enzyme substrate
181183-52-8 enzyme substrate
  • Dl-Aminoglutethimide
125-84-8 enzyme inducer

(131) Novoseek inferred chemical compound relationships for CYP2C19 Gene

Compound -log(P) Hits PubMed IDs
mephenytoin 91.2 35
4-hydroxymephenytoin 89.1 3
omeprazole 83.2 113
rabeprazole 80.7 30
lansoprazole 77.4 52
genes like me logo Genes that share compounds with CYP2C19: view

Transcripts for CYP2C19 Gene

mRNA/cDNA for CYP2C19 Gene

(18) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2C19 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C19 Gene

No ASD Table

Relevant External Links for CYP2C19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP2C19 Gene

mRNA expression in normal human tissues for CYP2C19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C19 Gene

This gene is overexpressed in Liver (41.6) and Small Intestine - Terminal Ileum (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP2C19 Gene

SOURCE GeneReport for Unigene cluster for CYP2C19 Gene Hs.282409

genes like me logo Genes that share expressions with CYP2C19: view

No data available for mRNA Expression by UniProt/SwissProt for CYP2C19 Gene

Orthologs for CYP2C19 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYP2C19 36
  • 98 (a)
LOC740956 35
  • 98.78 (n)
  • 98.57 (a)
(Bos Taurus)
Mammalia -- 36
  • 76 (a)
-- 36
  • 78 (a)
CYP2C18 36
  • 79 (a)
CYP2C19 35
  • 78.03 (n)
  • 68.16 (a)
CYP2C87 36
  • 78 (a)
(Canis familiaris)
Mammalia CYP2C18 35
  • 75.71 (n)
  • 70 (a)
(Mus musculus)
Mammalia Cyp2c29 36
  • 75 (a)
Cyp2c37 36
  • 72 (a)
Cyp2c38 36
  • 72 (a)
Cyp2c39 36
  • 73 (a)
Cyp2c40 36
  • 62 (a)
Cyp2c50 36
  • 72 (a)
Cyp2c54 36
  • 70 (a)
Cyp2c65 16
Cyp2c65 36
  • 76 (a)
Cyp2c66 36
  • 75 (a)
Cyp2c67 36
  • 66 (a)
Cyp2c68 36
  • 66 (a)
Cyp2c69 36
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
-- 36
  • 66 (a)
-- 36
  • 68 (a)
-- 36
  • 67 (a)
-- 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Cyp2c6v1 35
  • 80.3 (n)
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 32 (a)
Cyp303a1 37
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C41G6.1 37
  • 31 (a)
F41B5.2 37
  • 31 (a)
T10H4.11 37
  • 31 (a)
C45H4.2 37
  • 32 (a)
Y49C4A.9 37
  • 33 (a)
B0213.16 37
  • 30 (a)
F41B5.7 37
  • 32 (a)
K09A11.3 37
  • 32 (a)
C49C8.4 37
  • 33 (a)
C34B7.3 37
  • 30 (a)
B0213.14 37
  • 31 (a)
C25E10.2 37
  • 27 (a)
F41B5.3 37
  • 33 (a)
K07C6.2 37
  • 29 (a)
K09D9.2 37
  • 31 (a)
C12D5.7 37
  • 34 (a)
K07C6.5 37
  • 29 (a)
F44C8.1 37
  • 33 (a)
K05D4.4 37
  • 30 (a)
C49G7.8 37
  • 30 (a)
B0304.3 37
  • 32 (a)
C03G6.15 37
  • 30 (a)
F41B5.4 37
  • 32 (a)
K09A11.2 37
  • 33 (a)
R08F11.3 37
  • 31 (a)
B0213.11 37
  • 39 (a)
T09H2.1 37
  • 31 (a)
C45H4.17 37
  • 32 (a)
K07C6.3 37
  • 29 (a)
T10H4.10 37
  • 31 (a)
Species with no ortholog for CYP2C19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2C19 Gene

Gene Tree for CYP2C19 (if available)
Gene Tree for CYP2C19 (if available)

Paralogs for CYP2C19 Gene Pseudogenes for CYP2C19 Gene

genes like me logo Genes that share paralogs with CYP2C19: view

Variants for CYP2C19 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C19 Gene

Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIM:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM). The PM phenotype is inherited in an autosomal recessive manner, with the EM phenotype comprising both homozygous dominant and heteroyzgote genotypes. There are marked interracial differences in the frequency of this polymorphism. Poor metabolizers represent 2-5% of Caucasians, 13-23% of Asian populations, and as many as 38-79% of individuals of some of the islands of Polynesia and Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A), CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A (CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3), CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7, CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12, CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18, CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are characterized by a splice mutation and a stop codon, respectively, and account for most of the PM alleles. The sequence shown is that of allele CYP2C19*1B

Sequence variations from dbSNP and Humsavar for CYP2C19 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1322179 -- 94,815,485(-) TTAGG(A/G)CTGGG intron-variant
rs1322181 -- 94,849,307(-) CACAA(C/T)CACAT intron-variant
rs1555474 -- 94,845,570(+) ACTGA(C/G)TTTTA intron-variant
rs1853205 -- 94,815,312(-) ACATT(C/G)TGTAG intron-variant
rs1853209 -- 94,823,871(+) cctca(C/T)atagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2C19 Gene

Variant ID Type Subtype PubMed ID
nsv522538 CNV Loss 19592680
esv2739707 CNV Deletion 23290073
nsv895901 CNV Loss 21882294
esv2659638 CNV Deletion 23128226
nsv895902 CNV Loss 21882294
nsv516555 CNV Loss 19592680
nsv523259 CNV Gain 19592680
dgv803n71 CNV Loss 21882294
esv2674280 CNV Deletion 23128226
nsv820156 CNV Loss 19587683
esv2741937 CNV Deletion 23290073

Relevant External Links for CYP2C19 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)
The Human Cytochrome P450 Allele Nomenclature Database

Disorders for CYP2C19 Gene

(1) OMIM Diseases for CYP2C19 Gene (124020)

(4) University of Copenhagen DISEASES for CYP2C19 Gene

(28) Novoseek inferred disease relationships for CYP2C19 Gene

Disease -log(P) Hits PubMed IDs
peptic ulcer 15.6 5
gastroesophageal reflux disease 13.9 1
genetic susceptibility 11.6 1
gastric ulcer 8.33 1
reflux 5.88 1

Relevant External Links for CYP2C19

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CYP2C19: view

No data available for UniProtKB/Swiss-Prot for CYP2C19 Gene

Publications for CYP2C19 Gene

  1. Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia. (PMID: 11207032) Griese E.U. … Minchin R.F. (Pharmacogenetics 2001) 3 23 48
  2. Effects of CYP2C19 gene polymorphism on cure rates for Helicobacter pylori infection by triple therapy with proton pump inhibitor (omeprazole or rabeprazole), amoxycillin and clarithromycin in Japan. (PMID: 11785712) Dojo M. … Kuriyama M. (Dig Liver Dis 2001) 3 23 48
  3. Genotype/phenotype comparisons: a probe for the effect of disease progression on drug metabolism. (PMID: 11865668) Williams M.L. … Wainer I.W. (Curr Opin Drug Discov Devel 2002) 3 23 48
  4. The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels. (PMID: 11908757) Kerb R. … Brinkmann U. (Pharmacogenomics J. 2001) 3 23 48
  5. The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism. (PMID: 12656699) Kawamura M. … Shimosegawa T. (Aliment. Pharmacol. Ther. 2003) 3 23 48

Products for CYP2C19 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cancer Drug Resistance in human,mouse,rat
    • Cellular Stress Responses in human,mouse,rat
    • Drug Metabolism in human,mouse,rat
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP2C19
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2C19
    • Block miRNA regulation of CYP2C19 using miScript Target Protectors

    Sources for CYP2C19 Gene

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