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Aliases for CYP2C19 Gene

Aliases for CYP2C19 Gene

  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 2 3
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19 2 3
  • (R)-Limonene 6-Monooxygenase 3 4
  • (S)-Limonene 6-Monooxygenase 3 4
  • (S)-Limonene 7-Monooxygenase 3 4
  • Mephenytoin 4-Hydroxylase 3 4
  • Cytochrome P450-254C 3 4
  • Cytochrome P450-11A 3 4
  • CYPIIC17 3 4
  • CYPIIC19 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • S-Mephenytoin 4-Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P-450 II C 3
  • EC 1.14.13.80 4
  • EC 1.14.13.48 4
  • EC 1.14.13.49 4
  • EC 1.14.14.1 63
  • EC 1.14.13.- 4
  • P450IIC19 3
  • P450C2C 3
  • CYP2C 3
  • CPCJ 3

External Ids for CYP2C19 Gene

Previous HGNC Symbols for CYP2C19 Gene

  • CYP2C

Previous GeneCards Identifiers for CYP2C19 Gene

  • GC10P095415
  • GC10P095677
  • GC10P096574
  • GC10P096188
  • GC10P096189
  • GC10P096512
  • GC10P090150
  • GC10P096447

Summaries for CYP2C19 Gene

Entrez Gene Summary for CYP2C19 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C19 Gene

CYP2C19 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 19) is a Protein Coding gene. Diseases associated with CYP2C19 include voriconazole toxicity and resistance to clopidogrel. Among its related pathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C9.

UniProtKB/Swiss-Prot for CYP2C19 Gene

  • Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine

Tocris Summary for CYP2C19 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

Gene Wiki entry for CYP2C19 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C19 Gene

Genomics for CYP2C19 Gene

Regulatory Elements for CYP2C19 Gene

Genomic Location for CYP2C19 Gene

Chromosome:
10
Start:
94,762,624 bp from pter
End:
94,853,260 bp from pter
Size:
90,637 bases
Orientation:
Plus strand

Genomic View for CYP2C19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2C19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C19 Gene

Proteins for CYP2C19 Gene

  • Protein details for CYP2C19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33261-CP2CJ_HUMAN
    Recommended name:
    Cytochrome P450 2C19
    Protein Accession:
    P33261
    Secondary Accessions:
    • P33259
    • Q8WZB1
    • Q8WZB2
    • Q9UCD4

    Protein attributes for CYP2C19 Gene

    Size:
    490 amino acids
    Molecular mass:
    55931 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C19 Gene

neXtProt entry for CYP2C19 Gene

Proteomics data for CYP2C19 Gene at MOPED

Post-translational modifications for CYP2C19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CYP2C19 Gene

Gene Families for CYP2C19 Gene

Protein Domains for CYP2C19 Gene

Graphical View of Domain Structure for InterPro Entry

P33261

UniProtKB/Swiss-Prot:

CP2CJ_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C19: view

Function for CYP2C19 Gene

Molecular function for CYP2C19 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 19,with poor metabolizing phenotype mutant associated with CYP2C19,not predisposing to systemic lupus erythematosus
UniProtKB/Swiss-Prot CatalyticActivity:
(+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity:
(-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity:
(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens

Enzyme Numbers (IUBMB) for CYP2C19 Gene

Gene Ontology (GO) - Molecular Function for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 19651758
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IMP 18356043
GO:0016491 oxidoreductase activity IDA 16401082
genes like me logo Genes that share ontologies with CYP2C19: view
genes like me logo Genes that share phenotypes with CYP2C19: view

Animal Model Products

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miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2C19

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2C19 Gene

Localization for CYP2C19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C19 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2C19 Gene COMPARTMENTS Subcellular localization image for CYP2C19 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle TAS 3442670
genes like me logo Genes that share ontologies with CYP2C19: view

Pathways & Interactions for CYP2C19 Gene

genes like me logo Genes that share pathways with CYP2C19: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cancer Drug Resistance in human,mouse,rat
    • Cellular Stress Responses in human,mouse,rat

Gene Ontology (GO) - Biological Process for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0016098 monoterpenoid metabolic process IDA 16401082
GO:0017144 drug metabolic process IDA 19219744
GO:0019369 arachidonic acid metabolic process TAS --
genes like me logo Genes that share ontologies with CYP2C19: view

No data available for SIGNOR curated interactions for CYP2C19 Gene

Drugs & Compounds for CYP2C19 Gene

(330) Drugs for CYP2C19 Gene - From: NovoSeek, FDA Approved Drugs, PharmGKB, HMDB, ClinicalTrials, DrugBank, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma Enzyme, substrate, inhibitor 485
Esomeprazole Approved, Investigational Pharma Enzyme, substrate, inhibitor Proton pump inhibitor 289
Fluvoxamine Approved, Investigational Pharma Enzyme, inhibitor 44
Imipramine Approved Pharma Antagonist, Enzyme, substrate, inhibitor 26
Omeprazole Approved, Investigational Pharma Activator, Enzyme, substrate, inhibitor H+,K+-ATPase inhibitor 299

(91) Additional Compounds for CYP2C19 Gene - From: HMDB, NovoSeek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Paraxanthine
  • 1,7-Dimethyl-Xanthine
  • 1,7-Dimethylxanthine
611-59-6
(-)-trans-Carveol
  • Carveol
1197-07-5
(+)-Limonene
  • (+)-(4R)-Limonene
  • (+)-(R)-Limonene
5989-27-5
genes like me logo Genes that share compounds with CYP2C19: view

Transcripts for CYP2C19 Gene

mRNA/cDNA for CYP2C19 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2C19 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 19:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2C19

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C19 Gene

No ASD Table

Relevant External Links for CYP2C19 Gene

GeneLoc Exon Structure for
CYP2C19
ECgene alternative splicing isoforms for
CYP2C19

Expression for CYP2C19 Gene

mRNA expression in normal human tissues for CYP2C19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C19 Gene

This gene is overexpressed in Liver (x41.6) and Small Intestine - Terminal Ileum (x4.1).

Protein differential expression in normal tissues from HIPED for CYP2C19 Gene

This gene is overexpressed in Liver (53.8) and Gallbladder (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2C19 Gene



SOURCE GeneReport for Unigene cluster for CYP2C19 Gene Hs.282409

genes like me logo Genes that share expression patterns with CYP2C19: view

Protein tissue co-expression partners for CYP2C19 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CYP2C19 Gene

Orthologs for CYP2C19 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP2C19 35
  • 78.03 (n)
  • 68.16 (a)
-- 36
  • 76 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
CYP2C18 36
  • 79 (a)
ManyToMany
CYP2C87 36
  • 78 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CYP2C18 35
  • 75.71 (n)
  • 70 (a)
chimpanzee
(Pan troglodytes)
Mammalia LOC740956 35
  • 98.78 (n)
  • 98.57 (a)
CYP2C19 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp2c6v1 35
  • 80.3 (n)
  • 75 (a)
mouse
(Mus musculus)
Mammalia Cyp2c65 16
Cyp2c29 36
  • 75 (a)
ManyToMany
Cyp2c37 36
  • 72 (a)
ManyToMany
Cyp2c38 36
  • 72 (a)
ManyToMany
Cyp2c39 36
  • 73 (a)
ManyToMany
Cyp2c40 36
  • 62 (a)
ManyToMany
Cyp2c50 36
  • 72 (a)
ManyToMany
Cyp2c54 36
  • 70 (a)
ManyToMany
Cyp2c65 36
  • 76 (a)
ManyToMany
Cyp2c66 36
  • 75 (a)
ManyToMany
Cyp2c67 36
  • 66 (a)
ManyToMany
Cyp2c68 36
  • 66 (a)
ManyToMany
Cyp2c69 36
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 32 (a)
Cyp303a1 37
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.11 37
  • 39 (a)
B0213.14 37
  • 31 (a)
B0213.16 37
  • 30 (a)
B0304.3 37
  • 32 (a)
C03G6.15 37
  • 30 (a)
C12D5.7 37
  • 34 (a)
C25E10.2 37
  • 27 (a)
C34B7.3 37
  • 30 (a)
C41G6.1 37
  • 31 (a)
C45H4.17 37
  • 32 (a)
C45H4.2 37
  • 32 (a)
C49C8.4 37
  • 33 (a)
C49G7.8 37
  • 30 (a)
F41B5.2 37
  • 31 (a)
F41B5.3 37
  • 33 (a)
F41B5.4 37
  • 32 (a)
F41B5.7 37
  • 32 (a)
F44C8.1 37
  • 33 (a)
K05D4.4 37
  • 30 (a)
K07C6.2 37
  • 29 (a)
K07C6.3 37
  • 29 (a)
K07C6.5 37
  • 29 (a)
K09A11.2 37
  • 33 (a)
K09A11.3 37
  • 32 (a)
K09D9.2 37
  • 31 (a)
R08F11.3 37
  • 31 (a)
T09H2.1 37
  • 31 (a)
T10H4.10 37
  • 31 (a)
T10H4.11 37
  • 31 (a)
Y49C4A.9 37
  • 33 (a)
Species with no ortholog for CYP2C19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2C19 Gene

ENSEMBL:
Gene Tree for CYP2C19 (if available)
TreeFam:
Gene Tree for CYP2C19 (if available)

Paralogs for CYP2C19 Gene

Pseudogenes.org Pseudogenes for CYP2C19 Gene

genes like me logo Genes that share paralogs with CYP2C19: view

Variants for CYP2C19 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C19 Gene

P33261-CP2CJ_HUMAN
Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIM:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM). The PM phenotype is inherited in an autosomal recessive manner, with the EM phenotype comprising both homozygous dominant and heteroyzgote genotypes. There are marked interracial differences in the frequency of this polymorphism. Poor metabolizers represent 2-5% of Caucasians, 13-23% of Asian populations, and as many as 38-79% of individuals of some of the islands of Polynesia and Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A), CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A (CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3), CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7, CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12, CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18, CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are characterized by a splice mutation and a stop codon, respectively, and account for most of the PM alleles. The sequence shown is that of allele CYP2C19*1B

Sequence variations from dbSNP and Humsavar for CYP2C19 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1322179 -- 94,815,485(-) TTAGG(A/G)CTGGG intron-variant
rs1322181 -- 94,849,307(-) CACAA(C/T)CACAT intron-variant
rs1555474 -- 94,845,570(+) ACTGA(C/G)TTTTA intron-variant
rs1853205 -- 94,815,312(-) ACATT(C/G)TGTAG intron-variant
rs1853209 -- 94,823,871(+) cctca(C/T)atagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2C19 Gene

Variant ID Type Subtype PubMed ID
nsv522538 CNV Loss 19592680
esv2739707 CNV Deletion 23290073
nsv895901 CNV Loss 21882294
esv2659638 CNV Deletion 23128226
nsv895902 CNV Loss 21882294
nsv516555 CNV Loss 19592680
nsv523259 CNV Gain 19592680
dgv803n71 CNV Loss 21882294
esv2674280 CNV Deletion 23128226
nsv820156 CNV Loss 19587683
esv2741937 CNV Deletion 23290073

Variation tolerance for CYP2C19 Gene

Residual Variation Intolerance Score: 95.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2C19 Gene

HapMap Linkage Disequilibrium report
CYP2C19
Human Gene Mutation Database (HGMD)
CYP2C19
The Human Cytochrome P450 Allele Nomenclature Database
CYP2C19

Disorders for CYP2C19 Gene

MalaCards: The human disease database

(25) MalaCards diseases for CYP2C19 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Relevant External Links for CYP2C19

Genetic Association Database (GAD)
CYP2C19
Human Genome Epidemiology (HuGE) Navigator
CYP2C19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2C19
genes like me logo Genes that share disorders with CYP2C19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C19 Gene

Publications for CYP2C19 Gene

  1. A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens. (PMID: 18350255) Elsherbiny D.A. … Simonsson U.S. (J Pharmacokinet Pharmacodyn 2008) 23 25 26 67
  2. Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. (PMID: 16141567) Niwa T. … Takagi A. (Biol. Pharm. Bull. 2005) 23 25 26 67
  3. Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6. (PMID: 15049511) Salsali M. … Baker G.B. (Cell. Mol. Neurobiol. 2004) 23 25 26 67
  4. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. (PMID: 15258107) Li X.Q. … Weidolf L. (Drug Metab. Dispos. 2004) 23 25 26 67
  5. Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. (PMID: 9578596) Lasker J.M. … Raucy J.L. (Arch. Biochem. Biophys. 1998) 23 25 26 67

Products for CYP2C19 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cancer Drug Resistance in human,mouse,rat
    • Cellular Stress Responses in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP2C19
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2C19
    • Block miRNA regulation of CYP2C19 using miScript Target Protectors

    Sources for CYP2C19 Gene

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