Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYP2B6 Gene

Aliases for CYP2B6 Gene

  • Cytochrome P450 Family 2 Subfamily B Member 6 2 3 5
  • Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible), Polypeptide 6 2 3
  • Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 2 3
  • 1,4-Cineole 2-Exo-Monooxygenase 3 4
  • Cytochrome P450 IIB1 3 4
  • CYPIIB6 3 4
  • Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible) 2
  • Cytochrome P450, Family 2, Subfamily B 2
  • EC 1.14.14.1 63
  • EC 1.14.13.- 4
  • CYP2B7P 3
  • CYP2B7 3
  • CYP2B 3
  • CPB6 3
  • EFVM 3
  • IIB1 3
  • P450 3

External Ids for CYP2B6 Gene

Previous HGNC Symbols for CYP2B6 Gene

  • CYP2B

Previous GeneCards Identifiers for CYP2B6 Gene

  • GC19P042136
  • GC19P041888
  • GC19P046107
  • GC19P046123
  • GC19P046127
  • GC19P046189
  • GC19P041497
  • GC19P037929

Summaries for CYP2B6 Gene

Entrez Gene Summary for CYP2B6 Gene

  • This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2B6 Gene

CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with CYP2B6 include efavirenz, poor metabolism of and cyp2b6-related altered drug metabolism. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2B6 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.

Gene Wiki entry for CYP2B6 Gene

PharmGKB "VIP" Summary for CYP2B6 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2B6 Gene

Genomics for CYP2B6 Gene

Regulatory Elements for CYP2B6 Gene

Genomic Location for CYP2B6 Gene

Chromosome:
19
Start:
40,991,229 bp from pter
End:
41,018,398 bp from pter
Size:
27,170 bases
Orientation:
Plus strand

Genomic View for CYP2B6 Gene

Genes around CYP2B6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2B6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2B6 Gene

Proteins for CYP2B6 Gene

  • Protein details for CYP2B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20813-CP2B6_HUMAN
    Recommended name:
    Cytochrome P450 2B6
    Protein Accession:
    P20813
    Secondary Accessions:
    • B4DWP3
    • Q2V565
    • Q9UK46

    Protein attributes for CYP2B6 Gene

    Size:
    491 amino acids
    Molecular mass:
    56278 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2B6 Gene

    Alternative splice isoforms for CYP2B6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2B6 Gene

Proteomics data for CYP2B6 Gene at MOPED

Post-translational modifications for CYP2B6 Gene

  • Phosphorylation is accompanied by a decrease in enzyme activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2B6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CYP2B6 Gene

Gene Families for CYP2B6 Gene

Graphical View of Domain Structure for InterPro Entry

P20813

UniProtKB/Swiss-Prot:

CP2B6_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2B6: view

Function for CYP2B6 Gene

Molecular function for CYP2B6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=360 uM for 1,4-cineole {ECO:0000269 PubMed:11695850}; Vmax=3.4 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole {ECO:0000269 PubMed:11695850};
UniProtKB/Swiss-Prot CatalyticActivity:
1,4-cineole + NADPH + O(2) = 2-exo-hydroxy-1,4-cineole + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
UniProtKB/Swiss-Prot Induction:
By phenobarbital.

Enzyme Numbers (IUBMB) for CYP2B6 Gene

Gene Ontology (GO) - Molecular Function for CYP2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008392 arachidonic acid epoxygenase activity IBA --
genes like me logo Genes that share ontologies with CYP2B6: view
genes like me logo Genes that share phenotypes with CYP2B6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP2B6

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2B6 Gene

Localization for CYP2B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2B6 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2B6 Gene COMPARTMENTS Subcellular localization image for CYP2B6 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
cytosol 2
nucleus 2
peroxisome 2
plasma membrane 2
vacuole 2
extracellular 1
golgi apparatus 1
lysosome 1

No data available for Gene Ontology (GO) - Cellular Components for CYP2B6 Gene

Pathways & Interactions for CYP2B6 Gene

genes like me logo Genes that share pathways with CYP2B6: view

Interacting Proteins for CYP2B6 Gene

Gene Ontology (GO) - Biological Process for CYP2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0019373 epoxygenase P450 pathway IBA --
GO:0042738 exogenous drug catabolic process IDA 19029318
genes like me logo Genes that share ontologies with CYP2B6: view

No data available for SIGNOR curated interactions for CYP2B6 Gene

Drugs & Compounds for CYP2B6 Gene

(242) Drugs for CYP2B6 Gene - From: Novoseek, DrugBank, FDA Approved Drugs, HMDB, PharmGKB, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bupropion Approved Pharma Enzyme, substrate, inhibitor 308
Efavirenz Approved, Investigational Pharma Enzyme, substrate, inhibitor, inducer Reverse transcriptase inhibitor 398
Nevirapine Approved Pharma Enzyme, substrate, inducer 222
Propofol Approved, Investigational Pharma Enzyme, substrate 931
Doxorubicin Approved, Investigational Pharma Enzyme, inhibitor Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1582

(92) Additional Compounds for CYP2B6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxycyclophosphamide
40277-05-2
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
parathion
  • Alkron
  • Alleron
  • American cyanamid 3422
  • Aphamite
  • Aqua 9-Parathion
56-38-2
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
genes like me logo Genes that share compounds with CYP2B6: view

Transcripts for CYP2B6 Gene

Unigene Clusters for CYP2B6 Gene

Cytochrome P450, family 2, subfamily B, polypeptide 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2B6 Gene

No ASD Table

Relevant External Links for CYP2B6 Gene

GeneLoc Exon Structure for
CYP2B6
ECgene alternative splicing isoforms for
CYP2B6

Expression for CYP2B6 Gene

mRNA expression in normal human tissues for CYP2B6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2B6 Gene

This gene is overexpressed in Liver (x50.3).

Protein differential expression in normal tissues from HIPED for CYP2B6 Gene

This gene is overexpressed in Gallbladder (52.5) and Liver (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2B6 Gene



SOURCE GeneReport for Unigene cluster for CYP2B6 Gene Hs.1360

mRNA Expression by UniProt/SwissProt for CYP2B6 Gene

P20813-CP2B6_HUMAN
Tissue specificity: Expressed in liver, lung and heart right ventricle.
genes like me logo Genes that share expression patterns with CYP2B6: view

Protein tissue co-expression partners for CYP2B6 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYP2B6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2B6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP2B6 35
  • 83.21 (n)
  • 76.81 (a)
CYP2B6 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP2B6 35
  • 83.02 (n)
  • 77.38 (a)
CYP2B6 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp2b10 35
  • 79.41 (n)
  • 78.67 (a)
Cyp2b10 16
Cyp2b10 36
  • 78 (a)
OneToMany
Cyp2b13 36
  • 71 (a)
OneToMany
Cyp2b19 36
  • 75 (a)
OneToMany
Cyp2b23 36
  • 75 (a)
OneToMany
Cyp2b9 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC456052 35
  • 95.97 (n)
  • 92.37 (a)
CYP2B6 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp2b1 35
  • 79.03 (n)
  • 75.85 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 32 (a)
Cyp303a1 37
  • 31 (a)
Cyp304a1 37
  • 29 (a)
Cyp305a1 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.10 37
  • 30 (a)
B0213.11 37
  • 30 (a)
B0213.12 37
  • 32 (a)
B0213.14 37
  • 31 (a)
B0213.15 37
  • 30 (a)
B0213.16 37
  • 30 (a)
B0304.3 37
  • 32 (a)
C03G6.15 37
  • 29 (a)
C12D5.7 37
  • 33 (a)
C41G6.1 37
  • 32 (a)
C45H4.17 37
  • 33 (a)
C45H4.2 37
  • 33 (a)
C49G7.8 37
  • 30 (a)
C50H11.15 37
  • 34 (a)
F14H3.10 37
  • 29 (a)
F41B5.2 37
  • 31 (a)
F41B5.4 37
  • 33 (a)
F44C8.1 37
  • 32 (a)
K05D4.4 37
  • 31 (a)
K07C6.2 37
  • 28 (a)
K07C6.3 37
  • 30 (a)
K07C6.5 37
  • 29 (a)
K09D9.2 37
  • 29 (a)
R08F11.3 37
  • 33 (a)
T09H2.1 37
  • 29 (a)
T10H4.10 37
  • 30 (a)
T10H4.11 37
  • 31 (a)
Y49C4A.9 37
  • 32 (a)
Y5H2B.6 37
  • 31 (a)
Species with no ortholog for CYP2B6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2B6 Gene

ENSEMBL:
Gene Tree for CYP2B6 (if available)
TreeFam:
Gene Tree for CYP2B6 (if available)

Paralogs for CYP2B6 Gene

genes like me logo Genes that share paralogs with CYP2B6: view

Variants for CYP2B6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2B6 Gene

P20813-CP2B6_HUMAN
Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIM:614546]. Efavirenz is a non-nucleoside reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz concentration in the plasma.

Sequence variations from dbSNP and Humsavar for CYP2B6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3826711 - 41,006,919(+) TGGAC(C/G)CCAYC intron-variant, reference, missense
rs3745274 - 41,006,936(+) TTCCA(A/G/T)TCCAT intron-variant, reference, missense, splice-acceptor-variant
rs2279343 - 41,009,358(+) CCCCA(A/G)GGACC intron-variant, reference, missense
rs8192709 - 40,991,369(+) TTCAG(C/T)GCCAC reference, missense
rs45482602 - 41,009,350(+) CCCAG(A/C/T)GCCCC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP2B6 Gene

Variant ID Type Subtype PubMed ID
dgv1084e1 CNV Complex 17122850
esv2718571 CNV Deletion 23290073
dgv55n17 CNV Loss 16327808
nsv523686 CNV Gain 19592680
dgv1085e1 CNV Complex 17122850
nsv517597 CNV Loss 19592680
nsv509743 CNV Insertion 20534489
esv2718572 CNV Deletion 23290073
dgv3879n71 CNV Gain 21882294
esv2597443 CNV Loss 19546169
nsv433319 CNV Loss 18776910
nsv470141 CNV Loss 18288195
dgv408n27 CNV Loss 19166990
nsv442461 CNV CNV 18776908
esv2658055 CNV Deletion 23128226
nsv470142 CNV Gain 18288195
esv24009 CNV Gain 19812545

Variation tolerance for CYP2B6 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2B6 Gene

HapMap Linkage Disequilibrium report
CYP2B6
Human Gene Mutation Database (HGMD)
CYP2B6
The Human Cytochrome P450 Allele Nomenclature Database
CYP2B6

Disorders for CYP2B6 Gene

MalaCards: The human disease database

(17) MalaCards diseases for CYP2B6 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
efavirenz, poor metabolism of
  • efavirenz central nervous system toxicity
cyp2b6-related altered drug metabolism
  • efavirenz, poor metabolizer of
efavirenz toxicity
acute frontal sinusitis
male genital disorders
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP2B6

Genetic Association Database (GAD)
CYP2B6
Human Genome Epidemiology (HuGE) Navigator
CYP2B6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2B6
genes like me logo Genes that share disorders with CYP2B6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2B6 Gene

Publications for CYP2B6 Gene

  1. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. (PMID: 15622315) Haas D.W. … Acosta E.P. (AIDS 2004) 3 4 23 48 67
  2. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. (PMID: 14977870) Faucette S.R. … LeCluyse E.L. (Drug Metab. Dispos. 2004) 3 23 25 26
  3. Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling. (PMID: 19144770) Shebley M. … Hollenberg P.F. (Drug Metab. Dispos. 2009) 23 25 26
  4. Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. (PMID: 17101742) Walsky R.L. … Obach R.S. (J Clin Pharmacol 2006) 23 25 26
  5. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. (PMID: 15319333) RamA-rez J. … Ratain M.J. (Drug Metab. Dispos. 2004) 3 25 26

Products for CYP2B6 Gene

Sources for CYP2B6 Gene

Back to Top

Content