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Aliases for CYP2A13 Gene

Aliases for CYP2A13 Gene

  • Cytochrome P450, Family 2, Subfamily A, Polypeptide 13 2 3
  • Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 13 2 3
  • EC 1.14.14.1 4 63
  • CYPIIA13 3 4
  • Cytochrome P450 2A13 3
  • CYP2A 3
  • CPAD 3

External Ids for CYP2A13 Gene

Previous GeneCards Identifiers for CYP2A13 Gene

  • GC19P042233
  • GC19P041986
  • GC19P046108
  • GC19P046126
  • GC19P046130
  • GC19P046286
  • GC19P041594
  • GC19P038026

Summaries for CYP2A13 Gene

Entrez Gene Summary for CYP2A13 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2A13 Gene

CYP2A13 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 13) is a Protein Coding gene. Diseases associated with CYP2A13 include lung cancer. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2A13 Gene

  • Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.

Gene Wiki entry for CYP2A13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2A13 Gene

Genomics for CYP2A13 Gene

Regulatory Elements for CYP2A13 Gene

Genomic Location for CYP2A13 Gene

Start:
41,088,451 bp from pter
End:
41,096,195 bp from pter
Size:
7,745 bases
Orientation:
Plus strand

Genomic View for CYP2A13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2A13 Gene

Proteins for CYP2A13 Gene

  • Protein details for CYP2A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16696-CP2AD_HUMAN
    Recommended name:
    Cytochrome P450 2A13
    Protein Accession:
    Q16696
    Secondary Accessions:
    • Q53YR8
    • Q6R569
    • Q6R570
    • Q9H2X2

    Protein attributes for CYP2A13 Gene

    Size:
    494 amino acids
    Molecular mass:
    56688 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2A13 Gene

neXtProt entry for CYP2A13 Gene

Proteomics data for CYP2A13 Gene at MOPED

Post-translational modifications for CYP2A13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2A13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for CYP2A13 Gene

Gene Families for CYP2A13 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Suggested Antigen Peptide Sequences for CYP2A13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16696

UniProtKB/Swiss-Prot:

CP2AD_HUMAN :
  • Q16696
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2A13: view

Function for CYP2A13 Gene

Molecular function for CYP2A13 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 13
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.7 uM for phenacetin {ECO:0000269 PubMed:18779312};
UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function:
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.

Enzyme Numbers (IUBMB) for CYP2A13 Gene

Gene Ontology (GO) - Molecular Function for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA --
genes like me logo Genes that share ontologies with CYP2A13: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2A13

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP2A13 Gene

Localization for CYP2A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2A13 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2A13 Gene COMPARTMENTS Subcellular localization image for CYP2A13 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with CYP2A13: view

Pathways for CYP2A13 Gene

genes like me logo Genes that share pathways with CYP2A13: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CYP2A13 Gene

Gene Ontology (GO) - Biological Process for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0009804 coumarin metabolic process IBA --
GO:0019373 epoxygenase P450 pathway IBA --
GO:0042738 exogenous drug catabolic process IBA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CYP2A13: view

Compounds for CYP2A13 Gene

(50) HMDB Compounds for CYP2A13 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(4) Drugbank Compounds for CYP2A13 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Methoxsalen
  • Methoxalen
298-81-7 enzyme inhibitor
Nicotine
  • L-Nicotine
54-11-5 enzyme substrate
Phenacetin
  • Acetophenetidin
62-44-2 enzyme substrate
Testosterone
  • TES
58-22-0 enzyme substrate

(6) Novoseek inferred chemical compound relationships for CYP2A13 Gene

Compound -log(P) Hits PubMed IDs
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 93.2 15
coumarin 77.6 10
8 methoxypsoralen 74.8 4
aflatoxin b1 63 10
nicotine 62 7
genes like me logo Genes that share compounds with CYP2A13: view

Transcripts for CYP2A13 Gene

mRNA/cDNA for CYP2A13 Gene

(11) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2A13 Gene

Cytochrome P450, family 2, subfamily A, polypeptide 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2A13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2A13 Gene

No ASD Table

Relevant External Links for CYP2A13 Gene

GeneLoc Exon Structure for
CYP2A13
ECgene alternative splicing isoforms for
CYP2A13

Expression for CYP2A13 Gene

mRNA expression in normal human tissues for CYP2A13 Gene

mRNA differential expression in normal tissues according to GTEx for CYP2A13 Gene

This gene is overexpressed in Liver (19.9), Cervix - Ectocervix (5.5), Testis (5.3), Minor Salivary Gland (5.3), and Vagina (4.4).

SOURCE GeneReport for Unigene cluster for CYP2A13 Gene Hs.567252

mRNA Expression by UniProt/SwissProt for CYP2A13 Gene

Q16696-CP2AD_HUMAN
Tissue specificity: Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.
genes like me logo Genes that share expressions with CYP2A13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for CYP2A13 Gene

Orthologs for CYP2A13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2A13 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cyp2a5 35
  • 85.49 (n)
  • 88.46 (a)
Cyp2a4 16
Cyp2a12 36
  • 74 (a)
ManyToMany
Cyp2a22 36
  • 73 (a)
ManyToMany
Cyp2a4 36
  • 87 (a)
ManyToMany
Cyp2a5 36
  • 88 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2a3 35
  • 85.63 (n)
  • 88.87 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYP2A13 36
  • 88 (a)
ManyToMany
CYP2A13 36
  • 92 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC548374 35
  • 58.87 (n)
  • 56.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.43 35
zebrafish
(Danio rerio)
Actinopterygii zgc55856 35
fruit fly
(Drosophila melanogaster)
Insecta Cyp303a1 37
  • 28 (a)
Cyp304a1 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.10 37
  • 28 (a)
B0213.11 37
  • 30 (a)
B0213.14 37
  • 29 (a)
B0213.15 37
  • 30 (a)
B0304.3 37
  • 30 (a)
C03G6.14 37
  • 28 (a)
C03G6.15 37
  • 30 (a)
C12D5.7 37
  • 27 (a)
C25E10.2 37
  • 27 (a)
C34B7.3 37
  • 33 (a)
C41G6.1 37
  • 26 (a)
C45H4.17 37
  • 31 (a)
C49C8.4 37
  • 32 (a)
C49G7.8 37
  • 29 (a)
C50H11.15 37
  • 34 (a)
F14H3.10 37
  • 30 (a)
F41B5.2 37
  • 30 (a)
F41B5.3 37
  • 32 (a)
F41B5.4 37
  • 30 (a)
F41B5.7 37
  • 29 (a)
F42A9.5 37
  • 32 (a)
F44C8.1 37
  • 30 (a)
K05D4.4 37
  • 32 (a)
K07C6.2 37
  • 30 (a)
K07C6.3 37
  • 30 (a)
K07C6.5 37
  • 29 (a)
K09A11.2 37
  • 32 (a)
K09A11.3 37
  • 34 (a)
K09A11.4 37
  • 32 (a)
K09D9.2 37
  • 29 (a)
R08F11.3 37
  • 31 (a)
T10H4.10 37
  • 30 (a)
T10H4.11 37
  • 30 (a)
Y49C4A.9 37
  • 31 (a)
Y5H2B.6 37
  • 29 (a)
cyp-36A1 35
  • 43.1 (n)
  • 33.7 (a)
Species with no ortholog for CYP2A13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP2A13 Gene

ENSEMBL:
Gene Tree for CYP2A13 (if available)
TreeFam:
Gene Tree for CYP2A13 (if available)

Paralogs for CYP2A13 Gene

genes like me logo Genes that share paralogs with CYP2A13: view

Variants for CYP2A13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2A13 Gene

Q16696-CP2AD_HUMAN
The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested

Sequence variations from dbSNP and Humsavar for CYP2A13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs170054 -- 41,089,951(+) CACTC(C/T)CTCTC intron-variant
rs305987 -- 41,088,061(-) TTTTA(C/T)TAGGG upstream-variant-2KB
rs305988 -- 41,087,232(+) TGCCT(A/G)CTAAT upstream-variant-2KB
rs305989 -- 41,086,993(+) GATCA(C/T)GATGA upstream-variant-2KB
rs829560 -- 41,089,874(+) tctcG(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2A13 Gene

Variant ID Type Subtype PubMed ID
nsv2491 CNV Loss 18451855

Relevant External Links for CYP2A13 Gene

HapMap Linkage Disequilibrium report
CYP2A13
Human Gene Mutation Database (HGMD)
CYP2A13
Locus Specific Mutation Databases (LSDB)
CYP2A13
The Human Cytochrome P450 Allele Nomenclature Database
CYP2A13

Disorders for CYP2A13 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CYP2A13 Gene in MalaCards »

(1) Diseases for CYP2A13 Gene including...

(2) Novoseek inferred disease relationships for CYP2A13 Gene

Disease -log(P) Hits PubMed IDs
cancer lung 48.4 11
cancer 0 1

Relevant External Links for CYP2A13

Genetic Association Database (GAD)
CYP2A13
Human Genome Epidemiology (HuGE) Navigator
CYP2A13
genes like me logo Genes that share disorders with CYP2A13: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CYP2A13 Gene

Publications for CYP2A13 Gene

  1. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PMID: 7668294) Fernandez-Salguero P. … Idle J.R. (Am. J. Hum. Genet. 1995) 2 3 4 23
  2. Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility. (PMID: 15063809) Cauffiez C. … Broly F. (Biochem. Biophys. Res. Commun. 2004) 3 4 23 48
  3. Arg257Cys polymorphism of CYP2A13 in a Chinese population. (PMID: 15115698) Cheng X.Y. … Zhou H.H. (Clin. Chim. Acta 2004) 3 23 48
  4. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone. (PMID: 11016631) Su T. … Ding X. (Cancer Res. 2000) 3 4 23
  5. Eighteen novel polymorphisms of the CYP2A13 gene in Japanese. (PMID: 15618722) Fujieda M. … Kamataki T. (Drug Metab. Pharmacokinet. 2003) 3 4 23

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