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Aliases for SLC2A7 Gene

Aliases for SLC2A7 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 7 2 3
  • GLUT7 3 4 6
  • Intestinal Facilitative Glucose Transporter 7 2 3
  • Glucose Transporter Type 7 3 4
  • GLUT-7 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 7 3

External Ids for SLC2A7 Gene

Previous GeneCards Identifiers for SLC2A7 Gene

  • GC01U990466
  • GC01M008998
  • GC01M008985
  • GC01M008213

Summaries for SLC2A7 Gene

Entrez Gene Summary for SLC2A7 Gene

  • SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC2A7 Gene

SLC2A7 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 7) is a Protein Coding gene. Among its related pathways are HIF1Alpha Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include substrate-specific transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A7 Gene

  • High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose.

Gene Wiki entry for SLC2A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A7 Gene

Genomics for SLC2A7 Gene

Regulatory Elements for SLC2A7 Gene

Genomic Location for SLC2A7 Gene

Start:
9,003,300 bp from pter
End:
9,026,345 bp from pter
Size:
23,046 bases
Orientation:
Minus strand

Genomic View for SLC2A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A7 Gene

Proteins for SLC2A7 Gene

  • Protein details for SLC2A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PXP3-GTR7_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 7
    Protein Accession:
    Q6PXP3
    Secondary Accessions:
    • A2A333

    Protein attributes for SLC2A7 Gene

    Size:
    512 amino acids
    Molecular mass:
    55728 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SLC2A7 Gene

neXtProt entry for SLC2A7 Gene

Proteomics data for SLC2A7 Gene at MOPED

Post-translational modifications for SLC2A7 Gene

Other Protein References for SLC2A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A7 Gene

Domains for SLC2A7 Gene

Gene Families for SLC2A7 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Suggested Antigen Peptide Sequences for SLC2A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PXP3

UniProtKB/Swiss-Prot:

GTR7_HUMAN :
  • Q6PXP3
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A7: view

Function for SLC2A7 Gene

Molecular function for SLC2A7 Gene

UniProtKB/Swiss-Prot Function: High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose.

Gene Ontology (GO) - Molecular Function for SLC2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC2A7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC2A7 Gene

Localization for SLC2A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A7 Gene COMPARTMENTS Subcellular localization image for SLC2A7 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC2A7: view

Pathways for SLC2A7 Gene

genes like me logo Genes that share pathways with SLC2A7: view

Interacting Proteins for SLC2A7 Gene

Gene Ontology (GO) - Biological Process for SLC2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport --
GO:0015992 proton transport IBA --
GO:0035428 hexose transmembrane transport IBA --
GO:0046323 glucose import IBA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC2A7: view

Transcripts for SLC2A7 Gene

mRNA/cDNA for SLC2A7 Gene

(4) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC2A7 Gene

Solute carrier family 2 (facilitated glucose transporter), member 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC2A7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC2A7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A7 Gene

No ASD Table

Relevant External Links for SLC2A7 Gene

GeneLoc Exon Structure for
SLC2A7
ECgene alternative splicing isoforms for
SLC2A7

Expression for SLC2A7 Gene

mRNA expression in normal human tissues for SLC2A7 Gene

mRNA differential expression in normal tissues according to GTEx for SLC2A7 Gene

This gene is overexpressed in Testis (15.6) and Small Intestine - Terminal Ileum (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC2A7 Gene

SOURCE GeneReport for Unigene cluster for SLC2A7 Gene Hs.531239

mRNA Expression by UniProt/SwissProt for SLC2A7 Gene

Q6PXP3-GTR7_HUMAN
Tissue specificity: Expressed in small intestine and colon. Weakly expressed in testis and prostate.
genes like me logo Genes that share expressions with SLC2A7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC2A7 Gene

Orthologs for SLC2A7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC2A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A7 35
  • 99.41 (n)
  • 99.8 (a)
SLC2A7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a7 35
  • 78.15 (n)
  • 76.13 (a)
Slc2a7 16
Slc2a7 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A7 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100362644 35
  • 80.08 (n)
  • 77.8 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii slc2a11a 36
  • 40 (a)
ManyToMany
slc2a15b 36
  • 39 (a)
ManyToMany
Species with no ortholog for SLC2A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A7 Gene

ENSEMBL:
Gene Tree for SLC2A7 (if available)
TreeFam:
Gene Tree for SLC2A7 (if available)

Paralogs for SLC2A7 Gene

Selected SIMAP similar genes for SLC2A7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC2A7: view

Variants for SLC2A7 Gene

Sequence variations from dbSNP and Humsavar for SLC2A7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs707468 -- 9,018,014(-) GGCTC(A/T)GAGGC intron-variant
rs707469 -- 9,022,114(-) AATAG(C/T)GCTGA intron-variant
rs752845 -- 9,010,273(+) GAAGC(C/T)GCCTT intron-variant
rs769901 -- 9,008,942(-) TTTCC(C/T)TCGGA intron-variant
rs769902 -- 9,020,907(-) tgtgc(A/G)gaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A7 Gene

Variant ID Type Subtype PubMed ID
nsv871694 CNV Gain 21882294
nsv871609 CNV Loss 21882294
nsv462616 CNV Gain 19166990
nsv525092 CNV Gain 19592680
nsv462727 CNV Loss 19166990

Relevant External Links for SLC2A7 Gene

HapMap Linkage Disequilibrium report
SLC2A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A7 Gene

Disorders for SLC2A7 Gene

No disorders were found for SLC2A7 Gene.

No data available for UniProtKB/Swiss-Prot for SLC2A7 Gene

Publications for SLC2A7 Gene

  1. The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). (PMID: 11780753) Joost H.G. … Thorens B. (Mol. Membr. Biol. 2001) 2 3 23
  2. Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine. (PMID: 15033637) Li Q. … Cheeseman C.I. (Am. J. Physiol. 2004) 3 4 23
  3. Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7). (PMID: 16186102) Manolescu A. … Cheeseman C.I. (J. Biol. Chem. 2005) 3 23
  4. Insight into the "odd" hexose transporters GLUT3, GLUT5, and GLUT7. (PMID: 18460594) SchA1rmann A. (Am. J. Physiol. Endocrinol. Metab. 2008) 23
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for SLC2A7 Gene

Sources for SLC2A7 Gene

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