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Aliases for CYP3A7 Gene

Aliases for CYP3A7 Gene

  • Cytochrome P450 Family 3 Subfamily A Member 7 2 3 5
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 2 3
  • Cytochrome P450, Subfamily IIIA, Polypeptide 7 2 3
  • Cytochrome P450-HFLA 3 4
  • EC 1.14.14.1 4 63
  • CYPIIIA7 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • P-450(HFL33) 3
  • P-450111A7 3
  • P450-HFLA 3
  • CP37 3

External Ids for CYP3A7 Gene

Previous GeneCards Identifiers for CYP3A7 Gene

  • GC07M097828
  • GC07M098890
  • GC07M098904
  • GC07M098938
  • GC07M099135
  • GC07M099123
  • GC07M099293
  • GC07M093939
  • GC07M099702

Summaries for CYP3A7 Gene

Entrez Gene Summary for CYP3A7 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

GeneCards Summary for CYP3A7 Gene

CYP3A7 (Cytochrome P450 Family 3 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP4F8.

UniProtKB/Swiss-Prot for CYP3A7 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP3A7 Gene

Genomics for CYP3A7 Gene

Regulatory Elements for CYP3A7 Gene

Enhancers for CYP3A7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP3A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP3A7 Gene

Chromosome:
7
Start:
99,705,037 bp from pter
End:
99,735,200 bp from pter
Size:
30,164 bases
Orientation:
Minus strand

Genomic View for CYP3A7 Gene

Genes around CYP3A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP3A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP3A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP3A7 Gene

Proteins for CYP3A7 Gene

  • Protein details for CYP3A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24462-CP3A7_HUMAN
    Recommended name:
    Cytochrome P450 3A7
    Protein Accession:
    P24462
    Secondary Accessions:
    • A4D288
    • Q9H241

    Protein attributes for CYP3A7 Gene

    Size:
    503 amino acids
    Molecular mass:
    57526 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP3A7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP3A7 Gene

Proteomics data for CYP3A7 Gene at MOPED

Post-translational modifications for CYP3A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP3A7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CYP3A7 Gene

Gene Families for CYP3A7 Gene

Suggested Antigen Peptide Sequences for CYP3A7 Gene

Graphical View of Domain Structure for InterPro Entry

P24462

UniProtKB/Swiss-Prot:

CP3A7_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP3A7: view

Function for CYP3A7 Gene

Molecular function for CYP3A7 Gene

GENATLAS Biochemistry:
cytochrome P450,family III,polypeptide 7 (niphedipine oxidase);see CYP3A@
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP3A7 Gene

Gene Ontology (GO) - Molecular Function for CYP3A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity ISS --
GO:0019825 oxygen binding TAS --
genes like me logo Genes that share ontologies with CYP3A7: view
genes like me logo Genes that share phenotypes with CYP3A7: view

Animal Models for CYP3A7 Gene

MGI Knock Outs for CYP3A7:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CYP3A7 Gene

Localization for CYP3A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP3A7 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP3A7 Gene COMPARTMENTS Subcellular localization image for CYP3A7 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CYP3A7 Gene

Pathways & Interactions for CYP3A7 Gene

genes like me logo Genes that share pathways with CYP3A7: view

Interacting Proteins for CYP3A7 Gene

Gene Ontology (GO) - Biological Process for CYP3A7 Gene

None

No data available for SIGNOR curated interactions for CYP3A7 Gene

Drugs & Compounds for CYP3A7 Gene

(152) Drugs for CYP3A7 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Enzyme, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Carbamazepine Approved, Investigational Pharma Enzyme, substrate 128
Dexamethasone Approved, Investigational Pharma Agonist, Enzyme, substrate, inducer 1950
Midazolam Approved, Illicit Pharma Enzyme, substrate, inhibitor 651
Nifedipine Approved Pharma Antagonist, Gating inhibitor, Enzyme, substrate 106

(39) Additional Compounds for CYP3A7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate

(1) ApexBio Compounds for CYP3A7 Gene

Compound Action Cas Number
Cobicistat (GS-9350) Selective CYP3A inhibitor 1004316-88-4
genes like me logo Genes that share compounds with CYP3A7: view

Transcripts for CYP3A7 Gene

mRNA/cDNA for CYP3A7 Gene

Unigene Clusters for CYP3A7 Gene

Cytochrome P450, family 3, subfamily A, polypeptide 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A7 Gene

No ASD Table

Relevant External Links for CYP3A7 Gene

GeneLoc Exon Structure for
CYP3A7
ECgene alternative splicing isoforms for
CYP3A7

Expression for CYP3A7 Gene

mRNA expression in normal human tissues for CYP3A7 Gene

mRNA differential expression in normal tissues according to GTEx for CYP3A7 Gene

This gene is overexpressed in Liver (x43.8).

Protein differential expression in normal tissues from HIPED for CYP3A7 Gene

This gene is overexpressed in Fetal Liver (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP3A7 Gene



SOURCE GeneReport for Unigene cluster for CYP3A7 Gene Hs.111944

genes like me logo Genes that share expression patterns with CYP3A7: view

Protein tissue co-expression partners for CYP3A7 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CYP3A7 Gene

Orthologs for CYP3A7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP3A7 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cyp3a13 35
  • 79.57 (n)
  • 72.46 (a)
Cyp3a13 16
Cyp3a11 36
  • 70 (a)
ManyToMany
Cyp3a13 36
  • 72 (a)
ManyToMany
Cyp3a16 36
  • 68 (a)
ManyToMany
Cyp3a25 36
  • 67 (a)
ManyToMany
Cyp3a41a 36
  • 69 (a)
ManyToMany
Cyp3a41b 36
  • 69 (a)
ManyToMany
Cyp3a44 36
  • 67 (a)
ManyToMany
Cyp3a57 36
  • 66 (a)
ManyToMany
Cyp3a59 36
  • 65 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC100608616 35
  • 99.27 (n)
  • 99.2 (a)
CYP3A67 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp3a9 35
  • 79.13 (n)
  • 72.96 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
ManyToMany
CYP3A5 36
  • 70 (a)
ManyToMany
CYP3A5 36
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
CYP3A12 36
  • 76 (a)
ManyToMany
CYP3A26 36
  • 74 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP3A7 35
  • 64.4 (n)
  • 59.08 (a)
CYP3A37 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487665 35
  • 62.63 (n)
  • 59.88 (a)
zebrafish
(Danio rerio)
Actinopterygii cyp3a65 35
  • 60.61 (n)
  • 56.53 (a)
cyp3a65 36
  • 53 (a)
ManyToMany
cyp3c1 36
  • 48 (a)
ManyToMany
cyp3c1l2 36
  • 49 (a)
ManyToMany
cyp3c4 36
  • 48 (a)
ManyToMany
si:dkey-21n8.3 36
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp28a5 37
  • 26 (a)
Cyp28c1 37
  • 25 (a)
Cyp28d1 37
  • 28 (a)
Cyp28d2 37
  • 28 (a)
Cyp309a1 37
  • 24 (a)
Cyp309a2 37
  • 25 (a)
Cyp313a2 37
  • 25 (a)
Cyp317a1 37
  • 24 (a)
Cyp6a13 37
  • 32 (a)
Cyp6a14 37
  • 34 (a)
Cyp6a17 37
  • 33 (a)
Cyp6a18 37
  • 31 (a)
Cyp6a19 37
  • 30 (a)
Cyp6a2 37
  • 31 (a)
Cyp6a20 37
  • 32 (a)
Cyp6a21 37
  • 29 (a)
Cyp6a22 37
  • 30 (a)
Cyp6a23 37
  • 34 (a)
Cyp6a8 37
  • 30 (a)
Cyp6a9 37
  • 30 (a)
Cyp6d2 37
  • 28 (a)
Cyp6d4 37
  • 34 (a)
Cyp6g1 37
  • 34 (a)
Cyp6g2 37
  • 31 (a)
Cyp6t1 37
  • 25 (a)
Cyp6t3 37
  • 27 (a)
Cyp6u1 37
  • 27 (a)
Cyp6v1 37
  • 32 (a)
Cyp6w1 37
  • 30 (a)
Cyp9b1 37
  • 29 (a)
Cyp9b2 37
  • 31 (a)
Cyp9c1 37
  • 30 (a)
Cyp9f2 37
  • 32 (a)
Cyp9h1 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea C36A4.1 37
  • 30 (a)
C36A4.2 37
  • 29 (a)
C36A4.6 37
  • 27 (a)
F14F7.2 37
  • 30 (a)
F14F7.3 37
  • 29 (a)
F42A6.4 37
  • 27 (a)
K06G5.2 37
  • 25 (a)
T10B9.1 37
  • 28 (a)
T10B9.2 37
  • 28 (a)
T10B9.3 37
  • 28 (a)
T10B9.5 37
  • 29 (a)
T10B9.7 37
  • 29 (a)
T10B9.8 37
  • 29 (a)
ZK1320.4 37
  • 25 (a)
rice
(Oryza sativa)
Liliopsida Os02g0221900 35
  • 39.7 (n)
  • 27.74 (a)
Species with no ortholog for CYP3A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP3A7 Gene

ENSEMBL:
Gene Tree for CYP3A7 (if available)
TreeFam:
Gene Tree for CYP3A7 (if available)

Paralogs for CYP3A7 Gene

(10) SIMAP similar genes for CYP3A7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CYP3A7: view

Variants for CYP3A7 Gene

Sequence variations from dbSNP and Humsavar for CYP3A7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_020124 -
VAR_055564 -

Structural Variations from Database of Genomic Variants (DGV) for CYP3A7 Gene

Variant ID Type Subtype PubMed ID
nsv888771 CNV Loss 21882294
esv2734887 CNV Deletion 23290073
nsv522107 CNV Loss 19592680
esv8941 CNV Gain 19470904
esv29839 CNV Loss 19812545

Variation tolerance for CYP3A7 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP3A7 Gene

HapMap Linkage Disequilibrium report
CYP3A7
Human Gene Mutation Database (HGMD)
CYP3A7
The Human Cytochrome P450 Allele Nomenclature Database
CYP3A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP3A7 Gene

Disorders for CYP3A7 Gene

Relevant External Links for CYP3A7

Genetic Association Database (GAD)
CYP3A7
Human Genome Epidemiology (HuGE) Navigator
CYP3A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP3A7

No disorders were found for CYP3A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP3A7 Gene

Publications for CYP3A7 Gene

  1. Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450. (PMID: 2722762) Komori M. … Kamataki T. (J. Biochem. 1989) 2 3 4 67
  2. A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. (PMID: 15985487) Smit P. … Lamberts S.W. (J. Clin. Endocrinol. Metab. 2005) 3 23 25
  3. Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. (PMID: 8185679) Gorski J.C. … Wrighton S.A. (Biochem. Pharmacol. 1994) 23 25 26
  4. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) (Breast Cancer Res. Treat. 2010) 3 23
  5. Identification of a null allele of cytochrome P450 3A7: CYP3A7 polymorphism in a Korean population. (PMID: 19585271) Lee S.S. … Shin J.G. (Mol. Biol. Rep. 2010) 3 23

Products for CYP3A7 Gene

Sources for CYP3A7 Gene

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