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Aliases for CYP2A7 Gene

Aliases for CYP2A7 Gene

  • Cytochrome P450, Family 2, Subfamily A, Polypeptide 7 2 3
  • Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 7 2 3
  • Cytochrome P450 IIA4 3 4
  • EC 1.14.14.1 4 63
  • CYPIIA7 3 4
  • Cytochrome P450 2A7 3
  • Cytochrome P450IIA4 3
  • P450-IIA4 3
  • CYP2A 3
  • CPAD 3
  • CPA7 3

External Ids for CYP2A7 Gene

Previous GeneCards Identifiers for CYP2A7 Gene

  • GC19M042020
  • GC19M041773
  • GC19M046002
  • GC19M046018
  • GC19M046020
  • GC19M046073
  • GC19M041350
  • GC19M041381

Summaries for CYP2A7 Gene

Entrez Gene Summary for CYP2A7 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2A7 Gene

CYP2A7 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 7) is a Protein Coding gene. Among its related pathways are Metabolism and Biological oxidations. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2A7 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP2A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2A7 Gene

Genomics for CYP2A7 Gene

Regulatory Elements for CYP2A7 Gene

Genomic Location for CYP2A7 Gene

Start:
40,875,439 bp from pter
End:
40,882,752 bp from pter
Size:
7,314 bases
Orientation:
Minus strand

Genomic View for CYP2A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2A7 Gene

Proteins for CYP2A7 Gene

  • Protein details for CYP2A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20853-CP2A7_HUMAN
    Recommended name:
    Cytochrome P450 2A7
    Protein Accession:
    P20853
    Secondary Accessions:
    • Q13121

    Protein attributes for CYP2A7 Gene

    Size:
    494 amino acids
    Molecular mass:
    56425 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2A7 Gene

Proteomics data for CYP2A7 Gene at MOPED

Post-translational modifications for CYP2A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for CYP2A7 Gene

Gene Families for CYP2A7 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Suggested Antigen Peptide Sequences for CYP2A7 Gene

Graphical View of Domain Structure for InterPro Entry

P20853

UniProtKB/Swiss-Prot:

CP2A7_HUMAN :
  • P20853
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2A7: view

Function for CYP2A7 Gene

Molecular function for CYP2A7 Gene

GENATLAS Biochemistry: cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 7
UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
UniProtKB/Swiss-Prot Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens

Enzyme Numbers (IUBMB) for CYP2A7 Gene

Gene Ontology (GO) - Molecular Function for CYP2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
genes like me logo Genes that share ontologies with CYP2A7: view

Phenotypes for CYP2A7 Gene

GenomeRNAi human phenotypes for CYP2A7:
genes like me logo Genes that share phenotypes with CYP2A7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2A7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP2A7 Gene

Localization for CYP2A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2A7 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Gene Ontology (GO) - Cellular Components for CYP2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with CYP2A7: view

No data available for Subcellular locations from COMPARTMENTS for CYP2A7 Gene

Pathways for CYP2A7 Gene

genes like me logo Genes that share pathways with CYP2A7: view

Interacting Proteins for CYP2A7 Gene

Gene Ontology (GO) - Biological Process for CYP2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process IBA --
GO:0009804 coumarin metabolic process IBA --
GO:0019373 epoxygenase P450 pathway IBA --
GO:0042738 exogenous drug catabolic process IBA --
GO:0055114 oxidation-reduction process IBA --
genes like me logo Genes that share ontologies with CYP2A7: view

Compounds for CYP2A7 Gene

(49) HMDB Compounds for CYP2A7 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(2) Novoseek inferred chemical compound relationships for CYP2A7 Gene

Compound -log(P) Hits PubMed IDs
coumarin 74.4 1
nicotine 61.7 1
genes like me logo Genes that share compounds with CYP2A7: view

Transcripts for CYP2A7 Gene

Unigene Clusters for CYP2A7 Gene

Cytochrome P450, family 2, subfamily A, polypeptide 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2A7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2A7 Gene

No ASD Table

Relevant External Links for CYP2A7 Gene

GeneLoc Exon Structure for
CYP2A7
ECgene alternative splicing isoforms for
CYP2A7

Expression for CYP2A7 Gene

mRNA expression in normal human tissues for CYP2A7 Gene

mRNA differential expression in normal tissues according to GTEx for CYP2A7 Gene

This gene is overexpressed in Liver (50.6).

SOURCE GeneReport for Unigene cluster for CYP2A7 Gene Hs.719890

genes like me logo Genes that share expressions with CYP2A7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for CYP2A7 Gene

Orthologs for CYP2A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP2A7 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CYP2A13 36
  • 84 (a)
ManyToMany
CYP2A13 36
  • 87 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cyp2a12 36
  • 71 (a)
ManyToMany
Cyp2a22 36
  • 71 (a)
ManyToMany
Cyp2a4 36
  • 82 (a)
ManyToMany
Cyp2a5 35
  • 84.55 (n)
  • 83.92 (a)
Cyp2a5 36
  • 84 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cyp2a3 35
  • 83.99 (n)
  • 84.76 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC548374 35
  • 58.59 (n)
  • 54.7 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-36A1 35
  • 43.65 (n)
  • 34.18 (a)
F14H3.10 37
  • 29 (a)
B0213.12 37
  • 30 (a)
C41G6.1 37
  • 27 (a)
F41B5.2 37
  • 31 (a)
T10H4.11 37
  • 30 (a)
Y5H2B.6 37
  • 28 (a)
F42A9.5 37
  • 32 (a)
C45H4.2 37
  • 29 (a)
B0213.16 37
  • 30 (a)
F41B5.7 37
  • 28 (a)
K09A11.3 37
  • 34 (a)
K07C6.4 37
  • 26 (a)
C49C8.4 37
  • 31 (a)
C34B7.3 37
  • 33 (a)
B0213.10 37
  • 28 (a)
C50H11.15 37
  • 33 (a)
K09A11.4 37
  • 33 (a)
C03G6.14 37
  • 28 (a)
B0213.14 37
  • 30 (a)
C25E10.2 37
  • 26 (a)
F41B5.3 37
  • 31 (a)
K07C6.2 37
  • 29 (a)
K09D9.2 37
  • 28 (a)
K07C6.5 37
  • 30 (a)
K05D4.4 37
  • 33 (a)
C49G7.8 37
  • 28 (a)
B0304.3 37
  • 30 (a)
B0213.15 37
  • 31 (a)
C03G6.15 37
  • 30 (a)
K09A11.2 37
  • 32 (a)
R08F11.3 37
  • 31 (a)
B0213.11 37
  • 30 (a)
T09H2.1 37
  • 26 (a)
C45H4.17 37
  • 30 (a)
K07C6.3 37
  • 29 (a)
T10H4.10 37
  • 31 (a)
Species with no ortholog for CYP2A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2A7 Gene

ENSEMBL:
Gene Tree for CYP2A7 (if available)
TreeFam:
Gene Tree for CYP2A7 (if available)

Paralogs for CYP2A7 Gene

genes like me logo Genes that share paralogs with CYP2A7: view

Variants for CYP2A7 Gene

Sequence variations from dbSNP and Humsavar for CYP2A7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs696839 -- 40,875,543(+) GAGCC(C/G)CTTCT utr-variant-3-prime
rs1060087 -- 40,875,644(-) AAGGC(A/G)GGGTC utr-variant-3-prime
rs1060088 -- 40,875,640(-) CGGGG(C/T)CAGGG utr-variant-3-prime
rs1060089 -- 40,875,637(-) GGTCA(A/G)GGCGG utr-variant-3-prime
rs1060090 -- 40,875,635(-) TCAGG(A/G)CGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYP2A7 Gene

Variant ID Type Subtype PubMed ID
dgv1084e1 CNV Complex 17122850
dgv3872n71 CNV Gain 21882294
esv21610 CNV Gain+Loss 19812545
nsv9729 CNV Loss 18304495
dgv3875n71 CNV Gain 21882294
esv2718568 CNV Deletion 23290073
esv33053 CNV Gain 17666407
nsv911739 CNV Gain+Loss 21882294
dgv3876n71 CNV Loss 21882294
dgv3877n71 CNV Gain+Loss 21882294
dgv3878n71 CNV Loss 21882294
nsv435697 CNV Deletion 17901297
dgv563e201 CNV Deletion 23290073
dgv643e199 CNV Deletion 23128226
nsv911760 CNV Gain+Loss 21882294
nsv511622 CNV Loss 21212237
esv2718569 CNV Deletion 23290073
esv1005181 CNV Gain 20482838
esv1001236 CNV Deletion 20482838
esv2718570 CNV Deletion 23290073

Relevant External Links for CYP2A7 Gene

HapMap Linkage Disequilibrium report
CYP2A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2A7 Gene

Disorders for CYP2A7 Gene

Relevant External Links for CYP2A7

Genetic Association Database (GAD)
CYP2A7
Human Genome Epidemiology (HuGE) Navigator
CYP2A7
genes like me logo Genes that share disorders with CYP2A7: view

No data available for UniProtKB/Swiss-Prot for CYP2A7 Gene

Publications for CYP2A7 Gene

  1. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PMID: 7668294) Fernandez-Salguero P. … Idle J.R. (Am. J. Hum. Genet. 1995) 2 3 4 23
  2. Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity. (PMID: 12325023) Oscarson M. … Ingelman-Sundberg M. (Hum. Mutat. 2002) 3 23 48
  3. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. (PMID: 2322567) Yamano S. … Gonzalez F.J. (Biochemistry 1990) 3 4
  4. Expression of CYP2A genes in human liver and extrahepatic tissues. (PMID: 10353262) Koskela S. … Raunio H. (Biochem. Pharmacol. 1999) 3 23
  5. Expression and alternative splicing of the cytochrome P-450 CYP2A7. (PMID: 7864805) Ding S. … Wolf C.R. (Biochem. J. 1995) 3 23

Products for CYP2A7 Gene

Sources for CYP2A7 Gene

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