Aliases for ADRB2 Gene
External Ids for ADRB2 Gene
Previous HGNC Symbols for ADRB2 Gene
Previous GeneCards Identifiers for ADRB2 Gene
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRB2 Gene
ADRB2 (Adrenoceptor Beta 2, Surface) is a Protein Coding gene. Diseases associated with ADRB2 include status asthmaticus and asthma. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and adenylate cyclase binding. An important paralog of this gene is TAAR9.
UniProtKB/Swiss-Prot for ADRB2 Gene
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
The adrenergic beta2 receptor (beta2-adrenoceptor) is a member of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, alpha2A, alpha2B, alpha2C, beta1 and beta3. They are located primarily in the CNS, heart, kidney and muscle where they are involved in smooth muscle relaxation (e.g. bronchodilation). The human adrenergic beta2 receptor gene has been localized to chromosome 5 (5q31-q32).