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Aliases for IRX2 Gene

Aliases for IRX2 Gene

  • Iroquois Homeobox 2 2 3 5
  • Iroquois Homeobox Protein 2 3 4
  • Homeodomain Protein IRXA2 3 4
  • IRXA2 3 4

External Ids for IRX2 Gene

Previous GeneCards Identifiers for IRX2 Gene

  • GC05U990165
  • GC05M002901
  • GC05M002782
  • GC05M002792
  • GC05M002799

Summaries for IRX2 Gene

Entrez Gene Summary for IRX2 Gene

  • IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

GeneCards Summary for IRX2 Gene

IRX2 (Iroquois Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX3.

Gene Wiki entry for IRX2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX2 Gene

Genomics for IRX2 Gene

Regulatory Elements for IRX2 Gene

Enhancers for IRX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IRX2 on UCSC Golden Path with GeneCards custom track

Promoters for IRX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IRX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IRX2 Gene

2,741,863 bp from pter
2,751,662 bp from pter
9,800 bases
Minus strand

Genomic View for IRX2 Gene

Genes around IRX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX2 Gene

Proteins for IRX2 Gene

  • Protein details for IRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Iroquois-class homeodomain protein IRX-2
    Protein Accession:
    Secondary Accessions:
    • Q68A19
    • Q7Z2I7

    Protein attributes for IRX2 Gene

    471 amino acids
    Molecular mass:
    49129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX2 Gene

Proteomics data for IRX2 Gene at MOPED

Post-translational modifications for IRX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRX2 Gene

Domains & Families for IRX2 Gene

Gene Families for IRX2 Gene

Suggested Antigen Peptide Sequences for IRX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with IRX2: view

Function for IRX2 Gene

genes like me logo Genes that share phenotypes with IRX2: view

Animal Models for IRX2 Gene

MGI Knock Outs for IRX2:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRX2 Gene

Localization for IRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX2 Gene

Subcellular locations from

Jensen Localization Image for IRX2 Gene COMPARTMENTS Subcellular localization image for IRX2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for IRX2 Gene

Pathways & Interactions for IRX2 Gene

SuperPathways for IRX2 Gene

No Data Available

Interacting Proteins for IRX2 Gene

Gene Ontology (GO) - Biological Process for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEA --
genes like me logo Genes that share ontologies with IRX2: view

No data available for Pathways by source and SIGNOR curated interactions for IRX2 Gene

Drugs & Compounds for IRX2 Gene

No Compound Related Data Available

Transcripts for IRX2 Gene

mRNA/cDNA for IRX2 Gene

Unigene Clusters for IRX2 Gene

Iroquois homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRX2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: -

Relevant External Links for IRX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRX2 Gene

mRNA expression in normal human tissues for IRX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x8.2), Minor Salivary Gland (x7.9), Skin - Sun Exposed (Lower leg) (x6.3), Breast - Mammary Tissue (x5.1), and Lung (x4.0).

SOURCE GeneReport for Unigene cluster for IRX2 Gene Hs.282089

genes like me logo Genes that share expression patterns with IRX2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IRX2 Gene

Orthologs for IRX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IRX2 35
  • 93.62 (n)
  • 96.6 (a)
IRX2 36
  • 96 (a)
(Mus musculus)
Mammalia Irx2 35
  • 88.18 (n)
  • 92.14 (a)
Irx2 16
Irx2 36
  • 92 (a)
(Pan troglodytes)
Mammalia IRX2 35
  • 99.65 (n)
  • 99.79 (a)
IRX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Irx2 35
  • 88.68 (n)
  • 92.99 (a)
(Bos Taurus)
Mammalia IRX2 36
  • 93 (a)
(Monodelphis domestica)
Mammalia IRX2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia IRX2 36
  • 67 (a)
(Gallus gallus)
Aves IRX2 35
  • 78.02 (n)
  • 76.64 (a)
IRX2 36
  • 74 (a)
(Anolis carolinensis)
Reptilia IRX2 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia irx2 35
  • 69.42 (n)
  • 75.67 (a)
Str.7073 35
African clawed frog
(Xenopus laevis)
Amphibia irx2-A 35
(Danio rerio)
Actinopterygii irx2a 35
  • 69.34 (n)
  • 71.23 (a)
zgc65872 35
irx2a 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta mirr 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for IRX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX2 Gene

Gene Tree for IRX2 (if available)
Gene Tree for IRX2 (if available)

Paralogs for IRX2 Gene

Paralogs for IRX2 Gene

(2) SIMAP similar genes for IRX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRX2: view

Variants for IRX2 Gene

Sequence variations from dbSNP and Humsavar for IRX2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10167 -- 2,747,470(+) AGCAA(A/G)AAAAA intron-variant, utr-variant-3-prime
rs11432 -- 2,747,013(+) GTTGG(A/G)CAGGG intron-variant, utr-variant-3-prime
rs2935601 -- 2,747,870(-) GTTCG(A/G)AAAGA intron-variant
rs1055299 -- 2,741,903(-) TTTTT(G/T)TTGTT utr-variant-3-prime
rs1055365 -- 2,747,321(+) TATAT(A/T)TTTTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IRX2 Gene

Variant ID Type Subtype PubMed ID
dgv931n67 CNV Gain 20364138
nsv822972 CNV Gain 20364138
nsv461913 CNV Loss 19166990
nsv822975 CNV Gain 20364138
nsv822977 CNV Gain 20364138

Variation tolerance for IRX2 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IRX2 Gene

Disorders for IRX2 Gene

Relevant External Links for IRX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IRX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRX2 Gene

Publications for IRX2 Gene

  1. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PMID: 11435706) Ogura K. … Ogura T. (Cytogenet. Cell Genet. 2001) 2 3 4 67
  2. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PMID: 10370142) Lewis M.T. … Daniel C.W. (Cell Tissue Res. 1999) 3 23
  3. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 3
  4. Knockdown of IRX2 inhibits osteosarcoma cell proliferation and invasion by the AKT/MMP9 signaling pathway. (PMID: 24806332) Liu T. … Wang Y. (Mol Med Rep 2014) 3
  5. Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study. (PMID: 22210879) Kang H. … Willman C.L. (Blood 2012) 3

Products for IRX2 Gene

Sources for IRX2 Gene