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Aliases for IRX2 Gene

Aliases for IRX2 Gene

  • Iroquois Homeobox 2 2 3
  • Iroquois Homeobox Protein 2 3 4
  • Homeodomain Protein IRXA2 3 4
  • IRXA2 3 4
  • Iroquois-Class Homeodomain Protein IRX-2 3

External Ids for IRX2 Gene

Summaries for IRX2 Gene

Entrez Gene Summary for IRX2 Gene

  • IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

GeneCards Summary for IRX2 Gene

IRX2 (Iroquois Homeobox 2) is a Protein Coding gene. Diseases associated with IRX2 include soft tissue sarcoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is IRX3.

Gene Wiki entry for IRX2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX2 Gene

Genomics for IRX2 Gene

Genomic Location for IRX2 Gene

Start:
2,745,845 bp from pter
End:
2,751,662 bp from pter
Size:
5,818 bases
Orientation:
Minus strand

Genomic View for IRX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX2 Gene

Proteins for IRX2 Gene

  • Protein details for IRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZI1-IRX2_HUMAN
    Recommended name:
    Iroquois-class homeodomain protein IRX-2
    Protein Accession:
    Q9BZI1
    Secondary Accessions:
    • Q68A19
    • Q7Z2I7

    Protein attributes for IRX2 Gene

    Size:
    471 amino acids
    Molecular mass:
    49129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX2 Gene

Proteomics data for IRX2 Gene at MOPED

Post-translational modifications for IRX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRX2 Gene

Domains for IRX2 Gene

Gene Families for IRX2 Gene

HGNC:
  • TALE :Homeoboxes / TALE class

UniProtKB/Swiss-Prot:

IRX2_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q9BZI1
Family:
  • Belongs to the TALE/IRO homeobox family.:
    • Q9BZI1
genes like me logo Genes that share domains with IRX2: view

Function for IRX2 Gene

Gene Ontology (GO) - Molecular Function for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with IRX2: view

Phenotypes for IRX2 Gene

MGI mutant phenotypes for IRX2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with IRX2: view

miRNA for IRX2 Gene

miRTarBase miRNAs that target IRX2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IRX2 Gene

Localization for IRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRX2 Gene COMPARTMENTS Subcellular localization image for IRX2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IRX2: view

Pathways for IRX2 Gene

SuperPathways for IRX2 Gene

No Data Available

Interacting Proteins for IRX2 Gene

Gene Ontology (GO) - Biological Process for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0072086 specification of loop of Henle identity IEA --
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEA --
genes like me logo Genes that share ontologies with IRX2: view

No data available for Pathways by source for IRX2 Gene

Transcripts for IRX2 Gene

mRNA/cDNA for IRX2 Gene

Unigene Clusters for IRX2 Gene

Iroquois homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRX2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for IRX2 Gene

GeneLoc Exon Structure for
IRX2
ECgene alternative splicing isoforms for
IRX2

Expression for IRX2 Gene

mRNA expression in normal human tissues for IRX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (8.2), Minor Salivary Gland (7.9), Skin - Sun Exposed (Lower leg) (6.3), Breast - Mammary Tissue (5.1), and Lung (4.0).

SOURCE GeneReport for Unigene cluster for IRX2 Gene Hs.282089

genes like me logo Genes that share expressions with IRX2: view

Orthologs for IRX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRX2 36
  • 99.65 (n)
  • 99.79 (a)
IRX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRX2 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRX2 36
  • 93.62 (n)
  • 96.6 (a)
IRX2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irx2 36
  • 88.18 (n)
  • 92.14 (a)
Irx2 16
Irx2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRX2 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRX2 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irx2 36
  • 88.68 (n)
  • 92.99 (a)
chicken
(Gallus gallus)
Aves IRX2 36
  • 78.02 (n)
  • 76.64 (a)
IRX2 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRX2 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia irx2-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia irx2 36
  • 69.42 (n)
  • 75.67 (a)
Str.7073 36
zebrafish
(Danio rerio)
Actinopterygii irx2a 36
  • 69.34 (n)
  • 71.23 (a)
irx2a 37
  • 71 (a)
OneToOne
zgc65872 36
fruit fly
(Drosophila melanogaster)
Insecta mirr 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToMany
Species with no ortholog for IRX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX2 Gene

ENSEMBL:
Gene Tree for IRX2 (if available)
TreeFam:
Gene Tree for IRX2 (if available)

Paralogs for IRX2 Gene

Paralogs for IRX2 Gene

Selected SIMAP similar genes for IRX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRX2: view

Variants for IRX2 Gene

Sequence variations from dbSNP and Humsavar for IRX2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10167 -- 2,747,470(+) AGCAA(A/G)AAAAA intron-variant, utr-variant-3-prime
rs11432 -- 2,747,013(+) GTTGG(A/G)CAGGG intron-variant, utr-variant-3-prime
rs1055365 -- 2,747,321(+) TATAT(A/T)TTTTT intron-variant, utr-variant-3-prime
rs1540709 -- 2,746,115(-) AGAGC(G/T)CTAGT downstream-variant-500B
rs2935601 -- 2,747,870(-) GTTCG(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRX2 Gene

Variant ID Type Subtype PubMed ID
dgv931n67 CNV Gain 20364138
nsv822972 CNV Gain 20364138
nsv461913 CNV Loss 19166990
nsv822975 CNV Gain 20364138
nsv822977 CNV Gain 20364138

Relevant External Links for IRX2 Gene

HapMap Linkage Disequilibrium report
IRX2

Disorders for IRX2 Gene

(1) MalaCards Diseases for IRX2 Gene

Search for IRX2 Gene in MalaCards »

Relevant External Links for IRX2

Genetic Association Database (GAD)
IRX2
Human Genome Epidemiology (HuGE) Navigator
IRX2
genes like me logo Genes that share disorders with IRX2: view

No data available for UniProtKB/Swiss-Prot for IRX2 Gene

Publications for IRX2 Gene

  1. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PMID: 11435706) Ogura K. … Ogura T. (Cytogenet. Cell Genet. 2001) 2 3 4
  2. A genome-wide scan maps a novel high myopia locus to 5p15. (PMID: 18421076) Lam C.Y. … Lam D.S. (Invest. Ophthalmol. Vis. Sci. 2008) 3 49
  3. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PMID: 10370142) Lewis M.T. … Daniel C.W. (Cell Tissue Res. 1999) 3 23
  4. Combination immunotherapy of squamous cell carcinoma of the head and neck: a phase 2 trial. (PMID: 10722007) Barrera J.L. … Hadden J.W. (Arch. Otolaryngol. Head Neck Surg. 2000) 23
  5. A pilot study of perilymphatic leukocyte cytokine mixture (IRX-2) as neoadjuvant treatment for early stage cervical carcinoma. (PMID: 12188025) DueA+as-Gonzalez A. … Hadden J.W. (Int. Immunopharmacol. 2002) 23

Products for IRX2 Gene

Sources for IRX2 Gene

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