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Aliases for IRX2 Gene

Aliases for IRX2 Gene

  • Iroquois Homeobox 2 2 3
  • Iroquois Homeobox Protein 2 3 4
  • Homeodomain Protein IRXA2 3 4
  • IRXA2 3 4

External Ids for IRX2 Gene

Previous GeneCards Identifiers for IRX2 Gene

  • GC05U990165
  • GC05M002901
  • GC05M002782
  • GC05M002792
  • GC05M002799

Summaries for IRX2 Gene

Entrez Gene Summary for IRX2 Gene

  • IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

GeneCards Summary for IRX2 Gene

IRX2 (Iroquois Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX3.

Gene Wiki entry for IRX2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX2 Gene

Genomics for IRX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IRX2 Gene

Chromosome:
5
Start:
2,741,863 bp from pter
End:
2,751,662 bp from pter
Size:
9,800 bases
Orientation:
Minus strand

Genomic View for IRX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX2 Gene

Proteins for IRX2 Gene

  • Protein details for IRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZI1-IRX2_HUMAN
    Recommended name:
    Iroquois-class homeodomain protein IRX-2
    Protein Accession:
    Q9BZI1
    Secondary Accessions:
    • Q68A19
    • Q7Z2I7

    Protein attributes for IRX2 Gene

    Size:
    471 amino acids
    Molecular mass:
    49129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX2 Gene

Proteomics data for IRX2 Gene at MOPED

Post-translational modifications for IRX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IRX2 Gene

Domains & Families for IRX2 Gene

Gene Families for IRX2 Gene

Suggested Antigen Peptide Sequences for IRX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZI1

UniProtKB/Swiss-Prot:

IRX2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with IRX2: view

Function for IRX2 Gene

Gene Ontology (GO) - Molecular Function for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with IRX2: view
genes like me logo Genes that share phenotypes with IRX2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRX2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IRX2 Gene

Localization for IRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRX2 Gene COMPARTMENTS Subcellular localization image for IRX2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IRX2: view

Pathways & Interactions for IRX2 Gene

SuperPathways for IRX2 Gene

No Data Available

Interacting Proteins for IRX2 Gene

Gene Ontology (GO) - Biological Process for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0072086 specification of loop of Henle identity IEA --
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEA --
genes like me logo Genes that share ontologies with IRX2: view

No data available for Pathways by source and SIGNOR curated interactions for IRX2 Gene

Drugs & Compounds for IRX2 Gene

No Compound Related Data Available

Transcripts for IRX2 Gene

mRNA/cDNA for IRX2 Gene

Unigene Clusters for IRX2 Gene

Iroquois homeobox 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRX2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for IRX2 Gene

GeneLoc Exon Structure for
IRX2
ECgene alternative splicing isoforms for
IRX2

Expression for IRX2 Gene

mRNA expression in normal human tissues for IRX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x8.2), Minor Salivary Gland (x7.9), Skin - Sun Exposed (Lower leg) (x6.3), Breast - Mammary Tissue (x5.1), and Lung (x4.0).

SOURCE GeneReport for Unigene cluster for IRX2 Gene Hs.282089

genes like me logo Genes that share expression patterns with IRX2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IRX2 Gene

Orthologs for IRX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IRX2 35
  • 93.62 (n)
  • 96.6 (a)
IRX2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irx2 35
  • 88.18 (n)
  • 92.14 (a)
Irx2 16
Irx2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IRX2 35
  • 99.65 (n)
  • 99.79 (a)
IRX2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irx2 35
  • 88.68 (n)
  • 92.99 (a)
cow
(Bos Taurus)
Mammalia IRX2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRX2 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRX2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRX2 35
  • 78.02 (n)
  • 76.64 (a)
IRX2 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRX2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irx2 35
  • 69.42 (n)
  • 75.67 (a)
Str.7073 35
African clawed frog
(Xenopus laevis)
Amphibia irx2-A 35
zebrafish
(Danio rerio)
Actinopterygii irx2a 35
  • 69.34 (n)
  • 71.23 (a)
zgc65872 35
irx2a 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mirr 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for IRX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX2 Gene

ENSEMBL:
Gene Tree for IRX2 (if available)
TreeFam:
Gene Tree for IRX2 (if available)

Paralogs for IRX2 Gene

Paralogs for IRX2 Gene

(2) SIMAP similar genes for IRX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRX2: view

Variants for IRX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IRX2 Gene

Variant ID Type Subtype PubMed ID
dgv931n67 CNV Gain 20364138
nsv822972 CNV Gain 20364138
nsv461913 CNV Loss 19166990
nsv822975 CNV Gain 20364138
nsv822977 CNV Gain 20364138

Variation tolerance for IRX2 Gene

Residual Variation Intolerance Score: 25.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRX2 Gene

HapMap Linkage Disequilibrium report
IRX2

PCR Panel Products

  • Copy Number PCR Panels: for IRX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for IRX2 Gene

Disorders for IRX2 Gene

Relevant External Links for IRX2

Genetic Association Database (GAD)
IRX2
Human Genome Epidemiology (HuGE) Navigator
IRX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRX2
genes like me logo Genes that share disorders with IRX2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRX2 Gene

Publications for IRX2 Gene

  1. Immunotherapy of head and neck cancer: current and future considerations. (PMID: 19680453) Rapidis A.D. … Wolf G.T. (J Oncol 2009) 23 67
  2. IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death. (PMID: 19180118) Czystowska M. … Whiteside T.L. (Cell Death Differ. 2009) 23 67
  3. IRX-2, a novel in vivo immunotherapeutic, induces maturation and activation of human dendritic cells in vitro. (PMID: 17667526) Egan J.E. … Signorelli K.L. (J. Immunother. 2007) 23 67
  4. Immunopharmacology of thymosin alpha1 and cytokine synergy. (PMID: 17567942) Naylor P.H. … Hadden J.W. (Ann. N. Y. Acad. Sci. 2007) 23 67
  5. IRX-2 and thymosin alpha1 (Zadaxin) increase T lymphocytes in T lymphocytopenic mice and humans. (PMID: 17600288) Hadden J.W. … Hadden E. (Ann. N. Y. Acad. Sci. 2007) 23 67

Products for IRX2 Gene

Sources for IRX2 Gene

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