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Aliases for CYB561 Gene

Aliases for CYB561 Gene

  • Cytochrome B561 2 3
  • Ferric-Chelate Reductase 2 2 3
  • Cytochrome B-561 3 4
  • Cytochrome B561 Family, Member A1 3
  • Cytochrome B561 Family 2
  • Member A1 2
  • CYB561A1 3
  • FRRS2 3

External Ids for CYB561 Gene

Summaries for CYB561 Gene

GeneCards Summary for CYB561 Gene

CYB561 (Cytochrome B561) is a Protein Coding gene. GO annotations related to this gene include ferric-chelate reductase activity and transmembrane electron transfer carrier. An important paralog of this gene is CYB561A3.

UniProtKB/Swiss-Prot for CYB561 Gene

  • Secretory vesicle-specific electron transport protein

Gene Wiki entry for CYB561 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561 Gene

Genomics for CYB561 Gene

Genomic Location for CYB561 Gene

Start:
63,432,304 bp from pter
End:
63,446,378 bp from pter
Size:
14,075 bases
Orientation:
Minus strand

Genomic View for CYB561 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYB561 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB561 Gene

Regulatory Elements for CYB561 Gene

Proteins for CYB561 Gene

  • Protein details for CYB561 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49447-CY561_HUMAN
    Recommended name:
    Cytochrome b561
    Protein Accession:
    P49447
    Secondary Accessions:
    • B2RE96
    • B7Z775
    • D3DU11
    • Q5BJG9
    • Q9BU05
    • Q9BWR9

    Protein attributes for CYB561 Gene

    Size:
    251 amino acids
    Molecular mass:
    27559 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 2 heme groups non-covalently.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB561 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB561 Gene

Proteomics data for CYB561 Gene at MOPED

Post-translational modifications for CYB561 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYB561 Gene

Domains for CYB561 Gene

Gene Families for CYB561 Gene

HGNC:
  • CYB :Cytochrome b genes

UniProtKB/Swiss-Prot:

CY561_HUMAN
Domain:
  • Contains 1 cytochrome b561 domain.:
    • P49447
genes like me logo Genes that share domains with CYB561: view

Function for CYB561 Gene

Molecular function for CYB561 Gene

GENATLAS Biochemistry: cytochrome b561 (30kDaA), specific to catecholamine and neuropeptide secretory vesicles of neuroendocrine tissues
UniProtKB/Swiss-Prot Function: Secretory vesicle-specific electron transport protein

Gene Ontology (GO) - Molecular Function for CYB561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000293 ferric-chelate reductase activity ISS 14499595
GO:0005515 protein binding IPI 25416956
GO:0022865 transmembrane electron transfer carrier NAS 7559396
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB561: view
genes like me logo Genes that share phenotypes with CYB561: view

miRNA for CYB561 Gene

miRTarBase miRNAs that target CYB561

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYB561 Gene

Localization for CYB561 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB561 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYB561 Gene COMPARTMENTS Subcellular localization image for CYB561 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for CYB561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 7559396
genes like me logo Genes that share ontologies with CYB561: view

Pathways for CYB561 Gene

SuperPathways for CYB561 Gene

No Data Available

Interacting Proteins for CYB561 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354028%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000363680%0d%0a
Selected Interacting proteins: ENSP00000354028 P49447-CY561_HUMAN for CYB561 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CYB561 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022900 electron transport chain NAS 7559396
GO:0055085 transmembrane transport NAS 7559396
genes like me logo Genes that share ontologies with CYB561: view

No data available for Pathways by source for CYB561 Gene

Compounds for CYB561 Gene

(1) HMDB Compounds for CYB561 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8

(9) Novoseek inferred chemical compound relationships for CYB561 Gene

Compound -log(P) Hits PubMed IDs
peptidylglycine 66.5 2
ferricyanide 65 3
ascorbic acid 64.4 26
histidine 43.8 2
hydroxylamine 37.5 1
genes like me logo Genes that share compounds with CYB561: view

Transcripts for CYB561 Gene

Unigene Clusters for CYB561 Gene

Cytochrome b561:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYB561 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16:
SP17:
SP18: - - - - - -

ExUns: 11c ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k ^ 13
SP1: -
SP2: -
SP3: -
SP4: - - - - - - - - - - -
SP5: -
SP6: -
SP7: -
SP8: -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:

Relevant External Links for CYB561 Gene

GeneLoc Exon Structure for
CYB561
ECgene alternative splicing isoforms for
CYB561

Expression for CYB561 Gene

mRNA expression in normal human tissues for CYB561 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYB561 Gene

This gene is overexpressed in Pancreas (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYB561 Gene

SOURCE GeneReport for Unigene cluster for CYB561 Gene Hs.355264

genes like me logo Genes that share expressions with CYB561: view

Orthologs for CYB561 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB561 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB561 36
  • 99.07 (n)
  • 98.8 (a)
CYB561 37
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYB561 36
  • 86.59 (n)
  • 86.85 (a)
CYB561 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYB561 36
  • 87.92 (n)
  • 89.24 (a)
CYB561 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyb561 36
  • 86.36 (n)
  • 90.3 (a)
Cyb561 16
Cyb561 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYB561 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyb561 36
  • 84.53 (n)
  • 89.03 (a)
chicken
(Gallus gallus)
Aves CYB561 36
  • 73.65 (n)
  • 70.51 (a)
CYB561 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.27548 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb561 36
  • 61.37 (n)
  • 60.94 (a)
Str.125 36
zebrafish
(Danio rerio)
Actinopterygii cyb561 36
  • 61.58 (n)
  • 60.59 (a)
cyb561 37
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1275 37
  • 26 (a)
ManyToMany
nemy 37
  • 21 (a)
ManyToMany
CG1275 38
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_F55H2.5 36
  • 46.38 (n)
  • 40.57 (a)
F39G3.4 37
  • 18 (a)
ManyToMany
F39G3.5 37
  • 23 (a)
ManyToMany
F55H2.5 37
  • 31 (a)
ManyToMany
F55H2.5 38
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACYB-2 36
  • 46.58 (n)
  • 37.44 (a)
rice
(Oryza sativa)
Liliopsida Os10g0504200 36
  • 48.92 (n)
  • 40.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for CYB561:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYB561 Gene

ENSEMBL:
Gene Tree for CYB561 (if available)
TreeFam:
Gene Tree for CYB561 (if available)

Paralogs for CYB561 Gene

Paralogs for CYB561 Gene

genes like me logo Genes that share paralogs with CYB561: view

Variants for CYB561 Gene

Sequence variations from dbSNP and Humsavar for CYB561 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs6936 -- 63,432,305(+) TTTTT(A/C)TGCTG utr-variant-3-prime
rs10685 -- 63,432,365(-) GCCAA(C/T)CTTCT utr-variant-3-prime
rs11966 -- 63,432,306(+) TTTTC(G/T)GCTGT utr-variant-3-prime
rs14902 -- 63,432,340(-) GCTGT(C/T)GGTGC utr-variant-3-prime
rs875417 -- 63,447,803(+) CCCTT(C/G)CAAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYB561 Gene

Variant ID Type Subtype PubMed ID
nsv908682 CNV Loss 21882294

Relevant External Links for CYB561 Gene

HapMap Linkage Disequilibrium report
CYB561

Disorders for CYB561 Gene

Relevant External Links for CYB561

Genetic Association Database (GAD)
CYB561
Human Genome Epidemiology (HuGE) Navigator
CYB561
genes like me logo Genes that share disorders with CYB561: view

No data available for UniProtKB/Swiss-Prot for CYB561 Gene

Publications for CYB561 Gene

  1. Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane. (PMID: 7559396) Srivastava M. (J. Biol. Chem. 1995) 3 4 23
  2. The human cytochrome b561 gene (CYB561) is located at 17q11-qter. (PMID: 7959749) McBride O.W. … Srivastava M. (Genomics 1994) 2 3 23
  3. Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information. (PMID: 7980462) Srivastava M. … Fleming P.J. (Biochem. J. 1994) 3 4 23
  4. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PMID: 18180394) Fung M.M. … O'Connor D.T. (Circulation 2008) 3 23 49
  5. Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency. (PMID: 20680310) Kumar M. … Dada R. (Arch. Gynecol. Obstet. 2010) 3 49

Products for CYB561 Gene

Sources for CYB561 Gene

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