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Aliases for CUX1 Gene

Aliases for CUX1 Gene

  • Cut-Like Homeobox 1 2 3
  • CUTL1 3 4 6
  • CDP 3 4 6
  • Golgi Integral Membrane Protein 6 2 3
  • CCAAT Displacement Protein 3 4
  • Homeobox Protein Cux-1 3 4
  • Cut (Drosophila)-Like 1 (CCAAT Displacement Protein) 2
  • Cut-Like 1, CCAAT Displacement Protein (Drosophila) 2
  • Putative Protein Product Of Nbla10317 3
  • Protein CASP 3
  • Cut Homolog 3
  • Nbla10317 3
  • CDP/Cut 3
  • Cux/CDP 3
  • GOLIM6 3
  • P200 3
  • P100 3
  • CASP 3
  • P110 3
  • CDP1 3
  • COY1 3
  • Clox 3
  • P75 3
  • CUX 3

External Ids for CUX1 Gene

Previous HGNC Symbols for CUX1 Gene

  • CUTL1

Previous GeneCards Identifiers for CUX1 Gene

  • GC07P101247
  • GC07P101459
  • GC07P096049

Summaries for CUX1 Gene

Entrez Gene Summary for CUX1 Gene

  • The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]

GeneCards Summary for CUX1 Gene

CUX1 (Cut-Like Homeobox 1) is a Protein Coding gene. Diseases associated with CUX1 include norrie disease. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot for CUX1 Gene

  • May be involved in intra-Golgi retrograde transport.

  • Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5 and 3) of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).

Gene Wiki entry for CUX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CUX1 Gene

Genomics for CUX1 Gene

Regulatory Elements for CUX1 Gene

Transcription factor binding sites by QIAGEN in the CUX1 gene promoter:

Genomic Location for CUX1 Gene

Start:
101,815,904 bp from pter
End:
102,283,958 bp from pter
Size:
468,055 bases
Orientation:
Plus strand

Genomic View for CUX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CUX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CUX1 Gene

Proteins for CUX1 Gene

  • Protein details for CUX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39880-CUX1_HUMAN
    Recommended name:
    Homeobox protein cut-like 1
    Protein Accession:
    P39880
    Secondary Accessions:
    • B3KV79
    • J3KQV9
    • Q6NYH4
    • Q75LE5
    • Q75MT2
    • Q75MT3
    • Q86UJ7
    • Q9UEV5

    Protein attributes for CUX1 Gene

    Size:
    1505 amino acids
    Molecular mass:
    164187 Da
    Quaternary structure:
    • Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).
    Miscellaneous:
    • Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization

    Alternative splice isoforms for CUX1 Gene

  • Protein details for CUX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13948-CASP_HUMAN
    Recommended name:
    Protein CASP
    Protein Accession:
    Q13948
    Secondary Accessions:
    • B3KWH3
    • B3KWH8
    • B4DZZ2
    • G3V1Z6
    • J3KPQ6
    • Q53GU9
    • Q8TBS3

    Protein attributes for CUX1 Gene

    Size:
    678 amino acids
    Molecular mass:
    77455 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with GOLGA5.

    Alternative splice isoforms for CUX1 Gene

neXtProt entry for CUX1 Gene

Proteomics data for CUX1 Gene at MOPED

Post-translational modifications for CUX1 Gene

  • Ubiquitination at Lys83, Lys206, Lys388, and Lys611
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys94, Lys217, Lys399, Lys593, and Lys602

Antibody Products

No data available for DME Specific Peptides for CUX1 Gene

Domains for CUX1 Gene

Gene Families for CUX1 Gene

HGNC:
  • CUT :Homeoboxes / CUT class

Protein Domains for CUX1 Gene

Suggested Antigen Peptide Sequences for CUX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P39880

UniProtKB/Swiss-Prot:

CASP_HUMAN :
  • P39880
  • Q13948
Domain:
  • Contains 3 CUT DNA-binding domains.
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the CASP family.
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with CUX1: view

Function for CUX1 Gene

Molecular function for CUX1 Gene

UniProtKB/Swiss-Prot Function: May be involved in intra-Golgi retrograde transport.
UniProtKB/Swiss-Prot Function: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5 and 3) of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).

Gene Ontology (GO) - Molecular Function for CUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS --
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IDA 15656993
genes like me logo Genes that share ontologies with CUX1: view
genes like me logo Genes that share phenotypes with CUX1: view

Animal Models for CUX1 Gene

MGI Knock Outs for CUX1:

Animal Model Products

CRISPR Products

Transcription Factor Targeting for CUX1 Gene

Selected GeneGlobe predicted Target genes for CUX1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for CUX1 Gene

Localization for CUX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CUX1 Gene

Nucleus.
Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CUX1 Gene COMPARTMENTS Subcellular localization image for CUX1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15656993
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0030173 integral component of Golgi membrane IEA --
genes like me logo Genes that share ontologies with CUX1: view

Pathways for CUX1 Gene

genes like me logo Genes that share pathways with CUX1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001822 kidney development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1301999
GO:0006891 intra-Golgi vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with CUX1: view

Compounds for CUX1 Gene

(2) Novoseek inferred chemical compound relationships for CUX1 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 3.03 2
lysine 0 1
genes like me logo Genes that share compounds with CUX1: view

Transcripts for CUX1 Gene

Unigene Clusters for CUX1 Gene

Cut-like homeobox 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CUX1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CUX1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CUX1 Gene

No ASD Table

Relevant External Links for CUX1 Gene

GeneLoc Exon Structure for
CUX1
ECgene alternative splicing isoforms for
CUX1

Expression for CUX1 Gene

mRNA expression in normal human tissues for CUX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CUX1 Gene

SOURCE GeneReport for Unigene cluster for CUX1 Gene Hs.191482

genes like me logo Genes that share expressions with CUX1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CUX1 Gene

Orthologs for CUX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CUX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CUX1 35
  • 98.37 (n)
  • 97.76 (a)
CUX1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CUX1 35
  • 88.72 (n)
  • 92.21 (a)
CUX1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CUX1 35
  • 89.17 (n)
  • 93.21 (a)
CUX1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cux1 16
Cux1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CUX1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CUX1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cux1 35
  • 86.03 (n)
  • 90.62 (a)
chicken
(Gallus gallus)
Aves CUX1 35
  • 80.77 (n)
  • 85.9 (a)
CUX1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CUX1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cux1 35
  • 72.66 (n)
  • 79 (a)
zebrafish
(Danio rerio)
Actinopterygii cux1a 35
  • 67.99 (n)
  • 67.99 (a)
cux1a 36
  • 62 (a)
OneToOne
idibd1033 35
fruit fly
(Drosophila melanogaster)
Insecta ct 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-44 36
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COY1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.939 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for CUX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CUX1 Gene

ENSEMBL:
Gene Tree for CUX1 (if available)
TreeFam:
Gene Tree for CUX1 (if available)

Paralogs for CUX1 Gene

Paralogs for CUX1 Gene

genes like me logo Genes that share paralogs with CUX1: view

Variants for CUX1 Gene

Sequence variations from dbSNP and Humsavar for CUX1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1902 -- 102,125,511(+) TAGCA(C/T)GTCTT intron-variant
rs16379 -- 102,257,681(-) AGAGT(-/TTTCC)GGAAG utr-variant-3-prime, intron-variant
rs16708 -- 102,008,711(-) CCTGT(-/CCTA)CCTAG intron-variant
rs104933 -- 102,171,934(-) CATAC(A/G)GCAAG intron-variant
rs112513 -- 101,946,646(+) GGGGA(C/G)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CUX1 Gene

Variant ID Type Subtype PubMed ID
nsv831079 CNV Loss 17160897
nsv824243 CNV Gain 20364138
nsv824244 CNV Gain 20364138
nsv824245 CNV Gain 20364138
esv29675 CNV Loss 19812545
nsv824246 CNV Gain 20364138
nsv521041 CNV Loss 19592680
esv2734942 CNV Deletion 23290073
nsv526147 CNV Loss 19592680
nsv5878 CNV Insertion 18451855
nsv888827 CNV Gain 21882294
nsv483094 CNV Gain 15286789
nsv831080 CNV Loss 17160897
nsv8189 CNV Gain 18304495
esv995309 CNV Insertion 20482838
nsv510103 CNV Loss 20534489
nsv508474 CNV Loss 20534489
nsv821048 CNV Deletion 20802225
esv24041 CNV Gain 19812545
esv2664474 CNV Deletion 23128226
nsv509218 CNV Insertion 20534489
esv2734943 CNV Deletion 23290073
nsv831082 CNV Gain 17160897
esv988391 CNV Deletion 20482838
nsv824247 CNV Gain 20364138
dgv2121e1 CNV Complex 17122850
nsv428182 CNV Gain 18775914
esv1633410 CNV Insertion 17803354
nsv888828 CNV Loss 21882294
nsv888829 CNV Loss 21882294
nsv888830 CNV Loss 21882294

Relevant External Links for CUX1 Gene

HapMap Linkage Disequilibrium report
CUX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CUX1 Gene

Disorders for CUX1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CUX1 Gene including...

Search for CUX1 Gene in MalaCards »

(9) Novoseek inferred disease relationships for CUX1 Gene

Disease -log(P) Hits PubMed IDs
uterine leiomyoma 49.6 6
leiomyoma 32.7 2
mammary tumor 29.6 4
myeloid leukemia 24.9 2
tumors 12.4 24

Relevant External Links for CUX1

Genetic Association Database (GAD)
CUX1
Human Genome Epidemiology (HuGE) Navigator
CUX1
genes like me logo Genes that share disorders with CUX1: view

No data available for UniProtKB/Swiss-Prot for CUX1 Gene

Publications for CUX1 Gene

  1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4 23
  2. Exon/intron structure and alternative transcripts of the CUTL1 gene. (PMID: 10607901) Rong Zeng W. … Nepveu A. (Gene 2000) 3 4 23
  3. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. (PMID: 1301999) Neufeld E.J. … Orkin S.H. (Nat. Genet. 1992) 3 4 23
  4. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids. (PMID: 8468066) Scherer S.W. … Tsui L.C. (Genomics 1993) 2 3 23
  5. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3 23

Products for CUX1 Gene

Sources for CUX1 Gene

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