Aliases for CUX1 Gene
- Cut Like Homeobox 1 2 3
- Cut-Like Homeobox 1 2 3 5
- Golgi Integral Membrane Protein 6 2 3
- CCAAT Displacement Protein 3 4
- Homeobox Protein Cux-1 3 4
- CUTL1 3 4
- CDP 3 4
- Cut (Drosophila)-Like 1 (CCAAT Displacement Protein) 2
- Cut-Like 1, CCAAT Displacement Protein (Drosophila) 2
- Putative Protein Product Of Nbla10317 3
- Cut Homolog 3
- Nbla10317 3
- CDP/Cut 3
External Ids for CUX1 Gene
Previous HGNC Symbols for CUX1 Gene
Previous GeneCards Identifiers for CUX1 Gene
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
GeneCards Summary for CUX1 Gene
CUX1 (Cut Like Homeobox 1) is a Protein Coding gene. Diseases associated with CUX1 include Fiedler's Myocarditis and Norrie Disease. Among its related pathways are FGFR1 mutant receptor activation and Infectious disease. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is ONECUT1.
May be involved in intra-Golgi retrograde transport.
Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5 and 3) of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).