Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTSO Gene

Aliases for CTSO Gene

  • Cathepsin O 2 3 5
  • CTSO1 3 4
  • EC 4

External Ids for CTSO Gene

Previous HGNC Symbols for CTSO Gene

  • CTSO1

Previous GeneCards Identifiers for CTSO Gene

  • GC04M157734
  • GC04M157274
  • GC04M157422
  • GC04M157202
  • GC04M157064
  • GC04M156845
  • GC04M152584

Summaries for CTSO Gene

Entrez Gene Summary for CTSO Gene

  • The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSO Gene

CTSO (Cathepsin O) is a Protein Coding gene. Among its related pathways are Immune System and Lysosome. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSO Gene

  • Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Gene Wiki entry for CTSO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSO Gene

Genomics for CTSO Gene

Regulatory Elements for CTSO Gene

Enhancers for CTSO Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTSO on UCSC Golden Path with GeneCards custom track

Promoters for CTSO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTSO on UCSC Golden Path with GeneCards custom track

Genomic Location for CTSO Gene

155,924,118 bp from pter
155,953,917 bp from pter
29,800 bases
Minus strand

Genomic View for CTSO Gene

Genes around CTSO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSO Gene

Proteins for CTSO Gene

  • Protein details for CTSO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin O
    Protein Accession:

    Protein attributes for CTSO Gene

    321 amino acids
    Molecular mass:
    35958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSO Gene

Proteomics data for CTSO Gene at MOPED

Post-translational modifications for CTSO Gene

  • Glycosylation at Asn 62 and Asn 105
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTSO Gene

Domains & Families for CTSO Gene

Gene Families for CTSO Gene

Suggested Antigen Peptide Sequences for CTSO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSO: view

Function for CTSO Gene

Molecular function for CTSO Gene

GENATLAS Biochemistry:
cathepsin O,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.
UniProtKB/Swiss-Prot Function:
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Enzyme Numbers (IUBMB) for CTSO Gene

genes like me logo Genes that share phenotypes with CTSO: view

Animal Models for CTSO Gene

MGI Knock Outs for CTSO:
  • Ctso tm2b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSO

miRNA for CTSO Gene

miRTarBase miRNAs that target CTSO

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSO Gene

Localization for CTSO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSO Gene


Subcellular locations from

Jensen Localization Image for CTSO Gene COMPARTMENTS Subcellular localization image for CTSO gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for CTSO Gene

Pathways & Interactions for CTSO Gene

genes like me logo Genes that share pathways with CTSO: view

Pathways by source for CTSO Gene

2 KEGG pathways for CTSO Gene

Interacting Proteins for CTSO Gene

Gene Ontology (GO) - Biological Process for CTSO Gene


No data available for SIGNOR curated interactions for CTSO Gene

Drugs & Compounds for CTSO Gene

(1) Drugs for CTSO Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Papain Inhibitor Pharma Inhibitor of peptidase activity of Papain 0

(1) ApexBio Compounds for CTSO Gene

Compound Action Cas Number
Papain Inhibitor Inhibitor of peptidase activity of Papain 70195-20-9
genes like me logo Genes that share compounds with CTSO: view

Transcripts for CTSO Gene

mRNA/cDNA for CTSO Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(138) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTSO Gene

Cathepsin O:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSO Gene

No ASD Table

Relevant External Links for CTSO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSO Gene

mRNA expression in normal human tissues for CTSO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTSO Gene

This gene is overexpressed in NK cells (19.8), Islet of Langerhans (14.6), Prostate (12.3), and CD8 Tcells (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTSO Gene

SOURCE GeneReport for Unigene cluster for CTSO Gene Hs.75262

mRNA Expression by UniProt/SwissProt for CTSO Gene

Tissue specificity: Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.
genes like me logo Genes that share expression patterns with CTSO: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CTSO Gene

Orthologs for CTSO Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTSO 35
  • 82.76 (n)
  • 81.85 (a)
  • 79 (a)
(Canis familiaris)
Mammalia CTSO 35
  • 88.04 (n)
  • 87.71 (a)
  • 85 (a)
(Mus musculus)
Mammalia Ctso 35
  • 80.16 (n)
  • 76.82 (a)
Ctso 16
Ctso 36
  • 73 (a)
(Pan troglodytes)
Mammalia CTSO 35
  • 99.37 (n)
  • 99.37 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia CTSO 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
(Gallus gallus)
Aves CTSO 35
  • 74.18 (n)
  • 72.54 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia CTSO 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctso 35
  • 66.79 (n)
  • 62.77 (a)
(Danio rerio)
Actinopterygii ctso 35
  • 61.82 (n)
  • 58.91 (a)
ctso 36
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6991 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002720 35
  • 46.3 (n)
  • 42.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6347 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea R07E3.1 37
  • 33 (a)
R07E3.1 36
  • 23 (a)
R09F10.1 36
  • 22 (a)
tag-329 36
  • 22 (a)
Y113G7B.15 36
  • 22 (a)
Y40H7A.10 36
  • 24 (a)
Y51A2D.1 36
  • 19 (a)
Y51A2D.8 36
  • 20 (a)
Species with no ortholog for CTSO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSO Gene

Gene Tree for CTSO (if available)
Gene Tree for CTSO (if available)

Paralogs for CTSO Gene

Paralogs for CTSO Gene

(8) SIMAP similar genes for CTSO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTSO: view

Variants for CTSO Gene

Sequence variations from dbSNP and Humsavar for CTSO Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11303235 -- 155,950,857(+) ACCCC(A/C/G)ACACC intron-variant
rs11383821 -- 155,950,006(+) TTTTT(-/A)AAGGA intron-variant
rs34103300 -- 155,940,928(+) TGCTT(-/A)AAAAA intron-variant
rs141198252 -- 155,948,374(+) GCCTT(-/TGTGTGTG)TGTGT intron-variant
rs140877092 -- 155,948,374(+) GCCTT(-/TGTGTG)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSO Gene

Variant ID Type Subtype PubMed ID
nsv830121 CNV Gain 17160897
esv274871 CNV Loss 21479260
nsv4564 CNV Insertion 18451855
nsv262 CNV Insertion 15895083
esv999516 CNV Insertion 20482838
nsv437447 CNV Loss 16327808

Variation tolerance for CTSO Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 36.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CTSO Gene

Disorders for CTSO Gene

Relevant External Links for CTSO

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CTSO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTSO Gene

Publications for CTSO Gene

  1. Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO). (PMID: 9790772) SantamarA-a I. … LA^pez-OtA-n C. (Genomics 1998) 2 3 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3
  4. Molecular insight into propeptide-protein interactions in cathepsins L and O. (PMID: 23009386) Reif M.M. … Oostenbrink C. (Biochemistry 2012) 3
  5. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PMID: 19786962) Roeske D. … Schulte-KAPrne G. (Mol. Psychiatry 2011) 3

Products for CTSO Gene

Sources for CTSO Gene