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Aliases for CTSO Gene

Aliases for CTSO Gene

  • Cathepsin O 2 3
  • CTSO1 3 4
  • EC 4

External Ids for CTSO Gene

Previous HGNC Symbols for CTSO Gene

  • CTSO1

Previous GeneCards Identifiers for CTSO Gene

  • GC04M157734
  • GC04M157274
  • GC04M157422
  • GC04M157202
  • GC04M157064
  • GC04M156845
  • GC04M152584

Summaries for CTSO Gene

Entrez Gene Summary for CTSO Gene

  • The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSO Gene

CTSO (Cathepsin O) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Lysosome. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSO Gene

  • Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover

Gene Wiki entry for CTSO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSO Gene

Genomics for CTSO Gene

Genomic Location for CTSO Gene

155,924,118 bp from pter
155,953,917 bp from pter
29,800 bases
Minus strand

Genomic View for CTSO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSO Gene

No data available for Regulatory Elements for CTSO Gene

Proteins for CTSO Gene

  • Protein details for CTSO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin O
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CTSO Gene

    321 amino acids
    Molecular mass:
    35958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSO Gene

Proteomics data for CTSO Gene at MOPED

Post-translational modifications for CTSO Gene

  • Glycosylation at Asn62 and Asn105
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSO Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CTSO Gene

Domains for CTSO Gene

Gene Families for CTSO Gene

  • CTS :Cathepsins

Suggested Antigen Peptide Sequences for CTSO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P43234
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSO: view

Function for CTSO Gene

Molecular function for CTSO Gene

GENATLAS Biochemistry:
cathepsin O,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec
UniProtKB/Swiss-Prot Function:
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover

Enzyme Numbers (IUBMB) for CTSO Gene

Gene Ontology (GO) - Molecular Function for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 7929457
GO:0008234 cysteine-type peptidase activity --
genes like me logo Genes that share ontologies with CTSO: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSO

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CTSO Gene

Localization for CTSO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSO Gene


Subcellular locations from

Jensen Localization Image for CTSO Gene COMPARTMENTS Subcellular localization image for CTSO gene
Compartment Confidence
lysosome 5
vacuole 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with CTSO: view

Pathways for CTSO Gene

genes like me logo Genes that share pathways with CTSO: view

Pathways by source for CTSO Gene

2 Reactome pathways for CTSO Gene
1 KEGG pathway for CTSO Gene

Interacting Proteins for CTSO Gene

Gene Ontology (GO) - Biological Process for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CTSO: view

Compounds for CTSO Gene

(1) ApexBio Compounds for CTSO Gene

Compound Action Cas Number
Papain Inhibitor Inhibitor of peptidase activity of Papain [70195-20-9]
genes like me logo Genes that share compounds with CTSO: view

Transcripts for CTSO Gene

mRNA/cDNA for CTSO Gene

(138) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTSO Gene

Cathepsin O:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSO

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSO Gene

No ASD Table

Relevant External Links for CTSO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSO Gene

mRNA expression in normal human tissues for CTSO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CTSO Gene

This gene is overexpressed in NK cells (19.8), Islet of Langerhans (14.6), Prostate (12.3), and CD8 Tcells (12.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CTSO Gene

SOURCE GeneReport for Unigene cluster for CTSO Gene Hs.75262

mRNA Expression by UniProt/SwissProt for CTSO Gene

Tissue specificity: Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle
genes like me logo Genes that share expressions with CTSO: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for CTSO Gene

Orthologs for CTSO Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTSO 35
  • 82.76 (n)
  • 81.85 (a)
  • 79 (a)
(Canis familiaris)
Mammalia CTSO 35
  • 88.04 (n)
  • 87.71 (a)
  • 85 (a)
(Mus musculus)
Mammalia Ctso 35
  • 80.16 (n)
  • 76.82 (a)
Ctso 16
Ctso 36
  • 73 (a)
(Pan troglodytes)
Mammalia CTSO 35
  • 99.37 (n)
  • 99.37 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia CTSO 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
(Gallus gallus)
Aves CTSO 35
  • 74.18 (n)
  • 72.54 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia CTSO 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctso 35
  • 66.79 (n)
  • 62.77 (a)
(Danio rerio)
Actinopterygii ctso 35
  • 61.82 (n)
  • 58.91 (a)
ctso 36
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6991 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002720 35
  • 46.3 (n)
  • 42.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6347 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea R07E3.1 37
  • 33 (a)
R07E3.1 36
  • 23 (a)
R09F10.1 36
  • 22 (a)
tag-329 36
  • 22 (a)
Y113G7B.15 36
  • 22 (a)
Y40H7A.10 36
  • 24 (a)
Y51A2D.1 36
  • 19 (a)
Y51A2D.8 36
  • 20 (a)
Species with no ortholog for CTSO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSO Gene

Gene Tree for CTSO (if available)
Gene Tree for CTSO (if available)

Paralogs for CTSO Gene

Paralogs for CTSO Gene

Selected SIMAP similar genes for CTSO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTSO: view

Variants for CTSO Gene

Sequence variations from dbSNP and Humsavar for CTSO Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs573 -- 155,925,456(-) GACCA(C/T)GTAGA utr-variant-3-prime
rs9044 -- 155,924,935(-) CCATC(C/T)GAACT utr-variant-3-prime
rs10163 -- 155,924,823(+) GCAGG(A/C)TAATC utr-variant-3-prime
rs1355875 -- 155,938,038(+) TTTTG(C/T)AGATC intron-variant
rs1514016 -- 155,935,661(+) gccaa(C/T)atgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSO Gene

Variant ID Type Subtype PubMed ID
nsv830121 CNV Gain 17160897
esv274871 CNV Loss 21479260
nsv4564 CNV Insertion 18451855
nsv262 CNV Insertion 15895083
esv999516 CNV Insertion 20482838
nsv437447 CNV Loss 16327808

Relevant External Links for CTSO Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSO Gene

Disorders for CTSO Gene

Relevant External Links for CTSO

Genetic Association Database (GAD)

No disorders were found for CTSO Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CTSO Gene

Publications for CTSO Gene

  1. Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO). (PMID: 9790772) SantamarA-a I. … LA^pez-OtA-n C. (Genomics 1998) 2 3 23
  2. Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues. (PMID: 7929457) Velasco G. … Lopez-Otin C. (J. Biol. Chem. 1994) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PMID: 19786962) Roeske D. … Schulte-KAPrne G. (Mol. Psychiatry 2011) 3 48
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3

Products for CTSO Gene

Sources for CTSO Gene

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