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Aliases for SGO1 Gene

Aliases for SGO1 Gene

  • Shugoshin 1 2 3
  • SGOL1 3 4 5
  • Serologically Defined Breast Cancer Antigen NY-BR-85 3 4
  • Shugoshin-Like 1 (S. Pombe) 2 5
  • Shugoshin 1AB Protein 3
  • Shugoshin 1CD Protein 3
  • Shugoshin 1EF Protein 3
  • Shugoshin 1GH Protein 3
  • Shugoshin 1KL Protein 3
  • NY-BR-85 3
  • HSgo1 4
  • CAID 3
  • SGO 3

External Ids for SGO1 Gene

Previous HGNC Symbols for SGO1 Gene

  • SGOL1

Summaries for SGO1 Gene

Entrez Gene Summary for SGO1 Gene

  • The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

GeneCards Summary for SGO1 Gene

SGO1 (Shugoshin 1) is a Protein Coding gene. Diseases associated with SGO1 include chronic atrial and intestinal dysrhythmia and sick sinus syndrome. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases.

UniProtKB/Swiss-Prot for SGO1 Gene

  • Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.

Gene Wiki entry for SGO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGO1 Gene

Genomics for SGO1 Gene

Regulatory Elements for SGO1 Gene

Promoters for SGO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SGO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SGO1 Gene

Chromosome:
3
Start:
20,159,046 bp from pter
End:
20,188,131 bp from pter
Size:
29,086 bases
Orientation:
Minus strand

Genomic View for SGO1 Gene

Genes around SGO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGO1 Gene

Proteins for SGO1 Gene

  • Protein details for SGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FBB7-SGOL1_HUMAN
    Recommended name:
    Shugoshin-like 1
    Protein Accession:
    Q5FBB7
    Secondary Accessions:
    • Q588H5
    • Q5FBB4
    • Q5FBB5
    • Q5FBB6
    • Q5FBB8
    • Q8N579
    • Q8WVL0
    • Q9BVA8
    • Q9H275

    Protein attributes for SGO1 Gene

    Size:
    561 amino acids
    Molecular mass:
    64190 Da
    Quaternary structure:
    • Interacts with PPP2CA (or PPP2CB), PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, SET, LRRC59, RBM10 (or RBM5), RPL10A, RPL28, RPL7, RPL7A and RPLP1. Interaction with protein phosphatase 2A occurs most probably through direct binding to the regulatory B56 subunits: PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E. Interacts with PPP2R1A and NEK2. Isoform 3 interacts with PLK1.
    Miscellaneous:
    • Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).
    SequenceCaution:
    • Sequence=AAH01339.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH32696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SGO1 Gene

    Alternative splice isoforms for SGO1 Gene

neXtProt entry for SGO1 Gene

Proteomics data for SGO1 Gene at MOPED

Post-translational modifications for SGO1 Gene

  • Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB.
  • Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SGO1 Gene

Domains & Families for SGO1 Gene

Protein Domains for SGO1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5FBB7

UniProtKB/Swiss-Prot:

SGOL1_HUMAN :
  • The KEN box and D-box 3 are required for its ubiquitination and degradation.
  • Belongs to the shugoshin family.
Domain:
  • The KEN box and D-box 3 are required for its ubiquitination and degradation.
Family:
  • Belongs to the shugoshin family.
genes like me logo Genes that share domains with SGO1: view

No data available for Gene Families for SGO1 Gene

Function for SGO1 Gene

Molecular function for SGO1 Gene

UniProtKB/Swiss-Prot Function:
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.
genes like me logo Genes that share phenotypes with SGO1: view

Human Phenotype Ontology for SGO1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SGO1 Gene

MGI Knock Outs for SGO1:

miRNA for SGO1 Gene

miRTarBase miRNAs that target SGO1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SGO1 Gene

Localization for SGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGO1 Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase (PubMed:16541025). Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A (PubMed:16580887)(PubMed:16541025)(PubMed:15604152). Colocalizes with NEK2 at the kinetochore (PubMed:17621308). Colocalizes with and SS18L1 at the kinetochore (PubMed:16582621). Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore (PubMed:17617734). Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis (PubMed:16582621). Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent (PubMed:16582621). Isoform 3 does not localize to kinetochores during any stages of the cell cycle (PubMed:16582621). {ECO:0000269 PubMed:15604152, ECO:0000269 PubMed:16541025, ECO:0000269 PubMed:16580887, ECO:0000269 PubMed:16582621, ECO:0000269 PubMed:17617734, ECO:0000269 PubMed:17621308}.

Gene Ontology (GO) - Cellular Components for SGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA 16582621
GO:0000780 condensed nuclear chromosome, centromeric region IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SGO1: view

No data available for Subcellular locations from COMPARTMENTS for SGO1 Gene

Pathways & Interactions for SGO1 Gene

genes like me logo Genes that share pathways with SGO1: view

Pathways by source for SGO1 Gene

2 BioSystems pathways for SGO1 Gene
1 KEGG pathway for SGO1 Gene

SIGNOR curated interactions for SGO1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IDA 16580887
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with SGO1: view

Drugs & Compounds for SGO1 Gene

No Compound Related Data Available

Transcripts for SGO1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SGO1 Gene

No ASD Table

Relevant External Links for SGO1 Gene

GeneLoc Exon Structure for
SGO1
ECgene alternative splicing isoforms for
SGO1

Expression for SGO1 Gene

mRNA Expression by UniProt/SwissProt for SGO1 Gene

Q5FBB7-SGOL1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver and placenta. Strongly overexpressed in 90% of breast cancers tested.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SGO1 Gene

Orthologs for SGO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SGO1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SGOL1 35
  • 84.86 (n)
  • 73.85 (a)
SGOL1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sgol1 35
  • 71.96 (n)
  • 55.04 (a)
Sgol1 16
Sgol1 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SGOL1 35
  • 99.24 (n)
  • 97.72 (a)
SGOL1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgol1 35
  • 70.09 (n)
  • 56.52 (a)
cow
(Bos Taurus)
Mammalia SGOL1 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SGOL1 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGOL1 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves SGOL1 35
  • 50.51 (n)
  • 39.6 (a)
SGOL1 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGOL1 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SGOL1 36
  • 22 (a)
OneToOne
Species with no ortholog for SGO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SGO1 Gene

ENSEMBL:
Gene Tree for SGO1 (if available)
TreeFam:
Gene Tree for SGO1 (if available)

Paralogs for SGO1 Gene

Pseudogenes.org Pseudogenes for SGO1 Gene

genes like me logo Genes that share paralogs with SGO1: view

No data available for Paralogs for SGO1 Gene

Variants for SGO1 Gene

Sequence variations from dbSNP and Humsavar for SGO1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs955011 -- 20,161,934(+) attat(A/G)attcc intron-variant
rs1052930 -- 20,170,697(-) GGTTT(C/T)GTTGG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1828079 -- 20,159,144(-) CACTA(C/T)AGCTT utr-variant-3-prime
rs1828080 -- 20,158,980(-) GAGAA(A/T)AGACT downstream-variant-500B
rs2174843 -- 20,162,087(-) TACAT(C/T)TGCGG intron-variant

Variation tolerance for SGO1 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGO1 Gene

HapMap Linkage Disequilibrium report
SGO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SGO1 Gene

Disorders for SGO1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SGO1 Gene - From: OMIM, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chronic atrial and intestinal dysrhythmia
  • caid syndrome
sick sinus syndrome
  • sinus node infection
- elite association - COSMIC cancer census association via MalaCards
Search SGO1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SGOL1_HUMAN
  • Chronic atrial and intestinal dysrhythmia (CAID) [MIM:616201]: A disease characterized by dysregulation of the cardiac sinus node resulting in sick sinus syndrome, in association with chronic intestinal pseudo-obstruction, a disorder of gastrointestinal motility in which intestinal obstruction occurs in the absence of a mechanical obstacle. {ECO:0000269 PubMed:25282101}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SGO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGO1
genes like me logo Genes that share disorders with SGO1: view

No data available for Genatlas for SGO1 Gene

Publications for SGO1 Gene

  1. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 2 3 4 67
  2. Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes. (PMID: 20231385) Kiyomitsu T. … Yanagida M. (J. Cell Biol. 2010) 3 23
  3. Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer. (PMID: 18635744) Iwaizumi M. … Sugimura H. (Gut 2009) 3 23
  4. Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1. (PMID: 19015261) Karamysheva Z. … Yu H. (J. Biol. Chem. 2009) 3 23
  5. Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics. (PMID: 16582621) Wang X. … Dai W. (Cell Cycle 2006) 3 23

Products for SGO1 Gene

Sources for SGO1 Gene

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