Aliases for CTSB Gene
External Ids for CTSB Gene
Previous GeneCards Identifiers for CTSB Gene
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CTSB Gene
CTSB (Cathepsin B) is a Protein Coding gene. Diseases associated with CTSB include occlusion of gallbladder and tropical calcific pancreatitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Degradation of the extracellular matrix. GO annotations related to this gene include cysteine-type peptidase activity and cysteine-type endopeptidase activity. An important paralog of this gene is TINAG.
UniProtKB/Swiss-Prot for CTSB Gene
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis