Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTNND2 Gene

Aliases for CTNND2 Gene

  • Catenin (Cadherin-Associated Protein), Delta 2 2 3
  • NPRAP 3 4 6
  • Catenin (Cadherin-Associated Protein), Delta 2 (Neural Plakophilin-Related Arm-Repeat Protein) 2 3
  • Neurojungin 3 4
  • GT24 3 4
  • Neural Plakophilin-Related Arm-Repeat Protein 2
  • Neural Plakophilin-Related ARM-Repeat Protein 4
  • T-Cell Delta-Catenin 3
  • Catenin Delta-2 3
  • Delta-Catenin 4

External Ids for CTNND2 Gene

Previous GeneCards Identifiers for CTNND2 Gene

  • GC05M011139
  • GC05M011004
  • GC05M011024

Summaries for CTNND2 Gene

Entrez Gene Summary for CTNND2 Gene

  • This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

GeneCards Summary for CTNND2 Gene

CTNND2 (Catenin (Cadherin-Associated Protein), Delta 2) is a Protein Coding gene. Diseases associated with CTNND2 include cri-du-chat syndrome. An important paralog of this gene is PKP3.

UniProtKB/Swiss-Prot for CTNND2 Gene

  • Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNND2 Gene

Genomics for CTNND2 Gene

Regulatory Elements for CTNND2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTNND2 Gene

10,971,840 bp from pter
11,904,043 bp from pter
932,204 bases
Minus strand

Genomic View for CTNND2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTNND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNND2 Gene

Proteins for CTNND2 Gene

  • Protein details for CTNND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Catenin delta-2
    Protein Accession:
    Secondary Accessions:
    • B0FTZ7
    • O00379
    • O15390
    • O43206
    • O43840
    • Q13589
    • Q9UM66
    • Q9UPM3

    Protein attributes for CTNND2 Gene

    1225 amino acids
    Molecular mass:
    132656 Da
    Quaternary structure:
    • Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain).
    • Sequence=AAB68599.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB88185.1; Type=Frameshift; Positions=913; Evidence={ECO:0000305};

    Alternative splice isoforms for CTNND2 Gene


neXtProt entry for CTNND2 Gene

Proteomics data for CTNND2 Gene at MOPED

Post-translational modifications for CTNND2 Gene

Antibody Products

No data available for DME Specific Peptides for CTNND2 Gene

Domains for CTNND2 Gene

Gene Families for CTNND2 Gene

Protein Domains for CTNND2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta-catenin family.
  • Contains 9 ARM repeats.
  • Belongs to the beta-catenin family.
  • Contains 9 ARM repeats.
genes like me logo Genes that share domains with CTNND2: view

Function for CTNND2 Gene

Molecular function for CTNND2 Gene

GENATLAS Biochemistry:
catenin delta 2,interacting with presenilin 1,homologous to Drosophila Armadillo segment polarity gene,involved in the molecular organization of synaptic junctions through interaction with the synaptic scaffolding molecule
UniProtKB/Swiss-Prot Function:
Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.

Gene Ontology (GO) - Molecular Function for CTNND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 19706687
genes like me logo Genes that share ontologies with CTNND2: view

Phenotypes for CTNND2 Gene

MGI mutant phenotypes for CTNND2:
inferred from 1 alleles
GenomeRNAi human phenotypes for CTNND2:
genes like me logo Genes that share phenotypes with CTNND2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTNND2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTNND2 Gene

Localization for CTNND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNND2 Gene

Nucleus. Cell junction, adherens junction. Perikaryon. Note=Colocalizes with CDK5 in the cell body of neuronal cells.

Subcellular locations from

Jensen Localization Image for CTNND2 Gene COMPARTMENTS Subcellular localization image for CTNND2 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTNND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 9342840
GO:0005912 adherens junction IEA --
GO:0030054 cell junction --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with CTNND2: view

Pathways for CTNND2 Gene

SuperPathways for CTNND2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Extracellular Matrix & Adhesion Molecules in human,mouse,rat

Gene Ontology (GO) - Biological Process for CTNND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001763 morphogenesis of a branching structure IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007155 cell adhesion TAS 9223106
GO:0007165 signal transduction TAS 9223106
genes like me logo Genes that share ontologies with CTNND2: view

No data available for Pathways by source for CTNND2 Gene

Drugs for CTNND2 Gene

(3) Novoseek inferred chemical compound relationships for CTNND2 Gene

Compound -log(P) Hits PubMed IDs
cdcs 51.6 3
agar 19.4 1
tyrosine 18.4 5
genes like me logo Genes that share compounds with CTNND2: view

Transcripts for CTNND2 Gene

mRNA/cDNA for CTNND2 Gene

(8) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTNND2 Gene

Catenin (cadherin-associated protein), delta 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTNND2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNND2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: -

ExUns: 22

Relevant External Links for CTNND2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTNND2 Gene

mRNA expression in normal human tissues for CTNND2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNND2 Gene

This gene is overexpressed in Brain - Amygdala (5.8), Brain - Anterior cingulate cortex (BA24) (5.2), Brain - Frontal Cortex (BA9) (5.0), Brain - Cortex (4.9), Brain - Hippocampus (4.8), Brain - Putamen (basal ganglia) (4.7), and Brain - Caudate (basal ganglia) (4.1).

Protein differential expression in normal tissues for CTNND2 Gene

This gene is overexpressed in Brain (17.1), Cervix (14.9), Frontal cortex (12.7), and Fetal Brain (11.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTNND2 Gene

SOURCE GeneReport for Unigene cluster for CTNND2 Gene Hs.314543

mRNA Expression by UniProt/SwissProt for CTNND2 Gene

Tissue specificity: Predominantly expressed in brain; accumulates in cortical neurons (at protein level).
genes like me logo Genes that share expressions with CTNND2: view

Expression partners for CTNND2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CTNND2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTNND2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTNND2 35
  • 92.54 (n)
  • 97.55 (a)
  • 97 (a)
(Canis familiaris)
Mammalia CTNND2 35
  • 92.64 (n)
  • 96.7 (a)
  • 97 (a)
(Mus musculus)
Mammalia Ctnnd2 35
  • 91.51 (n)
  • 96.56 (a)
Ctnnd2 16
Ctnnd2 36
  • 95 (a)
(Pan troglodytes)
Mammalia CTNND2 35
  • 99.56 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ctnnd2 35
  • 90.89 (n)
  • 96.77 (a)
(Monodelphis domestica)
Mammalia CTNND2 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia CTNND2 36
  • 95 (a)
(Gallus gallus)
Aves CTNND2 35
  • 81.29 (n)
  • 91.23 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia CTNND2 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnnd2 35
  • 76.54 (n)
  • 88.08 (a)
(Danio rerio)
Actinopterygii ctnnd2a 35
  • 74.01 (n)
  • 80.76 (a)
ctnnd2a 36
  • 78 (a)
ctnnd2b 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta p120ctn 37
  • 50 (a)
p120ctn 35
  • 51.64 (n)
  • 53.07 (a)
p120ctn 36
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011273 35
  • 57.95 (n)
  • 56.98 (a)
(Caenorhabditis elegans)
Secernentea jac-1 37
  • 39 (a)
jac-1 36
  • 24 (a)
Species with no ortholog for CTNND2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTNND2 Gene

Gene Tree for CTNND2 (if available)
Gene Tree for CTNND2 (if available)

Paralogs for CTNND2 Gene

Paralogs for CTNND2 Gene

genes like me logo Genes that share paralogs with CTNND2: view

Variants for CTNND2 Gene

Sequence variations from dbSNP and Humsavar for CTNND2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs249237 -- 11,441,710(+) AATAT(A/G)GGATT intron-variant
rs249236 -- 11,502,383(+) TCCTA(C/T)ATAAT intron-variant
rs247648 -- 11,593,324(+) atatg(C/T)gttaa intron-variant
rs247647 -- 11,591,688(+) CTTTC(C/T)CTTAC intron-variant
rs245138 -- 11,228,563(-) ggctg(C/T)agtaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTNND2 Gene

Variant ID Type Subtype PubMed ID
nsv880520 CNV Gain 21882294
nsv518038 CNV Gain 19592680
nsv830202 CNV Gain 17160897
esv2729748 CNV Deletion 23290073
esv7282 CNV Loss 19470904
esv2729749 CNV Deletion 23290073
esv2729750 CNV Deletion 23290073
esv1539730 CNV Insertion 17803354
nsv819140 CNV Gain 19587683
esv2668679 CNV Deletion 23128226
nsv818314 CNV Loss 17921354
nsv441939 CNV CNV 18776908
nsv823001 CNV Loss 20364138
nsv327919 CNV Loss 16902084
nsv328573 CNV Loss 16902084
esv2548561 CNV Insertion 19546169
esv27150 CNV Gain 19812545
esv275312 CNV Loss 21479260
esv269035 CNV Insertion 20981092
dgv5936n71 CNV Loss 21882294
nsv521357 CNV Loss 19592680
nsv461976 CNV Loss 19166990
nsv880276 CNV Loss 21882294
nsv522498 CNV Loss 19592680
nsv515616 CNV Loss 19592680
nsv519562 CNV Loss 19592680
esv2729752 CNV Deletion 23290073
esv259601 OTHER Complex 20981092
nsv327742 CNV Insertion 16902084
esv25983 CNV Loss 19812545
esv2729753 CNV Deletion 23290073
esv2665180 CNV Deletion 23128226
esv1474334 CNV Insertion 17803354
esv2453497 CNV Deletion 19546169
esv2161141 CNV Deletion 18987734
esv996886 CNV Deletion 20482838
esv4317 CNV Deletion 18987735
esv996577 CNV Deletion 20482838
esv6986 CNV Loss 19470904
esv2729754 CNV Deletion 23290073
esv1023282 CNV Deletion 17803354
nsv830205 CNV Gain 17160897
nsv881624 CNV Loss 21882294
esv7916 CNV Gain 19470904
esv29160 CNV Loss 19812545
esv274133 CNV Insertion 20981092
esv270908 CNV Insertion 20981092
nsv880622 CNV Loss 21882294
nsv528520 CNV Loss 19592680
esv2665217 CNV Deletion 23128226
nsv428462 CNV Loss 18775914
esv2729755 CNV Deletion 23290073
nsv523245 CNV Loss 19592680
nsv818315 CNV Loss 17921354
nsv4715 CNV Loss 18451855
nsv524275 CNV Loss 19592680
nsv525891 CNV Loss 19592680
esv2729756 CNV Deletion 23290073
esv7810 OTHER Inversion 19470904
esv2660889 CNV Deletion 23128226
nsv513222 CNV Loss 21212237
esv2729757 CNV Deletion 23290073
esv1034832 CNV Deletion 17803354
esv2729758 CNV Deletion 23290073
esv2729759 CNV Deletion 23290073
esv2729760 CNV Deletion 23290073
esv1436814 CNV Insertion 17803354
esv2560131 CNV Deletion 19546169
esv2729761 CNV Deletion 23290073
esv2729763 CNV Deletion 23290073
esv1056345 CNV Deletion 17803354
esv2729764 CNV Deletion 23290073
esv2729765 CNV Deletion 23290073
nsv823002 CNV Gain 20364138
esv22991 CNV Loss 19812545

Relevant External Links for CTNND2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNND2 Gene

Disorders for CTNND2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CTNND2 Gene in MalaCards »

(1) Disease for CTNND2 Gene

(1) University of Copenhagen DISEASES for CTNND2 Gene

(6) Novoseek inferred disease relationships for CTNND2 Gene

Disease -log(P) Hits PubMed IDs
prostatic adenocarcinoma 60.1 4
mental retardation 26.1 3
prostate cancer 4.09 19
tumors 0 6
alzheimers disease 0 1

Relevant External Links for CTNND2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTNND2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CTNND2 Gene

Publications for CTNND2 Gene

  1. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. (PMID: 9223106) Zhou J. … Kosik K.S. (NeuroReport 1997) 2 3 4 23
  2. Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. (PMID: 9342840) Paffenholz R. … Franke W.W. (Differentiation 1997) 2 3 4 23
  3. Presenilins interact with armadillo proteins including neural- specific plakophilin-related protein and beta-catenin. (PMID: 10037471) Levesque G. … St George-Hyslop P.H. (J. Neurochem. 1999) 3 4 23
  4. Isolation of human delta-catenin and its binding specificity with presenilin 1. (PMID: 10208590) Tanahashi H. … Tabira T. (NeuroReport 1999) 3 4 23
  5. The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction. (PMID: 10413599) Paffenholz R. … Franke W.W. (Exp. Cell Res. 1999) 3 23

Products for CTNND2 Gene

Sources for CTNND2 Gene

Back to Top