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Aliases for ABCC13 Gene

Aliases for ABCC13 Gene

  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 13, Pseudogene 2 3
  • C21orf73 3 4
  • PRED6 3 4
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 13 2
  • ATP-Binding Cassette Transporter C13 3
  • ATP-Binding Cassette Protein C13 3

External Ids for ABCC13 Gene

Previous GeneCards Identifiers for ABCC13 Gene

  • GC21P012310
  • GC21P014567
  • GC21P015647
  • GC21P001016

Summaries for ABCC13 Gene

Entrez Gene Summary for ABCC13 Gene

  • This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC13 Gene

ABCC13 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 13, Pseudogene) is a Pseudogene. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.

Gene Wiki entry for ABCC13 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC13 Gene

Genomics for ABCC13 Gene

Regulatory Elements for ABCC13 Gene

Genomic Location for ABCC13 Gene

Start:
14,236,206 bp from pter
End:
14,362,754 bp from pter
Size:
126,549 bases
Orientation:
Plus strand

Genomic View for ABCC13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC13 Gene

Proteins for ABCC13 Gene

  • Protein details for ABCC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSE7-ABCCD_HUMAN
    Recommended name:
    Putative ATP-binding cassette sub-family C member 13
    Protein Accession:
    Q9NSE7
    Secondary Accessions:
    • Q8N6A4
    • Q8N6A5

    Protein attributes for ABCC13 Gene

    Size:
    274 amino acids
    Molecular mass:
    30831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC13 Gene

Proteomics data for ABCC13 Gene at MOPED

Post-translational modifications for ABCC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABCC13 Gene

Domains for ABCC13 Gene

Gene Families for ABCC13 Gene

HGNC:
  • ABCC :ATP binding cassette transporters / subfamily C

Protein Domains for ABCC13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABCC13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSE7

UniProtKB/Swiss-Prot:

ABCCD_HUMAN :
  • Q9NSE7
Domain:
  • Contains 1 ABC transmembrane type-1 domain.
Family:
  • Belongs to the binding-protein-dependent transport system permease family.
genes like me logo Genes that share domains with ABCC13: view

Function for ABCC13 Gene

Molecular function for ABCC13 Gene

UniProtKB/Swiss-Prot Induction: Down-regulated by cell differentiation in certain leukemia cells.

Gene Ontology (GO) - Molecular Function for ABCC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA --
genes like me logo Genes that share ontologies with ABCC13: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ABCC13 Gene

Localization for ABCC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCC13 Gene COMPARTMENTS Subcellular localization image for ABCC13 gene
Compartment Confidence
nucleus 5
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for ABCC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC13: view

Pathways for ABCC13 Gene

SuperPathways for ABCC13 Gene

No Data Available

Interacting Proteins for ABCC13 Gene

Gene Ontology (GO) - Biological Process for ABCC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with ABCC13: view

No data available for Pathways by source for ABCC13 Gene

Transcripts for ABCC13 Gene

Unigene Clusters for ABCC13 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC13 Gene

No ASD Table

Relevant External Links for ABCC13 Gene

GeneLoc Exon Structure for
ABCC13
ECgene alternative splicing isoforms for
ABCC13

Expression for ABCC13 Gene

mRNA expression in normal human tissues for ABCC13 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC13 Gene

This gene is overexpressed in Whole Blood (18.8), Colon - Transverse (13.4), and Small Intestine - Terminal Ileum (11.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ABCC13 Gene

SOURCE GeneReport for Unigene cluster for ABCC13 Gene Hs.366575

mRNA Expression by UniProt/SwissProt for ABCC13 Gene

Q9NSE7-ABCCD_HUMAN
Tissue specificity: Highest expression in fetal liver and fetal spleen. In the adult, highest levels are found in the colon ascending and transverse. Also expressed in brain, placenta, lung, liver, pancreas and ovary. In bone marrow cells, levels are several fold higher than in peripheral blood leukocytes.
genes like me logo Genes that share expressions with ABCC13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ABCC13 Gene

Orthologs for ABCC13 Gene

Evolution for ABCC13 Gene

ENSEMBL:
Gene Tree for ABCC13 (if available)
TreeFam:
Gene Tree for ABCC13 (if available)

No data available for Orthologs for ABCC13 Gene

Paralogs for ABCC13 Gene

Selected SIMAP similar genes for ABCC13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABCC13: view

No data available for Paralogs for ABCC13 Gene

Variants for ABCC13 Gene

Sequence variations from dbSNP and Humsavar for ABCC13 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs383375 -- 14,284,828(-) GTTTT(A/G)TATGT intron-variant
rs421987 -- 14,273,156(-) GTAGT(A/C)TATTA upstream-variant-2KB
rs429696 -- 14,282,865(-) CTCCC(A/G)GGTTC intron-variant
rs718670 -- 14,275,833(+) AGAAG(C/T)TAGCG intron-variant
rs718671 -- 14,275,858(+) CAACT(A/G)TAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC13 Gene

Variant ID Type Subtype PubMed ID
nsv520538 CNV Gain 19592680
nsv459095 CNV Gain 19166990
nsv470878 CNV Gain 18288195
esv2446530 CNV Insertion 19546169
esv272254 CNV Insertion 20981092
esv269832 CNV Insertion 20981092

Relevant External Links for ABCC13 Gene

HapMap Linkage Disequilibrium report
ABCC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC13 Gene

Disorders for ABCC13 Gene

Relevant External Links for ABCC13

Genetic Association Database (GAD)
ABCC13
genes like me logo Genes that share disorders with ABCC13: view

No data available for UniProtKB/Swiss-Prot for ABCC13 Gene

Publications for ABCC13 Gene

  1. ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver. (PMID: 12445816) Yabuuchi H. … Ishikawa T. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  3. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K. … Davisson M. (Genomics 2002) 3 4
  4. Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. (PMID: 12909339) Brun M.-E. … De Sario A. (Gene 2003) 3 4
  5. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4

Products for ABCC13 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ABCC13
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ABCC13
    • Block miRNA regulation of ABCC13 using miScript Target Protectors
    • antibodies-online proteins for ABCC13
    • antibodies-online antibodies for ABCC13
    • antibodies-online kits for ABCC13

    Sources for ABCC13 Gene

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