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Aliases for CTNNA1 Gene

Aliases for CTNNA1 Gene

  • Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa 2 3
  • Renal Carcinoma Antigen NY-REN-13 3 4
  • Alpha E-Catenin 3 4
  • Catenin (Cadherin-Associated Protein), Alpha 1 (102kD) 2
  • Cadherin-Associated Protein,102kDa 3
  • Cadherin-Associated Protein 4
  • Alpha-E-Catenin 3
  • AlphaE-Catenin 3
  • Alpha-Catenin 3
  • CAP102 3

External Ids for CTNNA1 Gene

Previous GeneCards Identifiers for CTNNA1 Gene

  • GC05P137992
  • GC05P138765
  • GC05P138119
  • GC05P138165
  • GC05P138193
  • GC05P138117
  • GC05P133278
  • GC05P137947

Summaries for CTNNA1 Gene

GeneCards Summary for CTNNA1 Gene

CTNNA1 (Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa) is a Protein Coding gene. Diseases associated with CTNNA1 include diffuse gastric cancer and acquired thrombocytopenia. Among its related pathways are Signaling by GPCR and Developmental Biology. GO annotations related to this gene include poly(A) RNA binding and actin filament binding. An important paralog of this gene is CTNNA3.

UniProtKB/Swiss-Prot for CTNNA1 Gene

  • Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation

Gene Wiki entry for CTNNA1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNA1 Gene

Genomics for CTNNA1 Gene

Regulatory Elements for CTNNA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTNNA1 Gene

Chromosome:
5
Start:
138,610,967 bp from pter
End:
138,935,034 bp from pter
Size:
324,068 bases
Orientation:
Plus strand

Genomic View for CTNNA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTNNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNA1 Gene

Proteins for CTNNA1 Gene

  • Protein details for CTNNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35221-CTNA1_HUMAN
    Recommended name:
    Catenin alpha-1
    Protein Accession:
    P35221
    Secondary Accessions:
    • Q12795
    • Q8N1C0

    Protein attributes for CTNNA1 Gene

    Size:
    906 amino acids
    Molecular mass:
    100071 Da
    Quaternary structure:
    • Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4 and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and beta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interacts with ARHGAP21 and with AJUBA. Interacts with LIMA1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CTNNA1 Gene

    Alternative splice isoforms for CTNNA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTNNA1 Gene

Proteomics data for CTNNA1 Gene at MOPED

Post-translational modifications for CTNNA1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTNNA1 (CTNNA1)

No data available for DME Specific Peptides for CTNNA1 Gene

Domains & Families for CTNNA1 Gene

Protein Domains for CTNNA1 Gene

Graphical View of Domain Structure for InterPro Entry

P35221

UniProtKB/Swiss-Prot:

CTNA1_HUMAN :
  • Belongs to the vinculin/alpha-catenin family.
Family:
  • Belongs to the vinculin/alpha-catenin family.
genes like me logo Genes that share domains with CTNNA1: view

No data available for Gene Families for CTNNA1 Gene

Function for CTNNA1 Gene

Molecular function for CTNNA1 Gene

GENATLAS Biochemistry:
catenin alpha 1,102kDa,desmosomal plaque component,regulating cell adhesion (component of the E cadherin multiprotein complex
UniProtKB/Swiss-Prot Function:
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation

Gene Ontology (GO) - Molecular Function for CTNNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 12477722
GO:0008013 beta-catenin binding IPI 7650039
GO:0017166 vinculin binding IPI 9700171
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CTNNA1: view
genes like me logo Genes that share phenotypes with CTNNA1: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTNNA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CTNNA1 Gene

Localization for CTNNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNA1 Gene

Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTNNA1 Gene COMPARTMENTS Subcellular localization image for CTNNA1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CTNNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IDA 7650039
genes like me logo Genes that share ontologies with CTNNA1: view

Pathways & Interactions for CTNNA1 Gene

genes like me logo Genes that share pathways with CTNNA1: view

PCR Array Products

SIGNOR curated interactions for CTNNA1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CTNNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0007015 actin filament organization IEA --
GO:0007155 cell adhesion NAS 8323564
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with CTNNA1: view

Drugs & Compounds for CTNNA1 Gene

(4) Drugs for CTNNA1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2505
Sphingosine Experimental Pharma 0
Calcium Nutra 0
tyrosine Nutra 547

(11) Additional Compounds for CTNNA1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
5-Aza-2deoxycytidine
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
Oligonucleotide
P00001
genes like me logo Genes that share compounds with CTNNA1: view

Transcripts for CTNNA1 Gene

Unigene Clusters for CTNNA1 Gene

Catenin (cadherin-associated protein), alpha 1, 102kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTNNA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a · 13b ^ 14 ^ 15a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: -
SP6: - - -
SP7:
SP8: - - -
SP9:
SP10:
SP11: - - - - -
SP12: -
SP13: -
SP14: - - - - - - - - - -
SP15:
SP16:
SP17: -
SP18:

ExUns: 15b ^ 16 ^ 17a · 17b · 17c · 17d · 17e · 17f ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b · 26c
SP1: - - - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14: -
SP15: - - -
SP16:
SP17:
SP18:

Relevant External Links for CTNNA1 Gene

GeneLoc Exon Structure for
CTNNA1
ECgene alternative splicing isoforms for
CTNNA1

Expression for CTNNA1 Gene

mRNA expression in normal human tissues for CTNNA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTNNA1 Gene



SOURCE GeneReport for Unigene cluster for CTNNA1 Gene Hs.445981

mRNA Expression by UniProt/SwissProt for CTNNA1 Gene

P35221-CTNA1_HUMAN
Tissue specificity: Expressed ubiquitously in normal tissues
genes like me logo Genes that share expression patterns with CTNNA1: view

Protein tissue co-expression partners for CTNNA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for CTNNA1 Gene

Orthologs for CTNNA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTNNA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTNNA1 35
  • 93.64 (n)
  • 99.12 (a)
CTNNA1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTNNA1 35
  • 92.75 (n)
  • 99.34 (a)
CTNNA1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctnna1 35
  • 91.83 (n)
  • 99.45 (a)
Ctnna1 16
Ctnna1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTNNA1 35
  • 99.56 (n)
  • 99.89 (a)
CTNNA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctnna1 35
  • 90.21 (n)
  • 99.45 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CTNNA1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTNNA1 35
  • 84.35 (n)
  • 98.01 (a)
CTNNA1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTNNA1 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnna1 35
  • 79.1 (n)
  • 94.12 (a)
Str.11082 35
zebrafish
(Danio rerio)
Actinopterygii ctnna 35
ctnna1 36
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alpha-Cat 37
  • 59 (a)
alpha-Cat 36
  • 61 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hmp-1 37
  • 38 (a)
hmp-1 36
  • 38 (a)
ManyToMany
Species with no ortholog for CTNNA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTNNA1 Gene

ENSEMBL:
Gene Tree for CTNNA1 (if available)
TreeFam:
Gene Tree for CTNNA1 (if available)

Paralogs for CTNNA1 Gene

Paralogs for CTNNA1 Gene

Pseudogenes.org Pseudogenes for CTNNA1 Gene

genes like me logo Genes that share paralogs with CTNNA1: view

Variants for CTNNA1 Gene

Sequence variations from dbSNP and Humsavar for CTNNA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_022303 -
VAR_022304 -

Structural Variations from Database of Genomic Variants (DGV) for CTNNA1 Gene

Variant ID Type Subtype PubMed ID
esv2730822 CNV Deletion 23290073
esv2730823 CNV Deletion 23290073
esv2200225 CNV Deletion 18987734
esv2730824 CNV Deletion 23290073
esv1333927 CNV Deletion 17803354
esv2672371 CNV Deletion 23128226
esv2675323 CNV Deletion 23128226
esv2659340 CNV Deletion 23128226

Variation tolerance for CTNNA1 Gene

Residual Variation Intolerance Score: 3.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTNNA1 Gene

HapMap Linkage Disequilibrium report
CTNNA1
Human Gene Mutation Database (HGMD)
CTNNA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNA1 Gene

Disorders for CTNNA1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CTNNA1 Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
diffuse gastric cancer
  • signet cell adenocarcinoma
acquired thrombocytopenia
  • secondary thrombocytopenia
gastric cancer risk after h. pylori infection
  • gastric cancer, somatic
microinvasive gastric cancer
  • early gastric cancer
lobular neoplasia
  • lobular intraepithelial neoplasia
- elite association

UniProtKB/Swiss-Prot

CTNA1_HUMAN
  • Hereditary diffuse gastric cancer (HDGC) [MIM:137215]: A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. {ECO:0000269 PubMed:23208944}. Note=The gene represented in this entry may be involved in disease pathogenesis.

Relevant External Links for CTNNA1

Genetic Association Database (GAD)
CTNNA1
Human Genome Epidemiology (HuGE) Navigator
CTNNA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTNNA1
genes like me logo Genes that share disorders with CTNNA1: view

No data available for Genatlas for CTNNA1 Gene

Publications for CTNNA1 Gene

  1. alpha-Catenin as a tension transducer that induces adherens junction development. (PMID: 20453849) Yonemura S. … Shibata M. (Nat. Cell Biol. 2010) 23 67
  2. AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion. (PMID: 20404114) Benjamin J.M. … Nelson W.J. (J. Cell Biol. 2010) 23 67
  3. A mathematical model of alpha-catenin dimerization at adherens junctions in polarized epithelial cells. (PMID: 19135061) Dawes A.T. (J. Theor. Biol. 2009) 23 67
  4. Focal reduction of alphaE-catenin causes premature differentiation and reduction of beta-catenin signaling during cortical development. (PMID: 19389371) Stocker A.M. … Chenn A. (Dev. Biol. 2009) 23 67
  5. Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. (PMID: 19458087) Bajpai S. … Wirtz D. (J. Biol. Chem. 2009) 23 67

Products for CTNNA1 Gene

Sources for CTNNA1 Gene

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