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Aliases for CTGF Gene

Aliases for CTGF Gene

  • Connective Tissue Growth Factor 2 3
  • Hypertrophic Chondrocyte-Specific Protein 24 3 4
  • Insulin-Like Growth Factor-Binding Protein 8 3 4
  • IGF-Binding Protein 8 3 4
  • CCN Family Member 2 3 4
  • IGFBP-8 3 4
  • IGFBP8 3 4
  • HCS24 3 4
  • IBP-8 3 4
  • NOV2 3 6
  • CCN2 3 4

External Ids for CTGF Gene

Summaries for CTGF Gene

Entrez Gene Summary for CTGF Gene

  • The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

GeneCards Summary for CTGF Gene

CTGF (Connective Tissue Growth Factor) is a Protein Coding gene. Diseases associated with CTGF include renal fibrosis and diffuse scleroderma. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for CTGF Gene

  • Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Gene Wiki entry for CTGF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTGF Gene

Genomics for CTGF Gene

Genomic Location for CTGF Gene

Start:
131,948,176 bp from pter
End:
131,951,378 bp from pter
Size:
3,203 bases
Orientation:
Minus strand

Genomic View for CTGF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTGF Gene

Regulatory Elements for CTGF Gene

Proteins for CTGF Gene

  • Protein details for CTGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29279-CTGF_HUMAN
    Recommended name:
    Connective tissue growth factor
    Protein Accession:
    P29279
    Secondary Accessions:
    • E1P578
    • Q6LCY0
    • Q96A79
    • Q96QX2
    • Q9UDL6

    Protein attributes for CTGF Gene

    Size:
    349 amino acids
    Molecular mass:
    38091 Da
    Quaternary structure:
    • Monomer

    Alternative splice isoforms for CTGF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTGF Gene

Proteomics data for CTGF Gene at MOPED

Post-translational modifications for CTGF Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn28, Thr193, and Asn225

Other Protein References for CTGF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CTGF Gene

Domains for CTGF Gene

UniProtKB/Swiss-Prot:

CTGF_HUMAN
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.:
    • P29279
  • Contains 1 IGFBP N-terminal domain.:
    • P29279
  • Contains 1 TSP type-1 domain.:
    • P29279
  • Contains 1 VWFC domain.:
    • P29279
Family:
  • Belongs to the CCN family.:
    • P29279
genes like me logo Genes that share domains with CTGF: view

No data available for Gene Families for CTGF Gene

Function for CTGF Gene

Molecular function for CTGF Gene

GENATLAS Biochemistry: connective tissue growth factor,homologous to NOV,immediate early response gene
UniProtKB/Swiss-Prot Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Gene Ontology (GO) - Molecular Function for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IEA --
GO:0005178 integrin binding IBA --
GO:0005515 protein binding IPI 16457822
GO:0005520 insulin-like growth factor binding IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with CTGF: view
genes like me logo Genes that share phenotypes with CTGF: view

Animal Models for CTGF Gene

MGI Knock Outs for CTGF:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CTGF Gene

Localization for CTGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTGF Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTGF Gene COMPARTMENTS Subcellular localization image for CTGF gene
Compartment Confidence
extracellular 4
golgi apparatus 4
plasma membrane 4
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IEA --
genes like me logo Genes that share ontologies with CTGF: view

Pathways for CTGF Gene

genes like me logo Genes that share pathways with CTGF: view

Gene Ontology (GO) - Biological Process for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0001503 ossification IEA --
GO:0001525 angiogenesis IEA --
GO:0001558 regulation of cell growth IEA --
GO:0001894 tissue homeostasis IEA --
genes like me logo Genes that share ontologies with CTGF: view

Compounds for CTGF Gene

(1) HMDB Compounds for CTGF Gene

Compound Synonyms Cas Number PubMed IDs
Aldosterone
  • (+)-Aldosterone
52-39-1

(72) Novoseek inferred chemical compound relationships for CTGF Gene

Compound -log(P) Hits PubMed IDs
tgf beta1 66 34
des-arg(10)-kallidin 57.8 6
vegf 53.9 80
ang ii 53.3 17
sp 600125 48.6 6
genes like me logo Genes that share compounds with CTGF: view

Transcripts for CTGF Gene

mRNA/cDNA for CTGF Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(962) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTGF Gene

Connective tissue growth factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTGF Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for CTGF Gene

GeneLoc Exon Structure for
CTGF
ECgene alternative splicing isoforms for
CTGF

Expression for CTGF Gene

mRNA expression in normal human tissues for CTGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTGF Gene

This gene is overexpressed in Artery - Aorta (9.0) and Artery - Coronary (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTGF Gene

SOURCE GeneReport for Unigene cluster for CTGF Gene Hs.410037

mRNA Expression by UniProt/SwissProt for CTGF Gene

P29279-CTGF_HUMAN
Tissue specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
genes like me logo Genes that share expressions with CTGF: view

Orthologs for CTGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTGF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTGF 36
  • 99.33 (n)
  • 98.85 (a)
CTGF 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTGF 36
  • 89.37 (n)
  • 90.8 (a)
CTGF 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTGF 37
  • 93 (a)
OneToOne
LOC476202 36
  • 91.4 (n)
  • 93.7 (a)
mouse
(Mus musculus)
Mammalia Ctgf 36
  • 88.6 (n)
  • 91.38 (a)
Ctgf 16
Ctgf 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTGF 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTGF 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctgf 36
  • 88.86 (n)
  • 91.93 (a)
chicken
(Gallus gallus)
Aves CTGF 36
  • 83.82 (n)
  • 88.37 (a)
CTGF 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTGF 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398003 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ctgf 36
  • 75.02 (n)
  • 82.51 (a)
Str.15550 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13898 36
zebrafish
(Danio rerio)
Actinopterygii ctgfa 36
  • 73.29 (n)
  • 78.65 (a)
ctgfa 37
  • 78 (a)
OneToOne
hmzeh1559 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
Species with no ortholog for CTGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTGF Gene

ENSEMBL:
Gene Tree for CTGF (if available)
TreeFam:
Gene Tree for CTGF (if available)

Paralogs for CTGF Gene

Paralogs for CTGF Gene

Selected SIMAP similar genes for CTGF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTGF: view

Variants for CTGF Gene

Sequence variations from dbSNP and Humsavar for CTGF Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11575 -- 131,949,528(-) AAAAT(C/T)TCCAA reference, synonymous-codon
rs15375 -- 131,948,423(-) CAAAG(A/G)GGAGG utr-variant-3-prime
rs15960 -- 131,949,428(+) TCTGT(A/G)GGGGG reference, missense
rs1049546 -- 131,949,089(-) CTATC(A/T)ACCCC utr-variant-3-prime
rs1049548 -- 131,949,088(-) TATCA(A/T)CCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CTGF Gene

Variant ID Type Subtype PubMed ID
nsv7968 CNV Loss 18304495

Relevant External Links for CTGF Gene

HapMap Linkage Disequilibrium report
CTGF
Human Gene Mutation Database (HGMD)
CTGF

Disorders for CTGF Gene

(94) Novoseek inferred disease relationships for CTGF Gene

Disease -log(P) Hits PubMed IDs
renal fibrosis 82.2 34
skin fibrosis 72.6 5
diabetic nephropathies 72.1 43
sclerosis systemic 69.5 29
scleroderma disease 66.8 1

Relevant External Links for CTGF

Genetic Association Database (GAD)
CTGF
Human Genome Epidemiology (HuGE) Navigator
CTGF
genes like me logo Genes that share disorders with CTGF: view

No data available for UniProtKB/Swiss-Prot for CTGF Gene

Publications for CTGF Gene

  1. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PMID: 12553878) Ball D.K. … Brigstock D.R. (J. Endocrinol. 2003) 3 4 23
  2. Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy. (PMID: 16501850) McKnight A.J. … Maxwell A.P. (J. Hum. Genet. 2006) 3 23 49
  3. Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia. (PMID: 17375628) Sa-nguanmoo P. … Poovorawan Y. (J Med Assoc Thai 2007) 3 23 49
  4. A polymorphism in the CTGF promoter region associated with systemic sclerosis. (PMID: 17881752) Fonseca C. … Abraham D.J. (N. Engl. J. Med. 2007) 3 23 49
  5. Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population. (PMID: 19054818) Kawaguchi Y. … Hara M. (Ann. Rheum. Dis. 2009) 3 23 49

Products for CTGF Gene

Sources for CTGF Gene

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