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Aliases for CTGF Gene

Aliases for CTGF Gene

  • Connective Tissue Growth Factor 2 3 5
  • Hypertrophic Chondrocyte-Specific Protein 24 3 4
  • Insulin-Like Growth Factor-Binding Protein 8 3 4
  • IGF-Binding Protein 8 3 4
  • CCN Family Member 2 3 4
  • IGFBP-8 3 4
  • IGFBP8 3 4
  • HCS24 3 4
  • IBP-8 3 4
  • CCN2 3 4
  • NOV2 3

External Ids for CTGF Gene

Previous GeneCards Identifiers for CTGF Gene

  • GC06M132116
  • GC06M132249
  • GC06M132311
  • GC06M129844
  • GC06M132269

Summaries for CTGF Gene

Entrez Gene Summary for CTGF Gene

  • The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

GeneCards Summary for CTGF Gene

CTGF (Connective Tissue Growth Factor) is a Protein Coding gene. Diseases associated with CTGF include Systemic Scleroderma and Renal Fibrosis. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is NOV.

UniProtKB/Swiss-Prot for CTGF Gene

  • Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Gene Wiki entry for CTGF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTGF Gene

Genomics for CTGF Gene

Regulatory Elements for CTGF Gene

Enhancers for CTGF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTGF on UCSC Golden Path with GeneCards custom track

Genomic Location for CTGF Gene

Chromosome:
6
Start:
131,948,176 bp from pter
End:
131,951,378 bp from pter
Size:
3,203 bases
Orientation:
Minus strand

Genomic View for CTGF Gene

Genes around CTGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTGF Gene

Proteins for CTGF Gene

  • Protein details for CTGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29279-CTGF_HUMAN
    Recommended name:
    Connective tissue growth factor
    Protein Accession:
    P29279
    Secondary Accessions:
    • E1P578
    • Q6LCY0
    • Q96A79
    • Q96QX2
    • Q9UDL6

    Protein attributes for CTGF Gene

    Size:
    349 amino acids
    Molecular mass:
    38091 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for CTGF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTGF Gene

Proteomics data for CTGF Gene at MOPED

Post-translational modifications for CTGF Gene

  • Glycosylation at Asn 28, Thr 193, and Asn 225
  • Modification sites at PhosphoSitePlus

Other Protein References for CTGF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CTGF Gene

Domains & Families for CTGF Gene

Gene Families for CTGF Gene

Graphical View of Domain Structure for InterPro Entry

P29279

UniProtKB/Swiss-Prot:

CTGF_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Belongs to the CCN family.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 TSP type-1 domain.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the CCN family.
genes like me logo Genes that share domains with CTGF: view

Function for CTGF Gene

Molecular function for CTGF Gene

GENATLAS Biochemistry:
connective tissue growth factor,homologous to NOV,immediate early response gene
UniProtKB/Swiss-Prot Function:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Gene Ontology (GO) - Molecular Function for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA,IBA --
genes like me logo Genes that share ontologies with CTGF: view
genes like me logo Genes that share phenotypes with CTGF: view

Human Phenotype Ontology for CTGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CTGF Gene

MGI Knock Outs for CTGF:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CTGF Gene

Localization for CTGF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTGF Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTGF Gene COMPARTMENTS Subcellular localization image for CTGF gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTGF: view

Pathways & Interactions for CTGF Gene

genes like me logo Genes that share pathways with CTGF: view

SIGNOR curated interactions for CTGF Gene

Activates:

Gene Ontology (GO) - Biological Process for CTGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0001503 ossification IEA --
GO:0001525 angiogenesis IEA --
GO:0001558 regulation of cell growth IEA --
GO:0001894 tissue homeostasis IEA --
genes like me logo Genes that share ontologies with CTGF: view

Drugs & Compounds for CTGF Gene

(38) Drugs for CTGF Gene - From: ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aldosterone Experimental Pharma Agonist 0
Mitogens Pharma 1418
FG-3019 Pharma inhibitor 0

(37) Additional Compounds for CTGF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTGF: view

Transcripts for CTGF Gene

mRNA/cDNA for CTGF Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(962) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTGF Gene

Connective tissue growth factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTGF Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for CTGF Gene

GeneLoc Exon Structure for
CTGF
ECgene alternative splicing isoforms for
CTGF

Expression for CTGF Gene

mRNA expression in normal human tissues for CTGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTGF Gene

This gene is overexpressed in Artery - Aorta (x9.0) and Artery - Coronary (x4.3).

Protein differential expression in normal tissues from HIPED for CTGF Gene

This gene is overexpressed in Amniocyte (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTGF Gene



SOURCE GeneReport for Unigene cluster for CTGF Gene Hs.410037

mRNA Expression by UniProt/SwissProt for CTGF Gene

P29279-CTGF_HUMAN
Tissue specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
genes like me logo Genes that share expression patterns with CTGF: view

Primer Products

No data available for Protein tissue co-expression partners for CTGF Gene

Orthologs for CTGF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTGF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTGF 35
  • 89.37 (n)
  • 90.8 (a)
CTGF 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC476202 35
  • 91.4 (n)
  • 93.7 (a)
CTGF 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctgf 35
  • 88.6 (n)
  • 91.38 (a)
Ctgf 16
Ctgf 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTGF 35
  • 99.33 (n)
  • 98.85 (a)
CTGF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctgf 35
  • 88.86 (n)
  • 91.93 (a)
oppossum
(Monodelphis domestica)
Mammalia CTGF 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTGF 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTGF 35
  • 83.82 (n)
  • 88.37 (a)
CTGF 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTGF 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctgf 35
  • 75.02 (n)
  • 82.51 (a)
Str.15550 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398003 35
zebrafish
(Danio rerio)
Actinopterygii ctgfa 35
  • 73.29 (n)
  • 78.65 (a)
hmzeh1559 35
ctgfa 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13898 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
Species with no ortholog for CTGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTGF Gene

ENSEMBL:
Gene Tree for CTGF (if available)
TreeFam:
Gene Tree for CTGF (if available)

Paralogs for CTGF Gene

Paralogs for CTGF Gene

(7) SIMAP similar genes for CTGF Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTGF: view

Variants for CTGF Gene

Sequence variations from dbSNP and Humsavar for CTGF Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs7451102 - 131,950,812(+) GAAGT(C/G)ACAGA reference, missense
rs1049546 -- 131,949,089(-) CTATC(A/T)ACCCC utr-variant-3-prime
rs1049548 -- 131,949,088(-) TATCA(A/T)CCCCA utr-variant-3-prime
rs9493150 -- 131,952,851(+) TGTTT(C/G)TGGTG upstream-variant-2KB
rs9654640 -- 131,950,254(+) GGGAG(A/T)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTGF Gene

Variant ID Type Subtype PubMed ID
nsv7968 CNV Loss 18304495

Variation tolerance for CTGF Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTGF Gene

Human Gene Mutation Database (HGMD)
CTGF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTGF Gene

Disorders for CTGF Gene

MalaCards: The human disease database

(40) MalaCards diseases for CTGF Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic scleroderma
  • diffuse scleroderma
renal fibrosis
limited scleroderma
  • crest syndrome
trachoma
  • active stage trachoma
gingival overgrowth
  • gingival enlargement
- elite association - COSMIC cancer census association via MalaCards
Search CTGF in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTGF

Genetic Association Database (GAD)
CTGF
Human Genome Epidemiology (HuGE) Navigator
CTGF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTGF
genes like me logo Genes that share disorders with CTGF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTGF Gene

Publications for CTGF Gene

  1. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PMID: 1654338) Bradham D.M. … Grotendorst G.R. (J. Cell Biol. 1991) 2 3 4 67
  2. Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor. (PMID: 17602195) Gauer S. … Goppelt-Struebe M. (Nephrol. Dial. Transplant. 2007) 3 23 26
  3. Connective tissue growth factor is a downstream mediator for preptin-induced proliferation and differentiation in human osteoblasts. (PMID: 19333718) Liu Y.S. … Liao E.Y. (Amino Acids 2010) 3 23
  4. Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro. (PMID: 19890996) Lee Y.T. … Young T.H. (J. Orthop. Res. 2010) 3 23
  5. Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate. (PMID: 20015945) Mizutani M. … Matsuo S. (Am. J. Physiol. Renal Physiol. 2010) 3 23

Products for CTGF Gene

Sources for CTGF Gene

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