Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTBP1 Gene

Aliases for CTBP1 Gene

  • C-Terminal Binding Protein 1 2 3
  • Brefeldin A-Ribosylated Substrate 2 3
  • C-Terminal-Binding Protein 1 3
  • EC 1.1.1.158 64
  • EC 1.1.1.- 4
  • EC 1.1.1 64
  • CtBP1 4
  • BARS 3
  • CTBP 4

External Ids for CTBP1 Gene

Summaries for CTBP1 Gene

Entrez Gene Summary for CTBP1 Gene

  • This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTBP1 Gene

CTBP1 (C-Terminal Binding Protein 1) is a Protein Coding gene. Among its related pathways are Pathways in cancer and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is CTBP2.

UniProtKB/Swiss-Prot for CTBP1 Gene

  • Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Gene Wiki entry for CTBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTBP1 Gene

Genomics for CTBP1 Gene

Genomic Location for CTBP1 Gene

Start:
1,211,440 bp from pter
End:
1,249,953 bp from pter
Size:
38,514 bases
Orientation:
Minus strand

Genomic View for CTBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTBP1 Gene

Regulatory Elements for CTBP1 Gene

Proteins for CTBP1 Gene

  • Protein details for CTBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13363-CTBP1_HUMAN
    Recommended name:
    C-terminal-binding protein 1
    Protein Accession:
    Q13363
    Secondary Accessions:
    • Q4W5N3
    • Q7Z2Q5

    Protein attributes for CTBP1 Gene

    Size:
    440 amino acids
    Molecular mass:
    47535 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540; Note=NAD is required for efficient interaction with E1A. Cofactor binding induces a conformation change.;
    Quaternary structure:
    • Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)-specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Interacts with BCL6; the interaction is required for BCL6 transcriptional autoinhibition and inhibition of some BCL6 target genes. Interacts with IKZF4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CTBP1 Gene

    Alternative splice isoforms for CTBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTBP1 Gene

Proteomics data for CTBP1 Gene at MOPED

Post-translational modifications for CTBP1 Gene

  • ADP-ribosylated; when cells are exposed to brefeldin A.
  • Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.
  • The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys194 and Lys273

Domains for CTBP1 Gene

UniProtKB/Swiss-Prot:

CTBP1_HUMAN
Family:
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.:
    • Q13363
genes like me logo Genes that share domains with CTBP1: view

No data available for Gene Families for CTBP1 Gene

Function for CTBP1 Gene

Molecular function for CTBP1 Gene

GENATLAS Biochemistry: C terminal binding protein 1,48kDa
UniProtKB/Swiss-Prot Function: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Enzyme Numbers (IUBMB) for CTBP1 Gene

Gene Ontology (GO) - Molecular Function for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IDA 16287852
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity --
GO:0005515 protein binding IPI 11568182
GO:0008022 protein C-terminus binding TAS 8440238
genes like me logo Genes that share ontologies with CTBP1: view
genes like me logo Genes that share phenotypes with CTBP1: view

Animal Models for CTBP1 Gene

MGI Knock Outs for CTBP1:

miRNA for CTBP1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for CTBP1 Gene

Localization for CTBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTBP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTBP1 Gene COMPARTMENTS Subcellular localization image for CTBP1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2
golgi apparatus 2
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005829 cytosol IEA --
GO:0017053 transcriptional repressor complex ISS --
genes like me logo Genes that share ontologies with CTBP1: view

Pathways for CTBP1 Gene

genes like me logo Genes that share pathways with CTBP1: view

Gene Ontology (GO) - Biological Process for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19162039
GO:0006098 pentose-phosphate shunt --
GO:0006351 transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation TAS 8440238
GO:0007030 Golgi organization IEA --
genes like me logo Genes that share ontologies with CTBP1: view

Compounds for CTBP1 Gene

(1) HMDB Compounds for CTBP1 Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9

(2) Drugbank Compounds for CTBP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Formic Acid
  • Aminic acid
64-18-6 target
Nicotinamide-Adenine-Dinucleotide
53-84-9 target

(7) Novoseek inferred chemical compound relationships for CTBP1 Gene

Compound -log(P) Hits PubMed IDs
nadh 60.5 27
nad+ 52.1 15
zinc 47.3 5
lysine 30.7 6
pyruvate 3.46 2
genes like me logo Genes that share compounds with CTBP1: view

Transcripts for CTBP1 Gene

Unigene Clusters for CTBP1 Gene

C-terminal binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: -
SP10: - - - - - - - - -
SP11: - - - - - -
SP12:
SP13: -
SP14: - - - - - - - - - - - -
SP15: - - - - - - - - -
SP16:

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CTBP1 Gene

GeneLoc Exon Structure for
CTBP1
ECgene alternative splicing isoforms for
CTBP1

Expression for CTBP1 Gene

mRNA expression in normal human tissues for CTBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTBP1 Gene

SOURCE GeneReport for Unigene cluster for CTBP1 Gene Hs.208597

mRNA Expression by UniProt/SwissProt for CTBP1 Gene

Q13363-CTBP1_HUMAN
Tissue specificity: Expressed in germinal center B-cells.
genes like me logo Genes that share expressions with CTBP1: view

Orthologs for CTBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTBP1 36
  • 98.67 (n)
  • 99.53 (a)
CTBP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTBP1 36
  • 90.48 (n)
  • 97.54 (a)
CTBP1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTBP1 37
  • 95 (a)
OneToOne
LOC612240 36
  • 89.75 (n)
  • 96.45 (a)
mouse
(Mus musculus)
Mammalia Ctbp1 36
  • 88.56 (n)
  • 98.86 (a)
Ctbp1 16
Ctbp1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTBP1 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTBP1 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctbp1 36
  • 88.52 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves CTBP1 36
  • 79.16 (n)
  • 96.49 (a)
CTBP1 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTBP1 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ctbp1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ctbp1 36
  • 78.71 (n)
  • 94.77 (a)
zebrafish
(Danio rerio)
Actinopterygii ctbp1 36
CTBP1 37
  • 91 (a)
OneToOne
zgc:136929 36
  • 79.04 (n)
  • 91.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CtBP 37
  • 57 (a)
OneToMany
CtBP 38
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea ctbp-1 36
  • 53.09 (n)
  • 53.37 (a)
ctbp-1 37
  • 27 (a)
OneToMany
F49E10.5 38
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SER3 37
  • 20 (a)
ManyToMany
SER33 37
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9232 37
  • 63 (a)
OneToMany
Species with no ortholog for CTBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTBP1 Gene

ENSEMBL:
Gene Tree for CTBP1 (if available)
TreeFam:
Gene Tree for CTBP1 (if available)

Paralogs for CTBP1 Gene

Paralogs for CTBP1 Gene

genes like me logo Genes that share paralogs with CTBP1: view

Variants for CTBP1 Gene

Sequence variations from dbSNP and Humsavar for CTBP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs730830 -- 1,246,303(+) TCCCT(C/T)GGGCG intron-variant, upstream-variant-2KB
rs730831 -- 1,246,511(+) TTGAC(G/T)TGGGC intron-variant, upstream-variant-2KB
rs884421 -- 1,233,681(+) AATCC(C/T)AGTCC intron-variant
rs900013 -- 1,246,662(-) TCCTG(C/T)GGCCA intron-variant, upstream-variant-2KB
rs900019 -- 1,229,048(-) GGTCT(G/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTBP1 Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
nsv829835 CNV Gain 17160897
nsv878328 CNV Loss 21882294
dgv5401n71 CNV Loss 21882294
nsv878330 CNV Loss 21882294
dgv636n27 CNV Loss 19166990
dgv5402n71 CNV Loss 21882294
nsv508988 CNV Insertion 20534489
nsv822430 CNV Loss 20364138
nsv822432 CNV Gain 20364138
esv24472 CNV Gain 19812545
nsv822433 CNV Gain 20364138
nsv878334 CNV Loss 21882294
esv2726769 CNV Deletion 23290073
esv1540743 CNV Insertion 17803354
esv1720969 CNV Insertion 17803354
dgv5403n71 CNV Loss 21882294
esv27609 CNV Loss 19812545

Relevant External Links for CTBP1 Gene

HapMap Linkage Disequilibrium report
CTBP1

Disorders for CTBP1 Gene

(10) Novoseek inferred disease relationships for CTBP1 Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 36 2
colon cancer 31.6 1
colorectal cancer 13.7 6
tumors 12.9 14
cancer 10.5 8

Relevant External Links for CTBP1

Genetic Association Database (GAD)
CTBP1
Human Genome Epidemiology (HuGE) Navigator
CTBP1
genes like me logo Genes that share disorders with CTBP1: view

No data available for UniProtKB/Swiss-Prot for CTBP1 Gene

Publications for CTBP1 Gene

  1. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. (PMID: 7479821) Schaeper U. … Chinnadurai G. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  2. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. (PMID: 8440238) Boyd J.M. … Chinnadurai G. (EMBO J. 1993) 3 4 23
  3. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. (PMID: 9479502) Katsanis N. … Fisher E.M.C. (Genomics 1998) 2 3 23
  4. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate polycomb proteins. (PMID: 9858600) Sewalt R.G.A.B. … Otte A.P. (Mol. Cell. Biol. 1999) 3 4 23
  5. Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP. (PMID: 11509661) Vo N. … Goodman R.H. (Mol. Cell. Biol. 2001) 3 4 23

Products for CTBP1 Gene

Sources for CTBP1 Gene

Back to Top

Content