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Aliases for CTBP1 Gene

Aliases for CTBP1 Gene

  • C-Terminal Binding Protein 1 2 3
  • Brefeldin A-Ribosylated Substrate 2 3
  • EC 1.1.1.158 63
  • EC 1.1.1.- 4
  • EC 1.1.1 63
  • CtBP1 4
  • BARS 3
  • CTBP 4

External Ids for CTBP1 Gene

Previous GeneCards Identifiers for CTBP1 Gene

  • GC04M001195
  • GC04M001158
  • GC04M001205
  • GC04M001173

Summaries for CTBP1 Gene

Entrez Gene Summary for CTBP1 Gene

  • This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTBP1 Gene

CTBP1 (C-Terminal Binding Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is CTBP2.

UniProtKB/Swiss-Prot for CTBP1 Gene

  • Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Gene Wiki entry for CTBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTBP1 Gene

Genomics for CTBP1 Gene

Regulatory Elements for CTBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTBP1 Gene

Chromosome:
4
Start:
1,211,440 bp from pter
End:
1,250,248 bp from pter
Size:
38,809 bases
Orientation:
Minus strand

Genomic View for CTBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTBP1 Gene

Proteins for CTBP1 Gene

  • Protein details for CTBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13363-CTBP1_HUMAN
    Recommended name:
    C-terminal-binding protein 1
    Protein Accession:
    Q13363
    Secondary Accessions:
    • Q4W5N3
    • Q7Z2Q5

    Protein attributes for CTBP1 Gene

    Size:
    440 amino acids
    Molecular mass:
    47535 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540; Note=NAD is required for efficient interaction with E1A. Cofactor binding induces a conformation change.;
    Quaternary structure:
    • Homo- or heterodimer. Heterodimer with CTBP2. Interacts with PRDM16; the interaction represses white adipose tissue (WAT)-specific genes expression. Interacts with GLIS2, FOXP2, HDAC4, HDAC5, HDAC9 and ZNF217. Interacts with adenovirus E1A protein (via its C-terminus); the interaction disrupts the interaction of CTBP1 with RBBP8. Interacts with Epstein-Barr virus EBNA3 and EBNA6. Interacts with ELK3 (via its PXDLS motif). Interacts with RBBP8 (via its PXDLS motif); the interaction is disrupted by binding to adenovirus E1A. Interacts with FOXP1, HIPK2, PNN, NRIP1, MECOM, ZNF366, ZFHX1B and WIZ. Interaction with SATB1 (non-acetylated form); the interaction stabilizes its attachment to DNA and promotes transcription repression. Interacts with BCL6; the interaction is required for BCL6 transcriptional autoinhibition and inhibition of some BCL6 target genes. Interacts with IKZF4 (By similarity). Interacts with human adenovirus 5 E1A protein; this interaction seems to potentiate viral replication (PubMed:23747199).

    Three dimensional structures from OCA and Proteopedia for CTBP1 Gene

    Alternative splice isoforms for CTBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTBP1 Gene

Proteomics data for CTBP1 Gene at MOPED

Post-translational modifications for CTBP1 Gene

  • ADP-ribosylated; when cells are exposed to brefeldin A.
  • Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.
  • The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
  • Ubiquitination at Lys 194
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTBP1 (CtBP1)

Domains & Families for CTBP1 Gene

Suggested Antigen Peptide Sequences for CTBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13363

UniProtKB/Swiss-Prot:

CTBP1_HUMAN :
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Family:
  • Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
genes like me logo Genes that share domains with CTBP1: view

No data available for Gene Families for CTBP1 Gene

Function for CTBP1 Gene

Molecular function for CTBP1 Gene

GENATLAS Biochemistry:
C terminal binding protein 1,48kDa
UniProtKB/Swiss-Prot Function:
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Enzyme Numbers (IUBMB) for CTBP1 Gene

Gene Ontology (GO) - Molecular Function for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IDA 16287852
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 11568182
GO:0008022 protein C-terminus binding TAS 8440238
GO:0008134 transcription factor binding IPI 16609867
genes like me logo Genes that share ontologies with CTBP1: view
genes like me logo Genes that share phenotypes with CTBP1: view

Animal Models for CTBP1 Gene

MGI Knock Outs for CTBP1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CTBP1 Gene

Localization for CTBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTBP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTBP1 Gene COMPARTMENTS Subcellular localization image for CTBP1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
cytoskeleton 1
endosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex ISS --
genes like me logo Genes that share ontologies with CTBP1: view

Pathways & Interactions for CTBP1 Gene

genes like me logo Genes that share pathways with CTBP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CTBP1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CTBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19162039
GO:0006351 transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation TAS 8440238
GO:0008152 metabolic process --
GO:0008285 negative regulation of cell proliferation TAS 7479821
genes like me logo Genes that share ontologies with CTBP1: view

Drugs & Compounds for CTBP1 Gene

(6) Drugs for CTBP1 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
Formic acid Experimental Pharma Target 0
NAD Pharma Agonist, Activator 0
lysine Nutra 70
NADH Nutra 0

(3) Additional Compounds for CTBP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nad+
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
retinoic acid
302-79-4
genes like me logo Genes that share compounds with CTBP1: view

Transcripts for CTBP1 Gene

Unigene Clusters for CTBP1 Gene

C-terminal binding protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: -
SP10: - - - - - - - - -
SP11: - - - - - -
SP12:
SP13: -
SP14: - - - - - - - - - - - -
SP15: - - - - - - - - -
SP16:

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CTBP1 Gene

GeneLoc Exon Structure for
CTBP1
ECgene alternative splicing isoforms for
CTBP1

Expression for CTBP1 Gene

mRNA expression in normal human tissues for CTBP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTBP1 Gene



SOURCE GeneReport for Unigene cluster for CTBP1 Gene Hs.208597

mRNA Expression by UniProt/SwissProt for CTBP1 Gene

Q13363-CTBP1_HUMAN
Tissue specificity: Expressed in germinal center B-cells.
genes like me logo Genes that share expression patterns with CTBP1: view

Protein tissue co-expression partners for CTBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for CTBP1 Gene

Orthologs for CTBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTBP1 35
  • 90.48 (n)
  • 97.54 (a)
CTBP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC612240 35
  • 89.75 (n)
  • 96.45 (a)
CTBP1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctbp1 35
  • 88.56 (n)
  • 98.86 (a)
Ctbp1 16
Ctbp1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTBP1 35
  • 98.67 (n)
  • 99.53 (a)
CTBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctbp1 35
  • 88.52 (n)
  • 98.59 (a)
oppossum
(Monodelphis domestica)
Mammalia CTBP1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTBP1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTBP1 35
  • 79.16 (n)
  • 96.49 (a)
CTBP1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTBP1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctbp1 35
  • 78.71 (n)
  • 94.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia ctbp1-A 35
zebrafish
(Danio rerio)
Actinopterygii ctbp1 35
zgc:136929 35
  • 79.04 (n)
  • 91.34 (a)
CTBP1 36
  • 91 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CtBP 37
  • 72 (a)
CtBP 36
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F49E10.5 37
  • 53 (a)
ctbp-1 35
  • 53.09 (n)
  • 53.37 (a)
ctbp-1 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SER3 36
  • 20 (a)
ManyToMany
SER33 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9232 36
  • 63 (a)
OneToMany
Species with no ortholog for CTBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTBP1 Gene

ENSEMBL:
Gene Tree for CTBP1 (if available)
TreeFam:
Gene Tree for CTBP1 (if available)

Paralogs for CTBP1 Gene

Paralogs for CTBP1 Gene

genes like me logo Genes that share paralogs with CTBP1: view

Variants for CTBP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CTBP1 Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
nsv829835 CNV Gain 17160897
nsv878328 CNV Loss 21882294
dgv5401n71 CNV Loss 21882294
nsv878330 CNV Loss 21882294
dgv636n27 CNV Loss 19166990
dgv5402n71 CNV Loss 21882294
nsv508988 CNV Insertion 20534489
nsv822430 CNV Loss 20364138
nsv822432 CNV Gain 20364138
esv24472 CNV Gain 19812545
nsv822433 CNV Gain 20364138
nsv878334 CNV Loss 21882294
esv2726769 CNV Deletion 23290073
esv1540743 CNV Insertion 17803354
esv1720969 CNV Insertion 17803354
dgv5403n71 CNV Loss 21882294
esv27609 CNV Loss 19812545

Variation tolerance for CTBP1 Gene

Residual Variation Intolerance Score: 26.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTBP1 Gene

HapMap Linkage Disequilibrium report
CTBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CTBP1 Gene

Disorders for CTBP1 Gene

Relevant External Links for CTBP1

Genetic Association Database (GAD)
CTBP1
Human Genome Epidemiology (HuGE) Navigator
CTBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTBP1
genes like me logo Genes that share disorders with CTBP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTBP1 Gene

Publications for CTBP1 Gene

  1. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. (PMID: 9479502) Katsanis N. … Fisher E.M.C. (Genomics 1998) 2 23 67
  2. CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA. (PMID: 20082324) Basu A. … Atchison M.L. (J. Cell. Biochem. 2010) 23 67
  3. ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus. (PMID: 20175752) Papadopoulou V. … Wagner S.D. (Biochem. J. 2010) 23 67
  4. An ARF/CtBP2 complex regulates BH3-only gene expression and p53-independent apoptosis. (PMID: 19798104) Kovi R.C. … Grossman S.R. (Cell Death Differ. 2010) 23 67
  5. Inhibition of CtBP1 activity by Akt-mediated phosphorylation. (PMID: 20361981) Merrill J.C. … Wotton D. (J. Mol. Biol. 2010) 23 67

Products for CTBP1 Gene

Sources for CTBP1 Gene

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