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Aliases for CTAG1B Gene

Aliases for CTAG1B Gene

  • Cancer/Testis Antigen 1B 2 3
  • CTAG1 3 4 6
  • Autoimmunogenic Cancer/Testis Antigen NY-ESO-1 3 4
  • Cancer/Testis Antigen 6.1 3 4
  • L Antigen Family Member 2 3 4
  • Cancer/Testis Antigen 1 2 3
  • LAGE-2 3 4
  • LAGE2B 3 4
  • CT6.1 3 4
  • ESO1 3 4
  • CTAG 3 4
  • New York Esophageal Squamous Cell Carcinoma 1 3
  • Cancer Antigen 3 3
  • CTAG1A CTAG1B 4
  • NY-ESO-1 3
  • LAGE2A 4
  • LAGE2 4

External Ids for CTAG1B Gene

Previous HGNC Symbols for CTAG1B Gene

  • CTAG
  • CTAG1

Previous GeneCards Identifiers for CTAG1B Gene

  • GC0XP152282
  • GC0XM153410
  • GC0XM153499
  • GC0XM153845
  • GC0XM142391

Summaries for CTAG1B Gene

Entrez Gene Summary for CTAG1B Gene

  • The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012]

GeneCards Summary for CTAG1B Gene

CTAG1B (Cancer/Testis Antigen 1B) is a Protein Coding gene. Diseases associated with CTAG1B include biphasic synovial sarcoma and soft tissue sarcoma. An important paralog of this gene is CTAG2.

Gene Wiki entry for CTAG1B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAG1B Gene

Genomics for CTAG1B Gene

Regulatory Elements for CTAG1B Gene

Genomic Location for CTAG1B Gene

Start:
154,617,604 bp from pter
End:
154,619,282 bp from pter
Size:
1,679 bases
Orientation:
Minus strand

Genomic View for CTAG1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTAG1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAG1B Gene

Proteins for CTAG1B Gene

  • Protein details for CTAG1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78358-CTG1B_HUMAN
    Recommended name:
    Cancer/testis antigen 1
    Protein Accession:
    P78358
    Secondary Accessions:
    • A1L417
    • B7WNL9
    • Q7LBY4
    • Q9NY13

    Protein attributes for CTAG1B Gene

    Size:
    180 amino acids
    Molecular mass:
    17992 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTAG1B Gene

    Alternative splice isoforms for CTAG1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTAG1B Gene

Proteomics data for CTAG1B Gene at MOPED

Post-translational modifications for CTAG1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAG1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CTAG1B Gene

Domains for CTAG1B Gene

Protein Domains for CTAG1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTAG1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78358

UniProtKB/Swiss-Prot:

CTG1B_HUMAN :
  • P78358
Family:
  • Belongs to the CTAG/PCC1 family.
genes like me logo Genes that share domains with CTAG1B: view

No data available for Gene Families for CTAG1B Gene

Function for CTAG1B Gene

Gene Ontology (GO) - Molecular Function for CTAG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17137291
genes like me logo Genes that share ontologies with CTAG1B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTAG1B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CTAG1B Gene

Localization for CTAG1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAG1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTAG1B Gene COMPARTMENTS Subcellular localization image for CTAG1B gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTAG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CTAG1B: view

Pathways for CTAG1B Gene

SuperPathways for CTAG1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTAG1B Gene

None

No data available for Pathways by source for CTAG1B Gene

Compounds for CTAG1B Gene

(2) Novoseek inferred chemical compound relationships for CTAG1B Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 65.8 9
pullulan 60.4 5
genes like me logo Genes that share compounds with CTAG1B: view

Transcripts for CTAG1B Gene

mRNA/cDNA for CTAG1B Gene

(1) REFSEQ mRNAs :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTAG1B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTAG1B Gene

No ASD Table

Relevant External Links for CTAG1B Gene

GeneLoc Exon Structure for
CTAG1B
ECgene alternative splicing isoforms for
CTAG1B

Expression for CTAG1B Gene

mRNA expression in normal human tissues for CTAG1B Gene

Protein differential expression in normal tissues for CTAG1B Gene

This gene is overexpressed in Bone (43.6), Liver, secretome (12.1), and Testis (6.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CTAG1B Gene

SOURCE GeneReport for Unigene cluster for CTAG1B Gene Hs.745351

mRNA Expression by UniProt/SwissProt for CTAG1B Gene

P78358-CTG1B_HUMAN
Tissue specificity: Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).
genes like me logo Genes that share expressions with CTAG1B: view

Expression partners for CTAG1B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CTAG1B Gene

Orthologs for CTAG1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTAG1B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 36
  • 33 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm6880 36
  • 21 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 91 (a)
ManyToMany
-- 36
  • 91 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01063556.1 36
  • 35 (a)
OneToMany
Species with no ortholog for CTAG1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAG1B Gene

ENSEMBL:
Gene Tree for CTAG1B (if available)
TreeFam:
Gene Tree for CTAG1B (if available)

Paralogs for CTAG1B Gene

Paralogs for CTAG1B Gene

Selected SIMAP similar genes for CTAG1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTAG1B: view

Variants for CTAG1B Gene

Structural Variations from Database of Genomic Variants (DGV) for CTAG1B Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680
nsv508816 CNV Insertion 20534489
nsv7469 OTHER Inversion 18451855
esv29893 CNV Gain 19812545
nsv518228 CNV Gain 19592680
esv27930 CNV Gain 19812545

Relevant External Links for CTAG1B Gene

HapMap Linkage Disequilibrium report
CTAG1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CTAG1B Gene

Disorders for CTAG1B Gene

(38) Novoseek inferred disease relationships for CTAG1B Gene

Disease -log(P) Hits PubMed IDs
testicular cancer 91.8 52
melanoma 70.1 55
cancer 68.2 103
tumors 64.9 163
metastatic melanoma 61.2 4
genes like me logo Genes that share disorders with CTAG1B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for CTAG1B Gene

Publications for CTAG1B Gene

  1. Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28. (PMID: 9605863) Chen Y.T. … Arden K.C. (Cytogenet. Cell Genet. 1997) 2 3 23
  2. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. (PMID: 9050879) Chen Y.-T. … Old L.J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  3. Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PMID: 11709543) Aradhya S. … Nelson D.L. (Hum. Mol. Genet. 2001) 2 3 4
  4. The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. (PMID: 12065688) Satie A.P. … Samson M. (Lab. Invest. 2002) 3 4
  5. Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign prostatic tissue. (PMID: 16114059) Hudolin T. … Cacic M. (Prostate 2006) 3 23

Products for CTAG1B Gene

Sources for CTAG1B Gene

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