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Aliases for SYT6 Gene

Aliases for SYT6 Gene

  • Synaptotagmin VI 2 3 4
  • SytVI 3 4

External Ids for SYT6 Gene

Previous GeneCards Identifiers for SYT6 Gene

  • GC01M115046
  • GC01M113515
  • GC01M113733
  • GC01M113931
  • GC01M113922
  • GC01M114346
  • GC01M114433
  • GC01M114631
  • GC01M112489

Summaries for SYT6 Gene

Entrez Gene Summary for SYT6 Gene

  • The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for SYT6 Gene

SYT6 (Synaptotagmin VI) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT6 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).

Gene Wiki entry for SYT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT6 Gene

Genomics for SYT6 Gene

Regulatory Elements for SYT6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYT6 Gene

Chromosome:
1
Start:
114,089,291 bp from pter
End:
114,153,919 bp from pter
Size:
64,629 bases
Orientation:
Minus strand

Genomic View for SYT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT6 Gene

Proteins for SYT6 Gene

  • Protein details for SYT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7P8-SYT6_HUMAN
    Recommended name:
    Synaptotagmin-6
    Protein Accession:
    Q5T7P8
    Secondary Accessions:
    • B1AMB8
    • B3KPK1

    Protein attributes for SYT6 Gene

    Size:
    510 amino acids
    Molecular mass:
    57325 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    • Homodimer (isoform 1). Isoform 1 forms heterodimers with SytIII, SytV and SytX. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent. Isoform 2 is not able to form homodimer and heterodimers (By similarity).

    Alternative splice isoforms for SYT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYT6 Gene

Proteomics data for SYT6 Gene at MOPED

Post-translational modifications for SYT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT6 Gene

Domains & Families for SYT6 Gene

Gene Families for SYT6 Gene

Protein Domains for SYT6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7P8

UniProtKB/Swiss-Prot:

SYT6_HUMAN :
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
Domain:
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT6: view

Function for SYT6 Gene

Molecular function for SYT6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).

Gene Ontology (GO) - Molecular Function for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0005544 NOT calcium-dependent phospholipid binding IDA 7791877
GO:0019905 syntaxin binding IDA 7791877
GO:0030276 clathrin binding IDA 7791877
genes like me logo Genes that share ontologies with SYT6: view
genes like me logo Genes that share phenotypes with SYT6: view

Animal Models for SYT6 Gene

MGI Knock Outs for SYT6:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYT6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SYT6 Gene

Localization for SYT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT6 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.
Isoform 1: Membrane; Single-pass membrane protein. Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment. {ECO:0000250}.
Isoform 2: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT6 Gene COMPARTMENTS Subcellular localization image for SYT6 gene
Compartment Confidence
cytosol 4
plasma membrane 4
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane ISS --
GO:0016021 integral component of membrane ISS --
GO:0019898 extrinsic component of membrane ISS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SYT6: view

Pathways & Interactions for SYT6 Gene

SuperPathways for SYT6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007340 acrosome reaction --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter IBA --
GO:0060478 acrosomal vesicle exocytosis IMP 11437455
genes like me logo Genes that share ontologies with SYT6: view

No data available for Pathways by source and SIGNOR curated interactions for SYT6 Gene

Drugs & Compounds for SYT6 Gene

(1) Drugs for SYT6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with SYT6: view

Transcripts for SYT6 Gene

Unigene Clusters for SYT6 Gene

Synaptotagmin VI:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYT6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: -
SP3: -
SP4: -
SP5: - -

Relevant External Links for SYT6 Gene

GeneLoc Exon Structure for
SYT6
ECgene alternative splicing isoforms for
SYT6

Expression for SYT6 Gene

mRNA expression in normal human tissues for SYT6 Gene

mRNA differential expression in normal tissues according to GTEx for SYT6 Gene

This gene is overexpressed in Brain - Hypothalamus (x13.8), Brain - Nucleus accumbens (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.4), Brain - Putamen (basal ganglia) (x4.8), and Brain - Spinal cord (cervical c-1) (x4.0).

Protein differential expression in normal tissues from HIPED for SYT6 Gene

This gene is overexpressed in Plasma (36.0), Fetal Brain (18.8), and Heart (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SYT6 Gene



SOURCE GeneReport for Unigene cluster for SYT6 Gene Hs.370963

genes like me logo Genes that share expression patterns with SYT6: view

Protein tissue co-expression partners for SYT6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SYT6 Gene

Orthologs for SYT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYT6 35
  • 90.78 (n)
  • 97.4 (a)
SYT6 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT6 35
  • 89.78 (n)
  • 94.34 (a)
SYT6 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt6 35
  • 90.35 (n)
  • 96.94 (a)
Syt6 16
Syt6 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYT6 35
  • 99.53 (n)
  • 99.76 (a)
rat
(Rattus norvegicus)
Mammalia Syt6 35
  • 90.12 (n)
  • 96.71 (a)
oppossum
(Monodelphis domestica)
Mammalia SYT6 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT6 35
  • 78.63 (n)
  • 86.84 (a)
SYT6 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT6 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5667 35
syt6 35
  • 73.49 (n)
  • 86.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18838 35
zebrafish
(Danio rerio)
Actinopterygii syt6a 35
  • 72.58 (n)
  • 81.09 (a)
SYT6 (1 of 2) 36
  • 70 (a)
OneToMany
syt6a 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3020 37
  • 35 (a)
CG5559 37
  • 43 (a)
Syt1 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C08G5.4 37
  • 39 (a)
R12A1.2 37
  • 40 (a)
snt-1 36
  • 35 (a)
ManyToMany
snt-2 36
  • 36 (a)
ManyToMany
snt-3 36
  • 46 (a)
ManyToMany
Species with no ortholog for SYT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT6 Gene

ENSEMBL:
Gene Tree for SYT6 (if available)
TreeFam:
Gene Tree for SYT6 (if available)

Paralogs for SYT6 Gene

Paralogs for SYT6 Gene

genes like me logo Genes that share paralogs with SYT6: view

Variants for SYT6 Gene

Sequence variations from dbSNP and Humsavar for SYT6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2432 -- 114,089,358(+) ACAAA(C/T)GAGTA utr-variant-3-prime, nc-transcript-variant
rs3838 -- 114,155,472(-) AGGCG(A/C)ATAGG upstream-variant-2KB
rs475852 -- 114,134,061(+) CACAG(A/G)CAGCA intron-variant
rs476567 -- 114,134,095(+) GAGCA(A/G)CCTCC intron-variant
rs479359 -- 114,120,248(+) TCACT(A/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT6 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV Loss 19812545
nsv528503 CNV Loss 19592680
nsv2476 CNV Insertion 18451855
nsv517962 CNV Loss 19592680

Variation tolerance for SYT6 Gene

Residual Variation Intolerance Score: 60.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.03; 84.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT6 Gene

HapMap Linkage Disequilibrium report
SYT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT6 Gene

Disorders for SYT6 Gene

Relevant External Links for SYT6

Genetic Association Database (GAD)
SYT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT6
genes like me logo Genes that share disorders with SYT6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT6 Gene

Publications for SYT6 Gene

  1. PTP1B dephosphorylates N-ethylmaleimide-sensitive factor and elicits SNARE complex disassembly during human sperm exocytosis. (PMID: 19208619) Zarelli V.E. … Tomes C.N. (J. Biol. Chem. 2009) 23 67
  2. Complexin/synaptotagmin interplay controls acrosomal exocytosis. (PMID: 17613520) Roggero C.M. … Mayorga L.S. (J. Biol. Chem. 2007) 23 67
  3. alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PMID: 15542541) Tomes C.N. … Mayorga L.S. (Mol. Hum. Reprod. 2005) 23 67
  4. Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis. (PMID: 16111671) Roggero C.M. … Mayorga L.S. (Dev. Biol. 2005) 23 67
  5. SNARE complex assembly is required for human sperm acrosome reaction. (PMID: 11884041) Tomes C.N. … Mayorga L.S. (Dev. Biol. 2002) 23 67

Products for SYT6 Gene

Sources for SYT6 Gene

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