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Aliases for ADRA1A Gene

Aliases for ADRA1A Gene

  • Adrenoceptor Alpha 1A 2 3 5
  • Adrenergic, Alpha-1A-, Receptor 2 3
  • Alpha-1C Adrenergic Receptor 3 4
  • Alpha-1A Adrenoreceptor 3 4
  • Alpha-1A Adrenoceptor 3 4
  • ADRA1C 3 4
  • Alpha-1A Adrenergic Receptor 3
  • Alpha-Adrenergic Receptor 1c 4
  • G Protein Coupled Receptor 3
  • ALPHA1AAR 3
  • ADRA1L1 3

External Ids for ADRA1A Gene

Previous HGNC Symbols for ADRA1A Gene

  • ADRA1C

Previous GeneCards Identifiers for ADRA1A Gene

  • GC08M026378
  • GC08M027048
  • GC08M026627
  • GC08M026661
  • GC08M025150
  • GC08M026605

Summaries for ADRA1A Gene

Entrez Gene Summary for ADRA1A Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1A Gene

ADRA1A (Adrenoceptor Alpha 1A) is a Protein Coding gene. Diseases associated with ADRA1A include Horner's Syndrome and Prostatic Hypertrophy. Among its related pathways are Vascular smooth muscle contraction and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1B.

UniProtKB/Swiss-Prot for ADRA1A Gene

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Tocris Summary for ADRA1A Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1A Gene

Genomics for ADRA1A Gene

Regulatory Elements for ADRA1A Gene

Enhancers for ADRA1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G026839 1 Ensembl ENCODE 29.4 +30.6 30609 2.0 TFAP4 FOXA2 MAX RAD21 YY1 HNF4G GATAD2A RFX1 FOXA3 HLF ADRA1A COX6B1P4
GH08G026861 0.6 FANTOM5 21.6 +9.8 9819 0.3 JUND ATF3 MAX HNF4A RAD21 NR2F2 YY1 ADRA1A PTK2B COX6B1P4
GH08G027359 2 FANTOM5 Ensembl ENCODE dbSUPER 5.6 -495.1 -495136 13.4 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YY1 ZNF766 PTK2B CLU ADRA1A EPHX2 MIR6842
GH08G027033 0.6 ENCODE 16.8 -162.6 -162561 0.1 FOSL1 JUND ATF1 ATF3 BHLHE40 FOS CREM ADRA1A GC08M026972 MIR548H4
GH08G026830 0.4 ENCODE 18.9 +39.9 39909 0.9 ZNF146 ADRA1A COX6B1P4 RPLP1P9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADRA1A on UCSC Golden Path with GeneCards custom track

Genomic Location for ADRA1A Gene

Chromosome:
8
Start:
26,742,847 bp from pter
End:
26,871,008 bp from pter
Size:
128,162 bases
Orientation:
Minus strand

Genomic View for ADRA1A Gene

Genes around ADRA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1A Gene

Proteins for ADRA1A Gene

  • Protein details for ADRA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35348-ADA1A_HUMAN
    Recommended name:
    Alpha-1A adrenergic receptor
    Protein Accession:
    P35348
    Secondary Accessions:
    • A8K0I3
    • B0ZBD1
    • B0ZBD2
    • B0ZBD4
    • B0ZBD5
    • B0ZBD6
    • B0ZBD8
    • B0ZBD9
    • O60451
    • Q13675
    • Q13729
    • Q4VBM7
    • Q6RUJ4
    • Q6RUJ5
    • Q6RUJ7
    • Q6RUJ8
    • Q6RUJ9
    • Q96RE8
    • Q9UD63
    • Q9UD67

    Protein attributes for ADRA1A Gene

    Size:
    466 amino acids
    Molecular mass:
    51487 Da
    Quaternary structure:
    • Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

    Alternative splice isoforms for ADRA1A Gene

neXtProt entry for ADRA1A Gene

Post-translational modifications for ADRA1A Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Glycosylation at posLast=77, posLast=1313, and posLast=2222
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADRA1A Gene

Domains & Families for ADRA1A Gene

Gene Families for ADRA1A Gene

Suggested Antigen Peptide Sequences for ADRA1A Gene

Graphical View of Domain Structure for InterPro Entry

P35348

UniProtKB/Swiss-Prot:

ADA1A_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
genes like me logo Genes that share domains with ADRA1A: view

Function for ADRA1A Gene

Molecular function for ADRA1A Gene

GENATLAS Biochemistry:
adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively spliced isoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system
UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Gene Ontology (GO) - Molecular Function for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IEA --
GO:0004937 alpha1-adrenergic receptor activity TAS,NAS 7737411
GO:0046982 protein heterodimerization activity IDA 22120526
genes like me logo Genes that share ontologies with ADRA1A: view
genes like me logo Genes that share phenotypes with ADRA1A: view

Animal Models for ADRA1A Gene

MGI Knock Outs for ADRA1A:

Animal Model Products

CRISPR Products

miRNA for ADRA1A Gene

miRTarBase miRNAs that target ADRA1A

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for ADRA1A (alpha-1A Adrenergic R/ADRA1A)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1A Gene

Localization for ADRA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1A Gene

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADRA1A gene
Compartment Confidence
plasma membrane 5
nucleus 5

Gene Ontology (GO) - Cellular Components for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22120526
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8396931
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADRA1A: view

Pathways & Interactions for ADRA1A Gene

genes like me logo Genes that share pathways with ADRA1A: view

Gene Ontology (GO) - Biological Process for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA --
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
GO:0003084 positive regulation of systemic arterial blood pressure IEA --
genes like me logo Genes that share ontologies with ADRA1A: view

No data available for SIGNOR curated interactions for ADRA1A Gene

Drugs & Compounds for ADRA1A Gene

(251) Drugs for ADRA1A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Prazosin Approved Pharma Inverse agonist, Antagonist, antagonist, Target 63
Alfuzosin Approved, Investigational Pharma antagonist, Target 52
Doxazosin Approved Pharma antagonist, Target 58
Terazosin Approved Pharma antagonist, Target α1-adrenergic receptor antagonist 21
Silodosin Approved Pharma Antagonist, Target, antagonist α1-adrenoceptor antagonist 23

(5) Additional Compounds for ADRA1A Gene - From: HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-niguldipine
Antagonist
8-Hydroxycarvedilol
Promazine 5-sulfoxide
(R)-(-)-Phenylephrine hydrochloride
61-76-7
Tamsulosin hydrochloride
  • ()-(R)-5-(2-((2-(O-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochloride
  • (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochloride
  • 5-[(2R)-2-{[2-(2-Ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide hydrochloride
  • Flomax
  • Harnal
106463-17-6

(5) Tocris Compounds for ADRA1A Gene

Compound Action Cas Number
(R)-(-)-Phenylephrine hydrochloride alpha1 agonist 61-76-7
A 61603 hydrobromide alpha1A agonist 107756-30-9
Cirazoline hydrochloride Selective alpha1 agonist 40600-13-3
RS 100329 hydrochloride Potent, subtype-selective alpha1A antagonist 1215654-26-4
Tamsulosin hydrochloride Selective alpha1A antagonist 106463-17-6

(122) ApexBio Compounds for ADRA1A Gene

Compound Action Cas Number
(R)-(-)-Niguldipine hydrochloride
(R)-(+)-m-Nitrobiphenyline oxalate 945618-97-3
(S)-(-)-Atenolol 93379-54-5
(S)-(-)-Pindolol 26328-11-0
(S)-(-)-Propranolol hydrochloride 4199-10-4
(S)-(+)-Niguldipine hydrochloride 113145-69-0
2-MPMDQ α1-adrenoceptor antagonist,potent and selective 149847-77-8
2-PMDQ 139047-55-5
3-MPPI 133399-65-2
A 61603 hydrobromide Potent α1A-AR agonist 107756-30-9
Acebutolol HCl 34381-68-5
Adrenalone HCl 62-13-5
Agmatine sulfate 2482-00-0
Alfuzosin 81403-80-7
Alfuzosin HCl α1 adrenoceptor antagonist,functionally uro-selective 81403-68-1
Alprenolol hydrochloride 13707-88-5
Atipamezole hydrochloride 104075-48-1
Bambuterol 81732-65-2
Betaxolol βadrenergic receptor blocker 659-18-7
Betaxolol HCl 63659-19-8
Bisoprolol fumarate 104344-23-2
Brimonidine Tartrate 70359-46-5
Bucindolol 71119-11-4
Carvedilol 72956-09-3
Cimaterol 54239-37-1
Cirazoline hydrochloride 40600-13-3
Cisatracurium Besylate Neuromuscular-blocking drug 96946-42-8
Clonidine HCl 4205-91-8
Detomidine 76631-46-4
Detomidine HCl 90038-01-0
Dexmedetomidine 113775-47-6
Dexmedetomidine HCl 145108-58-3
Dihydroergocristine mesylate 24730-10-7
DL-Adrenaline 329-65-7
Dobutamine hydrochloride 49745-95-1
Doxazosin 74191-85-8
Doxazosin Mesylate α1-adrenergic receptor antagonist 77883-43-3
Droxidopa 23651-95-8
DSP-4 40616-75-9
Efaroxan hydrochloride 89197-00-2
Epinephrine Bitartrate 51-42-3
Epinephrine HCl 55-31-2
Formoterol Hemifumarate 43229-80-7
Guanabenz Acetate 23256-50-0
Guanfacine 29110-47-2
HEAT hydrochloride 30007-39-7
ICI 215,001 hydrochloride 140850-02-8
ICI 89406 53671-71-9
Idazoxan hydrochloride 79944-56-2
Imiloxan hydrochloride 81167-22-8
Indacaterol Maleate 753498-25-8
Isoprenaline HCl 51-30-9
Ivabradine HCl 148849-67-6
JP 1302 dihydrochloride 1259314-65-2
L-(-)-α-Methyldopa hydrochloride Alpha-adrenergic agonist 884-39-9
L-748,337 244192-94-7
Labetalol HCl 32780-64-6
L-Adrenaline 51-43-4
Levalbuterol tartrate 661464-94-4
Maprotiline HCl 10347-81-6
Medetomidine HCl 86347-15-1
Methyldopa 555-30-6
Metoprolol Succinate 98418-47-4
Metoprolol Tartrate β1-adrenergic blocking agent 392-17-7
Mirabegron (YM178) 223673-61-8
Naftopidil α1-adrenergic receptor antagonist 57149-07-2
Naftopidil DiHCl 57149-08-3
Naphazoline HCl 550-99-2
Nebivolol 152520-56-4
Nedaplatin 95734-82-0
Noradrenaline bitartrate monohydrate 108341-18-0
NPEC-caged-noradrenalin 1257323-83-3
Oxprenolol hydrochloride 6452-73-9
Oxymetazoline HCl Alpha-1/alpha-2 agonist 2315-02-8
Phenoxybenzamine HCl 63-92-3
Phentolamine Mesylate Alpha 1/2-blocking agent 65-28-1
Phenylephrine HCl 61-76-7
Pindolol 13523-86-9
Prazosin 19216-56-9
Prazosin HCl α1 and α2B-adrenoceptor antagonist 19237-84-4
Procaterol hydrochloride 62929-91-3
Pronethalol hydrochloride 1951-02-5
Propranolol HCl 318-98-9
Rauwolscine hydrochloride 6211-32-1
Rec 15/2615 dihydrochloride 173059-17-1
Ritodrine HCl β-2 adrenergic receptor agonist 23239-51-2
RS 100329 hydrochloride 1215654-26-4
RS 17053 hydrochloride α1A-adrenoceptor antagonist, novel and selective 169505-93-5
RS 79948 hydrochloride 186002-54-0
RWJ 52353 245744-10-9
RX 821002 hydrochloride 109544-45-8
Salbutamol Sulfate β-2 adrenergic receptor agonist 51022-70-9
Salmefamol 18910-65-1
Salmeterol xinafoate β2-adrenergic receptor agonist 94749-08-3
Scopine 498-45-3
SDZ 21009 39731-05-0
Silodosin α1-adrenoceptor antagonist 160970-54-7
SKF 86466 hydrochloride 86129-54-6
SNAP 5089 157066-77-8
Sotalol 959-24-0
Spiroxatrine 1054-88-2
SR 58611A hydrochloride 121524-09-2
SR 59230A hydrochloride 1135278-41-9
ST 91 4749-61-5
Synephrine 1994-07-5
Synephrine HCl 5985-28-4
TC-G 1000 245744-18-7
Terazosin α1-adrenergic receptor antagonist 63590-64-7
Terazosin HCl 70024-40-7
Terbutaline Sulfate 23031-32-5
Tetrahydrozoline HCl 522-48-5
Timolol Maleate 26921-17-5
Tizanidine 51322-75-9
Tizanidine HCl 64461-82-1
Tolazoline HCl 59-97-2
WB 4101 hydrochloride 2170-58-3
Xamoterol hemifumarate 73210-73-8
Xylazine HCl α2 Adrenoceptor agonist 23076-35-9
Xylometazoline HCl 1218-35-5
ZD 2079 178600-17-4
ZD 7114 hydrochloride 129689-28-7
Zinterol hydrochloride 37000-20-7
genes like me logo Genes that share compounds with ADRA1A: view

Transcripts for ADRA1A Gene

Unigene Clusters for ADRA1A Gene

Adrenoceptor alpha 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for ADRA1A (alpha-1A Adrenergic R/ADRA1A)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for ADRA1A Gene

GeneLoc Exon Structure for
ADRA1A
ECgene alternative splicing isoforms for
ADRA1A

Expression for ADRA1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADRA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA1A Gene

This gene is overexpressed in Liver (x18.5) and Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for ADRA1A Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADRA1A Gene



Protein tissue co-expression partners for ADRA1A Gene

NURSA nuclear receptor signaling pathways regulating expression of ADRA1A Gene:

ADRA1A

SOURCE GeneReport for Unigene cluster for ADRA1A Gene:

Hs.709175

mRNA Expression by UniProt/SwissProt for ADRA1A Gene:

P35348-ADA1A_HUMAN
Tissue specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.

Evidence on tissue expression from TISSUES for ADRA1A Gene

  • Liver(4.5)
  • Heart(4.4)
  • Nervous system(4.3)
  • Blood(4.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with ADRA1A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADRA1A Gene

Orthologs for ADRA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA1A 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia ADRA1A 34 35
  • 91.85 (n)
cow
(Bos Taurus)
Mammalia ADRA1A 34 35
  • 90.2 (n)
rat
(Rattus norvegicus)
Mammalia Adra1a 34
  • 87.84 (n)
mouse
(Mus musculus)
Mammalia Adra1a 34 16 35
  • 87.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADRA1A 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRA1A 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADRA1A 34 35
  • 73.75 (n)
lizard
(Anolis carolinensis)
Reptilia ADRA1A 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492776 34
  • 65.52 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC798498 34
  • 60.48 (n)
ADRA1A (2 of 2) 35
  • 54 (a)
OneToMany
adra1ab 35
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Oamb 34 35
  • 55.94 (n)
DopR2 36
  • 44 (a)
CG7431 36
  • 41 (a)
5-HT1B 36
  • 38 (a)
DopR 36
  • 34 (a)
5-HT1A 36
  • 32 (a)
CG6989 36
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPROAR1 34
  • 53.03 (n)
worm
(Caenorhabditis elegans)
Secernentea dop-4 34 35
  • 46.51 (n)
C52B11.3 36
  • 38 (a)
Species where no ortholog for ADRA1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1A Gene

ENSEMBL:
Gene Tree for ADRA1A (if available)
TreeFam:
Gene Tree for ADRA1A (if available)

Paralogs for ADRA1A Gene

Variants for ADRA1A Gene

Sequence variations from dbSNP and Humsavar for ADRA1A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_035756 A breast cancer sample
rs1000011190 -- 26,787,139(+) CTCAT(A/G)TTTTA intron-variant
rs1000025875 -- 26,842,591(+) CAGCC(A/G)GCCTG intron-variant
rs1000031923 -- 26,768,756(+) ATCTG(G/T)AATCT intron-variant, downstream-variant-500B
rs1000072785 -- 26,856,035(+) AAAGC(A/G)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA1A Gene

Variant ID Type Subtype PubMed ID
esv3616666 OTHER inversion 21293372
nsv527478 CNV gain 19592680
nsv610864 CNV loss 21841781

Variation tolerance for ADRA1A Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA1A Gene

Human Gene Mutation Database (HGMD)
ADRA1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADRA1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1A Gene

Disorders for ADRA1A Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADRA1A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
horner's syndrome
  • bernard horner syndrome
prostatic hypertrophy
  • prostatic hyperplasia
ureter cancer
  • malignant tumour of ureter
ureterolithiasis
  • calculus of ureter
prostatitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADRA1A

Genetic Association Database (GAD)
ADRA1A
Human Genome Epidemiology (HuGE) Navigator
ADRA1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRA1A
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No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA1A Gene

Publications for ADRA1A Gene

  1. Genetic variation in the autonomic nervous system affects mortality: a study of 1,095 trauma patients. (PMID: 19476811) Morris J.A. … Canter J.A. (J. Am. Coll. Surg. 2009) 3 22 46 64
  2. Polymorphisms in the alpha1A-adrenoceptor gene do not modify the short- and long-term efficacy of alpha1-adrenoceptor antagonists in the treatment of benign prostatic hyperplasia. (PMID: 16536786) Mochtar C.A. … Kiemeney L.A. (BJU Int. 2006) 3 22 46 64
  3. Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (PMID: 16043131) Clark D.A. … Kerwin R.W. (Biol. Psychiatry 2005) 3 22 46 64
  4. Alpha 1A-adrenergic receptor polymorphism and vascular response. (PMID: 15179408) Sofowora G.G. … Stein C.M. (Clin. Pharmacol. Ther. 2004) 3 4 46 64
  5. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PMID: 15824464) Matayoshi T. … Kawano Y. (Hypertens. Res. 2004) 3 22 46 64

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