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Aliases for ADRA1A Gene

Aliases for ADRA1A Gene

  • Adrenoceptor Alpha 1A 2 3 5
  • Adrenergic, Alpha-1A-, Receptor 2 3
  • Alpha-1C Adrenergic Receptor 3 4
  • Alpha-1A Adrenoreceptor 3 4
  • Alpha-1A Adrenoceptor 3 4
  • ADRA1C 3 4
  • Alpha-Adrenergic Receptor 1c 4
  • G Protein Coupled Receptor 3
  • ALPHA1AAR 3
  • ADRA1L1 3

External Ids for ADRA1A Gene

Previous HGNC Symbols for ADRA1A Gene

  • ADRA1C

Previous GeneCards Identifiers for ADRA1A Gene

  • GC08M026378
  • GC08M027048
  • GC08M026627
  • GC08M026661
  • GC08M025150
  • GC08M026605

Summaries for ADRA1A Gene

Entrez Gene Summary for ADRA1A Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1A Gene

ADRA1A (Adrenoceptor Alpha 1A) is a Protein Coding gene. Diseases associated with ADRA1A include ureter cancer and horner's syndrome. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA1A Gene

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Tocris Summary for ADRA1A Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.

Gene Wiki entry for ADRA1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1A Gene

Genomics for ADRA1A Gene

Regulatory Elements for ADRA1A Gene

Genomic Location for ADRA1A Gene

Chromosome:
8
Start:
26,742,847 bp from pter
End:
26,871,008 bp from pter
Size:
128,162 bases
Orientation:
Minus strand

Genomic View for ADRA1A Gene

Genes around ADRA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADRA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADRA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1A Gene

Proteins for ADRA1A Gene

  • Protein details for ADRA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35348-ADA1A_HUMAN
    Recommended name:
    Alpha-1A adrenergic receptor
    Protein Accession:
    P35348
    Secondary Accessions:
    • A8K0I3
    • B0ZBD1
    • B0ZBD2
    • B0ZBD4
    • B0ZBD5
    • B0ZBD6
    • B0ZBD8
    • B0ZBD9
    • O60451
    • Q13675
    • Q13729
    • Q4VBM7
    • Q6RUJ4
    • Q6RUJ5
    • Q6RUJ7
    • Q6RUJ8
    • Q6RUJ9
    • Q96RE8
    • Q9UD63
    • Q9UD67

    Protein attributes for ADRA1A Gene

    Size:
    466 amino acids
    Molecular mass:
    51487 Da
    Quaternary structure:
    • Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

    Alternative splice isoforms for ADRA1A Gene

neXtProt entry for ADRA1A Gene

Proteomics data for ADRA1A Gene at MOPED

Post-translational modifications for ADRA1A Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Glycosylation at Asn 7, Asn 13, and Asn 22
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ADRA1A Gene

Domains & Families for ADRA1A Gene

Gene Families for ADRA1A Gene

Suggested Antigen Peptide Sequences for ADRA1A Gene

Graphical View of Domain Structure for InterPro Entry

P35348

UniProtKB/Swiss-Prot:

ADA1A_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
genes like me logo Genes that share domains with ADRA1A: view

Function for ADRA1A Gene

Molecular function for ADRA1A Gene

GENATLAS Biochemistry:
adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively spliced isoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system
UniProtKB/Swiss-Prot Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Gene Ontology (GO) - Molecular Function for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046982 protein heterodimerization activity IDA 22120526
genes like me logo Genes that share ontologies with ADRA1A: view
genes like me logo Genes that share phenotypes with ADRA1A: view

Animal Models for ADRA1A Gene

MGI Knock Outs for ADRA1A:

Animal Model Products

miRNA for ADRA1A Gene

miRTarBase miRNAs that target ADRA1A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADRA1A Gene

Localization for ADRA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1A Gene

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA1A Gene COMPARTMENTS Subcellular localization image for ADRA1A gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,ISS --
GO:0016020 membrane IEA --
GO:0030315 T-tubule IEA --
genes like me logo Genes that share ontologies with ADRA1A: view

Pathways & Interactions for ADRA1A Gene

genes like me logo Genes that share pathways with ADRA1A: view

Gene Ontology (GO) - Biological Process for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA --
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
GO:0003084 positive regulation of systemic arterial blood pressure IEA --
genes like me logo Genes that share ontologies with ADRA1A: view

No data available for SIGNOR curated interactions for ADRA1A Gene

Drugs & Compounds for ADRA1A Gene

(190) Drugs for ADRA1A Gene - From: IUPHAR, DGIdb, DrugBank, ApexBio, Novoseek, HMDB, FDA Approved Drugs, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Prazosin Approved Pharma Inverse agonist, Antagonist, antagonist, Target 51
Silodosin Approved Pharma Antagonist, Target, antagonist α1-adrenoceptor antagonist 22
Methoxamine Approved Pharma Full agonist, Agonist, stimulator, Target, agonist 3
Oxymetazoline Approved Pharma Full agonist, Agonist, agonist, Target 409
Phentolamine Approved Pharma Antagonist, antagonist, Target 15

(8) Additional Compounds for ADRA1A Gene - From: IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-niguldipine
Antagonist
8-Hydroxycarvedilol
Promazine 5-sulfoxide
(R)-(-)-Phenylephrine hydrochloride
61-76-7
A 61603 hydrobromide
107756-30-9
genes like me logo Genes that share compounds with ADRA1A: view

Transcripts for ADRA1A Gene

Unigene Clusters for ADRA1A Gene

Adrenoceptor alpha 1A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for ADRA1A Gene

GeneLoc Exon Structure for
ADRA1A
ECgene alternative splicing isoforms for
ADRA1A

Expression for ADRA1A Gene

mRNA expression in normal human tissues for ADRA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA1A Gene

This gene is overexpressed in Liver (x18.5) and Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for ADRA1A Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADRA1A Gene



SOURCE GeneReport for Unigene cluster for ADRA1A Gene Hs.709175

mRNA Expression by UniProt/SwissProt for ADRA1A Gene

P35348-ADA1A_HUMAN
Tissue specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
genes like me logo Genes that share expression patterns with ADRA1A: view

Protein tissue co-expression partners for ADRA1A Gene

Primer Products

In Situ Assay Products

Orthologs for ADRA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA1A 36
  • 99 (a)
OneToOne
ADRA1A 35
  • 99.29 (n)
  • 99.29 (a)
cow
(Bos Taurus)
Mammalia ADRA1A 36
  • 86 (a)
OneToOne
ADRA1A 35
  • 90.2 (n)
  • 92.06 (a)
dog
(Canis familiaris)
Mammalia ADRA1A 35
  • 91.85 (n)
  • 92.92 (a)
ADRA1A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adra1a 16
Adra1a 36
  • 85 (a)
OneToOne
Adra1a 35
  • 87.12 (n)
  • 91.85 (a)
oppossum
(Monodelphis domestica)
Mammalia ADRA1A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADRA1A 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adra1a 35
  • 87.84 (n)
  • 92.7 (a)
chicken
(Gallus gallus)
Aves ADRA1A 35
  • 73.75 (n)
  • 77.25 (a)
ADRA1A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRA1A 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492776 35
  • 65.52 (n)
  • 69.18 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC798498 35
  • 60.48 (n)
  • 62.86 (a)
ADRA1A (2 of 2) 36
  • 54 (a)
OneToMany
adra1ab 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPROAR1 35
  • 53.03 (n)
  • 45.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oamb 36
  • 23 (a)
OneToMany
5-HT1A 37
  • 32 (a)
5-HT1B 37
  • 38 (a)
CG6989 37
  • 32 (a)
CG7431 37
  • 41 (a)
DopR 37
  • 34 (a)
DopR2 37
  • 44 (a)
Oamb 35
  • 55.94 (n)
  • 45.86 (a)
worm
(Caenorhabditis elegans)
Secernentea C52B11.3 37
  • 38 (a)
dop-4 36
  • 27 (a)
OneToMany
dop-4 35
  • 46.51 (n)
  • 41.28 (a)
Species with no ortholog for ADRA1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1A Gene

ENSEMBL:
Gene Tree for ADRA1A (if available)
TreeFam:
Gene Tree for ADRA1A (if available)

Paralogs for ADRA1A Gene

genes like me logo Genes that share paralogs with ADRA1A: view

Variants for ADRA1A Gene

Sequence variations from dbSNP and Humsavar for ADRA1A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1048101 - 26,770,511(-) GTCTC(C/T)GCAGA reference, missense
VAR_035756 A breast cancer sample
rs2229125 - 26,864,371(-) CATCA(G/T)CCTGG reference, missense
rs3730247 - 26,770,309(-) GTCCA(A/G)AGACC reference, missense
rs2229126 - 26,770,155(-) GAGGA(A/T)GTCTA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADRA1A Gene

Variant ID Type Subtype PubMed ID
nsv527478 CNV Gain 19592680

Variation tolerance for ADRA1A Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADRA1A Gene

HapMap Linkage Disequilibrium report
ADRA1A
Human Gene Mutation Database (HGMD)
ADRA1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1A Gene

Disorders for ADRA1A Gene

MalaCards: The human disease database

(11) MalaCards diseases for ADRA1A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ureter cancer
  • malignant tumour of ureter
horner's syndrome
  • bernard horner syndrome
congenital horner syndrome
  • congenital claude-bernard-horner syndrome
ureterolithiasis
  • calculus of ureter
prostatic hypertrophy
  • prostatic hyperplasia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADRA1A

Genetic Association Database (GAD)
ADRA1A
Human Genome Epidemiology (HuGE) Navigator
ADRA1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADRA1A
genes like me logo Genes that share disorders with ADRA1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADRA1A Gene

Publications for ADRA1A Gene

  1. Alpha 1A-adrenergic receptor polymorphism and vascular response. (PMID: 15179408) Sofowora G.G. … Stein C.M. (Clin. Pharmacol. Ther. 2004) 3 4 48 67
  2. Update of TTD: Therapeutic Target Database. (PMID: 19933260) Zhu F. … Chen Y. (Nucleic Acids Res. 2010) 25 26
  3. Beta-adrenergic blocking agents and dental vasoconstrictors. (PMID: 20831932) Hersh E.V. … Giannakopoulos H. (Dent. Clin. North Am. 2010) 25 26
  4. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. (PMID: 20030735) Haenisch B. … BAPnisch H. (Fundam Clin Pharmacol 2010) 25 26
  5. Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity. (PMID: 20075651) Andersohn F. … Garbe E. (J Clin Psychopharmacol 2010) 25 26

Products for ADRA1A Gene

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