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Aliases for ADRA1A Gene

Aliases for ADRA1A Gene

  • Adrenoceptor Alpha 1A 2 3
  • ADRA1C 3 4 6
  • Alpha-1C Adrenergic Receptor 3 4
  • Alpha-1A Adrenoreceptor 3 4
  • Alpha-1A Adrenoceptor 3 4
  • Adrenergic, Alpha-1A-, Receptor Variant 11 3
  • Adrenergic, Alpha-1A-, Receptor Variant 1 3
  • Adrenergic, Alpha-1A-, Receptor Variant 3 3
  • Adrenergic, Alpha-1A-, Receptor Variant 5 3
  • Adrenergic, Alpha-1A-, Receptor Variant 8 3
  • Adrenergic, Alpha-1A-, Receptor 2
  • Alpha-1A Adrenergic Receptor 3
  • Alpha-Adrenergic Receptor 1c 4
  • G Protein Coupled Receptor 3
  • ALPHA1AAR 3
  • ADRA1L1 3

External Ids for ADRA1A Gene

Previous HGNC Symbols for ADRA1A Gene

  • ADRA1C

Previous GeneCards Identifiers for ADRA1A Gene

  • GC08M026378
  • GC08M027048
  • GC08M026627
  • GC08M026661
  • GC08M025150
  • GC08M026605

Summaries for ADRA1A Gene

Entrez Gene Summary for ADRA1A Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1A Gene

ADRA1A (Adrenoceptor Alpha 1A) is a Protein Coding gene. Diseases associated with ADRA1A include ureterolithiasis. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein heterodimerization activity and alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA1A Gene

  • This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Tocris Summary for ADRA1A Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors. lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1A Gene

Genomics for ADRA1A Gene

Regulatory Elements for ADRA1A Gene

Genomic Location for ADRA1A Gene

Start:
26,747,938 bp from pter
End:
26,869,486 bp from pter
Size:
121,549 bases
Orientation:
Minus strand

Genomic View for ADRA1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1A Gene

Proteins for ADRA1A Gene

  • Protein details for ADRA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35348-ADA1A_HUMAN
    Recommended name:
    Alpha-1A adrenergic receptor
    Protein Accession:
    P35348
    Secondary Accessions:
    • A8K0I3
    • B0ZBD1
    • B0ZBD2
    • B0ZBD4
    • B0ZBD5
    • B0ZBD6
    • B0ZBD8
    • B0ZBD9
    • O60451
    • Q13675
    • Q13729
    • Q4VBM7
    • Q6RUJ4
    • Q6RUJ5
    • Q6RUJ7
    • Q6RUJ8
    • Q6RUJ9
    • Q96RE8
    • Q9UD63
    • Q9UD67

    Protein attributes for ADRA1A Gene

    Size:
    466 amino acids
    Molecular mass:
    51487 Da
    Quaternary structure:
    • Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

    Alternative splice isoforms for ADRA1A Gene

neXtProt entry for ADRA1A Gene

Proteomics data for ADRA1A Gene at MOPED

Post-translational modifications for ADRA1A Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Glycosylation at Asn7, Asn13, and Asn22
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADRA1A Gene

Domains for ADRA1A Gene

Gene Families for ADRA1A Gene

HGNC:
  • ADRA :GPCR / Class A : Adrenoceptors : alpha
IUPHAR :

Suggested Antigen Peptide Sequences for ADRA1A Gene

Graphical View of Domain Structure for InterPro Entry

P35348

UniProtKB/Swiss-Prot:

ADA1A_HUMAN :
  • P35348
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
genes like me logo Genes that share domains with ADRA1A: view

Function for ADRA1A Gene

Molecular function for ADRA1A Gene

GENATLAS Biochemistry: adrenergic,alpha-1A,receptor,G protein coupled receptor superfamily,with four alternatively spliced isoforms,stimulating,acting through the phosphatidylinositol Ca2+ second messenger system
UniProtKB/Swiss-Prot Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Gene Ontology (GO) - Molecular Function for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004937 alpha1-adrenergic receptor activity TAS 7737411
GO:0046982 protein heterodimerization activity IDA 22120526
genes like me logo Genes that share ontologies with ADRA1A: view
genes like me logo Genes that share phenotypes with ADRA1A: view

miRNA for ADRA1A Gene

miRTarBase miRNAs that target ADRA1A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADRA1A Gene

Localization for ADRA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1A Gene

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA1A Gene COMPARTMENTS Subcellular localization image for ADRA1A gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22120526
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8396931
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADRA1A: view

Pathways for ADRA1A Gene

genes like me logo Genes that share pathways with ADRA1A: view

Gene Ontology (GO) - Biological Process for ADRA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA --
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA --
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA --
GO:0003084 positive regulation of systemic arterial blood pressure IEA --
genes like me logo Genes that share ontologies with ADRA1A: view

Compounds for ADRA1A Gene

(5) Tocris Compounds for ADRA1A Gene

Compound Action Cas Number
(R)-(-)-Phenylephrine hydrochloride alpha1 agonist [61-76-7]
A 61603 hydrobromide alpha1A agonist [107756-30-9]
Cirazoline hydrochloride Selective alpha1 agonist [40600-13-3]
Naftopidil hydrochloride alpha1 antagonist [1164469-60-6]
RS 17053 hydrochloride alpha1A antagonist [169505-93-5]

(7) HMDB Compounds for ADRA1A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Epinephrine
  • (-)-(R)-Epinephrine
51-43-4
Norepinephrine
  • (-)-(R)-Norepinephrine
51-41-2
Phenylephrine
  • Adrianol
59-42-7
Phenylpropanolamine
  • DL-Norephedrine
154-41-6

(79) Drugbank Compounds for ADRA1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4-Methoxyamphetamine
23239-32-9 target agonist
Acepromazine
  • 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone
61-00-7 target antagonist
Alfuzosin
81403-80-7 target antagonist
Amitriptyline
  • Amitriprolidine
50-48-6 target antagonist
Amoxapine
14028-44-5 target antagonist

(42) IUPHAR Ligand for ADRA1A Gene

Ligand Type Action Affinity Pubmed IDs
tamsulosin Antagonist Antagonist 10.7
silodosin Antagonist Antagonist 10.4
cyproheptadine Antagonist Antagonist 10.2
(+)-niguldipine Antagonist Antagonist 10
[125I]HEAT Agonist Full agonist 10
prazosin Antagonist Inverse agonist 9.9
[125I]BE-2254 Antagonist Antagonist 9.9
WB 4101 Antagonist Antagonist 9.8
Rec 15/2739 Antagonist Antagonist 9.6
RS-100329 Antagonist Antagonist 9.6
NAN 190 Antagonist Antagonist 9.4
SNAP5089 Antagonist Antagonist 9.4
RS-17053 Antagonist Antagonist 9.3
5-methylurapidil Antagonist Antagonist 9.2
Ro-70-0004 Antagonist Antagonist 8.9
terguride Antagonist Antagonist 8.9
spiroxatrine Agonist Full agonist 8.8
A-119637 Antagonist Antagonist 8.6
phentolamine Antagonist Antagonist 8.6
roxindole Antagonist Antagonist 8.6
indoramin Antagonist Antagonist 8.4
A61603 Agonist Full agonist 8.4
A-123189 Antagonist Antagonist 8.4
BMY-7378 Agonist Partial agonist 8
(+)-cyclazosin Antagonist Antagonist 7.9
risperidone Antagonist Antagonist 7.8
ritanserin Antagonist Antagonist 7.4
dabuzalgron Agonist Agonist 7.4
mianserin Antagonist Antagonist 7.3
lisuride Agonist Partial agonist 7.2
piribedil Agonist Partial agonist 6.9
oxymetazoline Agonist Full agonist 6.8
spiperone Antagonist Antagonist 6.7
clozapine Antagonist Antagonist 6.7
cabergoline Agonist Full agonist 6.7
ketanserin Inhibitor Inhibition 6.3
(-)-adrenaline Agonist Full agonist 6.2
NS-49 Agonist Partial agonist 6.2
(-)-noradrenaline Agonist Full agonist 6
phenylephrine Agonist Full agonist 5.4
methoxamine Agonist Full agonist 5.2
(+)-adrenaline Agonist Full agonist 5

(3) Novoseek inferred chemical compound relationships for ADRA1A Gene

Compound -log(P) Hits PubMed IDs
prazosin 52.9 1
norepinephrine 14 1
dopamine 0 1
genes like me logo Genes that share compounds with ADRA1A: view

Transcripts for ADRA1A Gene

Unigene Clusters for ADRA1A Gene

Adrenoceptor alpha 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for ADRA1A Gene

GeneLoc Exon Structure for
ADRA1A
ECgene alternative splicing isoforms for
ADRA1A

Expression for ADRA1A Gene

mRNA expression in normal human tissues for ADRA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADRA1A Gene

This gene is overexpressed in Liver (18.5) and Heart - Left Ventricle (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADRA1A Gene

SOURCE GeneReport for Unigene cluster for ADRA1A Gene Hs.709175

mRNA Expression by UniProt/SwissProt for ADRA1A Gene

P35348-ADA1A_HUMAN
Tissue specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
genes like me logo Genes that share expressions with ADRA1A: view

Orthologs for ADRA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA1A 35
  • 99.29 (n)
  • 99.29 (a)
ADRA1A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADRA1A 35
  • 90.2 (n)
  • 92.06 (a)
ADRA1A 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRA1A 35
  • 91.85 (n)
  • 92.92 (a)
ADRA1A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adra1a 35
  • 87.12 (n)
  • 91.85 (a)
Adra1a 16
Adra1a 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRA1A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADRA1A 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adra1a 35
  • 87.84 (n)
  • 92.7 (a)
chicken
(Gallus gallus)
Aves ADRA1A 35
  • 73.75 (n)
  • 77.25 (a)
ADRA1A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRA1A 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492776 35
  • 65.52 (n)
  • 69.18 (a)
zebrafish
(Danio rerio)
Actinopterygii ADRA1A (2 of 2) 36
  • 54 (a)
OneToMany
adra1ab 36
  • 52 (a)
OneToMany
LOC798498 35
  • 60.48 (n)
  • 62.86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPROAR1 35
  • 53.03 (n)
  • 45.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oamb 35
  • 55.94 (n)
  • 45.86 (a)
Oamb 36
  • 23 (a)
OneToMany
5-HT1A 37
  • 32 (a)
5-HT1B 37
  • 38 (a)
CG7431 37
  • 41 (a)
DopR2 37
  • 44 (a)
CG6989 37
  • 32 (a)
DopR 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea dop-4 35
  • 46.51 (n)
  • 41.28 (a)
dop-4 36
  • 27 (a)
OneToMany
C52B11.3 37
  • 38 (a)
Species with no ortholog for ADRA1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1A Gene

ENSEMBL:
Gene Tree for ADRA1A (if available)
TreeFam:
Gene Tree for ADRA1A (if available)

Paralogs for ADRA1A Gene

Paralogs for ADRA1A Gene

genes like me logo Genes that share paralogs with ADRA1A: view

Variants for ADRA1A Gene

Sequence variations from dbSNP and Humsavar for ADRA1A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs471188 -- 26,862,875(-) AGCCA(A/G/T)GGATA intron-variant
rs472151 -- 26,834,850(+) AACAT(A/G)CAGAC intron-variant
rs472585 -- 26,870,720(-) CTTTT(A/C)CTTCC upstream-variant-2KB
rs472865 -- 26,840,954(+) AGTCA(C/T)GATAG intron-variant
rs476631 -- 26,848,942(+) GTGAC(C/T)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA1A Gene

Variant ID Type Subtype PubMed ID
nsv527478 CNV Gain 19592680

Relevant External Links for ADRA1A Gene

HapMap Linkage Disequilibrium report
ADRA1A
Human Gene Mutation Database (HGMD)
ADRA1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1A Gene

Disorders for ADRA1A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADRA1A Gene including...

Search for ADRA1A Gene in MalaCards »

(2) University of Copenhagen DISEASES for ADRA1A Gene

(2) Novoseek inferred disease relationships for ADRA1A Gene

Disease -log(P) Hits PubMed IDs
benign prostatic hyperplasia 58.7 4
attention-deficit hyperactivity disorder 24.1 1

Relevant External Links for ADRA1A

Genetic Association Database (GAD)
ADRA1A
Human Genome Epidemiology (HuGE) Navigator
ADRA1A
genes like me logo Genes that share disorders with ADRA1A: view

No data available for UniProtKB/Swiss-Prot for ADRA1A Gene

Publications for ADRA1A Gene

  1. Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. (PMID: 8396931) Hirasawa A. … Tsujimoto G. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  2. Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors. (PMID: 10493934) Coge F. … Canet E. (Biochem. J. 1999) 3 4 23
  3. Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline. (PMID: 12519093) Snapir A. … Scheinin M. (Clin. Sci. 2003) 3 23 48
  4. The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. (PMID: 15824464) Matayoshi T. … Kawano Y. (Hypertens. Res. 2004) 3 23 48
  5. Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. (PMID: 16043131) Clark D.A. … Kerwin R.W. (Biol. Psychiatry 2005) 3 23 48

Products for ADRA1A Gene

Sources for ADRA1A Gene

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