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Aliases for CSTF2 Gene

Aliases for CSTF2 Gene

  • Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa 2
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kDa 2 3
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kD 2 3
  • Cleavage Stimulation Factor 64 KDa Subunit 3 4
  • CF-1 64 KDa Subunit 3 4
  • CSTF 64 KDa Subunit 3 4
  • CstF-64 3 4
  • Cleavage Stimulation Factor Subunit 2 3
  • BetaCstF-64 Variant 2 3
  • CSTF64 6

External Ids for CSTF2 Gene

Summaries for CSTF2 Gene

Entrez Gene Summary for CSTF2 Gene

  • This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSTF2 Gene

CSTF2 (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa) is a Protein Coding gene. Diseases associated with CSTF2 include cytomegalovirus infection. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Gene Expression. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBMX2.

UniProtKB/Swiss-Prot for CSTF2 Gene

  • One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).

Gene Wiki entry for CSTF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF2 Gene

Genomics for CSTF2 Gene

Genomic Location for CSTF2 Gene

Start:
100,820,359 bp from pter
End:
100,840,935 bp from pter
Size:
20,577 bases
Orientation:
Plus strand

Genomic View for CSTF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF2 Gene

Regulatory Elements for CSTF2 Gene

Proteins for CSTF2 Gene

  • Protein details for CSTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33240-CSTF2_HUMAN
    Recommended name:
    Cleavage stimulation factor subunit 2
    Protein Accession:
    P33240
    Secondary Accessions:
    • Q5H951
    • Q6LA74
    • Q8N502

    Protein attributes for CSTF2 Gene

    Size:
    577 amino acids
    Molecular mass:
    60959 Da
    Quaternary structure:
    • The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells. Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1.
    SequenceCaution:
    • Sequence=CAI42681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CSTF2 Gene

    Alternative splice isoforms for CSTF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSTF2 Gene

Proteomics data for CSTF2 Gene at MOPED

Post-translational modifications for CSTF2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys148, Lys189, and Lys572

Other Protein References for CSTF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CSTF2 Gene

Domains for CSTF2 Gene

Gene Families for CSTF2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

P33240

UniProtKB/Swiss-Prot:

CSTF2_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • P33240
genes like me logo Genes that share domains with CSTF2: view

Function for CSTF2 Gene

Molecular function for CSTF2 Gene

GENATLAS Biochemistry: cleavage stimulation factor,subunit 2,component of the 3 pre RNA polyadenylation
UniProtKB/Swiss-Prot Function: One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated during the G0 to S phase transition.

Gene Ontology (GO) - Molecular Function for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 1741396
GO:0005515 protein binding IPI 10477523
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CSTF2: view
genes like me logo Genes that share phenotypes with CSTF2: view

miRNA for CSTF2 Gene

miRTarBase miRNAs that target CSTF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CSTF2 Gene

Localization for CSTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF2 Gene

Nucleus. Note=Localized with DDX1 in cleavage bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSTF2 Gene COMPARTMENTS Subcellular localization image for CSTF2 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 1741396
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA 18305108
GO:0071920 cleavage body IDA 11598190
genes like me logo Genes that share ontologies with CSTF2: view

Pathways for CSTF2 Gene

genes like me logo Genes that share pathways with CSTF2: view

Gene Ontology (GO) - Biological Process for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation TAS 1741396
GO:0006379 mRNA cleavage TAS 1741396
genes like me logo Genes that share ontologies with CSTF2: view

Transcripts for CSTF2 Gene

Unigene Clusters for CSTF2 Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5:
SP6: - - - - - - - -
SP7: -

Relevant External Links for CSTF2 Gene

GeneLoc Exon Structure for
CSTF2
ECgene alternative splicing isoforms for
CSTF2

Expression for CSTF2 Gene

mRNA expression in normal human tissues for CSTF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSTF2 Gene

SOURCE GeneReport for Unigene cluster for CSTF2 Gene Hs.132370

genes like me logo Genes that share expressions with CSTF2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSTF2 Gene

Orthologs for CSTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSTF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSTF2 35
  • 99.94 (n)
  • 100 (a)
CSTF2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSTF2 35
  • 92.25 (n)
  • 95.98 (a)
CSTF2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSTF2 35
  • 92.72 (n)
  • 96.36 (a)
CSTF2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cstf2 35
  • 89.49 (n)
  • 93.76 (a)
Cstf2 16
Cstf2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cstf2 35
  • 90.44 (n)
  • 94.06 (a)
chicken
(Gallus gallus)
Aves CSTF2 35
  • 74.46 (n)
  • 82.4 (a)
CSTF2 36
  • 77 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cstf2 35
  • 71.84 (n)
  • 78.98 (a)
Str.5893 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7345 35
zebrafish
(Danio rerio)
Actinopterygii cstf2 36
  • 69 (a)
ManyToMany
cstf2 36
  • 69 (a)
ManyToMany
LOC100534697 35
  • 70.76 (n)
  • 76.27 (a)
wufb11e07 35
fruit fly
(Drosophila melanogaster)
Insecta CstF-64 36
  • 53 (a)
OneToMany
CstF-64 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea cpf-2 36
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
IST3 36
  • 22 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.21809 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for CSTF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSTF2 Gene

ENSEMBL:
Gene Tree for CSTF2 (if available)
TreeFam:
Gene Tree for CSTF2 (if available)

Paralogs for CSTF2 Gene

Paralogs for CSTF2 Gene

Selected SIMAP similar genes for CSTF2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CSTF2 Gene

genes like me logo Genes that share paralogs with CSTF2: view

Variants for CSTF2 Gene

Sequence variations from dbSNP and Humsavar for CSTF2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs12161 -- 100,838,347(+) AATCC(A/C)CTGGA reference, missense
rs875450 -- 100,818,511(+) ATTCA(A/G)TGGGG upstream-variant-2KB
rs879216 -- 100,819,268(-) ATTGC(A/G)CTCCA upstream-variant-2KB
rs929018 -- 100,819,551(-) GGCAT(G/T)GACGT upstream-variant-2KB
rs929082 -- 100,823,040(+) TCAAT(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSTF2 Gene

Variant ID Type Subtype PubMed ID
nsv510850 CNV Loss 20534489

Relevant External Links for CSTF2 Gene

HapMap Linkage Disequilibrium report
CSTF2
Locus Specific Mutation Databases (LSDB)
CSTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSTF2 Gene

Disorders for CSTF2 Gene

genes like me logo Genes that share disorders with CSTF2: view

No data available for UniProtKB/Swiss-Prot for CSTF2 Gene

Publications for CSTF2 Gene

  1. RNA recognition by the human polyadenylation factor CstF. (PMID: 9199325) Takagaki Y. … Manley J.L. (Mol. Cell. Biol. 1997) 3 4 23
  2. Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. (PMID: 9736695) Martincic K. … Milcarek C. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PMID: 10669729) Takagaki Y. … Manley J.L. (Mol. Cell. Biol. 2000) 3 4 23
  4. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (PMID: 11389848) Calvo O. … Manley J.L. (Mol. Cell 2001) 3 4 23
  5. Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. (PMID: 11598190) Bleoo S. … Godbout R. (Mol. Biol. Cell 2001) 3 4 23

Products for CSTF2 Gene

Sources for CSTF2 Gene

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