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Aliases for SLC47A2 Gene

Aliases for SLC47A2 Gene

  • Solute Carrier Family 47 Member 2 2 3 4 5
  • Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 2 2 3
  • Kidney-Specific H(+)/Organic Cation Antiporter 3 4
  • MATE2 3 4
  • Multidrug And Toxin Extrusion Protein 2 3
  • Multidrug And Toxin Extrusion 2 2
  • MATE2-B 3
  • MATE2-K 3
  • HMATE-2 4
  • MATE2K 3
  • MATE-2 4

External Ids for SLC47A2 Gene

Previous GeneCards Identifiers for SLC47A2 Gene

  • GC17M019524
  • GC17M019582
  • GC17M018960

Summaries for SLC47A2 Gene

Entrez Gene Summary for SLC47A2 Gene

  • This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC47A2 Gene

SLC47A2 (Solute Carrier Family 47 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metformin Pathway, Pharmacokinetics. GO annotations related to this gene include antiporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC47A1.

UniProtKB/Swiss-Prot for SLC47A2 Gene

  • Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.

Gene Wiki entry for SLC47A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC47A2 Gene

Genomics for SLC47A2 Gene

Regulatory Elements for SLC47A2 Gene


Enhancers around SLC47A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC47A2 Gene

Chromosome:
17
Start:
19,678,288 bp from pter
End:
19,718,979 bp from pter
Size:
40,692 bases
Orientation:
Minus strand

Genomic View for SLC47A2 Gene

Genes around SLC47A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC47A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC47A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC47A2 Gene

Proteins for SLC47A2 Gene

  • Protein details for SLC47A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VL8-S47A2_HUMAN
    Recommended name:
    Multidrug and toxin extrusion protein 2
    Protein Accession:
    Q86VL8
    Secondary Accessions:
    • A0JBX9
    • A0P8Z7
    • Q63HJ9
    • Q8IV44
    • Q96NA1

    Protein attributes for SLC47A2 Gene

    Size:
    602 amino acids
    Molecular mass:
    65085 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC47A2 Gene

neXtProt entry for SLC47A2 Gene

Post-translational modifications for SLC47A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC47A2 Gene

Domains & Families for SLC47A2 Gene

Gene Families for SLC47A2 Gene

Protein Domains for SLC47A2 Gene

Suggested Antigen Peptide Sequences for SLC47A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VL8

UniProtKB/Swiss-Prot:

S47A2_HUMAN :
  • Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
Family:
  • Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
genes like me logo Genes that share domains with SLC47A2: view

Function for SLC47A2 Gene

Molecular function for SLC47A2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.76 mM for TEA {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.11 mM for MPP {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.12 mM for cimetidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=1.98 mM for metformin {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.2 mM for guanidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=1.58 mM for procainamide {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.06 mM for topotecan {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.85 mM for estrone sulfate {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.32 mM for acyclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.28 mM for ganciclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.88 nmol/min/mg enzyme toward TEA {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.575 nmol/min/mg enzyme toward MPP {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.115 nmol/min/mg enzyme toward cimetidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.845 nmol/min/mg enzyme toward metformin {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.58 nmol/min/mg enzyme toward guanidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=3.385 nmol/min/mg enzyme toward procainamide {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.13 nmol/min/mg enzyme toward topotecan {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.945 nmol/min/mg enzyme toward acyclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.805 nmol/min/mg enzyme toward ganciclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; pH dependence: Optimum pH is 9.0. Active from pH 6 to 9. {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534};
UniProtKB/Swiss-Prot Function:
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.

Gene Ontology (GO) - Molecular Function for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015238 drug transmembrane transporter activity IEA --
GO:0015297 antiporter activity IEA --
GO:0015307 drug:proton antiporter activity TAS --
genes like me logo Genes that share ontologies with SLC47A2: view
genes like me logo Genes that share phenotypes with SLC47A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC47A2 Gene

Localization for SLC47A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC47A2 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC47A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC47A2: view

Pathways & Interactions for SLC47A2 Gene

genes like me logo Genes that share pathways with SLC47A2: view

Gene Ontology (GO) - Biological Process for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006855 drug transmembrane transport IEA --
GO:0046618 drug export IEA --
GO:0055085 transmembrane transport IEA,TAS --
genes like me logo Genes that share ontologies with SLC47A2: view

No data available for SIGNOR curated interactions for SLC47A2 Gene

Drugs & Compounds for SLC47A2 Gene

(5) Drugs for SLC47A2 Gene - From: DrugBank, PharmGKB, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aciclovir Approved Pharma Transporter, substrate 0
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1803
Rucaparib Approved, Investigational Pharma PARP inhibitor, PARP Inhibitors, Other 16
Cimetidine Approved Pharma Inhibition, Inhibitor, antagonist H2 receptor antagonist, H2 antagonist, I1 agonist 75
[<sup>14</sup>C]TEA Pharma 0
genes like me logo Genes that share compounds with SLC47A2: view

Transcripts for SLC47A2 Gene

Unigene Clusters for SLC47A2 Gene

Solute carrier family 47, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC47A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6:

Relevant External Links for SLC47A2 Gene

GeneLoc Exon Structure for
SLC47A2
ECgene alternative splicing isoforms for
SLC47A2

Expression for SLC47A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC47A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC47A2 Gene

This gene is overexpressed in Kidney - Cortex (x37.8).

Protein differential expression in normal tissues from HIPED for SLC47A2 Gene

This gene is overexpressed in Kidney (54.3) and Spinal cord (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC47A2 Gene



Protein tissue co-expression partners for SLC47A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC47A2 Gene:

SLC47A2

SOURCE GeneReport for Unigene cluster for SLC47A2 Gene:

Hs.126830

mRNA Expression by UniProt/SwissProt for SLC47A2 Gene:

Q86VL8-S47A2_HUMAN
Tissue specificity: Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.

Evidence on tissue expression from TISSUES for SLC47A2 Gene

  • Kidney(4.7)
  • Nervous system(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with SLC47A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC47A2 Gene

Orthologs for SLC47A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC47A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC47A2 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia SLC47A2 34 35
  • 82.57 (n)
cow
(Bos Taurus)
Mammalia SLC47A2 34 35
  • 79.65 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC47A2 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC47A2 35
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc47a2 35
  • 45 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC47A2 34 35
  • 63.71 (n)
lizard
(Anolis carolinensis)
Reptilia SLC47A2 35
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-175a17.4 35
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 18 (a)
ManyToMany
ERC1 35
  • 17 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23030 34
  • 43.72 (n)
rice
(Oryza sativa)
Liliopsida Os04g0571600 34
  • 46.69 (n)
Species where no ortholog for SLC47A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC47A2 Gene

ENSEMBL:
Gene Tree for SLC47A2 (if available)
TreeFam:
Gene Tree for SLC47A2 (if available)

Paralogs for SLC47A2 Gene

Paralogs for SLC47A2 Gene

(1) SIMAP similar genes for SLC47A2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SLC47A2 Gene

genes like me logo Genes that share paralogs with SLC47A2: view

Variants for SLC47A2 Gene

Sequence variations from dbSNP and Humsavar for SLC47A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12943590 drug-response 19,716,685(+) GGAGG(A/G)GCTAC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000030202 -- 19,694,891(+) AGCCC(A/G)GGTAA intron-variant
rs1000091291 -- 19,683,670(+) CCGTA(A/G)TACCC intron-variant
rs1000092305 -- 19,713,414(+) TAATA(-/ATC)ATCAT intron-variant
rs1000243817 -- 19,711,827(+) GATTC(A/G)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC47A2 Gene

Variant ID Type Subtype PubMed ID
esv3582566 CNV loss 25503493
esv3640179 CNV loss 21293372
esv3892981 CNV gain 25118596
nsv1061317 CNV gain 25217958
nsv1061408 CNV gain 25217958
nsv1063892 CNV gain 25217958
nsv428337 CNV loss 18775914
nsv526290 CNV loss 19592680

Variation tolerance for SLC47A2 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC47A2 Gene

Human Gene Mutation Database (HGMD)
SLC47A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC47A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC47A2 Gene

Disorders for SLC47A2 Gene

Relevant External Links for SLC47A2

Genetic Association Database (GAD)
SLC47A2
Human Genome Epidemiology (HuGE) Navigator
SLC47A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC47A2

No disorders were found for SLC47A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC47A2 Gene

Publications for SLC47A2 Gene

  1. The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (PMID: 16996621) Omote H. … Moriyama Y. (Trends Pharmacol. Sci. 2006) 2 3 4 64
  2. Identification and functional characterization of a new human kidney- specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. (PMID: 16807400) Masuda S. … Inui K. (J. Am. Soc. Nephrol. 2006) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. (PMID: 20016398) Toyama K. … Inui K. (Pharmacogenet. Genomics 2010) 3 46 64
  5. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. (PMID: 17509534) Tanihara Y. … Inui K. (Biochem. Pharmacol. 2007) 3 4 64

Products for SLC47A2 Gene

Sources for SLC47A2 Gene

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