Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC47A2 Gene

Aliases for SLC47A2 Gene

  • Solute Carrier Family 47 Member 2 2 3 4 5
  • Solute Carrier Family 47 (Multidrug And Toxin Extrusion), Member 2 2 3
  • Kidney-Specific H(+)/Organic Cation Antiporter 3 4
  • MATE2 3 4
  • Multidrug And Toxin Extrusion Protein 2 3
  • Multidrug And Toxin Extrusion 2 2
  • MATE2-B 3
  • MATE2-K 3
  • HMATE-2 4
  • MATE2K 3
  • MATE-2 4

External Ids for SLC47A2 Gene

Previous GeneCards Identifiers for SLC47A2 Gene

  • GC17M019524
  • GC17M019582
  • GC17M018960

Summaries for SLC47A2 Gene

Entrez Gene Summary for SLC47A2 Gene

  • This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC47A2 Gene

SLC47A2 (Solute Carrier Family 47 Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Gefitinib Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include antiporter activity and drug transmembrane transporter activity. An important paralog of this gene is SLC47A1.

UniProtKB/Swiss-Prot for SLC47A2 Gene

  • Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.

Gene Wiki entry for SLC47A2 Gene

Additional gene information for SLC47A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC47A2 Gene

Genomics for SLC47A2 Gene

GeneHancer (GH) Regulatory Elements for SLC47A2 Gene

Promoters and enhancers for SLC47A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I019718 Enhancer 1.3 Ensembl ENCODE dbSUPER 559.1 -0.9 -945 3.7 ELF3 FOXA2 MLX ARID4B THRB ZNF48 RAD21 RARA ZNF143 FOS SLC47A2 ENSG00000262681 ALDH3A1 SNORA59B SLC47A1 ENSG00000252349 ENSG00000261033 ENSG00000264785
GH17I019716 Promoter/Enhancer 0.9 EPDnew dbSUPER 550.8 +2.4 2375 0.1 RFX1 ZBTB48 ZIC2 SLC47A2 GC17M019706
GH17I019744 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 8.4 -26.5 -26537 2 HDGF CTCF KLF1 ZNF449 ZSCAN4 MAX ZNF2 RAD21 ZNF335 ZFHX2 ALDH3A1 SLC47A2 NOS2P3 ENSG00000264785
GH17I019456 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.3 +258.2 258193 8.8 HDGF PKNOX1 RB1 IRF4 ZNF766 ZNF143 ATF7 ETV6 IKZF2 RUNX3 LOC105371574 ZNF286B ENSG00000235979 ENSG00000264885 MFAP4 B9D1 MAPK7 UPF3AP2 LINC02094 EPN2
GH17I019726 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.2 -8.8 -8841 3.1 FOXA2 NFIB RAD21 YY1 ZNF335 ZNF23 RCOR1 ATF7 EGR2 ZNF362 UPF3AP2 ENSG00000252349 ALDH3A2 SLC47A1 PRPSAP2 B9D1 SLC47A2 ALDH3A1 MAPK7 ENSG00000264785
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC47A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC47A2 gene promoter:

Genomic Locations for SLC47A2 Gene

Genomic Locations for SLC47A2 Gene
40,692 bases
Minus strand

Genomic View for SLC47A2 Gene

Genes around SLC47A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC47A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC47A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC47A2 Gene

Proteins for SLC47A2 Gene

  • Protein details for SLC47A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multidrug and toxin extrusion protein 2
    Protein Accession:
    Secondary Accessions:
    • A0JBX9
    • A0P8Z7
    • Q63HJ9
    • Q8IV44
    • Q96NA1

    Protein attributes for SLC47A2 Gene

    602 amino acids
    Molecular mass:
    65085 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC47A2 Gene

neXtProt entry for SLC47A2 Gene

Post-translational modifications for SLC47A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC47A2 Gene

Domains & Families for SLC47A2 Gene

Gene Families for SLC47A2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC47A2 Gene

Suggested Antigen Peptide Sequences for SLC47A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
  • Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
genes like me logo Genes that share domains with SLC47A2: view

Function for SLC47A2 Gene

Molecular function for SLC47A2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.76 mM for TEA {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.11 mM for MPP {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.12 mM for cimetidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=1.98 mM for metformin {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.2 mM for guanidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=1.58 mM for procainamide {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.06 mM for topotecan {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=0.85 mM for estrone sulfate {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.32 mM for acyclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; KM=4.28 mM for ganciclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.88 nmol/min/mg enzyme toward TEA {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.575 nmol/min/mg enzyme toward MPP {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.115 nmol/min/mg enzyme toward cimetidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.845 nmol/min/mg enzyme toward metformin {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.58 nmol/min/mg enzyme toward guanidine {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=3.385 nmol/min/mg enzyme toward procainamide {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.13 nmol/min/mg enzyme toward topotecan {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.425 nmol/min/mg enzyme toward estrone sulfate {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.945 nmol/min/mg enzyme toward acyclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; Vmax=0.805 nmol/min/mg enzyme toward ganciclovir {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534}; pH dependence: Optimum pH is 9.0. Active from pH 6 to 9. {ECO:0000269 PubMed:16807400, ECO:0000269 PubMed:17509534};
UniProtKB/Swiss-Prot Function:
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.

Phenotypes From GWAS Catalog for SLC47A2 Gene

Gene Ontology (GO) - Molecular Function for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015238 drug transmembrane transporter activity IBA,IEA --
GO:0015297 antiporter activity IEA --
GO:0015307 drug:proton antiporter activity TAS --
genes like me logo Genes that share ontologies with SLC47A2: view
genes like me logo Genes that share phenotypes with SLC47A2: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC47A2 Gene

Localization for SLC47A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC47A2 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC47A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC47A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC47A2 Gene

Pathways & Interactions for SLC47A2 Gene

genes like me logo Genes that share pathways with SLC47A2: view

Gene Ontology (GO) - Biological Process for SLC47A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006855 drug transmembrane transport IEA,IBA --
GO:0046618 drug export IEA --
GO:0055085 transmembrane transport TAS,IEA --
genes like me logo Genes that share ontologies with SLC47A2: view

No data available for SIGNOR curated interactions for SLC47A2 Gene

Drugs & Compounds for SLC47A2 Gene

(7) Drugs for SLC47A2 Gene - From: DrugBank, PharmGKB, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rucaparib Approved, Investigational Pharma Transporter, inhibitor PARP inhibitor, PARP Inhibitors, Other 23
Abemaciclib Approved, Investigational Pharma Transporter, inhibitor 0
Aciclovir Approved Pharma Transporter, substrate 0
Copanlisib Approved, Investigational Pharma Transporter, inhibitor 0
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 1891
genes like me logo Genes that share compounds with SLC47A2: view

Transcripts for SLC47A2 Gene

Unigene Clusters for SLC47A2 Gene

Solute carrier family 47, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC47A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - - - - -

Relevant External Links for SLC47A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC47A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC47A2 Gene

mRNA differential expression in normal tissues according to GTEx for SLC47A2 Gene

This gene is overexpressed in Kidney - Cortex (x37.8).

Protein differential expression in normal tissues from HIPED for SLC47A2 Gene

This gene is overexpressed in Kidney (54.3) and Spinal cord (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC47A2 Gene

Protein tissue co-expression partners for SLC47A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC47A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC47A2 Gene:


mRNA Expression by UniProt/SwissProt for SLC47A2 Gene:

Tissue specificity: Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.

Evidence on tissue expression from TISSUES for SLC47A2 Gene

  • Kidney(4.7)
  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with SLC47A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC47A2 Gene

Orthologs for SLC47A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC47A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC47A2 33 34
  • 99.61 (n)
(Canis familiaris)
Mammalia SLC47A2 33 34
  • 82.57 (n)
(Bos Taurus)
Mammalia SLC47A2 33 34
  • 79.65 (n)
(Monodelphis domestica)
Mammalia SLC47A2 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia SLC47A2 34
  • 54 (a)
(Mus musculus)
Mammalia Slc47a2 34
  • 45 (a)
(Gallus gallus)
Aves SLC47A2 33 34
  • 63.71 (n)
(Anolis carolinensis)
Reptilia SLC47A2 34
  • 44 (a)
(Danio rerio)
Actinopterygii si:dkey-175a17.4 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 18 (a)
ERC1 34
  • 17 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G23030 33
  • 43.72 (n)
(Oryza sativa)
Liliopsida Os04g0571600 33
  • 46.69 (n)
Species where no ortholog for SLC47A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC47A2 Gene

Gene Tree for SLC47A2 (if available)
Gene Tree for SLC47A2 (if available)

Paralogs for SLC47A2 Gene

Paralogs for SLC47A2 Gene

(1) SIMAP similar genes for SLC47A2 Gene using alignment to 2 proteins: Pseudogenes for SLC47A2 Gene

genes like me logo Genes that share paralogs with SLC47A2: view

Variants for SLC47A2 Gene

Sequence variations from dbSNP and Humsavar for SLC47A2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs12943590 drug-response, metformin response - Efficacy 19,716,685(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000030202 -- 19,694,891(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000091291 -- 19,683,670(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000243817 -- 19,711,827(-) A/G intron_variant
rs1000373952 -- 19,694,319(-) TTT/TT genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC47A2 Gene

Variant ID Type Subtype PubMed ID
esv3582566 CNV loss 25503493
esv3640179 CNV loss 21293372
esv3892981 CNV gain 25118596
nsv1061317 CNV gain 25217958
nsv1061408 CNV gain 25217958
nsv1063892 CNV gain 25217958
nsv428337 CNV loss 18775914
nsv526290 CNV loss 19592680

Variation tolerance for SLC47A2 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC47A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC47A2 Gene

Disorders for SLC47A2 Gene

Additional Disease Information for SLC47A2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC47A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC47A2 Gene

Publications for SLC47A2 Gene

  1. Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. (PMID: 16807400) Masuda S … Inui K (Journal of the American Society of Nephrology : JASN 2006) 2 3 4 58
  2. The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. (PMID: 16996621) Omote H … Moriyama Y (Trends in pharmacological sciences 2006) 2 3 4 58
  3. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. (PMID: 20016398) Toyama K … Inui K (Pharmacogenetics and genomics 2010) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. (PMID: 17509534) Tanihara Y … Inui K (Biochemical pharmacology 2007) 3 4 58

Products for SLC47A2 Gene

Sources for SLC47A2 Gene

Loading form....