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Aliases for SLC25A10 Gene

Aliases for SLC25A10 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate Transporter), Member 10 2 3
  • DIC 3 4 6
  • Mitochondrial Dicarboxylate Carrier 3
  • Solute Carrier Family 25 Member 10 4
  • Dicarboxylate Ion Carrier 3

External Ids for SLC25A10 Gene

Previous HGNC Symbols for SLC25A10 Gene

  • DIC

Previous GeneCards Identifiers for SLC25A10 Gene

  • GC17U990019
  • GC17P080239
  • GC17P080375
  • GC17P077289
  • GC17P079679
  • GC17P075125
  • GC17P079674

Summaries for SLC25A10 Gene

Entrez Gene Summary for SLC25A10 Gene

  • This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for SLC25A10 Gene

SLC25A10 (Solute Carrier Family 25 (Mitochondrial Carrier; Dicarboxylate Transporter), Member 10) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include antiporter activity and phosphate ion transmembrane transporter activity. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for SLC25A10 Gene

  • Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane

Gene Wiki entry for SLC25A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A10 Gene

Genomics for SLC25A10 Gene

Regulatory Elements for SLC25A10 Gene

Genomic Location for SLC25A10 Gene

Start:
81,712,236 bp from pter
End:
81,721,016 bp from pter
Size:
8,781 bases
Orientation:
Plus strand

Genomic View for SLC25A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A10 Gene

Proteins for SLC25A10 Gene

  • Protein details for SLC25A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBX3-DIC_HUMAN
    Recommended name:
    Mitochondrial dicarboxylate carrier
    Protein Accession:
    Q9UBX3
    Secondary Accessions:
    • Q542Z3
    • Q96BA1
    • Q96IP1

    Protein attributes for SLC25A10 Gene

    Size:
    287 amino acids
    Molecular mass:
    31282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A10 Gene

Proteomics data for SLC25A10 Gene at MOPED

Post-translational modifications for SLC25A10 Gene

  • Ubiquitination at Lys254
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC25A10 Gene

Antibody Products

No data available for DME Specific Peptides for SLC25A10 Gene

Domains for SLC25A10 Gene

Gene Families for SLC25A10 Gene

Protein Domains for SLC25A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBX3

UniProtKB/Swiss-Prot:

DIC_HUMAN :
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A10: view

Function for SLC25A10 Gene

Molecular function for SLC25A10 Gene

UniProtKB/Swiss-Prot Function:
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane

Gene Ontology (GO) - Molecular Function for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005310 dicarboxylic acid transmembrane transporter activity TAS 9733776
GO:0005515 protein binding IPI 19060904
GO:0015114 phosphate ion transmembrane transporter activity --
GO:0015116 sulfate transmembrane transporter activity --
GO:0015117 thiosulfate transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC25A10: view

Animal Model Products

CRISPR Products

miRNA for SLC25A10 Gene

miRTarBase miRNAs that target SLC25A10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A10 Gene

Localization for SLC25A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A10 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A10 Gene COMPARTMENTS Subcellular localization image for SLC25A10 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane --
genes like me logo Genes that share ontologies with SLC25A10: view

Pathways for SLC25A10 Gene

genes like me logo Genes that share pathways with SLC25A10: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
    • Mitochondria in human,mouse,rat

Gene Ontology (GO) - Biological Process for SLC25A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
genes like me logo Genes that share ontologies with SLC25A10: view

Drugs for SLC25A10 Gene

(1) Drugbank Compounds for SLC25A10 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Succinic acid
  • 1,2-Ethanedicarboxylic acid
110-15-6 1110 Target approved, nutraceutical

(1) HMDB Compounds for SLC25A10 Gene

Compound Synonyms Cas Number PubMed IDs
Succinic acid
  • 1,2-Ethanedicarboxylate
110-15-6
genes like me logo Genes that share compounds with SLC25A10: view

Transcripts for SLC25A10 Gene

Unigene Clusters for SLC25A10 Gene

Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: - -

Relevant External Links for SLC25A10 Gene

GeneLoc Exon Structure for
SLC25A10
ECgene alternative splicing isoforms for
SLC25A10

Expression for SLC25A10 Gene

mRNA expression in normal human tissues for SLC25A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC25A10 Gene

This gene is overexpressed in Liver (6.1) and Kidney - Cortex (5.0).

Protein differential expression in normal tissues for SLC25A10 Gene

This gene is overexpressed in Nasal epithelium (45.0) and Gallbladder (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC25A10 Gene

SOURCE GeneReport for Unigene cluster for SLC25A10 Gene Hs.548187

mRNA Expression by UniProt/SwissProt for SLC25A10 Gene

Q9UBX3-DIC_HUMAN
Tissue specificity: Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.
genes like me logo Genes that share expressions with SLC25A10: view

Expression partners for SLC25A10 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC25A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A10 35
  • 86.37 (n)
  • 88.51 (a)
MRPL12 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC25A10 35
  • 88.4 (n)
  • 90.2 (a)
-- 36
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc25a10 35
  • 86.55 (n)
  • 90.18 (a)
Slc25a10 16
Slc25a10 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SLC25A10 35
  • 99.21 (n)
  • 98.65 (a)
rat
(Rattus norvegicus)
Mammalia Slc25a10 35
  • 84.8 (n)
  • 89.47 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC25A10 35
  • 81.16 (n)
  • 85.96 (a)
-- 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a10 35
  • 71.58 (n)
  • 83.16 (a)
Str.15496 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11739 35
zebrafish
(Danio rerio)
Actinopterygii LOC100332610 35
  • 71.99 (n)
  • 78.12 (a)
zgc56614 35
CABZ01059390.1 36
  • 77 (a)
ManyToMany
si:ch1073-100f3.2 36
  • 77 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH02431 37
  • 58 (a)
CG11196 37
  • 45 (a)
CG18363 37
  • 38 (a)
CG4323 37
  • 51 (a)
CG6893 36
  • 37 (a)
ManyToMany
Dic3 36
  • 46 (a)
ManyToMany
Dic4 36
  • 36 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003073 35
  • 57.94 (n)
  • 56.36 (a)
worm
(Caenorhabditis elegans)
Secernentea K11G12.5 37
  • 59 (a)
K11G12.5 36
  • 57 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIC1 35
  • 47.83 (n)
  • 41.26 (a)
DIC1 36
  • 35 (a)
OneToMany
DIC1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU01514 35
  • 53.09 (n)
  • 47.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2426 36
  • 53 (a)
OneToMany
Species with no ortholog for SLC25A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A10 Gene

ENSEMBL:
Gene Tree for SLC25A10 (if available)
TreeFam:
Gene Tree for SLC25A10 (if available)

Paralogs for SLC25A10 Gene

(10) SIMAP similar genes for SLC25A10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC25A10: view

Variants for SLC25A10 Gene

Sequence variations from dbSNP and Humsavar for SLC25A10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs536216853 -- 81,721,100(+) CCGGG(C/G)CAAGG downstream-variant-500B
rs74006104 -- 81,716,521(+) GACTG(C/T)GTTCC intron-variant
rs73354171 -- 81,720,891(+) TCCCC(A/G)ACAAG utr-variant-3-prime, downstream-variant-500B
rs73354169 -- 81,719,486(+) TTTGC(A/G)GAGCC intron-variant
rs73354160 -- 81,715,173(+) AGGAA(A/G)GACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A10 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
nsv909116 CNV Loss 21882294
dgv3334n71 CNV Loss 21882294
dgv3335n71 CNV Loss 21882294
dgv3336n71 CNV Loss 21882294
nsv909126 CNV Loss 21882294
nsv909127 CNV Loss 21882294

Relevant External Links for SLC25A10 Gene

HapMap Linkage Disequilibrium report
SLC25A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A10 Gene

Disorders for SLC25A10 Gene

Relevant External Links for SLC25A10

Genetic Association Database (GAD)
SLC25A10
Human Genome Epidemiology (HuGE) Navigator
SLC25A10

No disorders were found for SLC25A10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC25A10 Gene

Publications for SLC25A10 Gene

  1. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. (PMID: 10585886) Fiermonte G. … Palmieri F. (Biochem. J. 1999) 3 4 23
  2. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. (PMID: 16027120) Mizuarai S. … Kotani H. (J. Biol. Chem. 2005) 3 25 26
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for SLC25A10 Gene

Sources for SLC25A10 Gene

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