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Aliases for IL34 Gene

Aliases for IL34 Gene

  • Interleukin 34 2 3 5
  • C16orf77 3 4
  • IL-34 3 4
  • Chromosome 16 Open Reading Frame 77 2
  • Interleukin-34 3

External Ids for IL34 Gene

Previous HGNC Symbols for IL34 Gene

  • C16orf77

Previous GeneCards Identifiers for IL34 Gene

  • GC16P069239
  • GC16P070680
  • GC16P056451

Summaries for IL34 Gene

Entrez Gene Summary for IL34 Gene

  • Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

GeneCards Summary for IL34 Gene

IL34 (Interleukin 34) is a Protein Coding gene. Diseases associated with IL34 include Chronic Apical Periodontitis. Among its related pathways are Innate Immune System and Cytokine Signaling in Immune system. GO annotations related to this gene include cytokine activity and macrophage colony-stimulating factor receptor binding.

UniProtKB/Swiss-Prot for IL34 Gene

  • Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

Gene Wiki entry for IL34 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL34 Gene

Genomics for IL34 Gene

Regulatory Elements for IL34 Gene

Enhancers for IL34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G070646 1 ENCODE dbSUPER 13.1 +66.8 66765 1.2 CTCF PKNOX1 ZMYM3 MAX SIN3A BMI1 RAD21 SCRT2 SMC3 RFX1 EXOSC6 IL34 NPIPB14P ENSG00000279569 GC16P070621
GH16G070634 1 Ensembl ENCODE 12.8 +55.6 55635 1.7 BCOR SOX13 JUN ZNF140 ZMYM3 ZNF121 GATA2 NFE2 NR2F6 FOS EXOSC6 IL34 PDPR NPIPB14P VAC14 LOC100506083 GC16P070621 ENSG00000279569
GH16G070638 0.9 Ensembl ENCODE 11 +59.6 59631 1.1 GATAD2A CTCF PKNOX1 FOXA3 BHLHE40 REST NR2F2 TBX3 ZNF316 FOS EXOSC6 IL34 PDXDC2P-NPIPB14P VAC14 GC16P070621 ENSG00000279569
GH16G070609 0.6 dbSUPER 15.1 +28.8 28776 1.2 MAZ ESRRA HLF CEBPB CEBPG DPF2 ZNF48 E2F1 CTBP1 FOS PDXDC2P IL34 LOC100506083 NPIPB14P EXOSC6 GC16P070621
GH16G070608 0.6 dbSUPER 15.1 +28.8 28837 0.5 MAZ ESRRA HLF CEBPB CEBPG DPF2 ZNF48 E2F1 CTBP1 FOS IL34 NPIPB14P GC16P070621
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL34 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL34 Gene

Chromosome:
16
Start:
70,579,895 bp from pter
End:
70,660,684 bp from pter
Size:
80,790 bases
Orientation:
Plus strand

Genomic View for IL34 Gene

Genes around IL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL34 Gene

Proteins for IL34 Gene

  • Protein details for IL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMJ4-IL34_HUMAN
    Recommended name:
    Interleukin-34
    Protein Accession:
    Q6ZMJ4
    Secondary Accessions:
    • B2RC28
    • B2Z4A8
    • B2ZC70
    • Q8N6L2

    Protein attributes for IL34 Gene

    Size:
    242 amino acids
    Molecular mass:
    27482 Da
    Quaternary structure:
    • Homodimer. Interacts with CSF1R.

    Three dimensional structures from OCA and Proteopedia for IL34 Gene

    Alternative splice isoforms for IL34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL34 Gene

Post-translational modifications for IL34 Gene

Antibody Products

No data available for DME Specific Peptides for IL34 Gene

Domains & Families for IL34 Gene

Gene Families for IL34 Gene

Protein Domains for IL34 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMJ4

UniProtKB/Swiss-Prot:

IL34_HUMAN :
  • Belongs to the IL-34 family.
Family:
  • Belongs to the IL-34 family.
genes like me logo Genes that share domains with IL34: view

Function for IL34 Gene

Molecular function for IL34 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

Gene Ontology (GO) - Molecular Function for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005157 macrophage colony-stimulating factor receptor binding IDA 18467591
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL34: view
genes like me logo Genes that share phenotypes with IL34: view

Animal Models for IL34 Gene

MGI Knock Outs for IL34:
  • Il34 tm1b(EUCOMM)Wtsi
  • Il34 tm1a(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for IL34

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL34 Gene

Localization for IL34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL34 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL34 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18467591
genes like me logo Genes that share ontologies with IL34: view

Pathways & Interactions for IL34 Gene

genes like me logo Genes that share pathways with IL34: view

Pathways by source for IL34 Gene

Interacting Proteins for IL34 Gene

Gene Ontology (GO) - Biological Process for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 18467591
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IEA --
GO:0008284 positive regulation of cell proliferation IDA 18467591
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with IL34: view

No data available for SIGNOR curated interactions for IL34 Gene

Transcripts for IL34 Gene

Unigene Clusters for IL34 Gene

Interleukin 34:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL34 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1: - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for IL34 Gene

GeneLoc Exon Structure for
IL34
ECgene alternative splicing isoforms for
IL34

Expression for IL34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL34 Gene

mRNA differential expression in normal tissues according to GTEx for IL34 Gene

This gene is overexpressed in Spleen (x8.0), Nerve - Tibial (x6.2), Skin - Not Sun Exposed (Suprapubic) (x4.7), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for IL34 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL34 Gene



Protein tissue co-expression partners for IL34 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL34 Gene:

IL34

SOURCE GeneReport for Unigene cluster for IL34 Gene:

Hs.461214

mRNA Expression by UniProt/SwissProt for IL34 Gene:

Q6ZMJ4-IL34_HUMAN
Tissue specificity: Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

Evidence on tissue expression from TISSUES for IL34 Gene

  • Nervous system(4.5)
  • Spleen(2.6)
  • Skin(2)
genes like me logo Genes that share expression patterns with IL34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL34 Gene

Orthologs for IL34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL34 34 35
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia IL34 34 35
  • 83.92 (n)
dog
(Canis familiaris)
Mammalia IL34 34 35
  • 83.62 (n)
rat
(Rattus norvegicus)
Mammalia Il34 34
  • 79.87 (n)
mouse
(Mus musculus)
Mammalia Il34 34 16 35
  • 79.19 (n)
oppossum
(Monodelphis domestica)
Mammalia IL34 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL34 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL34 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il34 34
  • 47.02 (n)
zebrafish
(Danio rerio)
Actinopterygii il34 35 35
  • 30 (a)
OneToMany
Species where no ortholog for IL34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL34 Gene

ENSEMBL:
Gene Tree for IL34 (if available)
TreeFam:
Gene Tree for IL34 (if available)

Paralogs for IL34 Gene

No data available for Paralogs for IL34 Gene

Variants for IL34 Gene

Sequence variations from dbSNP and Humsavar for IL34 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000016773 -- 70,644,894(+) GAAGA(C/G)GAAGG intron-variant
rs1000024057 -- 70,588,711(+) GTGGT(A/G)TGATT intron-variant, upstream-variant-2KB
rs1000053051 -- 70,615,507(+) TCTCA(-/AAAT)AAATA intron-variant
rs1000102642 -- 70,638,090(+) TCAGT(A/G)TAAAA intron-variant
rs1000134704 -- 70,628,148(+) TGTGT(A/C)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL34 Gene

Variant ID Type Subtype PubMed ID
esv2660602 CNV deletion 23128226
esv26820 CNV loss 19812545
esv3553627 CNV deletion 23714750
esv3638957 CNV loss 21293372
esv3892881 CNV gain 25118596
esv3892883 CNV gain 25118596
nsv1117165 CNV tandem duplication 24896259
nsv1134560 CNV deletion 24896259
nsv471094 CNV loss 18288195
nsv517391 CNV loss 19592680
nsv572945 CNV gain 21841781
nsv572946 CNV loss 21841781
nsv7285 OTHER inversion 18451855

Variation tolerance for IL34 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL34 Gene

Human Gene Mutation Database (HGMD)
IL34
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL34 Gene

Disorders for IL34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL34 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chronic apical periodontitis
  • chronic apical periodontitis nos
- elite association - COSMIC cancer census association via MalaCards
Search IL34 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL34
genes like me logo Genes that share disorders with IL34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL34 Gene

Publications for IL34 Gene

  1. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. (PMID: 18467591) Lin H. … Williams L.T. (Science 2008) 2 3 4 64
  2. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. (PMID: 20504948) Wei S. … Stanley E.R. (J. Leukoc. Biol. 2010) 3 4 64
  3. miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis. (PMID: 26754294) Zhou S.L. … Zhou J. (Hepatology 2016) 3 64
  4. The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications. (PMID: 26849008) Zorena K. … WA8A1 P. (Biomarkers 2016) 3 64
  5. Baseline serum interleukin-34 levels independently predict radiographic progression in patients with rheumatoid arthritis. (PMID: 25027626) Chang S.H. … Lee Y.J. (Rheumatol. Int. 2015) 3 64

Products for IL34 Gene

Sources for IL34 Gene

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