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Aliases for IL34 Gene

Aliases for IL34 Gene

  • Interleukin 34 2 3
  • C16orf77 3 4 6
  • IL-34 3 4
  • Chromosome 16 Open Reading Frame 77 2
  • Interleukin-34 3

External Ids for IL34 Gene

Previous HGNC Symbols for IL34 Gene

  • C16orf77

Previous GeneCards Identifiers for IL34 Gene

  • GC16P069239
  • GC16P070680
  • GC16P056451

Summaries for IL34 Gene

Entrez Gene Summary for IL34 Gene

  • Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

GeneCards Summary for IL34 Gene

IL34 (Interleukin 34) is a Protein Coding gene. GO annotations related to this gene include cytokine activity and macrophage colony-stimulating factor receptor binding.

UniProtKB/Swiss-Prot for IL34 Gene

  • Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

Gene Wiki entry for IL34 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL34 Gene

Genomics for IL34 Gene

Regulatory Elements for IL34 Gene

Genomic Location for IL34 Gene

Start:
70,579,895 bp from pter
End:
70,660,682 bp from pter
Size:
80,788 bases
Orientation:
Plus strand

Genomic View for IL34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL34 Gene

Proteins for IL34 Gene

  • Protein details for IL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMJ4-IL34_HUMAN
    Recommended name:
    Interleukin-34
    Protein Accession:
    Q6ZMJ4
    Secondary Accessions:
    • B2RC28
    • B2Z4A8
    • B2ZC70
    • Q8N6L2

    Protein attributes for IL34 Gene

    Size:
    242 amino acids
    Molecular mass:
    27482 Da
    Quaternary structure:
    • Homodimer. Interacts with CSF1R.

    Three dimensional structures from OCA and Proteopedia for IL34 Gene

    Alternative splice isoforms for IL34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL34 Gene

Proteomics data for IL34 Gene at MOPED

Post-translational modifications for IL34 Gene

Other Protein References for IL34 Gene

No data available for DME Specific Peptides for IL34 Gene

Domains for IL34 Gene

Gene Families for IL34 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL34 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMJ4

UniProtKB/Swiss-Prot:

IL34_HUMAN :
  • Q6ZMJ4
Family:
  • Belongs to the IL-34 family.
genes like me logo Genes that share domains with IL34: view

Function for IL34 Gene

Molecular function for IL34 Gene

UniProtKB/Swiss-Prot Function: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.

Gene Ontology (GO) - Molecular Function for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005157 macrophage colony-stimulating factor receptor binding IDA 18467591
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL34: view
genes like me logo Genes that share phenotypes with IL34: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL34 Gene

Localization for IL34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL34 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL34 Gene COMPARTMENTS Subcellular localization image for IL34 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18467591
genes like me logo Genes that share ontologies with IL34: view

Pathways for IL34 Gene

SuperPathways for IL34 Gene

No Data Available

Interacting Proteins for IL34 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000288098%0d%0a9606.ENSP00000286301%0d%0a9606.ENSP00000244769%0d%0a
Selected Interacting proteins: Q6ZMJ4-IL34_HUMAN ENSP00000288098 for IL34 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for IL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 18467591
GO:0006954 inflammatory response IEA --
GO:0008284 positive regulation of cell proliferation IDA 18467591
GO:0045087 innate immune response IEA --
GO:0045651 positive regulation of macrophage differentiation IDA 23409120
genes like me logo Genes that share ontologies with IL34: view

No data available for Pathways by source for IL34 Gene

Transcripts for IL34 Gene

Unigene Clusters for IL34 Gene

Interleukin 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL34 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1: - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for IL34 Gene

GeneLoc Exon Structure for
IL34
ECgene alternative splicing isoforms for
IL34

Expression for IL34 Gene

mRNA expression in normal human tissues for IL34 Gene

mRNA differential expression in normal tissues according to GTEx for IL34 Gene

This gene is overexpressed in Spleen (8.0), Nerve - Tibial (6.2), Skin - Not Sun Exposed (Suprapubic) (4.7), and Skin - Sun Exposed (Lower leg) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL34 Gene

SOURCE GeneReport for Unigene cluster for IL34 Gene Hs.461214

mRNA Expression by UniProt/SwissProt for IL34 Gene

Q6ZMJ4-IL34_HUMAN
Tissue specificity: Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
genes like me logo Genes that share expressions with IL34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL34 Gene

Orthologs for IL34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL34 35
  • 99.17 (n)
  • 99.17 (a)
IL34 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL34 35
  • 83.92 (n)
  • 76.11 (a)
IL34 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL34 35
  • 83.62 (n)
  • 78.88 (a)
IL34 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il34 35
  • 79.19 (n)
  • 73.24 (a)
Il34 16
Il34 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL34 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL34 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il34 35
  • 79.87 (n)
  • 73.58 (a)
chicken
(Gallus gallus)
Aves IL34 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il34 35
  • 47.02 (n)
  • 40.4 (a)
zebrafish
(Danio rerio)
Actinopterygii il34 36
  • 30 (a)
OneToMany
il34 36
  • 30 (a)
OneToMany
Species with no ortholog for IL34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL34 Gene

ENSEMBL:
Gene Tree for IL34 (if available)
TreeFam:
Gene Tree for IL34 (if available)

Paralogs for IL34 Gene

No data available for Paralogs for IL34 Gene

Variants for IL34 Gene

Sequence variations from dbSNP and Humsavar for IL34 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs713499 -- 70,654,437(-) ATAGG(A/T)GACAA intron-variant
rs713500 -- 70,654,170(-) AAGCT(C/T)GTTGC intron-variant
rs767526 -- 70,604,141(+) ACAGC(A/G)AATCC intron-variant
rs1006984 -- 70,602,994(+) GGCCC(C/G/T)CCAAC intron-variant
rs1006985 -- 70,603,092(+) GGCCC(C/T)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL34 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
esv26820 CNV Loss 19812545
nsv517391 CNV Loss 19592680
esv2660602 CNV Deletion 23128226
dgv2904n71 CNV Loss 21882294
dgv2905n71 CNV Loss 21882294
nsv906881 CNV Loss 21882294
dgv2906n71 CNV Loss 21882294
nsv906883 CNV Loss 21882294
nsv471094 CNV Loss 18288195

Relevant External Links for IL34 Gene

HapMap Linkage Disequilibrium report
IL34
Human Gene Mutation Database (HGMD)
IL34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL34 Gene

Disorders for IL34 Gene

No disorders were found for IL34 Gene.

No data available for UniProtKB/Swiss-Prot for IL34 Gene

Publications for IL34 Gene

  1. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. (PMID: 18467591) Lin H. … Williams L.T. (Science 2008) 2 3 4
  2. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. (PMID: 20504948) Wei S. … Stanley E.R. (J. Leukoc. Biol. 2010) 3 4
  3. Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients. (PMID: 22039170) Chemel M. … Heymann D. (Ann. Rheum. Dis. 2012) 3
  4. Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis. (PMID: 22264405) Hwang S.J. … Chang E.J. (Arthritis Res. Ther. 2012) 3
  5. Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. (PMID: 23177320) Greter M. … Becher B. (Immunity 2012) 3

Products for IL34 Gene

Sources for IL34 Gene

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