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Aliases for NCAN Gene

Aliases for NCAN Gene

  • Neurocan 2 3 5
  • Chondroitin Sulfate Proteoglycan 3 2 4
  • Neurocan Proteoglycan 2 3
  • CSPG3 3 4
  • Chondroitin Sulfate Proteoglycan 3 (Neurocan) 3
  • NEUR 4

External Ids for NCAN Gene

Previous HGNC Symbols for NCAN Gene

  • CSPG3

Previous GeneCards Identifiers for NCAN Gene

  • GC19P019183
  • GC19P019322
  • GC19P018887

Summaries for NCAN Gene

Entrez Gene Summary for NCAN Gene

  • Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]

GeneCards Summary for NCAN Gene

NCAN (Neurocan) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Metabolism. GO annotations related to this gene include calcium ion binding and extracellular matrix structural constituent. An important paralog of this gene is HAPLN2.

UniProtKB/Swiss-Prot for NCAN Gene

  • May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Gene Wiki entry for NCAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAN Gene

Genomics for NCAN Gene

Regulatory Elements for NCAN Gene

Genomic Location for NCAN Gene

Chromosome:
19
Start:
19,211,964 bp from pter
End:
19,252,252 bp from pter
Size:
40,289 bases
Orientation:
Plus strand

Genomic View for NCAN Gene

Genes around NCAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAN Gene

Proteins for NCAN Gene

  • Protein details for NCAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14594-NCAN_HUMAN
    Recommended name:
    Neurocan core protein
    Protein Accession:
    O14594
    Secondary Accessions:
    • Q9UPK6

    Protein attributes for NCAN Gene

    Size:
    1321 amino acids
    Molecular mass:
    143093 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCAN Gene

Proteomics data for NCAN Gene at MOPED

Post-translational modifications for NCAN Gene

Other Protein References for NCAN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NCAN Gene

Domains & Families for NCAN Gene

Suggested Antigen Peptide Sequences for NCAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14594

UniProtKB/Swiss-Prot:

NCAN_HUMAN :
  • Contains 1 C-type lectin domain.
  • Belongs to the aggrecan/versican proteoglycan family.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 2 EGF-like domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 2 Link domains.
  • Contains 1 Sushi (CCP/SCR) domain.
Family:
  • Belongs to the aggrecan/versican proteoglycan family.
genes like me logo Genes that share domains with NCAN: view

Function for NCAN Gene

Molecular function for NCAN Gene

UniProtKB/Swiss-Prot Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Gene Ontology (GO) - Molecular Function for NCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
GO:0005540 hyaluronic acid binding IEA,IBA --
genes like me logo Genes that share ontologies with NCAN: view
genes like me logo Genes that share phenotypes with NCAN: view

Animal Models for NCAN Gene

MGI Knock Outs for NCAN:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAN Gene

Localization for NCAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAN Gene COMPARTMENTS Subcellular localization image for NCAN gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 3
plasma membrane 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for NCAN Gene

Pathways & Interactions for NCAN Gene

genes like me logo Genes that share pathways with NCAN: view

Gene Ontology (GO) - Biological Process for NCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0007155 cell adhesion IEA,IBA --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with NCAN: view

No data available for SIGNOR curated interactions for NCAN Gene

Drugs & Compounds for NCAN Gene

(4) Drugs for NCAN Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma Target, binder 362
Beta-D-Glucose Experimental Pharma Target 0
Thiodigalactoside Experimental Pharma Target 0
Chondroitin Nutra 40

(1) Additional Compounds for NCAN Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chondroitin sulfate
  • Chondritinsulfate
  • Chondritinsulphate
  • Chondroitin 6-sulfate
  • Chondroitin 6-sulphate
  • Chondroitin polysulfate
9007-28-7
genes like me logo Genes that share compounds with NCAN: view

Transcripts for NCAN Gene

Unigene Clusters for NCAN Gene

Neurocan:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCAN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2: -

Relevant External Links for NCAN Gene

GeneLoc Exon Structure for
NCAN
ECgene alternative splicing isoforms for
NCAN

Expression for NCAN Gene

mRNA expression in normal human tissues for NCAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCAN Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Amygdala (x6.4), Brain - Caudate (basal ganglia) (x6.1), Brain - Cortex (x5.7), Brain - Frontal Cortex (BA9) (x5.5), Brain - Putamen (basal ganglia) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.2), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for NCAN Gene

This gene is overexpressed in Fetal Brain (23.5), Frontal cortex (14.2), Brain (11.3), and Vitreous humor (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NCAN Gene



SOURCE GeneReport for Unigene cluster for NCAN Gene Hs.169047

mRNA Expression by UniProt/SwissProt for NCAN Gene

O14594-NCAN_HUMAN
Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with NCAN: view

Protein tissue co-expression partners for NCAN Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NCAN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCAN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCAN 35
  • 82.44 (n)
  • 78.27 (a)
NCAN 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAN 35
  • 83.59 (n)
  • 78.14 (a)
NCAN 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncan 35
  • 73.91 (n)
  • 70.8 (a)
Ncan 16
Ncan 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCAN 35
  • 99.27 (n)
  • 98.71 (a)
NCAN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncan 35
  • 73.52 (n)
  • 70.93 (a)
oppossum
(Monodelphis domestica)
Mammalia NCAN 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAN 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAN 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.20279 35
ncana 36
  • 34 (a)
OneToMany
ncanb 36
  • 38 (a)
OneToMany
Species with no ortholog for NCAN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCAN Gene

ENSEMBL:
Gene Tree for NCAN (if available)
TreeFam:
Gene Tree for NCAN (if available)

Paralogs for NCAN Gene

Paralogs for NCAN Gene

genes like me logo Genes that share paralogs with NCAN: view

Variants for NCAN Gene

Sequence variations from dbSNP and Humsavar for NCAN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1064389 - 19,248,823(+) TGTGG(C/T)CACCA reference, missense
rs2228603 - 19,219,115(+) ACTTG(A/C/T)CCATC reference, missense
rs2228601 - 19,219,049(+) GCGCA(A/G)CCCGA reference, missense
rs1064388 -- 19,248,762(+) CCAAG(A/T)ACAAT reference, missense
rs1064390 -- 19,250,027(+) AAACC(A/G)CATCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NCAN Gene

Variant ID Type Subtype PubMed ID
nsv911303 CNV Loss 21882294
nsv911304 CNV Loss 21882294
nsv911305 CNV Loss 21882294

Variation tolerance for NCAN Gene

Residual Variation Intolerance Score: 6.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCAN Gene

HapMap Linkage Disequilibrium report
NCAN
Human Gene Mutation Database (HGMD)
NCAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAN Gene

Disorders for NCAN Gene

Relevant External Links for NCAN

Genetic Association Database (GAD)
NCAN
Human Genome Epidemiology (HuGE) Navigator
NCAN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCAN

No disorders were found for NCAN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAN Gene

Publications for NCAN Gene

  1. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. (PMID: 21353194) Cichon S. … NAPthen M.M. (Am. J. Hum. Genet. 2011) 2 3 48 67
  2. Characterization of the human neurocan gene, CSPG3. (PMID: 9795216) Prange C.K. … Lennon G.G. (Gene 1998) 3 23 25
  3. Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. (PMID: 1326557) Rauch U. … Margolis R.K. (J. Biol. Chem. 1992) 2 3
  4. A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects. (PMID: 25220293) Raum H. … Krug A. (Hum Brain Mapp 2015) 3
  5. Genome-wide association study reveals two new risk loci for bipolar disorder. (PMID: 24618891) MA1hleisen T.W. … Cichon S. (Nat Commun 2014) 3

Products for NCAN Gene

Sources for NCAN Gene

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