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Aliases for CDAN1 Gene

Aliases for CDAN1 Gene

  • Codanin 1 2 3 5
  • Congenital Dyserythropoietic Anemia, Type I 2 3
  • Discs Lost Homolog 3
  • PRO1295 3
  • CDAN1A 3
  • CDA1 3
  • CDAI 3
  • DLT 3

External Ids for CDAN1 Gene

Previous GeneCards Identifiers for CDAN1 Gene

  • GC15U990007
  • GC15M035911
  • GC15M040594
  • GC15M040731
  • GC15M040803
  • GC15M043015
  • GC15M019864

Summaries for CDAN1 Gene

Entrez Gene Summary for CDAN1 Gene

  • This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]

GeneCards Summary for CDAN1 Gene

CDAN1 (Codanin 1) is a Protein Coding gene. Diseases associated with CDAN1 include Dyserythropoietic Anemia, Congenital, Type Ia and Congenital Dyserythropoietic Anemia.

UniProtKB/Swiss-Prot for CDAN1 Gene

  • May act as a negative regulator of ASF1 in chromatin assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDAN1 Gene

Genomics for CDAN1 Gene

Regulatory Elements for CDAN1 Gene

Enhancers for CDAN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDAN1 on UCSC Golden Path with GeneCards custom track

Promoters for CDAN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDAN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDAN1 Gene

Chromosome:
15
Start:
42,723,557 bp from pter
End:
42,737,219 bp from pter
Size:
13,663 bases
Orientation:
Minus strand

Genomic View for CDAN1 Gene

Genes around CDAN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDAN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDAN1 Gene

Proteins for CDAN1 Gene

  • Protein details for CDAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWY9-CDAN1_HUMAN
    Recommended name:
    Codanin-1
    Protein Accession:
    Q8IWY9
    Secondary Accessions:
    • Q6NYD0
    • Q7Z7L5
    • Q969N3

    Protein attributes for CDAN1 Gene

    Size:
    1227 amino acids
    Molecular mass:
    134120 Da
    Quaternary structure:
    • Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.
    SequenceCaution:
    • Sequence=AAH52568.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO14994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88832.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDAN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDAN1 Gene

Proteomics data for CDAN1 Gene at MOPED

Post-translational modifications for CDAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDAN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDAN1 Gene

Domains & Families for CDAN1 Gene

Protein Domains for CDAN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDAN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDAN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDAN1 Gene

Function for CDAN1 Gene

Molecular function for CDAN1 Gene

UniProtKB/Swiss-Prot Function:
May act as a negative regulator of ASF1 in chromatin assembly.
genes like me logo Genes that share phenotypes with CDAN1: view

Human Phenotype Ontology for CDAN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for CDAN1

miRNA for CDAN1 Gene

miRTarBase miRNAs that target CDAN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CDAN1 Gene

Localization for CDAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDAN1 Gene

Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDAN1 Gene COMPARTMENTS Subcellular localization image for CDAN1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0012505 endomembrane system IEA,IDA 21364188
genes like me logo Genes that share ontologies with CDAN1: view

Pathways & Interactions for CDAN1 Gene

SuperPathways for CDAN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008156 negative regulation of DNA replication IMP 22407294
GO:0031497 chromatin assembly IMP 22407294
genes like me logo Genes that share ontologies with CDAN1: view

No data available for Pathways by source and SIGNOR curated interactions for CDAN1 Gene

Drugs & Compounds for CDAN1 Gene

(1) Drugs for CDAN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDAN1: view

Transcripts for CDAN1 Gene

Unigene Clusters for CDAN1 Gene

Codanin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDAN1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CDAN1 Gene

GeneLoc Exon Structure for
CDAN1
ECgene alternative splicing isoforms for
CDAN1

Expression for CDAN1 Gene

mRNA expression in normal human tissues for CDAN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDAN1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (23.5), Adipocyte (18.2), Peripheral blood mononuclear cells (12.8), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDAN1 Gene



SOURCE GeneReport for Unigene cluster for CDAN1 Gene Hs.599232

mRNA Expression by UniProt/SwissProt for CDAN1 Gene

Q8IWY9-CDAN1_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells.
genes like me logo Genes that share expression patterns with CDAN1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDAN1 Gene

Orthologs for CDAN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDAN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDAN1 35
  • 88.4 (n)
  • 88.35 (a)
CDAN1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDAN1 35
  • 87.28 (n)
  • 87.4 (a)
CDAN1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdan1 35
  • 86.62 (n)
  • 88.74 (a)
Cdan1 16
Cdan1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDAN1 35
  • 99.27 (n)
  • 98.81 (a)
CDAN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdan1 35
  • 86.19 (n)
  • 88.82 (a)
oppossum
(Monodelphis domestica)
Mammalia CDAN1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDAN1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDAN1 35
  • 62.79 (n)
  • 59.98 (a)
CDAN1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDAN1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdan1 35
  • 58.58 (n)
  • 55.51 (a)
zebrafish
(Danio rerio)
Actinopterygii cdan1 35
  • 55.09 (n)
  • 49.69 (a)
cdan1 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010055 35
  • 42.14 (n)
  • 29.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta dlt 35
  • 40.96 (n)
  • 29.65 (a)
dlt 36
  • 21 (a)
OneToOne
Species with no ortholog for CDAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDAN1 Gene

ENSEMBL:
Gene Tree for CDAN1 (if available)
TreeFam:
Gene Tree for CDAN1 (if available)

Paralogs for CDAN1 Gene

No data available for Paralogs for CDAN1 Gene

Variants for CDAN1 Gene

Sequence variations from dbSNP and Humsavar for CDAN1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_017218 Anemia, congenital dyserythropoietic, 1A (CDAN1A)
VAR_017219 Anemia, congenital dyserythropoietic, 1A (CDAN1A)
VAR_017220 Anemia, congenital dyserythropoietic, 1A (CDAN1A)
rs80338696 Anemia, congenital dyserythropoietic, 1A (CDAN1A) 42,730,632(-) ATTAC(C/T)GGGAC nc-transcript-variant, reference, missense
VAR_017222 Anemia, congenital dyserythropoietic, 1A (CDAN1A)

Structural Variations from Database of Genomic Variants (DGV) for CDAN1 Gene

Variant ID Type Subtype PubMed ID
nsv528725 CNV Gain 19592680
nsv457122 CNV Loss 19166990
nsv517553 CNV Gain+Loss 19592680

Variation tolerance for CDAN1 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.08; 99.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDAN1 Gene

Human Gene Mutation Database (HGMD)
CDAN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDAN1 Gene

Disorders for CDAN1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDAN1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dyserythropoietic anemia, congenital, type ia
  • anemia, congenital dyserythropoietic, type i
congenital dyserythropoietic anemia
  • congenital dyshaematopoietic anaemia
angioid streaks
macrocytic anemia
  • anemia macrocytic
acrodysostosis
  • acrodysplasia
- elite association - COSMIC cancer census association via MalaCards
Search CDAN1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDAN1_HUMAN
  • Anemia, congenital dyserythropoietic, 1A (CDAN1A) [MIM:224120]: An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. {ECO:0000269 PubMed:12434312}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDAN1

Genetic Association Database (GAD)
CDAN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDAN1
genes like me logo Genes that share disorders with CDAN1: view

No data available for Genatlas for CDAN1 Gene

Publications for CDAN1 Gene

  1. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. (PMID: 12434312) Dgany O. … Tamary H. (Am. J. Hum. Genet. 2002) 2 3 4 23 67
  2. Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. (PMID: 19336738) Noy-Lotan S. … Tamary H. (Haematologica 2009) 3 23
  3. Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). (PMID: 18081704) Tamary H. … Delaunay J. (Eur. J. Haematol. 2008) 3 23
  4. Congenital dyserythropoietic anemia type I with bone abnormalities, mutations of the CDAN I gene, and significant responsiveness to alpha-interferon therapy. (PMID: 16767397) Goede J.S. … Heimpel H. (Ann. Hematol. 2006) 3 23
  5. Clinical features and studies of erythropoiesis in Israeli Bedouins with congenital dyserythropoietic anemia type I. (PMID: 8634422) Tamary H. … Zaizov R. (Blood 1996) 2 3

Products for CDAN1 Gene

Sources for CDAN1 Gene

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