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Aliases for CSNK2B Gene

Aliases for CSNK2B Gene

  • Casein Kinase 2, Beta Polypeptide 2 3
  • Protein G5a 3 4
  • CK II Beta 3 4
  • Phosvitin 3 4
  • CK2N 3 4
  • G5A 3 4
  • Casein Kinase II B Subunit Splicing Isoform 318 3
  • Casein Kinase II B Subunit Splicing Isoform 660 3
  • Casein Kinase II B Subunit Splicing Isoform 806 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 532 3
  • Chimera CSNK2B-LY6G5B Splicing Isoform 560 3
  • Alternative Name: G5a, Phosvitin 3
  • Casein Kinase II Beta Subunit 3
  • Casein Kinase II Subunit Beta 3
  • CSNK2B-LY6G5B-532 3
  • CSNK2B-LY6G5B-560 3
  • CSK2B 3
  • CK2B 3

External Ids for CSNK2B Gene

Summaries for CSNK2B Gene

Entrez Gene Summary for CSNK2B Gene

  • This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for CSNK2B Gene

CSNK2B (Casein Kinase 2, Beta Polypeptide) is a Protein Coding gene. Diseases associated with CSNK2B include egg allergy. Among its related pathways are L1CAM interactions and NF-KappaB Family Pathway. GO annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is ENSG00000263020.

UniProtKB/Swiss-Prot for CSNK2B Gene

  • Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

Tocris Summary for CSNK2B Gene

  • Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha) in a homomeric or heteromeric conformation. Whilst the alpha- and alpha-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Gene Wiki entry for CSNK2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2B Gene

Genomics for CSNK2B Gene

Genomic Location for CSNK2B Gene

Start:
31,665,236 bp from pter
End:
31,670,343 bp from pter
Size:
5,108 bases
Orientation:
Plus strand

Genomic View for CSNK2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for CSNK2B Gene

Proteins for CSNK2B Gene

  • Protein details for CSNK2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67870-CSK2B_HUMAN
    Recommended name:
    Casein kinase II subunit beta
    Protein Accession:
    P67870
    Secondary Accessions:
    • B0UXA9
    • P07312
    • P13862
    • Q4VX47

    Protein attributes for CSNK2B Gene

    Size:
    215 amino acids
    Molecular mass:
    24942 Da
    Quaternary structure:
    • Tetramer composed of an alpha subunit, an alpha subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.
    SequenceCaution:
    • Sequence=CAI18393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CSNK2B Gene

neXtProt entry for CSNK2B Gene

Proteomics data for CSNK2B Gene at MOPED

Post-translational modifications for CSNK2B Gene

  • Phosphorylated by alpha subunit.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys33, Lys100, Lys134, Lys139, Lys191, Lys208, and Lys212

Other Protein References for CSNK2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CSNK2B Gene

Domains for CSNK2B Gene

UniProtKB/Swiss-Prot:

CSK2B_HUMAN
Family:
  • Belongs to the casein kinase 2 subunit beta family.:
    • P67870
genes like me logo Genes that share domains with CSNK2B: view

Function for CSNK2B Gene

Molecular function for CSNK2B Gene

GENATLAS Biochemistry: caseine kinase II,beta unit,likely involved in regulation of cell growth
UniProtKB/Swiss-Prot Function: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

Gene Ontology (GO) - Molecular Function for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 contributes_to protein serine/threonine kinase activity TAS 1856204
GO:0005102 receptor binding IPI 19233263
GO:0005515 protein binding IPI 10094392
GO:0008134 transcription factor binding IPI 19324893
GO:0016301 kinase activity --
genes like me logo Genes that share ontologies with CSNK2B: view
genes like me logo Genes that share phenotypes with CSNK2B: view

Animal Models for CSNK2B Gene

MGI Knock Outs for CSNK2B:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CSNK2B Gene

Localization for CSNK2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK2B Gene COMPARTMENTS Subcellular localization image for CSNK2B gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21282530
GO:0005737 cytoplasm IDA 19233263
GO:0005829 cytosol TAS --
GO:0005886 colocalizes_with plasma membrane IDA 19233263
GO:0005956 protein kinase CK2 complex NAS 2666134
genes like me logo Genes that share ontologies with CSNK2B: view

Pathways for CSNK2B Gene

genes like me logo Genes that share pathways with CSNK2B: view

Pathways by source for CSNK2B Gene

Gene Ontology (GO) - Biological Process for CSNK2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006468 protein phosphorylation TAS 1856204
GO:0007165 signal transduction TAS 2513884
GO:0007411 axon guidance TAS --
GO:0008285 negative regulation of cell proliferation TAS 19324893
genes like me logo Genes that share ontologies with CSNK2B: view

Compounds for CSNK2B Gene

(4) Tocris Compounds for CSNK2B Gene

Compound Action Cas Number
Ellagic acid Selective inhibitor of CK2. Also inhibits glutathione S-transferase [476-66-4]
TBB Selective cell-permeable CK2 inhibitor [17374-26-4]
TMCB Dual-kinase inhibitor; inhibits CK2 and ERK8 [905105-89-7]
TTP 22 High affinity, selective CK2 inhibitor [329907-28-0]

(2) HMDB Compounds for CSNK2B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(21) Novoseek inferred chemical compound relationships for CSNK2B Gene

Compound -log(P) Hits PubMed IDs
lipovitellin 82.6 3
kemptide 65.1 3
phosphoserine 62.9 2
threonine 53.9 3
serine 48.9 6
genes like me logo Genes that share compounds with CSNK2B: view

Transcripts for CSNK2B Gene

mRNA/cDNA for CSNK2B Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSNK2B Gene

Casein kinase 2, beta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2B Gene

No ASD Table

Relevant External Links for CSNK2B Gene

GeneLoc Exon Structure for
CSNK2B
ECgene alternative splicing isoforms for
CSNK2B

Expression for CSNK2B Gene

mRNA expression in normal human tissues for CSNK2B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK2B Gene

SOURCE GeneReport for Unigene cluster for CSNK2B Gene Hs.73527

genes like me logo Genes that share expressions with CSNK2B: view

Orthologs for CSNK2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK2B 36
  • 99.84 (n)
  • 100 (a)
CSNK2B 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSNK2B 36
  • 95.04 (n)
  • 100 (a)
CSNK2B 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK2B 36
  • 95.81 (n)
  • 100 (a)
CSNK2B 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csnk2b 36
  • 93.8 (n)
  • 100 (a)
Csnk2b 16
Csnk2b 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSNK2B 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Csnk2b 36
  • 94.57 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia CSNK2B 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1152 36
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk2b 36
  • 81.86 (n)
  • 99.53 (a)
Str.7978 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.293 36
zebrafish
(Danio rerio)
Actinopterygii ck2b 36
  • 85.12 (n)
  • 99.07 (a)
ck2b 37
  • 99 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CkIIbeta 36
  • 74.88 (n)
  • 88.37 (a)
CkIIbeta 37
  • 80 (a)
OneToMany
CkIIbgr 38
  • 89 (a)
Ssl 38
  • 48 (a)
CkIIbgr2 38
  • 65 (a)
Ste12DOR 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-10 36
  • 69.83 (n)
  • 81 (a)
kin-10 37
  • 70 (a)
OneToMany
kin-10 38
  • 81 (a)
T01G9.6a 38
  • 81 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR087C 36
  • 55.72 (n)
  • 46.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKB2 36
  • 52.2 (n)
  • 47.8 (a)
CKB2 37
  • 38 (a)
OneToMany
CKB2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21869g 36
  • 50.33 (n)
  • 47 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1389 36
thale cress
(Arabidopsis thaliana)
eudicotyledons CKB4 36
  • 56.42 (n)
  • 57.81 (a)
corn
(Zea mays)
Liliopsida Zm.808 36
rice
(Oryza sativa)
Liliopsida Os.11223 36
Os07g0495100 36
  • 56.6 (n)
  • 59.37 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02754 36
  • 57.59 (n)
  • 52.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ckb1 36
  • 56.87 (n)
  • 61.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7419 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4732 37
  • 88 (a)
OneToMany
Species with no ortholog for CSNK2B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK2B Gene

ENSEMBL:
Gene Tree for CSNK2B (if available)
TreeFam:
Gene Tree for CSNK2B (if available)

Paralogs for CSNK2B Gene

Paralogs for CSNK2B Gene

genes like me logo Genes that share paralogs with CSNK2B: view

Variants for CSNK2B Gene

Sequence variations from dbSNP and Humsavar for CSNK2B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs117955969 -- 31,668,870(+) GTGAT(A/G)GACTG intron-variant
rs138850946 -- 31,668,616(+) TCCAC(G/T)CCCGC reference, missense
rs144365418 -- 31,668,364(+) TCTTC(A/G)TTTGA intron-variant
rs148414882 -- 31,668,400(+) TGGGT(C/G)CCATG intron-variant
rs149642695 -- 31,668,306(+) AGTTG(A/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK2B Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294

Relevant External Links for CSNK2B Gene

HapMap Linkage Disequilibrium report
CSNK2B

Disorders for CSNK2B Gene

(1) MalaCards Diseases for CSNK2B Gene

Search for CSNK2B Gene in MalaCards »

Relevant External Links for CSNK2B

Genetic Association Database (GAD)
CSNK2B
Human Genome Epidemiology (HuGE) Navigator
CSNK2B
genes like me logo Genes that share disorders with CSNK2B: view

No data available for UniProtKB/Swiss-Prot for CSNK2B Gene

Publications for CSNK2B Gene

  1. Structure of the gene encoding human casein kinase II subunit beta. (PMID: 1856204) Voss A. … Pyerin W. (J. Biol. Chem. 1991) 3 4 23
  2. Assignment of the human casein kinase II beta-subunit gene to 6p12----p21. (PMID: 2276748) Yang-Feng T.L. … Canaani D. (Genomics 1990) 2 3 23
  3. Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells. (PMID: 1694965) Teitz T. … Canaani D. (Mutat. Res. 1990) 3 4
  4. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PMID: 11239457) Keller D.M. … Lu H. (Mol. Cell 2001) 3 4
  5. Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. (PMID: 11298324) Ritter M. … Schmitz G. (Eur. J. Immunol. 2001) 3 4

Products for CSNK2B Gene

Sources for CSNK2B Gene

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