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Aliases for ADRA1D Gene

Aliases for ADRA1D Gene

  • Adrenoceptor Alpha 1D 2 3
  • ADRA1A 3 4 6
  • Adrenergic, Alpha-1D-, Receptor 2 3
  • Alpha-1A Adrenergic Receptor 3 4
  • Alpha-Adrenergic Receptor 1a 3 4
  • Alpha-1D Adrenoreceptor 3 4
  • Alpha-1D Adrenoceptor 3 4
  • Adrenergic, Alpha -1D-, Receptor 3
  • Adrenergic, Alpha-1A-, Receptor 3
  • Alpha-1D Adrenergic Receptor 3
  • Alpha-1D-Adrenergic Receptor 3
  • DJ779E11.2 3
  • ADRA1R 3
  • ALPHA1 3
  • ADRA1 3
  • DAR 3

External Ids for ADRA1D Gene

Previous GeneCards Identifiers for ADRA1D Gene

  • GC20M004189
  • GC20M004196
  • GC20M004149

Summaries for ADRA1D Gene

Entrez Gene Summary for ADRA1D Gene

  • Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADRA1D Gene

ADRA1D (Adrenoceptor Alpha 1D) is a Protein Coding gene. Diseases associated with ADRA1D include impotence. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include alpha1-adrenergic receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for ADRA1D Gene

  • This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium

Tocris Summary for ADRA1D Gene

  • Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors. lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the alpha1A subtype.

Gene Wiki entry for ADRA1D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADRA1D Gene

Genomics for ADRA1D Gene

Regulatory Elements for ADRA1D Gene

Genomic Location for ADRA1D Gene

Start:
4,220,631 bp from pter
End:
4,249,074 bp from pter
Size:
28,444 bases
Orientation:
Minus strand

Genomic View for ADRA1D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADRA1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADRA1D Gene

Proteins for ADRA1D Gene

  • Protein details for ADRA1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25100-ADA1D_HUMAN
    Recommended name:
    Alpha-1D adrenergic receptor
    Protein Accession:
    P25100
    Secondary Accessions:
    • Q9NPY0

    Protein attributes for ADRA1D Gene

    Size:
    572 amino acids
    Molecular mass:
    60463 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ADRA1D Gene

Proteomics data for ADRA1D Gene at MOPED

Post-translational modifications for ADRA1D Gene

  • Glycosylation at Asn65 and Asn82
  • Modification sites at PhosphoSitePlus

Other Protein References for ADRA1D Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADRA1D Gene

Domains for ADRA1D Gene

Gene Families for ADRA1D Gene

HGNC:
  • ADRA :GPCR / Class A : Adrenoceptors : alpha
IUPHAR :

Suggested Antigen Peptide Sequences for ADRA1D Gene

Graphical View of Domain Structure for InterPro Entry

P25100

UniProtKB/Swiss-Prot:

ADA1D_HUMAN :
  • P25100
Family:
  • Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
genes like me logo Genes that share domains with ADRA1D: view

Function for ADRA1D Gene

Molecular function for ADRA1D Gene

GENATLAS Biochemistry: adrenergic,alpha-1D-,receptor,G protein coupled receptor superfamily,stimulating,acting through the phosphadidylinositol/Ca2+ second messenger system
UniProtKB/Swiss-Prot Function: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium

Gene Ontology (GO) - Molecular Function for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004937 alpha1-adrenergic receptor activity IEA --
genes like me logo Genes that share ontologies with ADRA1D: view
genes like me logo Genes that share phenotypes with ADRA1D: view

Animal Models for ADRA1D Gene

MGI Knock Outs for ADRA1D:

miRNA for ADRA1D Gene

miRTarBase miRNAs that target ADRA1D

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADRA1D Gene

Localization for ADRA1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADRA1D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADRA1D Gene COMPARTMENTS Subcellular localization image for ADRA1D gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7746284
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADRA1D: view

Pathways for ADRA1D Gene

genes like me logo Genes that share pathways with ADRA1D: view

Gene Ontology (GO) - Biological Process for ADRA1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001986 negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure IEA --
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA --
GO:0006259 DNA metabolic process TAS 10969806
GO:0007186 G-protein coupled receptor signaling pathway TAS 1656955
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 10820200
genes like me logo Genes that share ontologies with ADRA1D: view

Compounds for ADRA1D Gene

(5) Tocris Compounds for ADRA1D Gene

Compound Action Cas Number
(R)-(-)-Phenylephrine hydrochloride alpha1 agonist [61-76-7]
A 61603 hydrobromide alpha1A agonist [107756-30-9]
Cirazoline hydrochloride Selective alpha1 agonist [40600-13-3]
Naftopidil hydrochloride alpha1 antagonist [1164469-60-6]
RS 17053 hydrochloride alpha1A antagonist [169505-93-5]

(1) HMDB Compounds for ADRA1D Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(26) Drugbank Compounds for ADRA1D Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alfuzosin
81403-80-7 target antagonist
Amitriptyline
  • Amitriprolidine
50-48-6 target antagonist
Bromocriptine
  • Bromergocryptine
25614-03-3 target agonist
Dapiprazole
72822-12-9 target antagonist
Doxazosin
  • Doxazosin mesilate
74191-85-8 target antagonist

(35) IUPHAR Ligand for ADRA1D Gene

Ligand Type Action Affinity Pubmed IDs
tamsulosin Antagonist Antagonist 10.7
silodosin Antagonist Antagonist 10.4
cyproheptadine Antagonist Antagonist 10.2
[125I]HEAT Agonist Full agonist 10
(+)-niguldipine Antagonist Antagonist 10
prazosin Antagonist Inverse agonist 9.9
[125I]BE-2254 Antagonist Antagonist 9.9
WB 4101 Antagonist Antagonist 9.8
RS-100329 Antagonist Antagonist 9.6
Rec 15/2739 Antagonist Antagonist 9.6
NAN 190 Antagonist Antagonist 9.4
RS-17053 Antagonist Antagonist 9.3
5-methylurapidil Antagonist Antagonist 9.2
Ro-70-0004 Antagonist Antagonist 8.9
spiroxatrine Agonist Full agonist 8.8
A-119637 Antagonist Antagonist 8.6
phentolamine Antagonist Antagonist 8.6
A-123189 Antagonist Antagonist 8.4
indoramin Antagonist Antagonist 8.4
BMY-7378 Agonist Partial agonist 8
(+)-cyclazosin Antagonist Antagonist 7.9
risperidone Antagonist Antagonist 7.8
ritanserin Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
SKF 105854 Antagonist Antagonist 7.1
oxymetazoline Agonist Full agonist 6.8
spiperone Antagonist Antagonist 6.7
clozapine Antagonist Antagonist 6.7
ketanserin Inhibitor Inhibition 6.3
(-)-adrenaline Agonist Full agonist 6.2
NS-49 Agonist Partial agonist 6.2
(-)-noradrenaline Agonist Full agonist 6
alpha-methylnoradrenaline Agonist Full agonist 5.6
methoxamine Agonist Full agonist 5.2
(+)-adrenaline Agonist Full agonist 5

(4) Novoseek inferred chemical compound relationships for ADRA1D Gene

Compound -log(P) Hits PubMed IDs
bmy7378 79.3 1
tamsulosin 67.2 1
norepinephrine 48.7 1
phenylephrine 35.4 1
genes like me logo Genes that share compounds with ADRA1D: view

Transcripts for ADRA1D Gene

mRNA/cDNA for ADRA1D Gene

(21) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADRA1D Gene

Adrenoceptor alpha 1D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADRA1D Gene

No ASD Table

Relevant External Links for ADRA1D Gene

GeneLoc Exon Structure for
ADRA1D
ECgene alternative splicing isoforms for
ADRA1D

Expression for ADRA1D Gene

mRNA expression in normal human tissues for ADRA1D Gene

mRNA differential expression in normal tissues according to GTEx for ADRA1D Gene

This gene is overexpressed in Artery - Aorta (5.5), Brain - Hippocampus (4.4), and Cervix - Ectocervix (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADRA1D Gene

SOURCE GeneReport for Unigene cluster for ADRA1D Gene Hs.557

genes like me logo Genes that share expressions with ADRA1D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ADRA1D Gene

Orthologs for ADRA1D Gene

This gene was present in the common ancestor of animals.

Orthologs for ADRA1D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADRA1D 35
  • 97.85 (n)
  • 97.14 (a)
cow
(Bos Taurus)
Mammalia ADRA1D 35
  • 82.33 (n)
  • 81.14 (a)
ADRA1D 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADRA1D 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adra1d 35
  • 82.27 (n)
  • 84.34 (a)
Adra1d 16
Adra1d 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADRA1D 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adra1d 35
  • 81.94 (n)
  • 84.31 (a)
chicken
(Gallus gallus)
Aves ADRA1D 35
  • 68.35 (n)
  • 63.56 (a)
ADRA1D 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADRA1D 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495969 35
  • 66.05 (n)
  • 63.58 (a)
zebrafish
(Danio rerio)
Actinopterygii adra1d 36
  • 59 (a)
OneToOne
LOC568614 35
  • 61.77 (n)
  • 61.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oamb 36
  • 24 (a)
OneToMany
5-HT1A 37
  • 34 (a)
5-HT1B 37
  • 38 (a)
CG7431 37
  • 44 (a)
DopR2 37
  • 45 (a)
CG6989 37
  • 33 (a)
Oamb 37
  • 53 (a)
CG6919 37
  • 34 (a)
DopR 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea dop-4 36
  • 25 (a)
OneToMany
Species with no ortholog for ADRA1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADRA1D Gene

ENSEMBL:
Gene Tree for ADRA1D (if available)
TreeFam:
Gene Tree for ADRA1D (if available)

Paralogs for ADRA1D Gene

Paralogs for ADRA1D Gene

Selected SIMAP similar genes for ADRA1D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADRA1D: view

Variants for ADRA1D Gene

Sequence variations from dbSNP and Humsavar for ADRA1D Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs709023 -- 4,220,483(+) GACAA(A/T)TTGTG downstream-variant-500B
rs709024 -- 4,221,337(+) CCCCA(C/T)TACTT utr-variant-3-prime
rs709025 -- 4,224,704(+) CAAGC(A/G)GGCCA intron-variant
rs709026 -- 4,229,396(+) tacta(A/G)ggaga intron-variant
rs835873 -- 4,222,155(+) ATACT(A/G)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADRA1D Gene

Variant ID Type Subtype PubMed ID
esv2722127 CNV Deletion 23290073
esv2722129 CNV Deletion 23290073
nsv178938 CNV Loss 16902084
esv2722130 CNV Deletion 23290073
nsv180352 CNV Loss 16902084
nsv833901 CNV Gain 17160897
esv2661469 CNV Deletion 23128226

Relevant External Links for ADRA1D Gene

HapMap Linkage Disequilibrium report
ADRA1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADRA1D Gene

Disorders for ADRA1D Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADRA1D Gene including...

Search for ADRA1D Gene in MalaCards »

(4) University of Copenhagen DISEASES for ADRA1D Gene

(3) Novoseek inferred disease relationships for ADRA1D Gene

Disease -log(P) Hits PubMed IDs
benign prostatic hyperplasia 43.8 1
essential hypertension 32.3 2
obstruction 0 1

Relevant External Links for ADRA1D

Genetic Association Database (GAD)
ADRA1D
Human Genome Epidemiology (HuGE) Navigator
ADRA1D
genes like me logo Genes that share disorders with ADRA1D: view

No data available for UniProtKB/Swiss-Prot for ADRA1D Gene

Publications for ADRA1D Gene

  1. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. (PMID: 7746284) Esbenshade T.A. … Murphy T.J. (Mol. Pharmacol. 1995) 3 4 23
  2. Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. (PMID: 12442007) Sugaya K. … Ogawa Y. (J. Urol. 2002) 3 23 48
  3. Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy. (PMID: 17404580) Nonen S. … Azuma J. (Pharmacogenomics J. 2008) 3 23 48
  4. Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding. (PMID: 18187928) Nagaoka Y. … Nagatomo T. (J. Pharmacol. Sci. 2008) 3 23 25
  5. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. (PMID: 16533813) Chen Z. … Minneman K.P. (J. Biol. Chem. 2006) 3 23

Products for ADRA1D Gene

  • antibodies-online peptides for ADRA1D
  • antibodies-online antibodies for ADRA1D
  • antibodies-online kits for ADRA1D

Sources for ADRA1D Gene

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