Aliases for ADRA1D Gene
External Ids for ADRA1D Gene
Previous GeneCards Identifiers for ADRA1D Gene
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADRA1D Gene
ADRA1D (Adrenoceptor Alpha 1D) is a Protein Coding gene. Diseases associated with ADRA1D include Hyperekplexia and Hypertension, Essential. Among its related pathways are Vascular smooth muscle contraction and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and alpha1-adrenergic receptor activity. An important paralog of this gene is ADRA1B.
UniProtKB/Swiss-Prot for ADRA1D Gene
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors.