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Aliases for CSNK1A1 Gene

Aliases for CSNK1A1 Gene

  • Casein Kinase 1, Alpha 1 2 3
  • Clock Regulator Kinase 2 3
  • EC 4 64
  • CKI-Alpha 3 4
  • CK1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 77p 3
  • Casein Kinase I Isoform Alpha 3
  • Down-Regulated In Lung Cancer 3
  • HEL-S-77p 3
  • HLCDGP1 3
  • PRO2975 3
  • CK1a 3
  • CKIa 3

External Ids for CSNK1A1 Gene

Summaries for CSNK1A1 Gene

GeneCards Summary for CSNK1A1 Gene

CSNK1A1 (Casein Kinase 1, Alpha 1) is a Protein Coding gene. Diseases associated with CSNK1A1 include lung cancer. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1A1 Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.

Tocris Summary for CSNK1A1 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport. CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1alpha is thought to phosphorylate beta-catenin as part of its degradation process. Upon binding of Wnt to its receptor (Frizzled) CK1epsilon phosphorylates the intracellular signaling protein, Dishevelled and CK1gamma directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1alpha plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound state, and then when Hh binds to Patched, CK1alpha phosphorylates the 7-TM co-receptor, Smoothened.

Gene Wiki entry for CSNK1A1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1A1 Gene

Genomics for CSNK1A1 Gene

Genomic Location for CSNK1A1 Gene

149,492,197 bp from pter
149,551,552 bp from pter
59,356 bases
Minus strand

Genomic View for CSNK1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSNK1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1 Gene

Regulatory Elements for CSNK1A1 Gene

Proteins for CSNK1A1 Gene

  • Protein details for CSNK1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Casein kinase I isoform alpha
    Protein Accession:
    Secondary Accessions:
    • D3DQG0
    • D3DQG1
    • Q4JJA0
    • Q5U046
    • Q5U047
    • Q6FGA2
    • Q71TU5
    • Q96HD2
    • Q9UDK3

    Protein attributes for CSNK1A1 Gene

    337 amino acids
    Molecular mass:
    38915 Da
    Quaternary structure:
    • Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation.

    Alternative splice isoforms for CSNK1A1 Gene


neXtProt entry for CSNK1A1 Gene

Proteomics data for CSNK1A1 Gene at MOPED

Post-translational modifications for CSNK1A1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8, Lys62, Lys65, Lys138, Lys225, and Lys304

Domains for CSNK1A1 Gene

Gene Families for CSNK1A1 Gene

Protein Domains for CSNK1A1 Gene


  • Contains 1 protein kinase domain.:
    • P48729
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.:
    • P48729
genes like me logo Genes that share domains with CSNK1A1: view

Function for CSNK1A1 Gene

Molecular function for CSNK1A1 Gene

GENATLAS Biochemistry: casein kinase I,catalytic unit,alpha 1,involved in the transduction of WNT signal
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.

Enzyme Numbers (IUBMB) for CSNK1A1 Gene

Gene Ontology (GO) - Molecular Function for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10777483
GO:0004674 protein serine/threonine kinase activity IDA 18305108
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16511560
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK1A1: view
genes like me logo Genes that share phenotypes with CSNK1A1: view

Animal Models for CSNK1A1 Gene

MGI Knock Outs for CSNK1A1:

miRNA for CSNK1A1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for CSNK1A1 Gene

Localization for CSNK1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.

Subcellular locations from

Jensen Localization Image for CSNK1A1 Gene COMPARTMENTS Subcellular localization image for CSNK1A1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005737 cytoplasm IBA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CSNK1A1: view

Pathways for CSNK1A1 Gene

genes like me logo Genes that share pathways with CSNK1A1: view

Pathways by source for CSNK1A1 Gene

1 R&D Systems pathway for CSNK1A1 Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CSNK1A1 Gene
2 Tocris pathways for CSNK1A1 Gene
2 Sino Biological pathways for CSNK1A1 Gene

Gene Ontology (GO) - Biological Process for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 18305108
GO:0006909 phagocytosis IBA --
GO:0007067 mitotic nuclear division IEA --
GO:0007165 signal transduction NAS 10777483
GO:0007166 cell surface receptor signaling pathway TAS 10777483
genes like me logo Genes that share ontologies with CSNK1A1: view

Compounds for CSNK1A1 Gene

(5) Tocris Compounds for CSNK1A1 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor [1056016-06-8]
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI [301836-43-1]
PF 4800567 hydrochloride Selective casein kinase 1epsilon inhibitor [1188296-52-7]
PF 670462 Potent and selective CK1epsilon and CK1delta inhibitor [950912-80-8]
TAK 715 Potent p38 MAPK inhibitor; anti-inflammatory [303162-79-0]

(2) HMDB Compounds for CSNK1A1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure

(4) Novoseek inferred chemical compound relationships for CSNK1A1 Gene

Compound -log(P) Hits PubMed IDs
threonine 41.9 1
glycogen 41.6 5
serine 37.8 1
tyrosine 0 1
genes like me logo Genes that share compounds with CSNK1A1: view

Transcripts for CSNK1A1 Gene

Unigene Clusters for CSNK1A1 Gene

Casein kinase 1, alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - -

Relevant External Links for CSNK1A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSNK1A1 Gene

mRNA expression in normal human tissues for CSNK1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK1A1 Gene

SOURCE GeneReport for Unigene cluster for CSNK1A1 Gene Hs.529862

genes like me logo Genes that share expressions with CSNK1A1: view

Orthologs for CSNK1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CSNK1A1 36
  • 99.91 (n)
  • 100 (a)
CSNK1A1 37
  • 100 (a)
(Bos Taurus)
Mammalia -- 37
  • 83 (a)
CSNK1A1 36
  • 96.4 (n)
  • 100 (a)
(Canis familiaris)
Mammalia -- 37
  • 100 (a)
CSNK1A1 36
  • 98.08 (n)
  • 100 (a)
(Mus musculus)
Mammalia Csnk1a1 36
  • 94.65 (n)
  • 100 (a)
Csnk1a1 16
Csnk1a1 37
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 99 (a)
-- 37
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 100 (a)
(Rattus norvegicus)
Mammalia Csnk1a1 36
  • 94.96 (n)
  • 99.69 (a)
(Gallus gallus)
Aves CSNK1A1 36
  • 90.5 (n)
  • 99.73 (a)
CSNK1A1 37
  • 100 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68433 36
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1a1 36
  • 84.77 (n)
  • 100 (a)
Str.3026 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.744 36
(Danio rerio)
Actinopterygii csnk1a1 36
csnk1a1 37
  • 99 (a)
csnk1a1 37
  • 99 (a)
LOC100334765 36
  • 83.56 (n)
  • 98.63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000627 36
  • 67.49 (n)
  • 81.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CkIalpha 36
  • 67.81 (n)
  • 78.57 (a)
CkIalpha 37
  • 76 (a)
CG7094 38
  • 64 (a)
CkIalpha 38
  • 76 (a)
dco 38
  • 70 (a)
CG9962 38
  • 49 (a)
CG12147 38
  • 55 (a)
CG2577 38
  • 58 (a)
(Caenorhabditis elegans)
Secernentea kin-19 37
  • 82 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl8 36
  • 61.43 (n)
  • 68.59 (a)
(Oryza sativa)
Liliopsida Os04g0514800 36
  • 66.44 (n)
  • 72.35 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hhp2 36
  • 61.55 (n)
  • 65.18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.22 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 92 (a)
  • 88 (a)
Species with no ortholog for CSNK1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1A1 Gene

Gene Tree for CSNK1A1 (if available)
Gene Tree for CSNK1A1 (if available)

Paralogs for CSNK1A1 Gene

genes like me logo Genes that share paralogs with CSNK1A1: view

Variants for CSNK1A1 Gene

Sequence variations from dbSNP and Humsavar for CSNK1A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs8221 -- 149,496,044(-) TTTTT(A/T)TTTTG utr-variant-3-prime
rs752821 -- 149,509,433(+) gtgca(A/G)tggca intron-variant
rs752822 -- 149,509,455(+) ccttg(C/T)aagac intron-variant
rs1056343 -- 149,495,511(-) CCCCT(C/T)CTGCT downstream-variant-500B
rs1126626 -- 149,498,154(-) GCCCA(A/T)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1A1 Gene

Variant ID Type Subtype PubMed ID
esv24490 CNV Gain 19812545
nsv516848 CNV Gain 19592680
nsv518039 CNV Gain 19592680
nsv5059 CNV Insertion 18451855
esv2585670 CNV Insertion 19546169
esv2730908 CNV Deletion 23290073

Relevant External Links for CSNK1A1 Gene

HapMap Linkage Disequilibrium report

Disorders for CSNK1A1 Gene

(1) MalaCards Diseases for CSNK1A1 Gene

Search for CSNK1A1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for CSNK1A1 Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 33.6 1
cancer 26.8 3

Relevant External Links for CSNK1A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CSNK1A1: view

No data available for UniProtKB/Swiss-Prot for CSNK1A1 Gene

Publications for CSNK1A1 Gene

  1. Cloning and chromosomal localization of the gene coding for human protein kinase CK1. (PMID: 8050587) Tapia C. … Allende J.E. (FEBS Lett. 1994) 2 3 4
  2. Association of CPI-17 with protein kinase C and casein kinase I. (PMID: 15003508) Zemlickova E. … Dubois T. (Biochem. Biophys. Res. Commun. 2004) 3 23
  3. Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity. (PMID: 9391750) Veis A. … Wu C.B. (Crit. Rev. Oral Biol. Med. 1997) 3 23
  4. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. (PMID: 9630228) Zhu J. … McKeon F. (Cell 1998) 3 23
  5. Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins. (PMID: 11278595) Dubois T. … Aitken A. (J. Biol. Chem. 2001) 3 23

Products for CSNK1A1 Gene

Sources for CSNK1A1 Gene

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