Aliases for CSNK1A1 Gene
Aliases for CSNK1A1 Gene
External Ids for CSNK1A1 Gene
- HGNC: 2451
- Entrez Gene: 1452
- Ensembl: ENSG00000113712
- OMIM: 600505
- UniProtKB: P48729
Previous GeneCards Identifiers for CSNK1A1 Gene
- GC05M148919
- GC05M148904
- GC05M148902
- GC05M148854
- GC05M144021
Summaries for CSNK1A1 Gene
GeneCards Summary for CSNK1A1 Gene
CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are NFAT and Cardiac Hypertrophy and Signaling by Wnt. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1L.
UniProtKB/Swiss-Prot for CSNK1A1 Gene
-
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
-
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.
No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1A1 Gene
Genomics for CSNK1A1 Gene
Regulatory Elements for CSNK1A1 Gene
Enhancers for CSNK1A1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CSNK1A1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CSNK1A1 Gene
- Chromosome:
- 5
- Start:
- 149,492,197 bp from pter
- End:
- 149,551,552 bp from pter
- Size:
- 59,356 bases
- Orientation:
- Minus strand
Genomic View for CSNK1A1 Gene
Genes around CSNK1A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q32 by Ensembl
- 5q32 by Entrez Gene
- 5q32 by HGNC
CSNK1A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSNK1A1 Gene
Proteins for CSNK1A1 Gene
-
Protein details for CSNK1A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48729-KC1A_HUMAN
- Recommended name:
- Casein kinase I isoform alpha
- Protein Accession:
- P48729
- D3DQG0
- D3DQG1
- Q4JJA0
- Q5U046
- Q5U047
- Q6FGA2
- Q71TU5
- Q96HD2
- Q9UDK3
Protein attributes for CSNK1A1 Gene
- Size:
- 337 amino acids
- Molecular mass:
- 38915 Da
- Quaternary structure:
-
- Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. Interacts with FAM83H; recruits CSNK1A1 to keratin filaments (PubMed:23902688).
Protein Expression for CSNK1A1 Gene
Selected DME Specific Peptides for CSNK1A1 Gene
- P48729:
-
- QGGVGIP
- ESKLYKI
- HRDIKPDN
- KYEKISEKK
- ESLGYVL
- DWTMLKQK
- RKIGSGSFG
- WYGQEKD
- LTGTARY
- LPWQGLKA
- HPQLLYESKLY
- RDIKPDNFL
- PDNFLMG
- LADQMISRI
- GQQAQTPTG
- YLRQLFR
- LLGPSLEDLF
- MYFNRTSLPWQGL
- DFGLAKKYRD
- GIEQSRRDD
- VAVKLESQK
Post-translational modifications for CSNK1A1 Gene
Other Protein References for CSNK1A1 Gene
Antibody Products
- R&D Systems Antibodies for CSNK1A1 (Casein Kinase 1 alpha)
- Cell Signaling Technology (CST) Antibodies for CSNK1A1 (CK1A)
-
Custom Antibody ServicesOriGene Antibodies for CSNK1A1
- Novus Biologicals Antibodies for CSNK1A1
-
Abcam antibodies for CSNK1A1
-
Cloud-Clone Corp. Antibodies for CSNK1A1
- Invitrogen Antibodies for CSNK1A1
- antibodies-online Antibodies for CSNK1A1: See all 136
- GeneTex CSNK1A1 antibody for CSNK1A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CSNK1A1
Protein Products
-
OriGene Purified Proteins for CSNK1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for CSNK1A1
- Origene Custom Protein Services for CSNK1A1
- Sino Biological Cell Lysates for CSNK1A1
- Sino Biological Recombinant Proteins for CSNK1A1
- ProSpec Recombinant Proteins for CSNK1A1
-
Cloud-Clone Corp. Proteins for CSNK1A1
- antibodies-online Proteins for CSNK1A1: See all 18
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CSNK1A1
Assay Products
- antibodies-online Kits for CSNK1A1: See all 6
Domains & Families for CSNK1A1 Gene
Gene Families for CSNK1A1 Gene
- IUPHAR :
Protein Domains for CSNK1A1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSNK1A1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P48729UniProtKB/Swiss-Prot:
KC1A_HUMAN :- Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Function for CSNK1A1 Gene
Molecular function for CSNK1A1 Gene
- GENATLAS Biochemistry:
- casein kinase I,catalytic unit,alpha 1,involved in the transduction of WNT signal
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Enzyme Numbers (IUBMB) for CSNK1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | TAS | 10777483 |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 16511560 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | TAS | -- |
Phenotypes for CSNK1A1 Gene
- MGI mutant phenotypes for CSNK1A1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CSNK1A1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Increased transferrin (TF) endocytosis
- Decreased viability after Maraba virus infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Decreased substrate adherent cell growth
- Wnt reporter downregulated
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Increased HPV16-GFP infection
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Increased Nanog expression
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased circadian period length
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased cilium length after serum starvation
- Increased viability with 4OH tamoxifen
Animal Models for CSNK1A1 Gene
- MGI Knock Outs for CSNK1A1:
-
- Csnk1a1 tm1.2Ybn
Animal Model Products
-
Taconic Biosciences Mouse Models for CSNK1A1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK1A1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK1A1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1A1 gene
- Search ViGene Biosciences for CSNK1A1
CRISPR Products
-
OriGene CRISPR knockouts for CSNK1A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1A1
- GenScript: Design CRISPR guide RNA sequences for CSNK1A1
miRNA for CSNK1A1 Gene
- miRTarBase miRNAs that target CSNK1A1
-
- hsa-mir-155-5p (MIRT006267)
- hsa-mir-186-5p (MIRT021178)
- hsa-mir-21-5p (MIRT030896)
- hsa-mir-652-3p (MIRT039466)
- hsa-mir-324-3p (MIRT042900)
- hsa-mir-548e-5p (MIRT312451)
- hsa-mir-6835-3p (MIRT312454)
- hsa-mir-4671-3p (MIRT478712)
- hsa-mir-519c-3p (MIRT478713)
- hsa-mir-519b-3p (MIRT478714)
- hsa-mir-519a-3p (MIRT478715)
- hsa-mir-5692a (MIRT478716)
- hsa-mir-548t-5p (MIRT478717)
- hsa-mir-548az-5p (MIRT478718)
- hsa-mir-106b-5p (MIRT478719)
- hsa-mir-17-5p (MIRT478720)
- hsa-mir-106a-5p (MIRT478721)
- hsa-mir-20a-5p (MIRT478722)
- hsa-mir-20b-5p (MIRT478723)
- hsa-mir-519d-3p (MIRT478724)
- hsa-mir-526b-3p (MIRT478725)
- hsa-mir-93-5p (MIRT478726)
- hsa-mir-520c-3p (MIRT478727)
- hsa-mir-302a-3p (MIRT478728)
- hsa-mir-302b-3p (MIRT478729)
- hsa-mir-302c-3p (MIRT478730)
- hsa-mir-302d-3p (MIRT478731)
- hsa-mir-520e (MIRT478732)
- hsa-mir-520d-3p (MIRT478733)
- hsa-mir-372-3p (MIRT478734)
- hsa-mir-373-3p (MIRT478735)
- hsa-mir-520b (MIRT478736)
- hsa-mir-302e (MIRT478737)
- hsa-mir-520a-3p (MIRT478738)
- hsa-mir-153-3p (MIRT478739)
- hsa-mir-3187-3p (MIRT558543)
- hsa-mir-7159-5p (MIRT558544)
- hsa-mir-4529-5p (MIRT558545)
- hsa-mir-4709-5p (MIRT558546)
- hsa-mir-4272 (MIRT558547)
- hsa-mir-1244 (MIRT558548)
- hsa-mir-181d-5p (MIRT558549)
- hsa-mir-181a-5p (MIRT558550)
- hsa-mir-181b-5p (MIRT558551)
- hsa-mir-4262 (MIRT558552)
- hsa-mir-181c-5p (MIRT558553)
- hsa-mir-505-3p (MIRT558554)
- hsa-mir-421 (MIRT558555)
- hsa-mir-199b-3p (MIRT558556)
- hsa-mir-199a-3p (MIRT558557)
- hsa-mir-3129-5p (MIRT558558)
- hsa-mir-3942-3p (MIRT567898)
- hsa-mir-205-3p (MIRT567899)
- hsa-mir-6809-3p (MIRT724476)
- hsa-mir-6833-3p (MIRT724477)
- hsa-mir-4768-5p (MIRT724478)
- hsa-mir-4753-3p (MIRT724479)
- hsa-mir-6873-3p (MIRT724480)
- hsa-mir-4465 (MIRT724481)
- hsa-mir-26b-5p (MIRT724482)
- hsa-mir-26a-5p (MIRT724483)
- hsa-mir-1297 (MIRT724484)
- hsa-mir-3160-5p (MIRT724485)
- hsa-mir-942-5p (MIRT724486)
- hsa-mir-1236-3p (MIRT724487)
- hsa-mir-6515-3p (MIRT724488)
- hsa-mir-6845-3p (MIRT724489)
- hsa-mir-136-5p (MIRT724490)
miRNA Products
- Search ViGene Biosciences for CSNK1A1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1A1
- Browse OriGene Inhibitory RNA Products For CSNK1A1
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1A1 gene
Clone Products
- Sino Biological Human cDNA Clone for CSNK1A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK1A1
- VectorBuilder custom plasmid, inducible vectors for CSNK1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CSNK1A1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CSNK1A1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1A1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1A1 Gene
Localization for CSNK1A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1 Gene
- Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). {ECO:0000269 PubMed:1409656, ECO:0000269 PubMed:23902688}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for CSNK1A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | S45 mutants of beta-catenin arent phosphorylated | ||
| 2 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 3 | Signaling by Hedgehog | ||
| 4 | Hedgehog Pathway |
.40
|
|
| 5 | Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling | ||
Pathways by source for CSNK1A1 Gene
2 Sino Biological pathways for CSNK1A1 Gene
1 GeneTex pathway for CSNK1A1 Gene
2 Cell Signaling Technology pathways for CSNK1A1 Gene
11 BioSystems pathways for CSNK1A1 Gene
3 KEGG pathways for CSNK1A1 Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1A1 Gene
4 R&D Systems pathways for CSNK1A1 Gene
2 Tocris pathways for CSNK1A1 Gene
6 Qiagen pathways for CSNK1A1 Gene
Interacting Proteins for CSNK1A1 Gene
Selected Interacting proteins:
P48729-KC1A_HUMAN
ENSP00000421689
for CSNK1A1 Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for CSNK1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 18305108 |
| GO:0006909 | phagocytosis | IBA | -- |
| GO:0007030 | Golgi organization | IMP | 25500533 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007067 | mitotic nuclear division | IEA | -- |
Drugs & Compounds for CSNK1A1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| IC261 | Experimental | Pharma | 0 | |||
| CKI 7 dihydrochloride | Pharma | CK1 inhibitor | 0 | |||
| PF-670462 | Pharma | CK1 ε/δ inhibitor, Potent and selective CK1eta and CK1delta inhibitor | 0 | |||
| CASEIN KINASE I INHIBITOR | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(5) Tocris Compounds for CSNK1A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CKI 7 dihydrochloride | CK1 inhibitor | 1177141-67-1 |
| D 4476 | Selective CK1 inhibitor. Also inhibits TGF-betaRI | 301836-43-1 |
| LH 846 | Selective casein kinase 1delta inhibitor | 639052-78-1 |
| PF 4800567 hydrochloride | Selective casein kinase 1eta inhibitor | 1391052-28-0 |
| PF 670462 | Potent and selective CK1eta and CK1delta inhibitor | 950912-80-8 |
(2) ApexBio Compounds for CSNK1A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CKI 7 dihydrochloride | 1177141-67-1 | |
| PF-670462 | CK1 ε/δ inhibitor | 950912-80-8 |
Transcripts for CSNK1A1 Gene
mRNA/cDNA for CSNK1A1 Gene
- (4) REFSEQ mRNAs :
- (25) Additional mRNA sequences :
- (837) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CSNK1A1 Gene
- Casein kinase 1, alpha 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CSNK1A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1A1
- GenScript: Design CRISPR guide RNA sequences for CSNK1A1
miRNA Products
- Search ViGene Biosciences for CSNK1A1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1A1
- Browse OriGene Inhibitory RNA Products For CSNK1A1
-
ViGene Biosciences ready-to-package AAV shRNAs for CSNK1A1 gene
Clone Products
- Sino Biological Human cDNA Clone for CSNK1A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CSNK1A1
- VectorBuilder custom plasmid, inducible vectors for CSNK1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for CSNK1A1 Gene
This gene is overexpressed in Cervix (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CSNK1A1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CSNK1A1 Gene:
CSNK1A1SOURCE GeneReport for Unigene cluster for CSNK1A1 Gene:
Hs.529862Evidence on tissue expression from TISSUES for CSNK1A1 Gene
- Nervous system(5)
- Lung(4.8)
- Skin(3.7)
- Kidney(3.3)
- Liver(3.2)
- Intestine(2.8)
- Pancreas(2.6)
- Blood(2.2)
- Heart(2.2)
- Eye(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for CSNK1A1
-
OriGene qPCR primer pairs for CSNK1A1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1A1 Gene
Orthologs for CSNK1A1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| CSNK1A1 34 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | CSNK1A1 35 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | CSNK1A1 34 |
|
||
| -- 35 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Csnk1a1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Csnk1a1 16 35 34 |
|
||
| chicken (Gallus gallus) |
Aves | CSNK1A1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | csnk1a1 34 |
|
||
| Str.3026 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68433 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | csnk1a1 35 35 34 |
|
ManyToMany | |
| LOC100334765 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.744 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | dco 36 |
|
|
|
| CkIalpha 36 34 35 |
|
||||
| CG7094 36 |
|
|
|||
| CG2577 36 |
|
|
|||
| CG12147 36 |
|
|
|||
| CG9962 36 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000627 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | kin-19 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ckl8 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0514800 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| CS-CKI 35 |
|
ManyToMany | |||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | hhp2 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.22 34 |
|
- Species where no ortholog for CSNK1A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CSNK1A1 Gene
Paralogs for CSNK1A1 Gene
(11) SIMAP similar genes for CSNK1A1 Gene using alignment to 12 proteins:
Pseudogenes.org Pseudogenes for CSNK1A1 Gene
Variants for CSNK1A1 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_042073 | A breast pleomorphic lobular carcinoma sample | ||||
| rs1000063395 | -- | 149,530,049(+) | TACCC(A/G)AATAT | intron-variant | |
| rs1000071421 | -- | 149,535,879(+) | GACCT(C/G)AAGTG | intron-variant | |
| rs1000091167 | -- | 149,518,355(+) | AGTGG(C/T)CACTC | intron-variant | |
| rs1000273147 | -- | 149,507,516(+) | AGTGC(A/G)GTAGT | intron-variant |
Residual Variation Intolerance Score:
33.5% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CSNK1A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CSNK1A1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1A1 Gene
Disorders for CSNK1A1 Gene
Relevant External Links for CSNK1A1
No disorders were found for CSNK1A1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1A1 Gene
Publications for CSNK1A1 Gene
- Cloning and chromosomal localization of the gene coding for human protein kinase CK1. (PMID: 8050587) Tapia C. … Allende J.E. (FEBS Lett. 1994) 2 3 4 64
- A novel mechanism of keratin cytoskeleton organization through casein kinase II+ and FAM83H in colorectal cancer. (PMID: 23902688) Kuga T. … Tomonaga T. (J. Cell. Sci. 2013) 3 4 64
- Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PMID: 21642993) Wu C. … Lin D. (Nat. Genet. 2011) 3 46 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. (PMID: 19805514) Liu J. … Fuchs S.Y. (Mol. Cell. Biol. 2009) 3 22 64
Products for CSNK1A1 Gene
- R&D Systems Antibodies for CSNK1A1 (Casein Kinase 1 alpha)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for CSNK1A1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CSNK1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for CSNK1A1
- Origene Custom Protein Services for CSNK1A1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CSNK1A1
- Browse OriGene Inhibitory RNA Products For CSNK1A1
- OriGene qPCR primer pairs and template standards for CSNK1A1
- OriGene qPCR primer pairs for CSNK1A1
- OriGene CRISPR knockouts for CSNK1A1
- OriGene ORF clones in human for CSNK1A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CSNK1A1
- GenScript: Next-day shipping cDNA ORF clone for CSNK1A1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CSNK1A1
- GenScript Custom Assay Services for CSNK1A1
- GenScript Custom overexpressing Cell Line Services for CSNK1A1
- GenScript: Design CRISPR guide RNA sequences for CSNK1A1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CSNK1A1
- Cell Signaling Technology (CST) Antibodies for CSNK1A1 (CK1A)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CSNK1A1
- Sino Biological Recombinant Proteins for CSNK1A1
- Sino Biological Cell Lysates for CSNK1A1
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CSNK1A1
- Novus Biologicals proteins and lysates for CSNK1A1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CSNK1A1
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for CSNK1A1
- Cloud-Clone Corp. Antibodies for CSNK1A1
- Cloud-Clone Corp. Proteins for CSNK1A1
- Browse Assay Kits at Cloud-Clone Corp.
- Taconic Biosciences Mouse Models for CSNK1A1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CSNK1A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CSNK1A1
- Addgene plasmids for CSNK1A1
- antibodies-online Antibodies for CSNK1A1: See all 136
- antibodies-online Kits for CSNK1A1: See all 6
- antibodies-online Proteins for CSNK1A1: See all 18
- Search antibodies-online for peptides
- GeneTex CSNK1A1 antibody for CSNK1A1
- Search GeneTex for Proteins for CSNK1A1
- ViGene Biosciences adenoviral particle packaged cDNA for CSNK1A1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CSNK1A1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CSNK1A1 gene
- Search ViGene Biosciences for CSNK1A1
- Santa Cruz Biotechnology (SCBT) Antibodies for CSNK1A1
- Search Santa Cruz Biotechnology (SCBT) for CSNK1A1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CSNK1A1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSNK1A1
- VectorBuilder custom plasmid, inducible vectors for CSNK1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CSNK1A1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CSNK1A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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- (128) Genetics Home Reference
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- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer