Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSNK1A1 Gene

Aliases for CSNK1A1 Gene

  • Casein Kinase 1 Alpha 1 2 3
  • Casein Kinase 1, Alpha 1 2 3 5
  • Clock Regulator Kinase 2 3
  • EC 2.7.11.1 4 63
  • CKI-Alpha 3 4
  • CK1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 77p 3
  • Down-Regulated In Lung Cancer 3
  • HEL-S-77p 3
  • HLCDGP1 3
  • PRO2975 3
  • CK1a 3
  • CKIa 3

External Ids for CSNK1A1 Gene

Previous GeneCards Identifiers for CSNK1A1 Gene

  • GC05M148919
  • GC05M148904
  • GC05M148902
  • GC05M148854
  • GC05M144021

Summaries for CSNK1A1 Gene

GeneCards Summary for CSNK1A1 Gene

CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are Basal cell carcinoma and Wnt signaling pathway (KEGG). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for CSNK1A1 Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).

Tocris Summary for CSNK1A1 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Gene Wiki entry for CSNK1A1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1A1 Gene

Genomics for CSNK1A1 Gene

Regulatory Elements for CSNK1A1 Gene

Enhancers for CSNK1A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSNK1A1 on UCSC Golden Path with GeneCards custom track

Promoters for CSNK1A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSNK1A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CSNK1A1 Gene

Chromosome:
5
Start:
149,492,197 bp from pter
End:
149,551,552 bp from pter
Size:
59,356 bases
Orientation:
Minus strand

Genomic View for CSNK1A1 Gene

Genes around CSNK1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1 Gene

Proteins for CSNK1A1 Gene

  • Protein details for CSNK1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48729-KC1A_HUMAN
    Recommended name:
    Casein kinase I isoform alpha
    Protein Accession:
    P48729
    Secondary Accessions:
    • D3DQG0
    • D3DQG1
    • Q4JJA0
    • Q5U046
    • Q5U047
    • Q6FGA2
    • Q71TU5
    • Q96HD2
    • Q9UDK3

    Protein attributes for CSNK1A1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38915 Da
    Quaternary structure:
    • Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. Interacts with FAM83H; recruits CSNK1A1 to keratin filaments (PubMed:23902688).

    Three dimensional structures from OCA and Proteopedia for CSNK1A1 Gene

    Alternative splice isoforms for CSNK1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK1A1 Gene

Proteomics data for CSNK1A1 Gene at MOPED

Post-translational modifications for CSNK1A1 Gene

  • Ubiquitination at Lys 8, Lys 62, Lys 65, Lys 138, Lys 225, and Lys 304
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CSNK1A1 (Casein Kinase 1 alpha)
  • Cloud-Clone Corp. Antibodies for CSNK1A1

Domains & Families for CSNK1A1 Gene

Gene Families for CSNK1A1 Gene

Protein Domains for CSNK1A1 Gene

Graphical View of Domain Structure for InterPro Entry

P48729

UniProtKB/Swiss-Prot:

KC1A_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1A1: view

Function for CSNK1A1 Gene

Molecular function for CSNK1A1 Gene

GENATLAS Biochemistry:
casein kinase I,catalytic unit,alpha 1,involved in the transduction of WNT signal
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).

Enzyme Numbers (IUBMB) for CSNK1A1 Gene

genes like me logo Genes that share phenotypes with CSNK1A1: view

Animal Models for CSNK1A1 Gene

MGI Knock Outs for CSNK1A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK1A1

miRNA for CSNK1A1 Gene

miRTarBase miRNAs that target CSNK1A1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1A1 Gene

Localization for CSNK1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). {ECO:0000269 PubMed:1409656, ECO:0000269 PubMed:23902688}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSNK1A1 Gene COMPARTMENTS Subcellular localization image for CSNK1A1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005847 colocalizes_with mRNA cleavage and polyadenylation specificity factor complex IDA 18305108
GO:0045095 colocalizes_with keratin filament IDA 23902688
genes like me logo Genes that share ontologies with CSNK1A1: view

Pathways & Interactions for CSNK1A1 Gene

SuperPathways for CSNK1A1 Gene

Superpath Contained pathways
1 S45 mutants of beta-catenin arent phosphorylated
2 Signaling by Hedgehog
3 Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways
4 CDK-mediated phosphorylation and removal of Cdc6
5 Wnt signaling pathway (KEGG)
genes like me logo Genes that share pathways with CSNK1A1: view

SIGNOR curated interactions for CSNK1A1 Gene

Gene Ontology (GO) - Biological Process for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IBA --
GO:0007067 mitotic nuclear division IEA --
GO:0007165 signal transduction NAS 10777483
GO:0007166 cell surface receptor signaling pathway TAS 10777483
GO:0008360 regulation of cell shape IBA --
genes like me logo Genes that share ontologies with CSNK1A1: view

Drugs & Compounds for CSNK1A1 Gene

(7) Drugs for CSNK1A1 Gene - From: DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
IC261 Experimental Pharma 0
CASEIN KINASE I INHIBITOR Pharma 0
TAK-715 Pharma p38 MAPK inhibitor, Potent p38 MAPK inhibitor; anti-inflammatory 0

(6) Additional Compounds for CSNK1A1 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
(R)-CR8
294646-77-8
(R)-DRF053 dihydrochloride
1241675-76-2
D 4476
301836-43-1
PF 670462
950912-80-8

(5) Tocris Compounds for CSNK1A1 Gene

Compound Action Cas Number
(R)-CR8 Dual cdk1/cdk5 inhibitor; also inhibits CK1 294646-77-8
(R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor 1241675-76-2
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
PF 670462 Potent and selective CK1epsilon and CK1delta inhibitor 950912-80-8
TAK 715 Potent p38 MAPK inhibitor; anti-inflammatory 303162-79-0
genes like me logo Genes that share compounds with CSNK1A1: view

Transcripts for CSNK1A1 Gene

Unigene Clusters for CSNK1A1 Gene

Casein kinase 1, alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for CSNK1A1 Gene

GeneLoc Exon Structure for
CSNK1A1
ECgene alternative splicing isoforms for
CSNK1A1

Expression for CSNK1A1 Gene

mRNA expression in normal human tissues for CSNK1A1 Gene

Protein differential expression in normal tissues from HIPED for CSNK1A1 Gene

This gene is overexpressed in Cervix (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSNK1A1 Gene



SOURCE GeneReport for Unigene cluster for CSNK1A1 Gene Hs.529862

genes like me logo Genes that share expression patterns with CSNK1A1: view

Protein tissue co-expression partners for CSNK1A1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSNK1A1 Gene

Orthologs for CSNK1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSNK1A1 35
  • 96.4 (n)
  • 100 (a)
-- 36
  • 83 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CSNK1A1 35
  • 98.08 (n)
  • 100 (a)
-- 36
  • 100 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Csnk1a1 35
  • 94.65 (n)
  • 100 (a)
Csnk1a1 16
Csnk1a1 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CSNK1A1 35
  • 99.91 (n)
  • 100 (a)
CSNK1A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1a1 35
  • 94.96 (n)
  • 99.69 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 100 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSNK1A1 35
  • 90.5 (n)
  • 99.73 (a)
CSNK1A1 36
  • 100 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 100 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1a1 35
  • 84.77 (n)
  • 100 (a)
Str.3026 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68433 35
zebrafish
(Danio rerio)
Actinopterygii csnk1a1 35
LOC100334765 35
  • 83.56 (n)
  • 98.63 (a)
csnk1a1 36
  • 99 (a)
ManyToMany
csnk1a1 36
  • 99 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.744 35
fruit fly
(Drosophila melanogaster)
Insecta CG12147 37
  • 55 (a)
CG2577 37
  • 58 (a)
CG7094 37
  • 64 (a)
CG9962 37
  • 49 (a)
CkIalpha 37
  • 76 (a)
dco 37
  • 70 (a)
CkIalpha 35
  • 67.81 (n)
  • 78.57 (a)
CkIalpha 36
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000627 35
  • 67.49 (n)
  • 81.06 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-19 36
  • 82 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl8 35
  • 61.43 (n)
  • 68.59 (a)
rice
(Oryza sativa)
Liliopsida Os04g0514800 35
  • 66.44 (n)
  • 72.35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.22 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hhp2 35
  • 61.55 (n)
  • 65.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 92 (a)
ManyToMany
CS-CKI 36
  • 88 (a)
ManyToMany
Species with no ortholog for CSNK1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1A1 Gene

ENSEMBL:
Gene Tree for CSNK1A1 (if available)
TreeFam:
Gene Tree for CSNK1A1 (if available)

Paralogs for CSNK1A1 Gene

genes like me logo Genes that share paralogs with CSNK1A1: view

Variants for CSNK1A1 Gene

Sequence variations from dbSNP and Humsavar for CSNK1A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_042073 A breast pleomorphic lobular carcinoma sample
rs8221 -- 149,496,044(-) TTTTT(A/T)TTTTG utr-variant-3-prime
rs752821 -- 149,509,433(+) gtgca(A/G)tggca intron-variant
rs752822 -- 149,509,455(+) ccttg(C/T)aagac intron-variant
rs2895861 -- 149,544,689(+) AACCC(A/C)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1A1 Gene

Variant ID Type Subtype PubMed ID
esv24490 CNV Gain 19812545
nsv516848 CNV Gain 19592680
nsv518039 CNV Gain 19592680
nsv5059 CNV Insertion 18451855
esv2585670 CNV Insertion 19546169
esv2730908 CNV Deletion 23290073

Variation tolerance for CSNK1A1 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSNK1A1 Gene

HapMap Linkage Disequilibrium report
CSNK1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1A1 Gene

Disorders for CSNK1A1 Gene

Relevant External Links for CSNK1A1

Genetic Association Database (GAD)
CSNK1A1
Human Genome Epidemiology (HuGE) Navigator
CSNK1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSNK1A1

No disorders were found for CSNK1A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1A1 Gene

Publications for CSNK1A1 Gene

  1. Cloning and chromosomal localization of the gene coding for human protein kinase CK1. (PMID: 8050587) Tapia C. … Allende J.E. (FEBS Lett. 1994) 2 3 4 67
  2. Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. (PMID: 19805514) Liu J. … Fuchs S.Y. (Mol. Cell. Biol. 2009) 3 23
  3. Association of CPI-17 with protein kinase C and casein kinase I. (PMID: 15003508) Zemlickova E. … Dubois T. (Biochem. Biophys. Res. Commun. 2004) 3 23
  4. Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways. (PMID: 11884395) Zhang Y. … Lin S.C. (J. Biol. Chem. 2002) 3 23
  5. Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins. (PMID: 11278595) Dubois T. … Aitken A. (J. Biol. Chem. 2001) 3 23

Products for CSNK1A1 Gene

Sources for CSNK1A1 Gene

Content