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Aliases for CSK Gene

Aliases for CSK Gene

  • C-Src Tyrosine Kinase 2 3
  • EC 2.7.10.2 4 64
  • Protein-Tyrosine Kinase CYL 4
  • C-Src Kinase 4
  • EC 2.7.10 64

External Ids for CSK Gene

Summaries for CSK Gene

GeneCards Summary for CSK Gene

CSK (C-Src Tyrosine Kinase) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include identical protein binding and protein tyrosine kinase activity. An important paralog of this gene is FER.

UniProtKB/Swiss-Prot for CSK Gene

  • Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Gene Wiki entry for CSK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSK Gene

Genomics for CSK Gene

Genomic Location for CSK Gene

Start:
74,782,057 bp from pter
End:
74,803,198 bp from pter
Size:
21,142 bases
Orientation:
Plus strand

Genomic View for CSK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSK Gene

Regulatory Elements for CSK Gene

Proteins for CSK Gene

  • Protein details for CSK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41240-CSK_HUMAN
    Recommended name:
    Tyrosine-protein kinase CSK
    Protein Accession:
    P41240
    Secondary Accessions:
    • Q2M3N2
    • Q6FGZ6

    Protein attributes for CSK Gene

    Size:
    450 amino acids
    Molecular mass:
    50704 Da
    Quaternary structure:
    • Homodimer (via SH3-domain) (PubMed:19888460). Interacts with PTPN22 (PubMed:15208781). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:11433379, PubMed:10790433, PubMed:14610046, PubMed:10838081). Interacts with SRCIN1 (PubMed:17525734). Interacts with RHOH (PubMed:20851766). Interacts (via SH2 domain) with SCIMP (PubMed:21930792).

    Three dimensional structures from OCA and Proteopedia for CSK Gene

neXtProt entry for CSK Gene

Proteomics data for CSK Gene at MOPED

Post-translational modifications for CSK Gene

  • Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys193, Lys196, Lys329, and Lys337

Other Protein References for CSK Gene

Domains for CSK Gene

Gene Families for CSK Gene

HGNC:
  • SH2D :SH2 domain containing
IUPHAR :

UniProtKB/Swiss-Prot:

CSK_HUMAN
Domain:
  • The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain:
    • P41240
  • Contains 1 protein kinase domain.:
    • P41240
  • Contains 1 SH2 domain.:
    • P41240
  • Contains 1 SH3 domain.:
    • P41240
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.:
    • P41240
genes like me logo Genes that share domains with CSK: view

Function for CSK Gene

Molecular function for CSK Gene

GENATLAS Biochemistry: tyrosine kinase,SRC downregulating (putative antioncogene)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Enzyme Numbers (IUBMB) for CSK Gene

Gene Ontology (GO) - Molecular Function for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 10026153
genes like me logo Genes that share ontologies with CSK: view
genes like me logo Genes that share phenotypes with CSK: view

Animal Models for CSK Gene

MGI Knock Outs for CSK:

miRNA for CSK Gene

No data available for Transcription Factor Targeting and HOMER Transcription for CSK Gene

Localization for CSK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSK Gene

Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSK Gene COMPARTMENTS Subcellular localization image for CSK gene
Compartment Confidence
cytoskeleton 4
cytosol 4
golgi apparatus 4
plasma membrane 4
nucleus 2
endoplasmic reticulum 1
endosome 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8890164
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with CSK: view

Pathways for CSK Gene

genes like me logo Genes that share pathways with CSK: view

Gene Ontology (GO) - Biological Process for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA --
GO:0002009 morphogenesis of an epithelium IBA --
GO:0006468 protein phosphorylation TAS 1945408
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CSK: view

Compounds for CSK Gene

(1) Drugbank Compounds for CSK Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Staurosporine
62996-74-1 target

(59) Novoseek inferred chemical compound relationships for CSK Gene

Compound -log(P) Hits PubMed IDs
tyrosine 87.9 166
phosphotyrosine 68.1 8
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 58.1 1
pd153035 53.6 1
ag 1478 50.5 1
genes like me logo Genes that share compounds with CSK: view

Transcripts for CSK Gene

Unigene Clusters for CSK Gene

C-src tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10: - - -

ExUns: 16d ^ 17a · 17b ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CSK Gene

GeneLoc Exon Structure for
CSK
ECgene alternative splicing isoforms for
CSK

Expression for CSK Gene

mRNA expression in normal human tissues for CSK Gene

mRNA differential expression in normal tissues according to GTEx for CSK Gene

This gene is overexpressed in Whole Blood (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSK Gene

SOURCE GeneReport for Unigene cluster for CSK Gene Hs.77793

mRNA Expression by UniProt/SwissProt for CSK Gene

P41240-CSK_HUMAN
Tissue specificity: Expressed in lung and macrophages.
genes like me logo Genes that share expressions with CSK: view

Orthologs for CSK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSK 36
  • 98.3 (n)
  • 98.44 (a)
CSK 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSK 36
  • 93.04 (n)
  • 98.67 (a)
CSK 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSK 36
  • 93.41 (n)
  • 99.11 (a)
CSK 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csk 36
  • 90.07 (n)
  • 99.11 (a)
Csk 16
Csk 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSK 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 20 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Csk 36
  • 90.22 (n)
  • 98.44 (a)
chicken
(Gallus gallus)
Aves CSK 36
  • 84.59 (n)
  • 93.33 (a)
CSK 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSK 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia csk-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia csk 36
  • 74.63 (n)
  • 84.37 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9844 36
zebrafish
(Danio rerio)
Actinopterygii csk 36
  • 77.88 (n)
  • 85.97 (a)
csk 37
  • 86 (a)
OneToMany
CSK (1 of 2) 37
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Csk 36
  • 64.74 (n)
  • 63.46 (a)
Csk 37
  • 25 (a)
OneToMany
Csk 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea csk-1 36
  • 53.38 (n)
  • 53.07 (a)
csk-1 37
  • 41 (a)
OneToMany
Y38H6C.20 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 37
  • 8 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9183 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5205 37
  • 50 (a)
OneToMany
Species with no ortholog for CSK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSK Gene

ENSEMBL:
Gene Tree for CSK (if available)
TreeFam:
Gene Tree for CSK (if available)

Paralogs for CSK Gene

Paralogs for CSK Gene

genes like me logo Genes that share paralogs with CSK: view

Variants for CSK Gene

Sequence variations from dbSNP and Humsavar for CSK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs7085 -- 74,803,142(+) GGAAT(C/T)GTAAT utr-variant-3-prime
rs15024 -- 74,803,143(+) GAATT(A/G)TAATA utr-variant-3-prime
rs1050308 -- 74,803,081(+) ACGTC(A/T)GTCAG utr-variant-3-prime
rs1050309 -- 74,803,084(+) TCTGT(A/C)AGGGG utr-variant-3-prime
rs1350193 -- 74,791,940(-) GGAAA(C/G)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSK Gene

Variant ID Type Subtype PubMed ID
nsv904380 CNV Loss 21882294
nsv833055 CNV Loss 17160897
dgv344e201 CNV Deletion 23290073
esv2749883 CNV Deletion 23290073
esv2749886 CNV Deletion 23290073

Relevant External Links for CSK Gene

HapMap Linkage Disequilibrium report
CSK
Human Gene Mutation Database (HGMD)
CSK

Disorders for CSK Gene

(25) Novoseek inferred disease relationships for CSK Gene

Disease -log(P) Hits PubMed IDs
breast cancer 39.6 18
colon cancer 37.5 10
osteopetrosis 35.9 1
colon carcinoma 31 2
cancer 28.7 13

Relevant External Links for CSK

Genetic Association Database (GAD)
CSK
Human Genome Epidemiology (HuGE) Navigator
CSK
Tumor Gene Database (TGDB):
CSK
genes like me logo Genes that share disorders with CSK: view

No data available for UniProtKB/Swiss-Prot for CSK Gene

Publications for CSK Gene

  1. The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. (PMID: 1377109) Armstrong E. … Alitalo K. (Cytogenet. Cell Genet. 1992) 2 3 23
  2. Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure. (PMID: 9148770) Joukov V. … Bergman M. (Biochem. J. 1997) 3 4 23
  3. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. (PMID: 11181701) Vang T. … Tasken K. (J. Exp. Med. 2001) 3 4 23
  4. beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. (PMID: 10753943) Miller W.E. … Lefkowitz R.J. (J. Biol. Chem. 2000) 3 23
  5. Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach. (PMID: 10210201) De Corte V. … Vandekerckhove J. (Protein Sci. 1999) 3 23

Products for CSK Gene

  • Addgene plasmids for CSK

Sources for CSK Gene

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