Aliases for CSK Gene
External Ids for CSK Gene
Previous GeneCards Identifiers for CSK Gene
GeneCards Summary for CSK Gene
CSK (C-Src Tyrosine Kinase) is a Protein Coding gene. Diseases associated with CSK include Colorectal Cancer and Breast Cancer. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Integrin alphaIIb beta3 signaling. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is BTK.
UniProtKB/Swiss-Prot for CSK Gene
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.