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Aliases for CSK Gene

Aliases for CSK Gene

  • C-Src Tyrosine Kinase 2 3 5
  • EC 2.7.10.2 4 63
  • Protein-Tyrosine Kinase CYL 4
  • C-Src Kinase 4
  • EC 2.7.10 63

External Ids for CSK Gene

Previous GeneCards Identifiers for CSK Gene

  • GC15M070982
  • GC15M068251
  • GC15P072650
  • GC15P072790
  • GC15P072861
  • GC15P075075
  • GC15P051872

Summaries for CSK Gene

GeneCards Summary for CSK Gene

CSK (C-Src Tyrosine Kinase) is a Protein Coding gene. Diseases associated with CSK include colorectal cancer and breast cancer. Among its related pathways are Insulin receptor recycling and VEGF Signaling. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is BTK.

UniProtKB/Swiss-Prot for CSK Gene

  • Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Gene Wiki entry for CSK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSK Gene

Genomics for CSK Gene

Regulatory Elements for CSK Gene

Enhancers for CSK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CSK on UCSC Golden Path with GeneCards custom track

Promoters for CSK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CSK on UCSC Golden Path with GeneCards custom track

Genomic Location for CSK Gene

Chromosome:
15
Start:
74,782,057 bp from pter
End:
74,803,198 bp from pter
Size:
21,142 bases
Orientation:
Plus strand

Genomic View for CSK Gene

Genes around CSK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSK Gene

Proteins for CSK Gene

  • Protein details for CSK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41240-CSK_HUMAN
    Recommended name:
    Tyrosine-protein kinase CSK
    Protein Accession:
    P41240
    Secondary Accessions:
    • Q2M3N2
    • Q6FGZ6

    Protein attributes for CSK Gene

    Size:
    450 amino acids
    Molecular mass:
    50704 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer (via SH3-domain) (PubMed:19888460). Interacts with PTPN22 (PubMed:15208781). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:11433379, PubMed:10790433, PubMed:14610046, PubMed:10838081). Interacts with SRCIN1 (PubMed:17525734). Interacts with RHOH (PubMed:20851766). Interacts (via SH2 domain) with SCIMP (PubMed:21930792).

    Three dimensional structures from OCA and Proteopedia for CSK Gene

neXtProt entry for CSK Gene

Proteomics data for CSK Gene at MOPED

Post-translational modifications for CSK Gene

  • Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
  • Ubiquitination at Lys 193, Lys 196, Lys 329, and Lys 337
  • Modification sites at PhosphoSitePlus

Other Protein References for CSK Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CSK (CSK)

Domains & Families for CSK Gene

Gene Families for CSK Gene

Graphical View of Domain Structure for InterPro Entry

P41240

UniProtKB/Swiss-Prot:

CSK_HUMAN :
  • The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Domain:
  • The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
genes like me logo Genes that share domains with CSK: view

Function for CSK Gene

Molecular function for CSK Gene

GENATLAS Biochemistry:
tyrosine kinase,SRC downregulating (putative antioncogene)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Enzyme Numbers (IUBMB) for CSK Gene

Gene Ontology (GO) - Molecular Function for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with CSK: view

Phenotypes for CSK Gene

MGI mutant phenotypes for CSK:
inferred from 5 alleles
GenomeRNAi human phenotypes for CSK:
genes like me logo Genes that share phenotypes with CSK: view

Animal Models for CSK Gene

MGI Knock Outs for CSK:

Animal Model Products

miRNA for CSK Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSK Gene

Localization for CSK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSK Gene

Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSK Gene COMPARTMENTS Subcellular localization image for CSK gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
cytoskeleton 3
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with CSK: view

Pathways & Interactions for CSK Gene

SuperPathways for CSK Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Immune System
3 ICos-ICosL Pathway in T-Helper Cell
4 Developmental Biology
5 Platelet activation, signaling and aggregation
genes like me logo Genes that share pathways with CSK: view

SIGNOR curated interactions for CSK Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006468 protein phosphorylation IEA,TAS 1945408
GO:0007417 central nervous system development IBA --
GO:0016477 cell migration IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with CSK: view

Drugs & Compounds for CSK Gene

(34) Drugs for CSK Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Staurosporine Experimental Pharma Positive, Allosteric regulator, Target Protein kinase inhibitor,potent and cell permeable 45
TG100801 Investigational Pharma Target 0
apatinib Pharma inhibitor VEGFR2 inhibitor, orally bioavailable, selective, Kinase Inhibitors 0

(28) Additional Compounds for CSK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CSK Gene

Compound Action Cas Number
Apatinib VEGFR2 inhibitor, orally bioavailable, selective 811803-05-1
genes like me logo Genes that share compounds with CSK: view

Transcripts for CSK Gene

Unigene Clusters for CSK Gene

C-src tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10: - - -

ExUns: 16d ^ 17a · 17b ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CSK Gene

GeneLoc Exon Structure for
CSK
ECgene alternative splicing isoforms for
CSK

Expression for CSK Gene

mRNA expression in normal human tissues for CSK Gene

mRNA differential expression in normal tissues according to GTEx for CSK Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for CSK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8), Lymph node (8.4), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSK Gene



SOURCE GeneReport for Unigene cluster for CSK Gene Hs.77793

mRNA Expression by UniProt/SwissProt for CSK Gene

P41240-CSK_HUMAN
Tissue specificity: Expressed in lung and macrophages.
genes like me logo Genes that share expression patterns with CSK: view

Protein tissue co-expression partners for CSK Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CSK Gene

Orthologs for CSK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSK 35
  • 93.04 (n)
  • 98.67 (a)
CSK 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSK 35
  • 93.41 (n)
  • 99.11 (a)
CSK 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csk 35
  • 90.07 (n)
  • 99.11 (a)
Csk 16
Csk 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSK 35
  • 98.3 (n)
  • 98.44 (a)
CSK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csk 35
  • 90.22 (n)
  • 98.44 (a)
oppossum
(Monodelphis domestica)
Mammalia CSK 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CSK 35
  • 84.59 (n)
  • 93.33 (a)
CSK 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSK 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csk 35
  • 74.63 (n)
  • 84.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia csk-A 35
zebrafish
(Danio rerio)
Actinopterygii csk 35
  • 77.88 (n)
  • 85.97 (a)
csk 36
  • 86 (a)
OneToMany
CSK (1 of 2) 36
  • 84 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9844 35
fruit fly
(Drosophila melanogaster)
Insecta Csk 37
  • 61 (a)
Csk 35
  • 64.74 (n)
  • 63.46 (a)
Csk 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y38H6C.20 37
  • 31 (a)
csk-1 35
  • 53.38 (n)
  • 53.07 (a)
csk-1 36
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 36
  • 8 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9183 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5205 36
  • 50 (a)
OneToMany
Species with no ortholog for CSK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSK Gene

ENSEMBL:
Gene Tree for CSK (if available)
TreeFam:
Gene Tree for CSK (if available)

Paralogs for CSK Gene

Paralogs for CSK Gene

genes like me logo Genes that share paralogs with CSK: view

Variants for CSK Gene

Sequence variations from dbSNP and Humsavar for CSK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34866753 - 74,801,568(+) GCTGG(A/G)CGGAG reference, missense
rs34616395 - 74,802,353(+) CCCTC(A/G)GGTGG reference, missense
rs35556162 - 74,802,485(+) TGAGC(A/G)CATCA reference, missense
VAR_041678 -
rs7085 -- 74,803,142(+) GGAAT(C/T)GTAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CSK Gene

Variant ID Type Subtype PubMed ID
nsv904380 CNV Loss 21882294
nsv833055 CNV Loss 17160897
dgv344e201 CNV Deletion 23290073
esv2749883 CNV Deletion 23290073
esv2749886 CNV Deletion 23290073

Variation tolerance for CSK Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSK Gene

HapMap Linkage Disequilibrium report
CSK
Human Gene Mutation Database (HGMD)
CSK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSK Gene

Disorders for CSK Gene

MalaCards: The human disease database

(2) MalaCards diseases for CSK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search CSK in MalaCards View complete list of genes associated with diseases

Relevant External Links for CSK

Genetic Association Database (GAD)
CSK
Human Genome Epidemiology (HuGE) Navigator
CSK
Tumor Gene Database (TGDB):
CSK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSK
genes like me logo Genes that share disorders with CSK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSK Gene

Publications for CSK Gene

  1. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. (PMID: 11181701) Vang T. … Tasken K. (J. Exp. Med. 2001) 3 4 23 67
  2. The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. (PMID: 1377109) Armstrong E. … Alitalo K. (Cytogenet. Cell Genet. 1992) 2 3 23
  3. Myoglobin induces vascular cell adhesion molecule-1 expression through c-Src kinase-activator protein-1/nuclear factor-kappaB pathways. (PMID: 19887846) Kim S.H. … Lee S.K. (Nephron Exp. Nephrol. 2010) 3 23
  4. Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization. (PMID: 20010872) Sirvent A. … Roche S. (Oncogene 2010) 3 23
  5. Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration. (PMID: 18482983) Mathew S. … Khurana S. (J. Biol. Chem. 2008) 3 23

Products for CSK Gene

Sources for CSK Gene

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