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Aliases for SLC2A14 Gene

Aliases for SLC2A14 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 14 2 3
  • GLUT14 3 4 6
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 Pseudogene 3 2 3
  • Glucose Transporter Type 14 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 14 3
  • SLC2A3P3 3
  • GLUT-14 4
  • GLUT3 4

External Ids for SLC2A14 Gene

Previous Symbols for SLC2A14 Gene

  • SLC2A3P3

Summaries for SLC2A14 Gene

Entrez Gene Summary for SLC2A14 Gene

  • Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC2A14 Gene

SLC2A14 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 14) is a Protein Coding gene. Among its related pathways are PAK Pathway. GO annotations related to this gene include glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A14 Gene

  • Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis.

Gene Wiki entry for SLC2A14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A14 Gene

Genomics for SLC2A14 Gene

Genomic Location for SLC2A14 Gene

Start:
7,812,512 bp from pter
End:
7,891,196 bp from pter
Size:
78,685 bases
Orientation:
Minus strand

Genomic View for SLC2A14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A14 Gene

Regulatory Elements for SLC2A14 Gene

Proteins for SLC2A14 Gene

  • Protein details for SLC2A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDB8-GTR14_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 14
    Protein Accession:
    Q8TDB8
    Secondary Accessions:
    • B3KVB5
    • B3KWW7
    • B7Z844
    • B7ZAC3
    • Q6UY84
    • Q8TDB9

    Protein attributes for SLC2A14 Gene

    Size:
    520 amino acids
    Molecular mass:
    56320 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • GLUT14 is a recent (less than 5 M year old) duplication of GLUT3

    Alternative splice isoforms for SLC2A14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A14 Gene

Proteomics data for SLC2A14 Gene at MOPED

Post-translational modifications for SLC2A14 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn67

No data available for DME Specific Peptides for SLC2A14 Gene

Domains for SLC2A14 Gene

Gene Families for SLC2A14 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

UniProtKB/Swiss-Prot:

GTR14_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.:
    • Q8TDB8
genes like me logo Genes that share domains with SLC2A14: view

Function for SLC2A14 Gene

Molecular function for SLC2A14 Gene

UniProtKB/Swiss-Prot Function: Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis.

Gene Ontology (GO) - Molecular Function for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A14: view

Phenotypes for SLC2A14 Gene

GenomeRNAi human phenotypes for SLC2A14:
genes like me logo Genes that share phenotypes with SLC2A14: view

miRNA for SLC2A14 Gene

miRTarBase miRNAs that target SLC2A14

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC2A14 Gene

Localization for SLC2A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A14 Gene COMPARTMENTS Subcellular localization image for SLC2A14 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC2A14: view

Pathways for SLC2A14 Gene

SuperPathways for SLC2A14 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with SLC2A14: view

Pathways by source for SLC2A14 Gene

1 Qiagen pathway for SLC2A14 Gene

Interacting Proteins for SLC2A14 Gene

Gene Ontology (GO) - Biological Process for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0015758 glucose transport --
GO:0015992 proton transport IBA --
genes like me logo Genes that share ontologies with SLC2A14: view

Transcripts for SLC2A14 Gene

Unigene Clusters for SLC2A14 Gene

Solute carrier family 2 (facilitated glucose transporter), member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A14 Gene

No ASD Table

Relevant External Links for SLC2A14 Gene

GeneLoc Exon Structure for
SLC2A14
ECgene alternative splicing isoforms for
SLC2A14

Expression for SLC2A14 Gene

mRNA expression in normal human tissues for SLC2A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A14 Gene

This gene is overexpressed in Testis (26.4) and Whole Blood (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A14 Gene

SOURCE GeneReport for Unigene cluster for SLC2A14 Gene Hs.655169

mRNA Expression by UniProt/SwissProt for SLC2A14 Gene

Q8TDB8-GTR14_HUMAN
Tissue specificity: Expressed mainly in testis.
genes like me logo Genes that share expressions with SLC2A14: view

Orthologs for SLC2A14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A14 36
  • 99.13 (n)
  • 98.69 (a)
SLC2A14 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A3 37
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC2A3 37
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc2a3 37
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC2A3 37
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100330897 36
  • 60.01 (n)
  • 60.69 (a)
slc2a3a 37
  • 57 (a)
ManyToMany
slc2a3b 37
  • 54 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Glut1 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C03B1.13 37
  • 20 (a)
ManyToMany
C35A11.4 37
  • 26 (a)
ManyToMany
F13B12.2 37
  • 22 (a)
ManyToMany
F14E5.1 37
  • 25 (a)
ManyToMany
F48E3.2 37
  • 20 (a)
ManyToMany
F53H8.3 37
  • 24 (a)
ManyToMany
fgt-1 37
  • 38 (a)
ManyToMany
K08F9.1 37
  • 26 (a)
ManyToMany
K08H10.6 37
  • 21 (a)
ManyToMany
R09B5.11 37
  • 35 (a)
ManyToMany
slcf-2 37
  • 17 (a)
ManyToMany
Y37A1A.3 37
  • 22 (a)
ManyToMany
Y39E4B.5 37
  • 19 (a)
ManyToMany
Y61A9LA.1 37
  • 20 (a)
ManyToMany
ZK829.9 37
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 27 (a)
ManyToMany
HXT13 39
VPS73 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 37
  • 44 (a)
OneToMany
Species with no ortholog for SLC2A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC2A14 Gene

ENSEMBL:
Gene Tree for SLC2A14 (if available)
TreeFam:
Gene Tree for SLC2A14 (if available)

Paralogs for SLC2A14 Gene

genes like me logo Genes that share paralogs with SLC2A14: view

Variants for SLC2A14 Gene

Sequence variations from dbSNP and Humsavar for SLC2A14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1043712 -- 7,827,582(-) GTGCT(A/G)GAGCT synonymous-codon, reference
rs1056992 -- 7,843,806(+) CCTCT(A/G)GATCC intron-variant
rs1128810 -- 7,871,955(+) TGAGC(A/C)CTGaa intron-variant
rs1894820 -- 7,813,930(-) TACAT(A/G)TGAGT utr-variant-3-prime
rs1894821 -- 7,813,909(-) GAGGG(G/T)GTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC2A14 Gene

Variant ID Type Subtype PubMed ID
dgv5e196 CNV Duplication 17116639
dgv6e196 CNV Duplication 17116639
esv2422393 CNV Duplication 17116639
dgv57e55 CNV Gain 17911159
dgv454e1 CNV Complex 17122850
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv1354n71 CNV Gain 21882294
dgv456e1 CNV Complex 17122850
nsv7227 OTHER Inversion 18451855
esv2745493 CNV Deletion 23290073
dgv457e1 CNV Complex 17122850
nsv596 CNV Insertion 18451855
esv2656717 CNV Deletion 23128226
nsv516107 CNV Gain+Loss 19592680
dgv58e55 CNV Gain 17911159
essv10974 CNV CNV 17122850
esv34016 CNV Loss 18971310
esv2751114 CNV Loss 17911159
nsv499606 OTHER Inversion 21111241
esv2745494 CNV Deletion 23290073
esv2671590 CNV Deletion 23128226
dgv1355n71 CNV Loss 21882294
dgv179n27 CNV Gain 19166990
dgv1356n71 CNV Gain 21882294
dgv1357n71 CNV Gain 21882294
esv2658754 CNV Deletion 23128226
dgv185e201 CNV Deletion 23290073
nsv818883 CNV Gain 17921354
nsv470264 CNV Gain 18288195
nsv898650 CNV Gain 21882294
dgv1358n71 CNV Gain 21882294
dgv1359n71 CNV Gain 21882294
dgv1360n71 CNV Gain 21882294
dgv1361n71 CNV Gain+Loss 21882294
nsv470265 CNV Loss 18288195
dgv180n27 CNV Gain 19166990
dgv186e201 CNV Deletion 23290073
esv29743 CNV Gain 19812545
dgv181n27 CNV Loss 19166990
dgv182n27 CNV Loss 19166990
nsv818884 CNV Gain 17921354
esv2422117 CNV Duplication 20811451
dgv183n27 CNV Loss 19166990
nsv826225 CNV Gain 20364138
dgv1362n71 CNV Loss 21882294
nsv442253 CNV CNV 18776908
nsv898695 CNV Loss 21882294
nsv898701 CNV Gain 21882294
dgv59e55 CNV Gain 17911159
esv2751118 CNV Gain 17911159
essv22724 CNV CNV 17122850
dgv60e55 CNV Loss 17911159
dgv458e1 CNV Complex 17122850
esv2751124 CNV Gain 17911159
nsv469100 CNV Gain 19166990
dgv1363n71 CNV Gain 21882294

Relevant External Links for SLC2A14 Gene

HapMap Linkage Disequilibrium report
SLC2A14

Disorders for SLC2A14 Gene

Relevant External Links for SLC2A14

Genetic Association Database (GAD)
SLC2A14
genes like me logo Genes that share disorders with SLC2A14: view

No data available for UniProtKB/Swiss-Prot for SLC2A14 Gene

Publications for SLC2A14 Gene

  1. GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms. (PMID: 12504846) Wu X. … Freeze H.H. (Genomics 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for SLC2A14 Gene

Sources for SLC2A14 Gene

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