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Aliases for OR2AG1 Gene

Aliases for OR2AG1 Gene

  • Olfactory Receptor Family 2 Subfamily AG Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-79 3 4
  • Olfactory Receptor 2AG3 3 4
  • OR2AG3 3 4
  • Olfactory Receptor, Family 2, Subfamily AG, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 2, Subfamily AG, Member 1 3
  • Olfactory Receptor, Family 2, Subfamily AG, Member 3 3
  • HT3 Olfactory Receptor 3
  • OR11-79 3
  • HT3 4

External Ids for OR2AG1 Gene

Previous HGNC Symbols for OR2AG1 Gene

  • OR2AG3

Previous GeneCards Identifiers for OR2AG1 Gene

  • GC11U990571
  • GC11P006771
  • GC11P006762

Summaries for OR2AG1 Gene

Entrez Gene Summary for OR2AG1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR2AG1 Gene

OR2AG1 (Olfactory Receptor Family 2 Subfamily AG Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2T1.

UniProtKB/Swiss-Prot for OR2AG1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2AG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2AG1 Gene

Genomics for OR2AG1 Gene

Regulatory Elements for OR2AG1 Gene

Enhancers for OR2AG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR2AG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2AG1 Gene

Chromosome:
11
Start:
6,785,017 bp from pter
End:
6,786,014 bp from pter
Size:
998 bases
Orientation:
Plus strand

Genomic View for OR2AG1 Gene

Genes around OR2AG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2AG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2AG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2AG1 Gene

Proteins for OR2AG1 Gene

  • Protein details for OR2AG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H205-O2AG1_HUMAN
    Recommended name:
    Olfactory receptor 2AG1
    Protein Accession:
    Q9H205
    Secondary Accessions:
    • B9EKV7
    • Q6IFG7
    • Q96R26

    Protein attributes for OR2AG1 Gene

    Size:
    316 amino acids
    Molecular mass:
    35270 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2AG1 Gene

Proteomics data for OR2AG1 Gene at MOPED

Post-translational modifications for OR2AG1 Gene

  • Glycosylation at Asn 5 and Asn 19

Other Protein References for OR2AG1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2AG1 Gene

Domains & Families for OR2AG1 Gene

Gene Families for OR2AG1 Gene

Protein Domains for OR2AG1 Gene

Suggested Antigen Peptide Sequences for OR2AG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H205

UniProtKB/Swiss-Prot:

O2AG1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2AG1: view

Function for OR2AG1 Gene

Molecular function for OR2AG1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR2AG1: view
genes like me logo Genes that share phenotypes with OR2AG1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2AG1 Gene

Localization for OR2AG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2AG1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2AG1 Gene COMPARTMENTS Subcellular localization image for OR2AG1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR2AG1: view

Pathways & Interactions for OR2AG1 Gene

genes like me logo Genes that share pathways with OR2AG1: view

Pathways by source for OR2AG1 Gene

1 BioSystems pathway for OR2AG1 Gene
1 KEGG pathway for OR2AG1 Gene

Gene Ontology (GO) - Biological Process for OR2AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2AG1: view

No data available for SIGNOR curated interactions for OR2AG1 Gene

Drugs & Compounds for OR2AG1 Gene

No Compound Related Data Available

Transcripts for OR2AG1 Gene

mRNA/cDNA for OR2AG1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR2AG1 Gene

No ASD Table

Relevant External Links for OR2AG1 Gene

GeneLoc Exon Structure for
OR2AG1
ECgene alternative splicing isoforms for
OR2AG1

Expression for OR2AG1 Gene

mRNA expression in normal human tissues for OR2AG1 Gene

Protein differential expression in normal tissues from HIPED for OR2AG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2AG1 Gene



SOURCE GeneReport for Unigene cluster for OR2AG1 Gene Hs.553608

genes like me logo Genes that share expression patterns with OR2AG1: view

Protein tissue co-expression partners for OR2AG1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR2AG1 Gene

Orthologs for OR2AG1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2AG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100125776 35
  • 86.09 (n)
  • 81.21 (a)
mouse
(Mus musculus)
Mammalia Olfr705 35
  • 83.12 (n)
  • 82.59 (a)
Olfr705 16
chimpanzee
(Pan troglodytes)
Mammalia LOC466417 35
  • 98.73 (n)
  • 97.78 (a)
rat
(Rattus norvegicus)
Mammalia Olr217 35
  • 82.59 (n)
  • 83.23 (a)
Species with no ortholog for OR2AG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2AG1 Gene

ENSEMBL:
Gene Tree for OR2AG1 (if available)
TreeFam:
Gene Tree for OR2AG1 (if available)

Paralogs for OR2AG1 Gene

(445) SIMAP similar genes for OR2AG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2AG1: view

Variants for OR2AG1 Gene

Sequence variations from dbSNP and Humsavar for OR2AG1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_053140 -
VAR_059985 -, -

Structural Variations from Database of Genomic Variants (DGV) for OR2AG1 Gene

Variant ID Type Subtype PubMed ID
nsv832060 CNV Gain 17160897
nsv467701 CNV Loss 19166990

Variation tolerance for OR2AG1 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.03; 75.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR2AG1 Gene

Disorders for OR2AG1 Gene

Relevant External Links for OR2AG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2AG1

No disorders were found for OR2AG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2AG1 Gene

Publications for OR2AG1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3
  3. Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1. (PMID: 19909339) Dooley R. … Neuhaus E.M. (FEBS J. 2009) 3
  4. A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins. (PMID: 16565291) Neuhaus E.M. … Hatt H. (Chem. Senses 2006) 3
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3

Products for OR2AG1 Gene

Sources for OR2AG1 Gene

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