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Aliases for CSF2RB Gene

Aliases for CSF2RB Gene

  • Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (Granulocyte-Macrophage) 2 3
  • GM-CSF/IL-3/IL-5 Receptor Common Beta Subunit 3 4
  • CDw131 3 4
  • IL3RB 3 4
  • SMDP5 3 6
  • IL5RB 3 4
  • Interleukin 3 Receptor/Granulocyte-Macrophage Colony Stimulating Factor 3 Receptor, Beta (High Affinity) 3
  • Colony-Stimulating Factor-2 Receptor, Beta, Low-Affinity 3
  • GM-CSF/IL-3/IL-5 Receptor Common Beta-Chain 3
  • Cytokine Receptor Common Subunit Beta 3
  • CD131 Antigen 4
  • CD131 3

External Ids for CSF2RB Gene

Previous HGNC Symbols for CSF2RB Gene

  • IL3RB

Previous GeneCards Identifiers for CSF2RB Gene

  • GC22P033932
  • GC22P035552
  • GC22P035561
  • GC22P035642
  • GC22P037309
  • GC22P020271

Summaries for CSF2RB Gene

Entrez Gene Summary for CSF2RB Gene

  • The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

GeneCards Summary for CSF2RB Gene

CSF2RB (Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (Granulocyte-Macrophage)) is a Protein Coding gene. Diseases associated with CSF2RB include surfactant metabolism dysfunction, pulmonary, 5 and congenital pulmonary alveolar proteinosis. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor activity and interleukin-5 receptor activity.

UniProtKB/Swiss-Prot for CSF2RB Gene

  • High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF2RB Gene

Genomics for CSF2RB Gene

Regulatory Elements for CSF2RB Gene

Genomic Location for CSF2RB Gene

Start:
36,913,597 bp from pter
End:
36,940,449 bp from pter
Size:
26,853 bases
Orientation:
Plus strand

Genomic View for CSF2RB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSF2RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF2RB Gene

Proteins for CSF2RB Gene

  • Protein details for CSF2RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32927-IL3RB_HUMAN
    Recommended name:
    Cytokine receptor common subunit beta
    Protein Accession:
    P32927
    Secondary Accessions:
    • Q5JZI1
    • Q6ICE0

    Protein attributes for CSF2RB Gene

    Size:
    897 amino acids
    Molecular mass:
    97336 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN (By similarity).

    Three dimensional structures from OCA and Proteopedia for CSF2RB Gene

    Alternative splice isoforms for CSF2RB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSF2RB Gene

Proteomics data for CSF2RB Gene at MOPED

Post-translational modifications for CSF2RB Gene

Other Protein References for CSF2RB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CSF2RB Gene

Domains for CSF2RB Gene

Gene Families for CSF2RB Gene

HGNC:
  • CD :CD molecules
  • FN3 :Fibronectin type III domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for CSF2RB Gene

Graphical View of Domain Structure for InterPro Entry

P32927

UniProtKB/Swiss-Prot:

IL3RB_HUMAN :
  • P32927
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
  • The box 1 motif is required for JAK interaction and/or activation
  • Contains 2 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 4 subfamily.
genes like me logo Genes that share domains with CSF2RB: view

Function for CSF2RB Gene

Molecular function for CSF2RB Gene

GENATLAS Biochemistry: colony-stimulating factor 2 (granulocyte,macrophage), interleukin 3,interleukin 5 receptor common subunit beta (high affinity),critical for the activation of both the JAK/STAT (JAK2,STAT5) and MAP kinase pathways,involved in LYN binding
UniProtKB/Swiss-Prot Function: High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor

Gene Ontology (GO) - Molecular Function for CSF2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9410898
GO:0004896 cytokine receptor activity --
GO:0004912 contributes_to interleukin-3 receptor activity TAS 9410898
GO:0004914 contributes_to interleukin-5 receptor activity TAS 9410898
GO:0005515 protein binding IPI 1495999
genes like me logo Genes that share ontologies with CSF2RB: view

Phenotypes for CSF2RB Gene

genes like me logo Genes that share phenotypes with CSF2RB: view

Animal Models for CSF2RB Gene

MGI Knock Outs for CSF2RB:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CSF2RB Gene

Localization for CSF2RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF2RB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSF2RB Gene COMPARTMENTS Subcellular localization image for CSF2RB gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSF2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 1702217
GO:0016021 integral component of membrane --
GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex TAS 9410898
genes like me logo Genes that share ontologies with CSF2RB: view

Pathways for CSF2RB Gene

genes like me logo Genes that share pathways with CSF2RB: view

Gene Ontology (GO) - Biological Process for CSF2RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 1702217
GO:0007585 respiratory gaseous exchange TAS 9410898
GO:0019221 cytokine-mediated signaling pathway --
GO:0032496 response to lipopolysaccharide IEA --
GO:0036016 cellular response to interleukin-3 TAS 9410898
genes like me logo Genes that share ontologies with CSF2RB: view

Compounds for CSF2RB Gene

(2) Drugbank Compounds for CSF2RB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
Sargramostim
  • Colony-stimulating factor
83869-56-1 target agonist
genes like me logo Genes that share compounds with CSF2RB: view

Transcripts for CSF2RB Gene

Unigene Clusters for CSF2RB Gene

Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CSF2RB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -
SP3:

Relevant External Links for CSF2RB Gene

GeneLoc Exon Structure for
CSF2RB
ECgene alternative splicing isoforms for
CSF2RB

Expression for CSF2RB Gene

mRNA expression in normal human tissues for CSF2RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSF2RB Gene

This gene is overexpressed in Whole Blood (28.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CSF2RB Gene

SOURCE GeneReport for Unigene cluster for CSF2RB Gene Hs.592192

genes like me logo Genes that share expressions with CSF2RB: view

No data available for mRNA Expression by UniProt/SwissProt for CSF2RB Gene

Orthologs for CSF2RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSF2RB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSF2RB 35
  • 98.72 (n)
  • 98.19 (a)
CSF2RB 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSF2RB 35
  • 77.06 (n)
  • 66.78 (a)
CSF2RB 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSF2RB 35
  • 77.22 (n)
  • 65.66 (a)
CSF2RB 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csf2rb 16
Csf2rb 36
  • 56 (a)
OneToMany
Csf2rb2 35
  • 69.84 (n)
  • 57.57 (a)
Csf2rb2 36
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CSF2RB 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSF2RB 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csf2rb 35
  • 70.22 (n)
  • 56.34 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 25 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
CSF2RB 35
  • 49.44 (n)
  • 37.68 (a)
lizard
(Anolis carolinensis)
Reptilia CSF2RB 36
  • 25 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii csf2rb 36
  • 21 (a)
OneToOne
Species with no ortholog for CSF2RB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CSF2RB Gene

ENSEMBL:
Gene Tree for CSF2RB (if available)
TreeFam:
Gene Tree for CSF2RB (if available)

Paralogs for CSF2RB Gene

Pseudogenes.org Pseudogenes for CSF2RB Gene

genes like me logo Genes that share paralogs with CSF2RB: view

No data available for Paralogs for CSF2RB Gene

Variants for CSF2RB Gene

Sequence variations from dbSNP and Humsavar for CSF2RB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs1803 -- 36,939,284(+) GCTGG(C/T)GGGAC utr-variant-3-prime
rs16845 - 36,930,401(+) ACCTG(C/G)AGTGC missense, reference
rs16846 -- 36,929,791(+) GTTTG(C/T)TGGGA reference, synonymous-codon
rs131840 -- 36,937,752(-) TGTCC(C/T)GGTCC reference, synonymous-codon, downstream-variant-500B
rs131841 -- 36,938,790(+) GGGAG(A/T)TGGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CSF2RB Gene

Variant ID Type Subtype PubMed ID
dgv1405e1 CNV Complex 17122850
nsv915010 CNV Loss 21882294

Relevant External Links for CSF2RB Gene

HapMap Linkage Disequilibrium report
CSF2RB
Human Gene Mutation Database (HGMD)
CSF2RB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF2RB Gene

Disorders for CSF2RB Gene

(1) OMIM Diseases for CSF2RB Gene (138981)

UniProtKB/Swiss-Prot

IL3RB_HUMAN
  • Pulmonary surfactant metabolism dysfunction 5 (SMDP5) [MIM:614370]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269 PubMed:21075760}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CSF2RB Gene

Relevant External Links for CSF2RB

Genetic Association Database (GAD)
CSF2RB
Human Genome Epidemiology (HuGE) Navigator
CSF2RB
genes like me logo Genes that share disorders with CSF2RB: view

Publications for CSF2RB Gene

  1. An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. (PMID: 16754968) Carr P.D. … Young I.G. (Acta Crystallogr. F 2006) 3 4 23
  2. Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population. (PMID: 18547720) Sun S. … Zhang X.Y. (Neurosci. Lett. 2008) 3 23 48
  3. Localization of the human GM-CSF receptor beta chain gene (CSF2RB) to chromosome 22q12.2-->q13.1. (PMID: 1424804) Shen Y. … Gough N.M. (Cytogenet. Cell Genet. 1992) 2 3 25
  4. The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony- stimulating factor, interleukin-3 and interleukin-5. (PMID: 10736232) Mulhern T.D. … Bagley C.J. (J. Mol. Biol. 2000) 3 4
  5. Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist. (PMID: 10753826) Rossjohn J. … Bagley C.J. (Blood 2000) 3 4

Products for CSF2RB Gene

Sources for CSF2RB Gene

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