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Aliases for CSF2 Gene

Aliases for CSF2 Gene

  • Colony Stimulating Factor 2 2 3 5
  • Sargramostim 2 3 4
  • Molgramostin 2 3 4
  • Colony Stimulating Factor 2 (Granulocyte-Macrophage) 2 3
  • GMCSF 3 4
  • CSF 3 4
  • Granulocyte-Macrophage Colony Stimulating Factor 2
  • Granulocyte Macrophage-Colony Stimulating Factor 3
  • Granulocyte-Macrophage Colony-Stimulating Factor 3
  • Colony-Stimulating Factor 4
  • GM-CSF 4

External Ids for CSF2 Gene

Previous GeneCards Identifiers for CSF2 Gene

  • GC05P130931
  • GC05P131856
  • GC05P131440
  • GC05P131485
  • GC05P131437
  • GC05P131409
  • GC05P126601

Summaries for CSF2 Gene

Entrez Gene Summary for CSF2 Gene

  • The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSF2 Gene

CSF2 (Colony Stimulating Factor 2) is a Protein Coding gene. Diseases associated with CSF2 include Mucositis and Candida Glabrata. Among its related pathways are RET signaling and IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. GO annotations related to this gene include cytokine activity and granulocyte macrophage colony-stimulating factor receptor binding.

UniProtKB/Swiss-Prot for CSF2 Gene

  • Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

Gene Wiki entry for CSF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF2 Gene

Genomics for CSF2 Gene

Regulatory Elements for CSF2 Gene

Enhancers for CSF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G132070 1.2 FANTOM5 ENCODE 26 -3.0 -3020 0.4 ATF1 TCF12 ZNF766 GATA2 EGR1 FOS CREM ZEB2 ELF1 ZNF592 CSF2 IL3 P4HA2 P4HA2-AS1 LOC107987500 PDLIM4 IL5 FNIP1 RAPGEF6 SLC22A4
GH05G132110 0.6 FANTOM5 dbSUPER 44.5 +37.3 37309 0.3 ATF2 IL3 CSF2 IL5 ENSG00000253067 P4HA2-AS1 LOC107987500 RAD50 RAPGEF6 ENSG00000227616
GH05G132100 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +29.2 29199 4.5 PKNOX1 ATF1 ARNT ZNF121 ZNF766 ELK1 GATA2 FOS JUNB NCOA1 SLC22A5 P4HA2 ENSG00000253067 CSF2 IL3 LOC107987500 P4HA2-AS1 SLC22A4 RAPGEF6 IRF1
GH05G132099 1.3 FANTOM5 ENCODE dbSUPER 13.5 +25.6 25622 0.9 PKNOX1 USF1 TBL1XR1 BACH1 EBF1 NFYB EED ETV6 IKZF2 CREM P4HA2 CSF2 IL3 LOC107987500 P4HA2-AS1 RAPGEF6 IRF1 FNIP1 ENSG00000253067 ENSG00000227616
GH05G132098 1.3 ENCODE dbSUPER 12.3 +24.6 24573 0.2 PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 KLF13 KDM4B CAVIN1 CSF2 IL3 LOC107987500 P4HA2-AS1 ENSG00000253067 ENSG00000227616
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CSF2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CSF2 gene promoter:

Genomic Location for CSF2 Gene

Chromosome:
5
Start:
132,073,790 bp from pter
End:
132,076,170 bp from pter
Size:
2,381 bases
Orientation:
Plus strand

Genomic View for CSF2 Gene

Genes around CSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF2 Gene

Proteins for CSF2 Gene

  • Protein details for CSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04141-CSF2_HUMAN
    Recommended name:
    Granulocyte-macrophage colony-stimulating factor
    Protein Accession:
    P04141
    Secondary Accessions:
    • Q14CE8
    • Q2VPI8
    • Q8NFI6

    Protein attributes for CSF2 Gene

    Size:
    144 amino acids
    Molecular mass:
    16295 Da
    Quaternary structure:
    • Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.

    Three dimensional structures from OCA and Proteopedia for CSF2 Gene

neXtProt entry for CSF2 Gene

Post-translational modifications for CSF2 Gene

  • Glycosylation at isoforms=22, Ser24, Ser26, isoforms=27, Asn44, and Asn54
  • Modification sites at PhosphoSitePlus

Other Protein References for CSF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSF2 Gene

Domains & Families for CSF2 Gene

Suggested Antigen Peptide Sequences for CSF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04141

UniProtKB/Swiss-Prot:

CSF2_HUMAN :
  • Belongs to the GM-CSF family.
Family:
  • Belongs to the GM-CSF family.
genes like me logo Genes that share domains with CSF2: view

No data available for Gene Families for CSF2 Gene

Function for CSF2 Gene

Molecular function for CSF2 Gene

GENATLAS Biochemistry:
colony-stimulating factor 2,16.3kDa,(granulocyte-macrophage)
UniProtKB/Swiss-Prot Function:
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

LifeMap Function Summary for CSF2 Gene

CSF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for CSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005125 cytokine activity IDA,IEA 3925454
GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding IEA,TAS --
GO:0005515 protein binding IPI 18692472
genes like me logo Genes that share ontologies with CSF2: view
genes like me logo Genes that share phenotypes with CSF2: view

Animal Models for CSF2 Gene

MGI Knock Outs for CSF2:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CSF2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CSF2 Gene

Localization for CSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSF2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2
endoplasmic reticulum 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for CSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IDA 3925454
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CSF2: view

Pathways & Interactions for CSF2 Gene

SuperPathway Contained pathways
1 RET signaling
2 PEDF Induced Signaling
3 ERK Signaling
4 G beta-gamma signalling through PI3Kgamma
5 Signaling by GPCR
genes like me logo Genes that share pathways with CSF2: view

SIGNOR curated interactions for CSF2 Gene

Activates:

Gene Ontology (GO) - Biological Process for CSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001821 histamine secretion IEA --
GO:0001892 embryonic placenta development IEA --
GO:0006955 immune response IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with CSF2: view

Drugs & Compounds for CSF2 Gene

(87) Drugs for CSF2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KB002 Investigational Pharma Target 0
GM-CSF Pharma 0
MOR103 Pharma 0
MT203 Pharma 0

(61) Additional Compounds for CSF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSF2: view

Transcripts for CSF2 Gene

mRNA/cDNA for CSF2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSF2 Gene

Colony stimulating factor 2 (granulocyte-macrophage):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CSF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSF2 Gene

No ASD Table

Relevant External Links for CSF2 Gene

GeneLoc Exon Structure for
CSF2
ECgene alternative splicing isoforms for
CSF2

Expression for CSF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSF2 Gene

This gene is overexpressed in Lung (x19.8) and Small Intestine - Terminal Ileum (x8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CSF2 Gene



Protein tissue co-expression partners for CSF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CSF2 Gene:

CSF2

SOURCE GeneReport for Unigene cluster for CSF2 Gene:

Hs.1349

Evidence on tissue expression from TISSUES for CSF2 Gene

  • Blood(4.8)
  • Bone marrow(3.5)
  • Spleen(3.5)
  • Lymph node(3.4)
  • Lung(2.9)
  • Skin(2.5)
  • Heart(2.3)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with CSF2: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSF2 Gene

Orthologs for CSF2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CSF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSF2 34 35
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia CSF2 34 35
  • 82.98 (n)
dog
(Canis familiaris)
Mammalia CSF2 34 35
  • 81.48 (n)
rat
(Rattus norvegicus)
Mammalia Csf2 34
  • 74.31 (n)
mouse
(Mus musculus)
Mammalia Csf2 34 16 35
  • 71.16 (n)
Species where no ortholog for CSF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSF2 Gene

ENSEMBL:
Gene Tree for CSF2 (if available)
TreeFam:
Gene Tree for CSF2 (if available)

Paralogs for CSF2 Gene

No data available for Paralogs for CSF2 Gene

Variants for CSF2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CSF2 Gene

CSF2_HUMAN-P04141
Variant Ile-117 may be a risk factor for atopic asthma.

Sequence variations from dbSNP and Humsavar for CSF2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000494540 -- 132,072,999(+) TTCTG(A/G)GGGCT upstream-variant-2KB
rs1002165189 -- 132,074,623(+) TGGGC(A/G)GGGCA intron-variant
rs1002685758 -- 132,072,358(+) ACAGG(G/T)AAACT upstream-variant-2KB
rs1002820215 -- 132,072,075(+) CTTCC(C/G)TGCCC upstream-variant-2KB
rs1003808899 -- 132,073,466(+) TCCCA(C/T)GCCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CSF2 Gene

Variant ID Type Subtype PubMed ID
esv25745 CNV gain 19812545
nsv1024604 CNV gain 25217958

Variation tolerance for CSF2 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.70; 86.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CSF2 Gene

Human Gene Mutation Database (HGMD)
CSF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSF2

Disorders for CSF2 Gene

MalaCards: The human disease database

(83) MalaCards diseases for CSF2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mucositis
  • inflammatory disease of mucous membrane
candida glabrata
engraftment syndrome
pulmonary alveolar proteinosis
stomatitis
- elite association - COSMIC cancer census association via MalaCards
Search CSF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CSF2

Genetic Association Database (GAD)
CSF2
Human Genome Epidemiology (HuGE) Navigator
CSF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CSF2
genes like me logo Genes that share disorders with CSF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSF2 Gene

Publications for CSF2 Gene

  1. Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD. (PMID: 18353856) He J.Q. … Sandford A.J. (Eur. Respir. J. 2008) 3 22 46 64
  2. Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. (PMID: 3898082) Cantrell M.A. … Cosman D. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 64
  3. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PMID: 22446963) Okada Y. … Yamamoto K. (Nat. Genet. 2012) 3 46 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64

Products for CSF2 Gene

Sources for CSF2 Gene

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