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Aliases for CSF1 Gene

Aliases for CSF1 Gene

  • Colony Stimulating Factor 1 (Macrophage) 2 3
  • MCSF 3 4 6
  • Lanimostim 3 4
  • CSF-1 3 4
  • Macrophage Colony-Stimulating Factor 1 3
  • M-CSF 4

External Ids for CSF1 Gene

Previous GeneCards Identifiers for CSF1 Gene

  • GC01U990031
  • GC01P109555
  • GC01P109752
  • GC01P110165
  • GC01P110254
  • GC01P110453
  • GC01P108322

Summaries for CSF1 Gene

Entrez Gene Summary for CSF1 Gene

  • The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for CSF1 Gene

CSF1 (Colony Stimulating Factor 1 (Macrophage)) is a Protein Coding gene. Diseases associated with CSF1 include tenosynovial giant cell tumor and neutropenia, cyclic. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include protein homodimerization activity and growth factor activity.

UniProtKB/Swiss-Prot for CSF1 Gene

  • Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Gene Wiki entry for CSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSF1 Gene

Genomics for CSF1 Gene

Regulatory Elements for CSF1 Gene

Transcription factor binding sites by QIAGEN in the CSF1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CSF1 Gene

Start:
109,910,242 bp from pter
End:
109,930,994 bp from pter
Size:
20,753 bases
Orientation:
Plus strand

Genomic View for CSF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF1 Gene

Proteins for CSF1 Gene

  • Protein details for CSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09603-CSF1_HUMAN
    Recommended name:
    Macrophage colony-stimulating factor 1
    Protein Accession:
    P09603
    Secondary Accessions:
    • A8K6J5
    • Q13130
    • Q14086
    • Q14806
    • Q5VVF3
    • Q5VVF4
    • Q9UQR8

    Protein attributes for CSF1 Gene

    Size:
    554 amino acids
    Molecular mass:
    60179 Da
    Quaternary structure:
    • Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

    Three dimensional structures from OCA and Proteopedia for CSF1 Gene

    Alternative splice isoforms for CSF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSF1 Gene

Proteomics data for CSF1 Gene at MOPED

Post-translational modifications for CSF1 Gene

  • N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.
  • Glycosylation at Asn154, Asn172, Ser256, Thr257, Thr266, Thr363, Thr365, Thr376, Thr383, Thr387, Ser391, Ser428, Ser430, Ser431, Ser433, Ser451, Ser461, Ser473, and Thr477
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

No data available for DME Specific Peptides for CSF1 Gene

Domains for CSF1 Gene

Protein Domains for CSF1 Gene

Suggested Antigen Peptide Sequences for CSF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CSF1 Gene

Function for CSF1 Gene

Molecular function for CSF1 Gene

GENATLAS Biochemistry:
colony-stimulating factor 1,60kDa,(macrophage),expressed in fibroblast,endothelium,epithelium with two alternatively spliced isoforms,homodimerizing
UniProtKB/Swiss-Prot Function:
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

LifeMap Function Summary for CSF1 Gene

It affects the following cells:
CSF1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for CSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 10652277
GO:0005157 macrophage colony-stimulating factor receptor binding TAS 2460758
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity NAS 1791839
GO:0042803 protein homodimerization activity IDA 3264878
genes like me logo Genes that share ontologies with CSF1: view
genes like me logo Genes that share phenotypes with CSF1: view

Animal Models for CSF1 Gene

MGI Knock Outs for CSF1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CSF1 Gene

Localization for CSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF1 Gene

Cell membrane; Single-pass type I membrane protein.
Processed macrophage colony-stimulating factor 1: Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CSF1 Gene COMPARTMENTS Subcellular localization image for CSF1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 2460758
GO:0005886 plasma membrane IEA --
GO:0016020 membrane NAS 2460758
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IEA --
genes like me logo Genes that share ontologies with CSF1: view

Pathways for CSF1 Gene

genes like me logo Genes that share pathways with CSF1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001954 positive regulation of cell-matrix adhesion ISS 18566389
GO:0002158 osteoclast proliferation IEA --
GO:0003006 developmental process involved in reproduction ISS 19017797
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with CSF1: view

Compounds for CSF1 Gene

(142) Novoseek inferred chemical compound relationships for CSF1 Gene

Compound -log(P) Hits PubMed IDs
rantes 62.2 42
tyrosine 61.6 128
tartrate 53.2 2
gm-csf 50.7 11
pixy321 50.2 3
genes like me logo Genes that share compounds with CSF1: view

Transcripts for CSF1 Gene

Unigene Clusters for CSF1 Gene

Colony stimulating factor 1 (macrophage):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CSF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - -
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for CSF1 Gene

GeneLoc Exon Structure for
CSF1
ECgene alternative splicing isoforms for
CSF1

Expression for CSF1 Gene

mRNA expression in normal human tissues for CSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CSF1 Gene

This gene is overexpressed in Urine (53.7) and Cerebrospinal fluid (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CSF1 Gene

SOURCE GeneReport for Unigene cluster for CSF1 Gene Hs.173894

genes like me logo Genes that share expressions with CSF1: view

Expression partners for CSF1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CSF1 Gene

Orthologs for CSF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CSF1 35
  • 84.39 (n)
  • 75.59 (a)
CSF1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSF1 35
  • 82.07 (n)
  • 74.31 (a)
CSF1 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csf1 35
  • 80.58 (n)
  • 70.6 (a)
Csf1 16
Csf1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CSF1 35
  • 99.45 (n)
  • 99.72 (a)
CSF1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csf1 35
  • 78.85 (n)
  • 67.16 (a)
oppossum
(Monodelphis domestica)
Mammalia CSF1 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSF1 36
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSF1 36
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSF1 36
  • 37 (a)
OneToOne
Species with no ortholog for CSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CSF1 Gene

ENSEMBL:
Gene Tree for CSF1 (if available)
TreeFam:
Gene Tree for CSF1 (if available)

Paralogs for CSF1 Gene

No data available for Paralogs for CSF1 Gene

Variants for CSF1 Gene

Sequence variations from dbSNP and Humsavar for CSF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs333946 -- 109,930,106(+) GCTGA(A/G)CAGGT utr-variant-3-prime
rs333947 -- 109,928,142(+) ACAAA(A/G)CGTCC intron-variant
rs333948 -- 109,927,970(+) TTTAT(A/G)GTTCC intron-variant
rs333951 -- 109,909,068(-) GAGGA(A/G)CGTAA upstream-variant-2KB
rs333952 -- 109,912,683(-) GGGAC(C/T)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CSF1 Gene

Variant ID Type Subtype PubMed ID
esv2658285 CNV Deletion 23128226

Relevant External Links for CSF1 Gene

HapMap Linkage Disequilibrium report
CSF1
Human Gene Mutation Database (HGMD)
CSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF1 Gene

Disorders for CSF1 Gene

UniProtKB/Swiss-Prot

CSF1_HUMAN
  • Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.
  • Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.

(3) University of Copenhagen DISEASES for CSF1 Gene

(90) Novoseek inferred disease relationships for CSF1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 76.4 115
osteopetrosis 67.5 15
tumors 65.1 219
bone destruction 56 2
leukemia 55.8 66

Relevant External Links for CSF1

Genetic Association Database (GAD)
CSF1
Human Genome Epidemiology (HuGE) Navigator
CSF1
genes like me logo Genes that share disorders with CSF1: view

No data available for OMIM and Genatlas for CSF1 Gene

Publications for CSF1 Gene

  1. Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. (PMID: 1455231) Pandit J. … Kim S.H. (Science 1992) 3 4 23
  2. Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis. (PMID: 1739124) Clinton S.K. … Libby P. (Am. J. Pathol. 1992) 3 23
  3. Analysis of the synergistic stimulation of mouse macrophage proliferation by macrophage colony-stimulating factor (CSF-1) and tumor necrosis factor alpha (TNF-alpha). (PMID: 8336080) Guilbert L.J. … Garcia-Lloret M. (J. Leukoc. Biol. 1993) 3 23
  4. Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1. (PMID: 2145044) Stein J. … Rettenmier C.W. (Blood 1990) 3 23
  5. The promoter of macrophage colony-stimulating factor receptor is active in astrocytes. (PMID: 9147389) Tkachuk M. … Gisler R.H. (Neurosci. Lett. 1997) 3 23

Products for CSF1 Gene

Sources for CSF1 Gene

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