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Aliases for MAPK14 Gene

Aliases for MAPK14 Gene

  • Mitogen-Activated Protein Kinase 14 2 3 5
  • Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein 3 4
  • Mitogen-Activated Protein Kinase P38 Alpha 3 4
  • MAX-Interacting Protein 2 3 4
  • CSAID-Binding Protein 3 4
  • MAP Kinase P38 Alpha 3 4
  • P38 MAP Kinase 2 3
  • MAP Kinase 14 3 4
  • EC 2.7.11.24 4 63
  • SAPK2A 3 4
  • CSBP1 3 4
  • CSBP2 3 4
  • CSPB1 3 4
  • CSBP 3 4
  • Mxi2 3 4
  • Cytokine Suppressive Anti-Inflammatory Drug Binding Protein 3
  • P38 Mitogen Activated Protein Kinase 3
  • Stress-Activated Protein Kinase 2A 3
  • Stress-Activated Protein Kinase 2a 4
  • Csaids Binding Protein 3
  • MAP Kinase Mxi2 3
  • MAP Kinase MXI2 4
  • P38alpha Exip 3
  • EC 2.7.11 63
  • P38ALPHA 3
  • MAPK 14 4
  • PRKM14 3
  • PRKM15 3
  • EXIP 3
  • P38 3
  • RK 3

External Ids for MAPK14 Gene

Previous HGNC Symbols for MAPK14 Gene

  • CSPB1
  • CSBP1
  • CSBP2

Previous GeneCards Identifiers for MAPK14 Gene

  • GC06P035997
  • GC06P036042
  • GC06P036103
  • GC06P035715
  • GC06P035995
  • GC06P036834
  • GC06P036915

Summaries for MAPK14 Gene

Entrez Gene Summary for MAPK14 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK14 Gene

MAPK14 (Mitogen-Activated Protein Kinase 14) is a Protein Coding gene. Diseases associated with MAPK14 include Patellar Tendinitis and Lumbosacral Lipoma. Among its related pathways are RANK Signaling in Osteoclasts and IL-2 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK14 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at Thr-113.

Tocris Summary for MAPK14 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

Gene Wiki entry for MAPK14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK14 Gene

Genomics for MAPK14 Gene

Regulatory Elements for MAPK14 Gene

Enhancers for MAPK14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAPK14 on UCSC Golden Path with GeneCards custom track

Promoters for MAPK14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPK14 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAPK14 gene promoter:

Genomic Location for MAPK14 Gene

Chromosome:
6
Start:
36,027,635 bp from pter
End:
36,111,236 bp from pter
Size:
83,602 bases
Orientation:
Plus strand

Genomic View for MAPK14 Gene

Genes around MAPK14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK14 Gene

Proteins for MAPK14 Gene

  • Protein details for MAPK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16539-MK14_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 14
    Protein Accession:
    Q16539
    Secondary Accessions:
    • A6ZJ92
    • A8K6P4
    • B0LPH0
    • B5TY32
    • O60776
    • Q13083
    • Q14084
    • Q8TDX0

    Protein attributes for MAPK14 Gene

    Size:
    360 amino acids
    Molecular mass:
    41293 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B. Interacts with PPM1D. Interacts with CDK5RAP3; recruits PPM1D to MAPK14 and may regulate its dephosphorylation (PubMed:21283629).

    Three dimensional structures from OCA and Proteopedia for MAPK14 Gene

    Alternative splice isoforms for MAPK14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK14 Gene

Proteomics data for MAPK14 Gene at MOPED

Post-translational modifications for MAPK14 Gene

  • Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3.
  • Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16. PPM1D also mediates dephosphorylation and inactivation of MAPK14 (PubMed:21283629).
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.
  • Ubiquitination at Lys 15, Lys 45, Lys 139, Lys 152, Lys 165, and Lys 233
  • Modification sites at PhosphoSitePlus

Domains & Families for MAPK14 Gene

Graphical View of Domain Structure for InterPro Entry

Q16539

UniProtKB/Swiss-Prot:

MK14_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK14: view

Function for MAPK14 Gene

Molecular function for MAPK14 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase14
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1. Activation occurs through dual phosphorylation of Thr-180 and Tyr-182 by either of two dual specificity kinases, MAP2K3/MKK3 or MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1-mediated autophosphorylation. MAPK14 phosphorylated on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on Thr-180, whereas MAPK14 phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis, Tyr-182 may be required for auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an alternative activation pathway in response to TCR signaling in T-cells. This alternative pathway is inhibited by GADD45A. Inhibited by dual specificity phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6. SB203580 is an inhibitor of MAPK14.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at Thr-113.

Enzyme Numbers (IUBMB) for MAPK14 Gene

Gene Ontology (GO) - Molecular Function for MAPK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004708 MAP kinase kinase activity TAS 10706854
genes like me logo Genes that share ontologies with MAPK14: view
genes like me logo Genes that share phenotypes with MAPK14: view

Animal Models for MAPK14 Gene

MGI Knock Outs for MAPK14:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK14

CRISPR Products

miRNA for MAPK14 Gene

miRTarBase miRNAs that target MAPK14

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK14 Gene

Localization for MAPK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK14 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK14 Gene COMPARTMENTS Subcellular localization image for MAPK14 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3
mitochondrion 3
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
lysosome 1

No data available for Gene Ontology (GO) - Cellular Components for MAPK14 Gene

Pathways & Interactions for MAPK14 Gene

SuperPathways for MAPK14 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 Toll-Like receptor Signaling Pathways
4 4-1BB Pathway
5 Interleukin-3, 5 and GM-CSF signaling
genes like me logo Genes that share pathways with MAPK14: view

Pathways by source for MAPK14 Gene

Gene Ontology (GO) - Biological Process for MAPK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IEA --
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0000902 cell morphogenesis IEA --
GO:0001502 cartilage condensation IEA --
genes like me logo Genes that share ontologies with MAPK14: view

Drugs & Compounds for MAPK14 Gene

(135) Drugs for MAPK14 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
SB220025 Experimental Pharma Target 0
BIRB 796 Experimental Pharma Target 0
[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE Experimental Pharma Target 0
[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE Experimental Pharma Target 0

(84) Additional Compounds for MAPK14 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
SB 202190
152121-30-7
SB 203580 hydrochloride
869185-85-3
SB 239063
193551-21-2
SKF 86002 dihydrochloride
116339-68-5

(5) Tocris Compounds for MAPK14 Gene

Compound Action Cas Number
SB 202190 Potent, selective inhibitor of p38 MAPK 152121-30-7
SB 203580 Selective inhibitor of p38 MAPK 152121-47-6
SB 203580 hydrochloride Selective inhibitor of p38 MAPK; water-soluble 869185-85-3
SB 239063 Potent, selective p38 MAPK inhibitor; orally active 193551-21-2
SKF 86002 dihydrochloride p38 MAPK inhibitor; anti-inflammatory agent 116339-68-5

(11) ApexBio Compounds for MAPK14 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) P38 MAPK inhibitor,cell permeable and highly selective 285983-48-4
Losmapimod 585543-15-3
LY2228820 P38 MAP kinase inhibitor 862507-23-1
PH-797804 P38 MAP kinase inhibitor, potent and selective 586379-66-0
Piperine MAPK inhibitor 94-62-2
SB 203580 P38 MAP kinase inhibitor 152121-47-6
SB202190 (FHPI) P38 MAPK inhibitor 152121-30-7
Skepinone-L P38-MAPK inhibitor,potent and selective 1221485-83-1
TAK-715 p38 MAPK inhibitor 303162-79-0
VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive 479543-46-9
VX-745 P38α inhibitor,highly potent and selective 209410-46-8
genes like me logo Genes that share compounds with MAPK14: view

Drug Products

Transcripts for MAPK14 Gene

Unigene Clusters for MAPK14 Gene

Mitogen-activated protein kinase 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK14 Gene

No ASD Table

Relevant External Links for MAPK14 Gene

GeneLoc Exon Structure for
MAPK14
ECgene alternative splicing isoforms for
MAPK14

Expression for MAPK14 Gene

mRNA expression in normal human tissues for MAPK14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK14 Gene

This gene is overexpressed in Whole Blood (x9.8).

Protein differential expression in normal tissues from HIPED for MAPK14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.6) and Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK14 Gene



SOURCE GeneReport for Unigene cluster for MAPK14 Gene Hs.485233

mRNA Expression by UniProt/SwissProt for MAPK14 Gene

Q16539-MK14_HUMAN
Tissue specificity: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
genes like me logo Genes that share expression patterns with MAPK14: view

Protein tissue co-expression partners for MAPK14 Gene

- Elite partner

Orthologs for MAPK14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK14 35
  • 95.28 (n)
  • 100 (a)
MAPK14 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK14 35
  • 92.31 (n)
  • 95.83 (a)
MAPK14 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk14 35
  • 90 (n)
  • 99.44 (a)
Mapk14 16
Mapk14 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPK14 35
  • 99.72 (n)
  • 100 (a)
MAPK14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk14 35
  • 90 (n)
  • 99.17 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPK14 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK14 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPK14 35
  • 82.04 (n)
  • 92.5 (a)
MAPK14 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK14 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk14 35
  • 75.67 (n)
  • 86.63 (a)
Str.15151 35
African clawed frog
(Xenopus laevis)
Amphibia mapk14a-prov 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
mapk14a 35
  • 77.69 (n)
  • 89.44 (a)
mapk14a 36
  • 89 (a)
OneToMany
mapk14b 36
  • 92 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mpk2 37
  • 68 (a)
p38b 37
  • 69 (a)
p38c 37
  • 44 (a)
p38b 35
  • 64.19 (n)
  • 70 (a)
Mpk2 36
  • 66 (a)
ManyToMany
p38b 36
  • 68 (a)
ManyToMany
p38c 36
  • 44 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012148 35
  • 63.95 (n)
  • 69.19 (a)
worm
(Caenorhabditis elegans)
Secernentea C49C3.10a 37
  • 32 (a)
C49C3.10b 37
  • 34 (a)
F09C12.2 37
  • 41 (a)
pmk-1 37
  • 65 (a)
pmk-3 37
  • 43 (a)
Y51B9A.9 37
  • 34 (a)
pmk-1 35
  • 60.11 (n)
  • 64.04 (a)
pmk-1 36
  • 60 (a)
ManyToMany
pmk-2 36
  • 48 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR048C 35
  • 56.18 (n)
  • 53.24 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20053g 35
  • 53.57 (n)
  • 52.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 35
  • 56.15 (n)
  • 53.57 (a)
HOG1 36
  • 42 (a)
OneToMany
HOG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK3 35
  • 54 (n)
  • 46.49 (a)
rice
(Oryza sativa)
Liliopsida Os03g0285800 35
  • 53.21 (n)
  • 47.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6890 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07024 35
  • 54.86 (n)
  • 52.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sty1 35
  • 55.85 (n)
  • 55.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for MAPK14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK14 Gene

ENSEMBL:
Gene Tree for MAPK14 (if available)
TreeFam:
Gene Tree for MAPK14 (if available)

Paralogs for MAPK14 Gene

Paralogs for MAPK14 Gene

genes like me logo Genes that share paralogs with MAPK14: view

Variants for MAPK14 Gene

Sequence variations from dbSNP and Humsavar for MAPK14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_042270 A gastric adenocarcinoma sample
VAR_042271 A lung adenocarcinoma sample
rs45496794 - 36,108,392(+) CTATG(A/G)TGAAG reference, missense, utr-variant-3-prime
rs1050576 -- 36,096,013(+) TTTTA(A/C)GACTC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1050577 -- 36,096,015(+) TTAAG(A/T)CTCGT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAPK14 Gene

Variant ID Type Subtype PubMed ID
nsv528432 CNV Gain 19592680
esv269948 CNV Insertion 20981092
esv2731916 CNV Deletion 23290073
esv2399081 CNV Deletion 18987734
esv2731919 CNV Deletion 23290073

Variation tolerance for MAPK14 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAPK14 Gene

Disorders for MAPK14 Gene

MalaCards: The human disease database

(15) MalaCards diseases for MAPK14 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
patellar tendinitis
  • patellar tendonitis
lumbosacral lipoma
myocardial infarction
  • myocardial infarction, protection against
doxorubicin induced cardiomyopathy
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAPK14

Genetic Association Database (GAD)
MAPK14
Human Genome Epidemiology (HuGE) Navigator
MAPK14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK14
genes like me logo Genes that share disorders with MAPK14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK14 Gene

Publications for MAPK14 Gene

  1. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. (PMID: 7997261) Lee J.C. … Young P.R. (Nature 1994) 2 3 4 67
  2. Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways. (PMID: 19520919) Wang T. … Garcia J.G. (Am. J. Respir. Cell Mol. Biol. 2010) 3 23
  3. Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells. (PMID: 19676104) Rubio S. … EstAcvez F. (Mol. Carcinog. 2010) 3 23
  4. Interferon-alpha induces the growth inhibition of human T-cell leukaemia line Jurkat through p38alpha and p38beta. (PMID: 20053787) Lee W.H. … Huang H.M. (J. Biochem. 2010) 3 23
  5. TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase. (PMID: 20070945) Su L.T. … Runnels L.W. (J. Mol. Biol. 2010) 3 23

Products for MAPK14 Gene

Sources for MAPK14 Gene

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