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Aliases for MAPK14 Gene

Aliases for MAPK14 Gene

  • Mitogen-Activated Protein Kinase 14 2 3
  • CSBP1 3 4 6
  • Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein 3 4
  • Mitogen-Activated Protein Kinase P38 Alpha 3 4
  • MAX-Interacting Protein 2 3 4
  • CSAID-Binding Protein 3 4
  • MAP Kinase P38 Alpha 3 4
  • P38 MAP Kinase 2 3
  • MAP Kinase 14 3 4
  • EC 2.7.11.24 4 63
  • SAPK2A 3 4
  • CSBP2 3 4
  • CSPB1 3 4
  • CSBP 3 4
  • Mxi2 3 4
  • Cytokine Suppressive Anti-Inflammatory Drug Binding Protein 3
  • P38 Mitogen Activated Protein Kinase 3
  • Stress-Activated Protein Kinase 2A 3
  • Stress-Activated Protein Kinase 2a 4
  • Csaids Binding Protein 3
  • MAP Kinase Mxi2 3
  • MAP Kinase MXI2 4
  • P38alpha Exip 3
  • EC 2.7.11 63
  • P38ALPHA 3
  • MAPK 14 4
  • PRKM14 3
  • PRKM15 3
  • EXIP 3
  • P38 3
  • RK 3

External Ids for MAPK14 Gene

Previous HGNC Symbols for MAPK14 Gene

  • CSPB1
  • CSBP1
  • CSBP2

Previous GeneCards Identifiers for MAPK14 Gene

  • GC06P035997
  • GC06P036042
  • GC06P036103
  • GC06P035715
  • GC06P035995

Summaries for MAPK14 Gene

Entrez Gene Summary for MAPK14 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK14 Gene

MAPK14 (Mitogen-Activated Protein Kinase 14) is a Protein Coding gene. Diseases associated with MAPK14 include alexander disease and influenza. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK14 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at Thr-113.

Tocris Summary for MAPK14 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases (ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7), ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38 MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and inflammation (p38).

Gene Wiki entry for MAPK14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK14 Gene

Genomics for MAPK14 Gene

Regulatory Elements for MAPK14 Gene

Transcription factor binding sites by QIAGEN in the MAPK14 gene promoter:

Genomic Location for MAPK14 Gene

Start:
36,027,677 bp from pter
End:
36,111,236 bp from pter
Size:
83,560 bases
Orientation:
Plus strand

Genomic View for MAPK14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK14 Gene

Proteins for MAPK14 Gene

  • Protein details for MAPK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16539-MK14_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 14
    Protein Accession:
    Q16539
    Secondary Accessions:
    • A6ZJ92
    • A8K6P4
    • B0LPH0
    • B5TY32
    • O60776
    • Q13083
    • Q14084
    • Q8TDX0

    Protein attributes for MAPK14 Gene

    Size:
    360 amino acids
    Molecular mass:
    41293 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B.

    Three dimensional structures from OCA and Proteopedia for MAPK14 Gene

    Alternative splice isoforms for MAPK14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK14 Gene

Proteomics data for MAPK14 Gene at MOPED

Post-translational modifications for MAPK14 Gene

  • Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3.
  • Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16.
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.
  • Ubiquitination at Lys15, Lys45, Lys139, Lys152, Lys165, and Lys233
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK14 Gene

Domains for MAPK14 Gene

Gene Families for MAPK14 Gene

Graphical View of Domain Structure for InterPro Entry

Q16539

UniProtKB/Swiss-Prot:

MK14_HUMAN :
  • Q16539
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK14: view

Function for MAPK14 Gene

Molecular function for MAPK14 Gene

GENATLAS Biochemistry: mitogen-activated protein kinase14
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1. Activation occurs through dual phosphorylation of Thr-180 and Tyr-182 by either of two dual specificity kinases, MAP2K3/MKK3 or MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1-mediated autophosphorylation. MAPK14 phosphorylated on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on Thr-180, whereas MAPK14 phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis, Tyr-182 may be required for auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an alternative activation pathway in response to TCR signaling in T-cells. This alternative pathway is inhibited by GADD45A. Inhibited by dual specificity phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6. SB203580 is an inhibitor of MAPK14.
UniProtKB/Swiss-Prot Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at Thr-113.

Enzyme Numbers (IUBMB) for MAPK14 Gene

Gene Ontology (GO) - Molecular Function for MAPK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004707 MAP kinase activity IDA 10330143
GO:0004708 MAP kinase kinase activity TAS 10706854
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with MAPK14: view
genes like me logo Genes that share phenotypes with MAPK14: view

Animal Models for MAPK14 Gene

MGI Knock Outs for MAPK14:

No data available for Transcription Factor Targeting and HOMER Transcription for MAPK14 Gene

Localization for MAPK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK14 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK14 Gene COMPARTMENTS Subcellular localization image for MAPK14 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 2
mitochondrion 2
plasma membrane 2
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MAPK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005623 cell --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MAPK14: view

Pathways for MAPK14 Gene

SuperPathways for MAPK14 Gene

Superpath Contained pathways
1 IL-2 Pathway
2 MAPK targets/ Nuclear events mediated by MAP kinases
3 NOD-like Receptor Signaling Pathways
4 4-1BB Pathway
5 Toll Like Receptor 7/8 (TLR7/8) Cascade
genes like me logo Genes that share pathways with MAPK14: view

Pathways by source for MAPK14 Gene

Gene Ontology (GO) - Biological Process for MAPK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IEA --
GO:0000165 MAPK cascade --
GO:0000187 activation of MAPK activity TAS --
GO:0000902 cell morphogenesis IEA --
GO:0001502 cartilage condensation IEA --
genes like me logo Genes that share ontologies with MAPK14: view

Compounds for MAPK14 Gene

(10) ApexBio Compounds for MAPK14 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) Cell pemeable p38 MAP Kinase Inhibitor [285983-48-4]
LY2228820 Potent and ATP-competitive p38 MAP kinase inhibitor [862507-23-1]
PD 169316 p38 MAPK inhibitor [152121-53-4]
PH-797804 Potent and selective p38 MAP kinase inhibitor [586379-66-0]
SB 203580 Cell permeable, reversible, and ATP-competitive p38 MAP kinase inhibitor [152121-47-6]
SB202190 (FHPI) highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. [152121-30-7]
Skepinone-L selective p38 mitogen-activated protein kinase inhibitor. [1221485-83-1]
TAK-715 inhibitor of p38 MAPK [303162-79-0]
VX-702 P38 MAPK inhibitor [479543-46-9]
VX-745 highly potent and selective p38alpha inhibitor [209410-46-8]

(5) Tocris Compounds for MAPK14 Gene

Compound Action Cas Number
SB 202190 Potent, selective inhibitor of p38 MAPK [152121-30-7]
SB 203580 Selective inhibitor of p38 MAPK [152121-47-6]
SB 203580 hydrochloride Selective inhibitor of p38 MAPK; water-soluble [869185-85-3]
SB 239063 Potent, selective p38 MAPK inhibitor; orally active [193551-21-2]
SCIO 469 hydrochloride Selective p38 MAPK inhibitor [309913-83-5]

(3) HMDB Compounds for MAPK14 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(140) Novoseek inferred chemical compound relationships for MAPK14 Gene

Compound -log(P) Hits PubMed IDs
sb 203580 97.5 143
sp 600125 90 65
pd 98,059 90 101
pyridinylimidazole 87.2 35
pd 169316 87 35
genes like me logo Genes that share compounds with MAPK14: view

Transcripts for MAPK14 Gene

Unigene Clusters for MAPK14 Gene

Mitogen-activated protein kinase 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK14 Gene

No ASD Table

Relevant External Links for MAPK14 Gene

GeneLoc Exon Structure for
MAPK14
ECgene alternative splicing isoforms for
MAPK14

Expression for MAPK14 Gene

mRNA expression in normal human tissues for MAPK14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK14 Gene

This gene is overexpressed in Whole Blood (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK14 Gene

SOURCE GeneReport for Unigene cluster for MAPK14 Gene Hs.485233

mRNA Expression by UniProt/SwissProt for MAPK14 Gene

Q16539-MK14_HUMAN
Tissue specificity: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney
genes like me logo Genes that share expressions with MAPK14: view

Orthologs for MAPK14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK14 35
  • 99.72 (n)
  • 100 (a)
MAPK14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK14 35
  • 95.28 (n)
  • 100 (a)
MAPK14 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK14 35
  • 92.31 (n)
  • 95.83 (a)
MAPK14 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk14 35
  • 90 (n)
  • 99.44 (a)
Mapk14 16
Mapk14 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK14 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK14 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk14 35
  • 90 (n)
  • 99.17 (a)
chicken
(Gallus gallus)
Aves MAPK14 35
  • 82.04 (n)
  • 92.5 (a)
MAPK14 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK14 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mapk14a-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk14 35
  • 75.67 (n)
  • 86.63 (a)
Str.15151 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
mapk14a 35
  • 77.69 (n)
  • 89.44 (a)
mapk14a 36
  • 89 (a)
OneToMany
mapk14b 36
  • 92 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012148 35
  • 63.95 (n)
  • 69.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mpk2 36
  • 66 (a)
ManyToMany
p38b 35
  • 64.19 (n)
  • 70 (a)
p38b 36
  • 68 (a)
ManyToMany
p38c 36
  • 44 (a)
ManyToMany
Mpk2 37
  • 68 (a)
p38b 37
  • 69 (a)
p38c 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea pmk-1 35
  • 60.11 (n)
  • 64.04 (a)
pmk-1 36
  • 60 (a)
ManyToMany
pmk-2 36
  • 48 (a)
ManyToMany
Y51B9A.9 37
  • 34 (a)
pmk-3 37
  • 43 (a)
C49C3.10a 37
  • 32 (a)
F09C12.2 37
  • 41 (a)
pmk-1 37
  • 65 (a)
C49C3.10b 37
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR048C 35
  • 56.18 (n)
  • 53.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 35
  • 56.15 (n)
  • 53.57 (a)
HOG1 36
  • 42 (a)
OneToMany
HOG1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20053g 35
  • 53.57 (n)
  • 52.79 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK3 35
  • 54 (n)
  • 46.49 (a)
rice
(Oryza sativa)
Liliopsida Os03g0285800 35
  • 53.21 (n)
  • 47.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07024 35
  • 54.86 (n)
  • 52.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sty1 35
  • 55.85 (n)
  • 55.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6890 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for MAPK14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK14 Gene

ENSEMBL:
Gene Tree for MAPK14 (if available)
TreeFam:
Gene Tree for MAPK14 (if available)

Paralogs for MAPK14 Gene

Paralogs for MAPK14 Gene

genes like me logo Genes that share paralogs with MAPK14: view

Variants for MAPK14 Gene

Sequence variations from dbSNP and Humsavar for MAPK14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs8510 -- 36,110,403(+) ATCCT(C/T)ACCAT utr-variant-3-prime
rs140718 -- 36,036,544(-) GTGAA(-/GC)TTGCT intron-variant
rs603869 -- 36,031,675(-) gtaat(C/T)tcagc intron-variant
rs620491 -- 36,036,828(-) gggag(A/G)tggag intron-variant
rs620493 -- 36,036,822(-) tggag(G/T)gtgca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK14 Gene

Variant ID Type Subtype PubMed ID
nsv528432 CNV Gain 19592680
esv269948 CNV Insertion 20981092
esv2731916 CNV Deletion 23290073
esv2399081 CNV Deletion 18987734
esv2731919 CNV Deletion 23290073

Relevant External Links for MAPK14 Gene

HapMap Linkage Disequilibrium report
MAPK14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK14 Gene

Disorders for MAPK14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MAPK14 Gene including...

Search for MAPK14 Gene in MalaCards »

(4) University of Copenhagen DISEASES for MAPK14 Gene

(94) Novoseek inferred disease relationships for MAPK14 Gene

Disease -log(P) Hits PubMed IDs
necrosis 74.1 105
inflammation 68.4 66
tumors 61 104
shock 55.9 71
rheumatoid arthritis 46.7 24

Relevant External Links for MAPK14

Genetic Association Database (GAD)
MAPK14
Human Genome Epidemiology (HuGE) Navigator
MAPK14
genes like me logo Genes that share disorders with MAPK14: view

No data available for UniProtKB/Swiss-Prot for MAPK14 Gene

Publications for MAPK14 Gene

  1. Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2. (PMID: 10838079) Sanz V. … Crespo P. (FEBS Lett. 2000) 3 4 23
  2. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. (PMID: 7535770) Raingeaud J. … Davis R.J. (J. Biol. Chem. 1995) 3 4 23
  3. Molecular cloning of human p38 MAP kinase. (PMID: 7696354) Han J. … Ulevitch R.J. (Biochim. Biophys. Acta 1995) 3 4 23
  4. Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase. (PMID: 10747897) Sayed M. … Pelech S.L. (J. Biol. Chem. 2000) 3 4 23
  5. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. (PMID: 11847341) Ge B. … Han J. (Science 2002) 3 4 23

Products for MAPK14 Gene

Sources for MAPK14 Gene

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