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Aliases for CRYZ Gene

Aliases for CRYZ Gene

  • Crystallin Zeta 2 3 5
  • EC 1.6.5.5 4 63
  • Crystallin, Zeta (Quinone Reductase) 2
  • NADPH:Quinone Reductase 4
  • Zeta-Crystallin 4

External Ids for CRYZ Gene

Previous GeneCards Identifiers for CRYZ Gene

  • GC01M075290
  • GC01M074149
  • GC01M074533
  • GC01M074541
  • GC01M074883
  • GC01M074943
  • GC01M075171
  • GC01M073305

Summaries for CRYZ Gene

Entrez Gene Summary for CRYZ Gene

  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

GeneCards Summary for CRYZ Gene

CRYZ (Crystallin Zeta) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and mRNA 3-UTR binding. An important paralog of this gene is ZADH2.

UniProtKB/Swiss-Prot for CRYZ Gene

  • Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.

Gene Wiki entry for CRYZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYZ Gene

Genomics for CRYZ Gene

Regulatory Elements for CRYZ Gene

Enhancers for CRYZ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRYZ on UCSC Golden Path with GeneCards custom track

Promoters for CRYZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRYZ on UCSC Golden Path with GeneCards custom track

Genomic Location for CRYZ Gene

Chromosome:
1
Start:
74,705,482 bp from pter
End:
74,733,408 bp from pter
Size:
27,927 bases
Orientation:
Minus strand

Genomic View for CRYZ Gene

Genes around CRYZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYZ Gene

Proteins for CRYZ Gene

  • Protein details for CRYZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08257-QOR_HUMAN
    Recommended name:
    Quinone oxidoreductase
    Protein Accession:
    Q08257
    Secondary Accessions:
    • A6NN60
    • D3DQ76
    • Q53FT0
    • Q59EU7
    • Q5HYE7
    • Q6NSK9

    Protein attributes for CRYZ Gene

    Size:
    329 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for CRYZ Gene

    Alternative splice isoforms for CRYZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRYZ Gene

Proteomics data for CRYZ Gene at MOPED

Selected DME Specific Peptides for CRYZ Gene

Post-translational modifications for CRYZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CRYZ Gene

Suggested Antigen Peptide Sequences for CRYZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08257

UniProtKB/Swiss-Prot:

QOR_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with CRYZ: view

No data available for Gene Families for CRYZ Gene

Function for CRYZ Gene

Molecular function for CRYZ Gene

GENATLAS Biochemistry:
crystallin,zeta polypeptide (quinone reductase)
UniProtKB/Swiss-Prot CatalyticActivity:
NADPH + 2 quinone = NADP(+) + 2 semiquinone.
UniProtKB/Swiss-Prot Function:
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.

Enzyme Numbers (IUBMB) for CRYZ Gene

Gene Ontology (GO) - Molecular Function for CRYZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003960 NADPH:quinone reductase activity IDA 17497241
genes like me logo Genes that share ontologies with CRYZ: view
genes like me logo Genes that share phenotypes with CRYZ: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CRYZ

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYZ Gene

Localization for CRYZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRYZ Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRYZ Gene COMPARTMENTS Subcellular localization image for CRYZ gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
golgi apparatus 2
mitochondrion 2
chloroplast 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CRYZ Gene

Pathways & Interactions for CRYZ Gene

SuperPathways for CRYZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRYZ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRYZ Gene

Drugs & Compounds for CRYZ Gene

(2) Drugs for CRYZ Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dicumarol Approved Pharma Target, inhibitor 0
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0

(3) Additional Compounds for CRYZ Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Quinone
  • 1,4-Benzoquine
  • 1,4-Benzoquinone
  • 1,4-Cyclohexadiene dioxide
  • 1,4-Cyclohexadienedione
  • 1,4-Diossibenzene
106-51-4
genes like me logo Genes that share compounds with CRYZ: view

Transcripts for CRYZ Gene

Unigene Clusters for CRYZ Gene

Crystallin, zeta (quinone reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRYZ Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - -
SP9: - - -
SP10:
SP11: - - -
SP12: - - -
SP13:

Relevant External Links for CRYZ Gene

GeneLoc Exon Structure for
CRYZ
ECgene alternative splicing isoforms for
CRYZ

Expression for CRYZ Gene

mRNA expression in normal human tissues for CRYZ Gene

mRNA differential expression in normal tissues according to GTEx for CRYZ Gene

This gene is overexpressed in Liver (x5.9) and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for CRYZ Gene

This gene is overexpressed in Liver, secretome (13.8) and Kidney (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRYZ Gene



SOURCE GeneReport for Unigene cluster for CRYZ Gene Hs.83114

mRNA Expression by UniProt/SwissProt for CRYZ Gene

Q08257-QOR_HUMAN
Tissue specificity: Only very low amounts in the lens.
genes like me logo Genes that share expression patterns with CRYZ: view

Protein tissue co-expression partners for CRYZ Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CRYZ Gene

Orthologs for CRYZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CRYZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRYZ 35
  • 88.35 (n)
  • 87.54 (a)
CRYZ 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRYZ 35
  • 86.32 (n)
  • 86.63 (a)
-- 36
  • 77 (a)
OneToMany
CRYZ 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cryz 35
  • 79.03 (n)
  • 81.16 (a)
Cryz 16
Cryz 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRYZ 35
  • 98.38 (n)
  • 99.09 (a)
CRYZ 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cryz 35
  • 78.12 (n)
  • 80.85 (a)
oppossum
(Monodelphis domestica)
Mammalia CRYZ 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves CRYZ 35
  • 67.89 (n)
  • 70.03 (a)
CRYZ 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRYZ 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cryz 35
  • 67.17 (n)
  • 67.48 (a)
Str.8276 35
zebrafish
(Danio rerio)
Actinopterygii cryz 35
  • 65.54 (n)
  • 68.31 (a)
Dr.14514 35
cryz 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5597 35
worm
(Caenorhabditis elegans)
Secernentea F39B2.3 37
  • 41 (a)
F39B2.3 35
  • 50.8 (n)
  • 43.13 (a)
F39B2.3 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 36
  • 25 (a)
OneToMany
-- 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.728 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1760 36
  • 50 (a)
OneToOne
Species with no ortholog for CRYZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRYZ Gene

ENSEMBL:
Gene Tree for CRYZ (if available)
TreeFam:
Gene Tree for CRYZ (if available)

Paralogs for CRYZ Gene

Paralogs for CRYZ Gene

(4) SIMAP similar genes for CRYZ Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CRYZ Gene

genes like me logo Genes that share paralogs with CRYZ: view

Variants for CRYZ Gene

Sequence variations from dbSNP and Humsavar for CRYZ Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11551729 - 74,723,186(-) TCTTA(C/T)CCTAT reference, missense, utr-variant-5-prime
rs3819946 - 74,710,202(+) CAAAA(C/T)CTTTA reference, missense
rs17095822 - 74,710,181(+) TTCCT(C/T)AGTAC reference, missense
rs6673 -- 74,705,527(-) TGTCT(C/G/T)GTAAC utr-variant-3-prime
rs17459 -- 74,706,067(+) ACATG(C/T)TATTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CRYZ Gene

Variant ID Type Subtype PubMed ID
nsv830259 CNV Gain 17160897
nsv871152 CNV Gain 21882294
esv2662359 CNV Deletion 23128226
esv2668367 CNV Deletion 23128226
nsv509346 CNV Insertion 20534489
nsv1422 CNV Insertion 18451855
esv21668 CNV Gain 19812545

Variation tolerance for CRYZ Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.06; 92.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYZ Gene

HapMap Linkage Disequilibrium report
CRYZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYZ Gene

Disorders for CRYZ Gene

Relevant External Links for CRYZ

Genetic Association Database (GAD)
CRYZ
Human Genome Epidemiology (HuGE) Navigator
CRYZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRYZ

No disorders were found for CRYZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYZ Gene

Publications for CRYZ Gene

  1. Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). (PMID: 8088825) Gonzalez P. … Zigler J.S. Jr. (Genomics 1994) 3 4 23 67
  2. Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation. (PMID: 17305492) Hao H. … Ding Z. (Curr. Drug Metab. 2007) 25 26
  3. The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol. (PMID: 16700548) Asher G. … Shaul Y. (Biochemistry 2006) 25 26
  4. Duroquinone reduction during passage through the pulmonary circulation. (PMID: 12882764) Audi S.H. … Merker M.P. (Am. J. Physiol. Lung Cell Mol. Physiol. 2003) 25 26
  5. Decreased intracellular proteolysis correlates with the maintenance of a specific isoenzyme of cytochrome P-450. (PMID: 10561120) Evans P.J. (Cell Biol. Int. 1999) 25 26

Products for CRYZ Gene

Sources for CRYZ Gene

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