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Aliases for CRYGD Gene

Aliases for CRYGD Gene

  • Crystallin, Gamma D 2 3
  • Gamma-Crystallin 4 3 4
  • Gamma-D-Crystallin 3 4
  • CRYG4 3 4
  • Gamma Crystallin 4 3
  • Cry-G-D 3
  • CTRCT4 3
  • CACA 3
  • CCA3 3
  • CCP 3
  • PCC 3

External Ids for CRYGD Gene

Previous HGNC Symbols for CRYGD Gene

  • CRYG4

Previous GeneCards Identifiers for CRYGD Gene

  • GC02M207153
  • GC02M207698
  • GC02M208950
  • GC02M209189
  • GC02M209190
  • GC02M208811
  • GC02M208694
  • GC02M208986
  • GC02M200834

Summaries for CRYGD Gene

Entrez Gene Summary for CRYGD Gene

  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYGD Gene

CRYGD (Crystallin, Gamma D) is a Protein Coding gene. Diseases associated with CRYGD include coralliform cataract and cataract 4, multiple types. GO annotations related to this gene include structural constituent of eye lens. An important paralog of this gene is CRYGC.

UniProtKB/Swiss-Prot for CRYGD Gene

  • Crystallins are the dominant structural components of the vertebrate eye lens

Gene Wiki entry for CRYGD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGD Gene

Genomics for CRYGD Gene

Regulatory Elements for CRYGD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRYGD Gene

208,121,607 bp from pter
208,124,589 bp from pter
2,983 bases
Minus strand

Genomic View for CRYGD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRYGD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGD Gene

Proteins for CRYGD Gene

  • Protein details for CRYGD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-crystallin D
    Protein Accession:
    Secondary Accessions:
    • Q17RF7
    • Q53R51
    • Q99681

    Protein attributes for CRYGD Gene

    174 amino acids
    Molecular mass:
    20738 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CRYGD Gene

neXtProt entry for CRYGD Gene

Proteomics data for CRYGD Gene at MOPED

Post-translational modifications for CRYGD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYGD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CRYGD Gene

Domains & Families for CRYGD Gene

Protein Domains for CRYGD Gene

Suggested Antigen Peptide Sequences for CRYGD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Has a two-domain beta-structure, folded into four very similar Greek key motifs
  • Belongs to the beta/gamma-crystallin family.
  • Has a two-domain beta-structure, folded into four very similar Greek key motifs
  • Contains 4 beta/gamma crystallin Greek key domains.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYGD: view

No data available for Gene Families for CRYGD Gene

Function for CRYGD Gene

Molecular function for CRYGD Gene

GENATLAS Biochemistry:
crystallin,gamma polypeptide D
UniProtKB/Swiss-Prot Function:
Crystallins are the dominant structural components of the vertebrate eye lens

Gene Ontology (GO) - Molecular Function for CRYGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens NAS 12507494
GO:0005515 protein binding IPI 8943244
genes like me logo Genes that share ontologies with CRYGD: view
genes like me logo Genes that share phenotypes with CRYGD: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRYGD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRYGD Gene

Localization for CRYGD Gene

Subcellular locations from

Jensen Localization Image for CRYGD Gene COMPARTMENTS Subcellular localization image for CRYGD gene
Compartment Confidence
nucleus 4
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CRYGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with CRYGD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRYGD Gene

Pathways & Interactions for CRYGD Gene

SuperPathways for CRYGD Gene

No Data Available

Interacting Proteins for CRYGD Gene

Gene Ontology (GO) - Biological Process for CRYGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002088 lens development in camera-type eye ISS --
GO:0007601 visual perception IMP 9927684
GO:0034614 cellular response to reactive oxygen species IDA 8943244
GO:0070306 lens fiber cell differentiation ISS --
genes like me logo Genes that share ontologies with CRYGD: view

No data available for Pathways by source and SIGNOR curated interactions for CRYGD Gene

Drugs & Compounds for CRYGD Gene

(2) Drugs for CRYGD Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
proline Nutra 20
threonine Nutra 16
genes like me logo Genes that share compounds with CRYGD: view

Transcripts for CRYGD Gene

mRNA/cDNA for CRYGD Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYGD Gene

Crystallin, gamma D:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRYGD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGD Gene

No ASD Table

Relevant External Links for CRYGD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYGD Gene

mRNA expression in normal human tissues for CRYGD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGD Gene

This gene is overexpressed in Ovary (x12.2), Brain - Amygdala (x5.2), Brain - Hypothalamus (x4.8), and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for CRYGD Gene

This gene is overexpressed in Vitreous humor (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRYGD Gene

SOURCE GeneReport for Unigene cluster for CRYGD Gene Hs.546247

genes like me logo Genes that share expression patterns with CRYGD: view

Protein tissue co-expression partners for CRYGD Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CRYGD Gene

Orthologs for CRYGD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGD Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CRYGD 35
  • 88.44 (n)
  • 85.55 (a)
  • 85 (a)
(Mus musculus)
Mammalia Crygd 35
  • 88.63 (n)
  • 84.97 (a)
Crygd 16
Crygd 36
  • 84 (a)
Cryge 36
  • 80 (a)
Crygf 36
  • 79 (a)
(Pan troglodytes)
Mammalia CRYGD 35
  • 99.62 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Crygd 35
  • 88.44 (n)
  • 85.55 (a)
(Bos Taurus)
Mammalia CRYGD 36
  • 86 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
-- 36
  • 69 (a)
-- 36
  • 70 (a)
-- 36
  • 70 (a)
-- 36
  • 76 (a)
-- 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 62 (a)
(Danio rerio)
Actinopterygii crygmxl1 35
  • 64.52 (n)
  • 60.82 (a)
Dr.18937 35
si:dkey-57a22.15 36
  • 60 (a)
Species with no ortholog for CRYGD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGD Gene

Gene Tree for CRYGD (if available)
Gene Tree for CRYGD (if available)

Paralogs for CRYGD Gene

(16) SIMAP similar genes for CRYGD Gene using alignment to 1 proteins: Pseudogenes for CRYGD Gene

genes like me logo Genes that share paralogs with CRYGD: view

Variants for CRYGD Gene

Sequence variations from dbSNP and Humsavar for CRYGD Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_010733 Cataract 4, multiple types (CTRCT4)
VAR_010734 Cataract 4, multiple types (CTRCT4)
VAR_010735 Cataract 4, multiple types (CTRCT4)
VAR_021145 Cataract 4, multiple types (CTRCT4)
VAR_021146 -

Structural Variations from Database of Genomic Variants (DGV) for CRYGD Gene

Variant ID Type Subtype PubMed ID
nsv875744 CNV Loss 21882294
nsv508882 CNV Insertion 20534489
dgv4417n71 CNV Loss 21882294

Variation tolerance for CRYGD Gene

Residual Variation Intolerance Score: 77.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRYGD Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYGD Gene

Disorders for CRYGD Gene

MalaCards: The human disease database

(12) MalaCards diseases for CRYGD Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
coralliform cataract
cataract 4, multiple types
  • aculeiform cataract
cataract, autosomal dominant congenital 4
  • cataract 4, multiple types
cerulean cataract
  • cataract, congenital, blue dot type 1
cataract 2, multiple types
  • cataract 2, multiple types, with or without microcornea
- elite association
Search CRYGD in MalaCards View complete list of genes associated with diseases


  • Cataract 4, multiple types (CTRCT4) [MIM:115700]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT4 includes crystalline aculeiform, congenital cerulean and non-nuclear polymorphic cataracts, among others. Crystalline aculeiform cataract is characterized by fiberglass-like or needle-like crystals projecting in different directions, through or close to the axial region of the lens. Non-nuclear polymorphic cataract is a partial opacity with variable location between the fetal nucleus of the lens and the equator. The fetal nucleus is normal. The opacities are irregular and look similar to a bunch of grapes and may be present simultaneously in different lens layers. Congenital cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract. {ECO:0000269 PubMed:10521291, ECO:0000269 PubMed:10915766, ECO:0000269 PubMed:12011157, ECO:0000269 PubMed:12676897, ECO:0000269 PubMed:16943771, ECO:0000269 PubMed:17564961, ECO:0000269 PubMed:21031598, ECO:0000269 PubMed:9927684}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CRYGD

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRYGD: view

No data available for Genatlas for CRYGD Gene

Publications for CRYGD Gene

  1. [Progress in pathogenic genes and their functions of congenital cataract]. (PMID: 20450675) Wang K.J. … Cheng J. (Zhonghua Yan Ke Za Zhi 2010) 23 67
  2. A novel human CRYGD mutation in a juvenile autosomal dominant cataract. (PMID: 20508808) Roshan M. … Satyamoorthy K. (Mol. Vis. 2010) 23 67
  3. The cataract-associated R14C mutant of human gamma D-crystallin shows a variety of intermolecular disulfide cross-links: a Raman spectroscopic study. (PMID: 19382745) Pande A. … Pande J. (Biochemistry 2009) 23 67
  4. Mutation analysis of CRYAA, CRYGC, and CRYGD associated with autosomal dominant congenital cataract in Brazilian families. (PMID: 19390652) Santana A. … Barbosa de Melo M. (Mol. Vis. 2009) 23 67
  5. NMR study of the cataract-linked P23T mutant of human gammaD-crystallin shows minor changes in hydrophobic patches that reflect its retrograde solubility. (PMID: 19275895) Pande A. … Pande J. (Biochem. Biophys. Res. Commun. 2009) 23 67

Products for CRYGD Gene

Sources for CRYGD Gene

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